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| 1 | In vivo self-assembled small RNAs as a new generation of RNAi therapeutics显示文摘RNAi therapy has undergone two stages of development,direct injection of synthetic siRNAs and delivery with artificial vehicles or conjugated ligands;both have not solved the problem of efficient in vivo siRNA delivery.Here,we present a proof-of-principle strategy that reprogrammes host liver with genetic circuits to direct the synthesis and self-assembly of siRNAs into secretory exosomes and facilitate the in vivo delivery of siRNAs through circulating exosomes.By combination of different genetic circuit modules,in vivo assembled siRNAs are systematically distributed to multiple tissues or targeted to specific tissues(e.g.,brain),inducing potent target gene silencing in these tissues.The therapeutic value of our strategy is demonstrated by programmed silencing of critical targets associated with various diseases,including EGFR/KRAS in lung cancer,EGFR/TNC in glioblastoma and PTP1B in obesity.Overall,our strategy represents a next generation RNAi therapeutics,which makes RNAi therapy feasible. | Zheng Fu Xiang Zhang Xinyan Zhou Uzair Ur-Rehman Mengchao Yu Hongwei Liang Hongyuan Guo Xu Guo Yan Kong Yuanyuan Su Yangyang Ye Xiuting Hu Wei Cheng Jinrong Wu Yanbo Wang Yayun Gu Sheng-feng Lu Dianqing Wu Ke Zen Jing Li Chao Yan Chen-Yu Zhang Xi Chen | 2021 | Cell Research2021，31，6： | 10 |
| 2 | Targeting a novel inducible GPX4 alternative isoform to alleviate ferroptosis and treat metabolic-associated fatty liver disease显示文摘Metabolic-associated fatty liver disease(MAFLD),which is previously known as non-alcoholic fatty liver disease(NAFLD),represents a major health concern worldwide with limited therapy.Here,we provide evidence that ferroptosis,a novel form of regulated cell death characterized by iron-driven lipid peroxidation,was comprehensively activated in liver tissues from MAFLD patients.The canonical-GPX4(cGPX4),which is the most important negative controller of ferroptosis,is downregulated at protein but not mRNA level.Interestingly,a non-canonical GPX4 transcript-variant is induced(inducible-GPX4,iGPX4)in MAFLD condition.The high fat-fructose/sucrose diet(HFFD)and methionine/choline-deficient diet(MCD)-induced MAFLD pathologies,including hepatocellular ballooning,steatohepatitis andfibrosis,were attenuated and aggravated,respectively,in cGPX4-and iGPX4-knockin mice.cGPX4 and iGPX4 isoforms also displayed opposing effects on oxidative stress and ferroptosis in hepatocytes.Knockdown of iGPX4 by siRNA alleviated lipid stress,ferroptosis and cell injury.Mechanistically,the triggered iGPX4 interacts with cGPX4 to facilitate the transformation of cGPX4 from enzymatic-active monomer to enzymatic-inactive oligomers upon lipid stress,and thus promotes ferroptosis.Co-immunoprecipitation and nano LC–MS/MS analyses confirmed the interaction between iGPX4 and cGPX4.Our results reveal a detrimental role of non-canonical GPX4 isoform in ferroptosis,and indicate selectively targeting iGPX4 may be a promising therapeutic strategy for MAFLD. | Jie Tong Dongjie Li Hongbo Meng Diyang Sun Xiuting Lan Min Ni Jiawei Ma Feiyan Zeng Sijia Sun Jiangtao Fu Guoqiang Li Qingxin Ji Guoyan Zhang Qirui Shen Yuanyuan Wang Jiahui Zhu Yi Zhao Xujie Wang Yi Liu Shenxi Ouyang Chunquan Sheng Fuming Shen Pei Wang | 2022 | Acta Pharmaceutica Sinica B2022，12，9： | 3 |
