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| 1 | Endoscopic findings in patients with Schatzki rings:Evidence for an association with eosinophilic esophagitis显示文摘AIM:To investigate endoscopic findings in patients with Schatzki rings(SRs) with a focus on evidence for eosinophilic esophagitis(EoE).METHODS:We consecutively approached all adult patients scheduled for elective outpatient upper endoscopy for a variety of indications at the German Diagnostic Clinic,Wiesbaden,Germany between July 2007 and July 2010.All patients with endoscopically diagnosed SRs,defined as thin,symmetrical,mucosal structures located at the esophagogastric junction,were prospectively registered.Additional endoscopic findings,clinical information and histopathological findings with a focus on esophageal eosinophilia(≥ 20 eosinophils/high power field) were recorded.The criteria for active EoE were defined as:(1) eosinophilic tissue infiltration ≥ 20 eosinophils/hpf;(2) symptoms of esophageal dysfunction;and(3) exclusion of other causes of esophageal eosinophilia.Gastroesophageal reflux disease was excluded by proton pump inhibitor treatment prior to endoscopy.The presence of ≥ 20 eosinophils/hpf in esophageal biopsies in patients that did not fulfil the criteria of EoE was defined as esophageal hypereosinophilia.RESULTS:A SR was diagnosed in 171(3.3%;128 males,43 females,mean age 66 ± 12.9 years) of the 5163 patients that underwent upper gastrointestinalendoscopy.Twenty of the 116 patients(17%) from whom esophageal biopsies were obtained showed histological hypereosinophilia(≥ 20 eosinophils/hpf).Nine of these patients(8 males,1 female,mean age 49 ± 10 years) did not fulfill all diagnostic criteria of EoE,whereas in 11(9%) patients with ≥ 20 eosinophils/hpf,a definite diagnosis of EoE was made.Three of the 11 patients(27%) with definite EoE had no suspicious endoscopic features of EoE.In contrast,in the 25 patients in whom EoE was suspected by endoscopic features,EoE was only confirmed in 7(28%) patients.Patients with EoE were younger(mean age 41.5 ± 6.5 vs 50.5 ± 11.5 years,P = 0.012),were more likely to have a history of allergies(73% vs 29%,P = 0.007) and complained more often of dysphagia(91% vs 34%,P = 0.004) and food impaction(36% vs 6%,P = 0.007) than patients without EoE.Endoscopically,additional webs were found significantly more often in patients with EoE than in patients without EoE(36% vs 11%,P = 0.04).Furthermore,the SR had a tendency to be narrower in patients with EoE than in those without EoE(36% vs 18%,P = 0.22).The percentage of males(73% vs 72%,P = 1.0) and frequency of heartburn(27% vs 27%,P = 1.0) were not significantly different in both groups.The 9 patients with esophageal hypereosinophilia that did not fulfil the diagnostic criteria of EoE were younger(mean age 49 ± 10 years vs 58 ± 6 years,P = 0.0008) and were more likely to have a history of allergies(78% vs 24%,P = 0.003) than patients with < 20 eosinophils/hpf.Predictors of EoE were younger age,presence of dysphagia or food impaction and a history of allergies.CONCLUSION:A significant proportion of patients with SRs also have EoE,which may not always be suspected according to other endoscopic features. | Michaela Müller Alexander J Eckardt Annette Fisseler-Eckhoff Susanne Haas Ines Gockel Till Wehrmann | 2012 | World Journal of Gastroenterology2012，18，47： | 2 |