| 3 | Development of two-port surface acoustic wave resonator with Al/Au electrodes for gas sensing显示文摘Simple and efficient surface acoustic wave(SAW)two-port resonators with low insertion loss and high Q-values on ST-X quartz substrate using a corrosion-proof A1/Au-stripe electrode structure are developed for gas sensing.It was composed of two shorted grating reflectors and adjacent intedigital transducers(IDT),and an active metal film in the cavity between the IDTs for the sensitive film coating.The devices are expected to provide good protection towards metal electrode for gas sensors application in chemically reactive environments.Excellent device performance as low insertion loss,high Q factor and single-mode are achieved by carefully selecting the metallic electrode thickness,cavity length and acoustic aperture.Prior to fabrication,the coupling of modes(COM)model was performed for device simulation to determine the optimal design parameters.The fabricated single-mode SAW resonator at operation frequency of 300 MHz range exhibits matched insertion loss of^6.5 dB and loaded Q factor in the 3000 range.Using the fabricated resonator as the feedback element,a dualresonator-oscillator with excellent frequency stability(0.1 ppm)was developed and evaluated experimentally,and it is significant for performance improvement of SAW gas sensor. | WANG Wen XIE Xiao SHAO Xiuting LIU Minghua HE Shitang | 2014 | Chinese Journal of Acoustics2014，33，1： | 3 |
| 4 | Towards an intelligent photonic system显示文摘The emerging intelligence technologies represented by deep learning have broadened their applications to various fields.Beyond the conventional electronics-based processing systems,the convergence of photonics and artificial intelligence(AI)technology enhances the performance and learning ability of AI.In this review,we propose the concept of an intelligent photonic system(IPS),illustrating it as a developing architecture with three different versions.For each version of IPS,we review several representative studies.Moreover we discuss the challenges towards an IPS and provide some prospects for the future development. | Weiwen ZOU Bowen MA Shaofu XU Xiuting ZOU Xingjun WANG | 2020 | Science China(Information Sciences)2020，63，6： | 3 |
| 5 | Effect of AAPH oxidation on digestion characteristics of seed watermelon(Citrullus lanatus var)kernels protein isolates显示文摘Seed watermelon kernel is a typical complex food with high fat and protein contents.During storage and processing,it is often affected by various factors to undergo interactions between components,which lead to its quality change.In this experiment,seed watermelon kernels were used as research objects,and the effects of 2-Azobis(2-amidinopropane)dihydrochloride(AAPH)on seed watermelon kernel protein isolates(WMP)were investigated.The structure and digestion characteristics of WMP after oxidation were studied.The results showed that with the increase of AAPH concentration(0.05−5 mol/L),WMP showed obvious aggregation,and its solubility decreased from 6.76 mg/mL to 9.59 mg/mL.The free sulfhydryl content of WMP was 18.24 mmol/g decreased to 11.25 mmol/g,α-helix decreased andβ-sheet decreased in secondary structure,and its disulfide bond increased by 43.06 mmol/g from 39.57 mmol/g,enthalpy(H)and denaturation temperature increased(Td)(P<0.05).By mass spectrometry results of simulated gastric digestion products,it was found that oxidation adversely affected the digestion characteristics of WMP.It can be seen that the lipid oxidation product APPH of seed watermelon kernel can significantly affect the structure and function of the protein extracted from the seed kernel. | Shugang Li Zhihao Li Xiuting Li Ping Wang Xiongwei Yu Qinli Fu Sihai Gao | 2020 | Food Science and Human Wellness2020，9，4： | 3 |
| 6 | Comparative Study on the Efficacies of 11 Chemical Agents against Taro Soft Rot Caused by Pectobacterium aroidearum显示文摘[Objective]The paper was to screen the effective agents for effectively controlling the occurrence and prevalence of taro soft rot.[Method]The fungicidal effects of 11 fungicides on taro soft rot were determined by inhibition zone method.[Result]0.3%Tetramycin,25%bromothalonil,3%Zhongshengmycin and 30%zinc thiazole had better antifungal effect on Pectobacterium aroidearum at recommended concentration.The indoor toxicity of four fungicides showed that the EC50 of 0.3%tetramycin AS was the smallest of 0.6μg/mL,indicating that tetramycin had the largest toxicity and the best inhibitory effect against P.aroidearum;followed by 25%bromothalonil EC and 3%Zhongshengmycin WP,with the EC_(50) of 2.57 and 97.72μg/mL,respectively;the inhibitory effect of 30%zinc thiazole SC against P.aroidearum was the poorest.[Conclusion]The study provides a reference for screening out new and efficient chemical agents against taro soft rot. | Dongkun Wang Xiuting Ji Huaixu Zhan Chengpeng Zheng Hao Zong Xiaolei Tan Xiuchun Du Weimin Wang Jingjing Wu Fenglong Wang Xiaoqiang Wang | 2021 | Plant Diseases and Pests2021，12，2： | 2 |
| 7 | Food Safety Risks and Contributing Factors of Cronobacter spp.显示文摘Cronobacter species are a group of Gram-negative opportunistic pathogens,which cause meningitis,sep-ticemia,and necrotizing enterocolitis in neonates and infants,with neurological sequelae in severe cases.Interest in Cronobacter has increased significantly in recent years due to its high virulence in children.In this review,we summarize the current understanding of the prevalence of Cronobacter species in several important food types.We discuss the response mechanisms enabling persistence in adverse growth con-ditions,as well as its pathogenicity.We emphasize the food safety concerns caused by Cronobacter and subsequent control methods and clinical treatments. | Na Ling Xiuting Jiang Stephen Forsythe Danfeng Zhang Yizhong Shen Yu Ding Juan Wang Jumei Zhang Qingping Wu Yingwang Ye | 2022 | Engineering2022，8，5： | 2 |
| 8 | An adaptive mutation--dissipation binary particle swarm optimizations for multidimensional knapsack problem 显示文摘 | Wang Ling Wang Xiuting Fei Minrui | 2009 | International Journal of Modelling Identification and Control2009，8，4： | 1 |
| 9 | A Novel Probability Binary Particle Swarm Optimization Algorithm and Its Application显示文摘 | Wang Ling Wang Xiuting Fu Jingqi | 2008 | Journal of Soft- ware2008，9，3： | 1 |
| 10 | Characterization of efficient aerobic denitrifiers isolated from two different sequencing batch reactors by 16S-rRNA analysis显示文摘 | Wang ping Li xiuting Xiang mufei | 2007 | Journal of Bioscience and Bioengingeering2007，103，6： | 1 |
| 11 | A near-complete genome assembly of the allotetrapolyploid Cenchrus fungigraminus(JUJUNCAO)provides insights into its evolution and C4 photosynthesis显示文摘JUJUNCAO(Cenchrus fungigraminus;2n=4x=28)is a Cenchrus grass with the highest biomass production among cultivated plants,and it can be used for mushroom cultivation,animal feed,and biofuel production.Here,we report a nearly complete genome assembly of JUJUNCAO and reveal that JUJUNCAO is an allopolyploid that originated2.7 million years ago(mya).Its genome consists of two subgenomes,and subgenome A shares high collinear synteny with pearl millet.We also investigated the genome evolution of JUJUNCAO and suggest that the ancestral karyotype of Cenchrus split into the A and B ancestral karyotypes of JUJUNCAO.Comparative transcriptome and DNA methylome analyses revealed functional divergence of homeologous gene pairs between the two subgenomes,which was a further indication of asymmetric DNA methylation.The three types of centromeric repeat in the JUJUNCAO genome(CEN137,CEN148,and CEN156)may have evolved independently within each subgenome,with some introgressions of CEN156 from the B to the A subgenome.We investigated the photosynthetic characteristics of JUJUNCAO,revealing its typical C4 Kranz anatomy and high photosynthetic efficiency.NADP-ME and PEPCK appear to cooperate in the major C4 decarboxylation reaction of JUJUNCAO,which is different from other C4 photosynthetic subtypes and may contribute to its high photosynthetic efficiency and biomass yield.Taken together,our results provide insights into the highly efficient photosynthetic mechanism of JUJUNCAO and provide a valuable reference genome for future genetic and evolutionary studies,as well as genetic improvement of Cenchrus grasses. | Huakun Zheng Baiyu Wang Xiuting Hua Ruiting Gao Yuhao Wang Zixin Zhang Yixing Zhang Jing Mei Yongji Huang Yumin Huang Hui Lin Xingtan Zhang Dongmei Lin Siren Lan Zhongjian Liu Guodong Lu Zonghua Wang Ray Ming Jisen Zhang Zhanxi Lin | 2023 | Plant Communications2023，4，5： | 1 |