| 2 | Pathogenesis of chronic renal failure in the primary glomerulopathies,renal vasculopathies,and chronic interstitial nephritides 显示文摘 | Bohle A Muller GA Wehrmann M | 1996 | Kidney Int1996，49，154： | 1 |
| 3 | Giant Mullerian duct cyst with malignant transformation in 15-year-old boy显示文摘 | Warmann SW Vogel M Wehrmann M | 2006 | Urolo- gy2006，67，2： | 1 |
| 4 | Significance of postglomerular capillaries in the pathogenesis of chronic renal failure显示文摘 | Bohle A Mackensen-Haen S Wehrmann M | 1996 | Kidney Blood Press Res1996，19，34： | 1 |
| 5 | Significance of postglomerular capillaries in the pathogenesis of chronic renal failure显示文摘 | BOLHE A MACKENSEN-HAEN S WEHRMANN M | 1996 | Kidney Blood Press Res1996，19，34： | 1 |
| 6 | The long term prognosis of the primary glomerulonephritides 显示文摘 | Bohle A Wehrmann M Bogenschutz O | 1992 | Pathol Res Pract1992，188，7： | 1 |
| 7 | Endoscopic sedation and monitoring practice in Germany:results from the first nationwide survey显示文摘 | Riphaus A Rabofski M Wehrmann T | | 0，，03： | 1 |
| 8 | Endoscopic sedation and monitoring practice in Germany: results from the first nationwide survey 显示文摘 | Riphaus A Rabofski M Wehrmann T | 2010 | Z Gastroentero12010，48，3： | 1 |
| 9 | Differential cytokine activity andmorphology during wound healing in the neomatal and adult ratskin显示文摘 | WAGNER W WEHRMANN M | 2007 | J Cell Mol Med2007，11，6： | 1 |
| 10 | Pathogenesis of Chronic Renal Failure in Primary Glomerulopathies显示文摘 | Bohle A Wehrmann M Maekensen-Haen S | 1994 | Nephrol Dial Transplant1994，9，： | 1 |
| 11 | Carbon dioxide, hypoxia and low pH lead to overexpression of c-myc and HMGB-1 oncogenes in neuroblastoma cells显示文摘 | REISMANN M WEHRMANN F SCHUKFEH N e al | 2009 | Eur J Pedi- air Surg2009，19，4： | 1 |
| 12 | A Functioning adrenocortical hemangioma显示文摘 | Slumvoll M Fritsche A Wehrmann M | 1996 | J Urol1996，155，2： | 1 |
| 13 | Differential eytokine activity and mor- phology during wound healiny in the neonatal and adult rat skin 显示文摘 | Wagner W Wehrmann M | 2007 | J Cell Mol Med2007，11，6： | 1 |
| 14 | Pathogenesis of chronic renal failure in the primary glomerulopathies,renal vasculopathies,and chronic interstitial nephritides显示文摘 | Bohle A Muller GA Wehrmann M | 1996 | Kidney Int1996，54，： | 1 |
| 15 | Unique authigenic min- eral assemblages reveal different diagenetic histories in two neighbour- ing cold-water coral mounds on Pen Duick Escarpment, Gulf of Cadiz 显示文摘 | Pirlet H Wehrmann L M Foubert A | 2012 | Sedimentology2012，59，： | 1 |
| 16 | Long-term prognosis of chronicd idiopathic membranous glomerulonephritis显示文摘 | Wehrmann M Bohle A Bogenschutz O | 1989 | Clin Nephrol1989，31，： | 1 |
| 17 | Immunophenotyping of acute lymphoblastic leukaemia in routinely processed bone marrow biopsy specimens显示文摘 | Toth B Wehrmann M Kaiserling E | 1999 | J Clin Pathol1999，52，9： | 1 |
| 18 | Cholangiocytes as immune modulators in rotavirus-induced murine biliary atresia显示文摘 | BARNES B H TUCKER R M WEHRMANN F | 2009 | Liver Int2009，29，8： | 1 |
| 19 | Differential eytokine activity and morpholo-gy during wound healing in the neonatal and adult rat skin显示文摘 | Wagner W Wehrmann M | 2007 | J CellMol Med2007，11，6： | 1 |
| 20 | Long-term prognosis of chronic idiopathic membranous glomerulonephritis显示文摘 | Wehrmann M Bohle A Bogenschutz O | 1989 | Clin Nephrol1989，31，： | 1 |
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