| 12 | CNTs/CNF-supported multi-active components as highly efficient bifunctional oxygen electrocatalysts and their applications in zincair batteries显示文摘Rational construction of active components has been the biggest challenge in preparing efficient bifunctional oxygen electrocatalysts.Herein,electrospinning and chemical vapor deposition(CVD)were employed to embed active species including FeCo nanoparticles,MNx(M=Fe,Co),and FePx in porous and graphitized carbon nanotubes(CNTs)/carbon nanofiber(CNF).The as-prepared FeCo@CoNx@FePx/C exhibited a half-wave potential as high as 0.86 V in oxygen reduction reaction(ORR)and low oxygen evolution reaction(OER)overpotential of 368 mV at 10 mA·cm^(−2),which are superior to Pt/C(0.83 V)and IrO_(2)(375 mV)respectively.The assembled Zn-air battery(ZAB)showed a high energy efficiency(Edischarge/Echarge)of 65%at 20 mA·cm^(−2)and stabilized for 700 charge-discharge cycles.The spectroscopic and microscopic characterizations evidenced that the outstanding bifunctionality of the electrocatalyst can be ascribed to three main reasons:First,FeCo nanoparticles are rich in MOH/MOOH active sites for OER,and FePx/CNTs constructed with CVD also modulate electronic structure to improve electron transfer;second,both MNx in carbon matrix and FePx/CNTs are highly active towards ORR;third,the CNTs/CNF are highly porous and graphitized,which promotes mass transport and improves electrical conductivity and stability of the electrocatalysts.This work gives important implications on the design of bifunctional electrocatalysts. | Weiyuan Ding Ali Saad Yuchen Wu Zhiwei Wang Xiuting Li | 2023 | Nano Research2023，16，4： | 0 |
| 13 | Research on Corrosion Effect of Sulfate Ions on Concrete Under Wetting-Drying Cycle显示文摘Saline soil is widely distributed in the marine sediments along the coast of the world and the arid-semi-arid areas of the Middle East and Iraq,and calcium sulfate erosion has become one of the important factors affecting the durability of concrete in this area.In order to clarify the mechanism of sulfate ion damage to concrete,this paper mainly takes saline soil with high sulfate content in coastal area as well as arid-semi-arid area as the research object,and uses indoor geotechnical test,field test and numerical simulation to study the influence of different dry-wet cycle times on the unconfined compressive strength of concrete test blocks,and puts forward the relationship between the erosion arrival depth and time of sulfate ion in concrete,so as to predict the long-term erosion depth by using the erosion depth of sulfate ion in concrete in short time.The results show that the shorter the erosion time when the erosion reaches a certain depth,and the larger the erosion reaches when the erosion time is the same,the faster the erosion reaches the depth with the increase of erosion time.Compared with rectangular section concrete,circular section concrete penetrates faster.The results of this study can provide a reference for the durability design of concrete in saline soil sites containing sulfate. | WANG Xiuhai TIAN Zhuangcai ZHANG Yanan SU Xiuting LIU Hongjun LIU Tao | 2022 | Journal of Ocean University of China2022，21，1： | 0 |
| 14 | Effects of time-delayed vibration absorber on bandwidth of beam for low broadband vibration suppression显示文摘The effects of time-delayed vibration absorber(TDVA) on the dynamic characteristics of a flexible beam are investigated. First, the vibration suppression effect of a single TDVA on a continuous beam is studied. The first optimization criterion is given,and the results show that the introduction of time-delayed feedback control(TDFC) is beneficial to improving the vibration suppression at the anti-resonance band. When a single TDVA is used, the anti-resonance is located at a specific frequency by the optimum design of TDFC parameters. Then, in order to obtain low-frequency and broad bands for vibration suppression, multiple TDVAs are uniformly distributed on a continuous beam,and the relationship between the dynamic responses and the TDFC parameters is investigated. The obtained relationship shows that the TDVA has a significant regulatory effect on the vibration behavior of the continuous beam. The effects of the number of TDVAs and the nonlinearity on the bandgap variation are discussed. As the multiple TDVAs are applied, according to the different requirements on the location and bandwidth of the effective vibration suppression band, the optimization criteria for the TDFC parameters are given, which provides guidance for the applications of TDVAs in practical projects such as bridge and aerospace. | Xiuting SUN Yipeng QU Feng WANG Jian XU | 2023 | Applied Mathematics and Mechanics(English Edition)2023，44，10： | 0 |
| 15 | Research on the temperature characteristic of Love wave device with structure of multi-waveguides used for gas sensor显示文摘This paper aimed at extracting optimal structural parameters for Love wave device with structure of multi-waveguides to improve its temperature stability.The theoretical model dealing with the Love wave propagation in multi-waveguides was established first,the dispersion characteristic is depicted by the acoustic propagation theory of stratified media and boundary conditions.Combing with the dispersion characteristics and Tomar's method,the optimal structural parameters for the Love wave device with zero temperature coefficient were extracted,and confirmed by the following experimental results.Excellent temperature coefficient of the Love wave device with SU-8/SiO_2 on ST-90°X quartz substrate was evaluated experimentally as only 2.16 ppm/℃,which agrees well with the calculated results.The optimized Love wave device is very promising in gas sensing application. | WANG Wen HOU Jiaoli SHAO Xiuting LIU Minghua HE Shitang | 2013 | Chinese Journal of Acoustics2013，32，4： | 0 |
| 16 | Development of a surface acoustic wave wireless and passive temperature sensor incorporating reflective delay line显示文摘based on optimal design on the core element of the sensor,a wireless and passive surface acoustic wave(SAW)temperature sensor integrated with ID Tag was presented.A reflective delay line,which consists of a transducer and eight reflectors on YZ LiNbO3 substrate.Was fabricated as the sensor element,in which,three reflectors were used for temperature sensing,and the other five were for the ID Tag using phase encoding.Single phase unidirectional transducers(SPUDTs)and shorted grating were used to structure the sAW device,leading to excellent signal to noise ratio(SNR).The performance of the SAW device was simulated by the coupling of modes(COM)prior to fabrication.Using the network analyzer,the response in time domain of the fabricated 434 MHz SAW sensor was characterized,the measured S11 agrees well with the simulated one,sharp reflection peaks,high signal/noise,and low spurious noise between the reflection peaks were observed.Using the radar system based on FSCW as the reader unit.the developed SAW temperature sensors were evaluated wirelessly.Excellent1 inearity and good resolution of士1℃ were observed. | WANG Wen XUE Xufeng SHAO Xiuting WANG Jianming LIANG Yong | 2014 | Chinese Journal of Acoustics2014，33，4： | 0 |
| 17 | Mechanism of Suppressing Transverse Wavevectors for Antidiffracting Propagation via Coherent Beam Combination显示文摘The elimination of transverse wavevectors during the propagation of electromagnetic waves is highly desirable because this would have a wide range of applications in probing,imaging,and communication.In this research,we propose and experimentally demonstrate a simple method to suppress transverse wavevectors by using coherent wave combinations.Using theoretical analysis and numerical simulation,we show that transverse wavevectors can be greatly suppressed during propagation.For further verification,we perform experiments with light waves to realize coherently combined beams;our experimental results are in good agreement with the simulated results.More importantly,we generate pin-like optical beams using this method,and pin-like optical beams exhibit superior propagation behavior over conventional Gaussian beams in turbulent fluids. | Yang Xiuting Ren Yuhang Zhang Ze Liang Xinli Chen Yan Gao Lu Zhao Juanying Cheng Wang Christodoulides Demetrios Chen Zhigang | 2021 | 激光与光电子学进展2021，58，7： | 0 |
| 18 | Inhibitory Effects of 12 Chemical Agents against Alternaria alternata显示文摘[Objective]The paper was to screen highly efficient fungicides for the prevention and control of tobacco brown spot(Alternaria alternata).[Method]The inhibitory effects of 12 chemical agents against A.alternata were determined indoors by mycelium growth rate method.[Result]Toxicity test showed that 30%kresoxim-methyl·boscalid SC had the best inhibitory effect,with an EC_(50)of 1.05μg/mL,followed by 9%pyraclostrobin CS,with an EC_(50)of 2.09μg/mL.As a broad spectrum protective fungicide,77%copper calcium sulfate WP showed a low sensitivity against A.alternata in the petri dish test since it had a mechanism of action different from that of other chemical agents.[Conclusion]The study lays the foundation for subsequent screening of fungicides for the prevention and control of A.alternata in the field. | Shen Hong Zhang Jiatao Cui Zhiyan Sun Guangjun Li Bin Zhang Yongfeng Xu Chuantao Ai Yongfeng Song Guanglong Ji Xiuting Wang Xiaoqiang | 2020 | Plant Diseases and Pests2020，11，4： | 0 |
| 19 | Development and Validation of a Prognostic Risk Score System for COVID-19 Inpatients:A Multi-Center Retrospective Study in China显示文摘Coronavirus disease 2019(COVID-19)has become a worldwide pandemic.Hospitalized patients of COVID-19 suffer from a high mortality rate,motivating the development of convenient and practical methods that allow clinicians to promptly identify high-risk patients.Here,we have developed a risk score using clinical data from 1479 inpatients admitted to Tongji Hospital,Wuhan,China(development cohort)and externally validated with data from two other centers:141 inpatients from Jinyintan Hospital,Wuhan,China(validation cohort 1)and 432 inpatients from The Third People’s Hospital of Shenzhen,Shenzhen,China(validation cohort 2).The risk score is based on three biomarkers that are readily available in routine blood samples and can easily be translated into a probability of death.The risk score can predict the mortality of individual patients more than 12 d in advance with more than 90%accuracy across all cohorts.Moreover,the Kaplan-Meier score shows that patients can be clearly differentiated upon admission as low,intermediate,or high risk,with an area under the curve(AUC)score of 0.9551.In summary,a simple risk score has been validated to predict death in patients infected with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2);it has also been validated in independent cohorts. | Ye Yuan Chuan Sun Xiuchuan Tang Cheng Cheng Laurent Mombaerts Maolin Wang Tao Hu Chenyu Sun Yuqi Guo Xiuting Li Hui Xu Tongxin Ren Yang Xiao Yaru Xiao Hongling Zhu Honghan Wu Kezhi Li Chuming Chen Yingxia Liu Zhichao Liang Zhiguo Cao Hai-Tao Zhang Ioannis Ch.Paschaldis Quanying Liu Jorge Goncalves Qiang Zhong Li Yan | 2022 | Engineering2022，8，1： | 0 |
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