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| 1 | Development of a Chinese land data assimilation system:its progress and prospects显示文摘陆地数据吸收的目的是为改进陆地表面状态的评价把多来源观察合成陆地表面模型的动力学。我们为中国的陆地领土开发了一个陆地数据吸收系统。在这个系统,普通陆地模型和简单生物圈,模型 2 被用来模仿陆地表面过程。当转移的观察操作员为预言建模进估计的亮度温度,融化并且结冰的土壤,雪,湖,和植被的放射的转移模型被使用。一个 Monte-Carlo 顺序的过滤器,整体 Kalman 过滤器,作为数据吸收方法被实现集成当模特儿并且观察。系统能够遥远地吸收被动微波察觉到的数据象特殊传感器微波成像器那样(SSM 我) , TRMM 微波成像器(TMI ) ,和先进微波扫描辐射计为曙光女神(AMSRE ) 提高了并且在土壤和雪的 situmeasurements 常规。与 0.25 度的一个空间决定和一个小时的时间的分辨率,为土壤潮湿,土壤温度,雪和冻结的土壤的空间与时间地一致的吸收数据集被生产了。这篇论文介绍在数据吸收算法,陆地表面水文学变量的陆地表面建模微波遥感,和大气的强迫的数据的准备上做的中国陆地数据吸收系统和进步的开发。为未来开发开发陆地数据吸收系统和观点的不同特征和挑战也被讨论。 | Li Xin Huang Chunlin Che Tao Jin Rui Wang Shugong Wang Jiemin Gao Feng Zhang Shuwen Qiu Chongjian Wang Chenghai | 2007 | Progress in Natural Science:Materials International2007，17，8： | 30 |
| 2 | Petrogenesis of Shangyu gabbro-diorites in western Shandong:Geochronological and geochemical evidence显示文摘Chronology and geochemistry of the Shangyu gabbro-diorite in western Shandong were studied to understand their petrogenesis and the nature of the Mesozoic lithospheric mantle. The Shangyu intru-sion is mainly composed of a suite of gabbro-diorite. Zircons from the intrusion display eu-hedral-subhedral in shape and have high Th/U ratios (1.23―2.87), implying their magmatic origin. LA-ICP-MS zircon U-Pb dating results for two samples indicate that they were formed in the Early Cre-taceous, yielding weighted mean 206Pb/238U ages of 129±1Ma and 134±2Ma, respectively. Except for early cumulate such as sample QT-19, their SiO2 and MgO contents range from 50.12% to 56.37% and from 3.52% to 6.37%, respectively. Moreover, the gabbro-diorites are characterized by high Mg# (0.54―0.63), enrichment in Na (Na2O/K2O ratios more than 1), Cr (73×10-6―217×10-6) and Ni (34×10-6―241×10-6), and intensive enrichments in light rare earth elements (LREEs) and large ion lithophile elements (LILEs) and depletion in high field strength elements (HFSEs). Their initial 87Sr/86Sr ratios and ε Nd(t) values range from 0.70962 to 0.71081 and from-16.60 to-13.04, respectively. Taken together with the Early Creta-ceous high-Mg diorites and the mantle xenoliths from the Tietonggou and Jinling as well as basalts from the Fangcheng and Feixian, it is suggested that the primary magma for the Shangyu gab-bro-diorites should be derived from the enriched lithospheric mantle intensively modified by conti-nental crust. The Sr-Nd-Pb isotopic compositions for the Early Cretaceous high-Mg diorites in western Shandong display a trend of spatial variations, i.e., initial 87Sr/86Sr, 207Pb/204Pb and 208Pb/204Pb ratios de-creasing and ε Nd(t) values increasing from southeast to northwest in western Shandong, which is con-sistent with the tectonic model that the Yangtze Craton subducted beneath the North China Craton oriented in north-west direction in the Early Mesozoic. | YANG ChengHai XU WenLiang YANG DeBin WANG Wei WANG WeiDe LIU JinMin | 2008 | Science China Earth Sciences2008，51，4： | 24 |
| 3 | Guidance for the clinical evaluation of traditional Chinese medicine-induced liver injury Issued by China Food and Drug Administration显示文摘1. Introduction Drug-induced liver injury (DILI), defined as liver injury caused by a drug and/or its metabolites, is a common clinical adverse drug reaction1–4. This type of injury can cause acute liver failure and even death in severe cases5. | Xiaohe Xiao Jianyuan Tang Yimin Mao Xiuhui Li Jiabo Wang Chenghai Liu Kewei Sun Yong’an Ye Zhengsheng Zou Cheng Peng Ling Yang Yuming Guo Zhaofang Bai Tingting He Jing Jing Fengyi Li Na An | 2019 | Acta Pharmaceutica Sinica B2019，9，3： | 22 |
| 4 | Comparison of sensible and latent heat fluxes during the transition season over the western Tibetan Plateau from reanalysis datasets显示文摘The sensible and latent heat fluxes during the transition season over the western Tibetan Plateau from the NCEP-1 (NCEP/NCAR Reanalysis 1), AR-Ⅱ (NCEP-DOE Reanalysis 2) and ERA40 reanalysis datasets were compared and analyzed. The results show that the phase change in soil moisture has a significant effect on the sensible and latent heat fluxes over the western Tibetan Plateau (TP) due to the freezing-thawing processes during the transition from the dry to the wet period. The uncertainties in the sensible and latent heat fluxes over the western TP are quite high in the reanalysis data, and depend largely on the success of the soil moisture simulations in the models. Improving the hydrological process simulations in the land-surface models in seasonally frozen ground and in the active frozen soil layer may be an effective way of enhancing the reliability of the surface heat fluxes from the reanalysis data over the Tibetan Plateau. | Yang Cui, Chenghai Wang Disaster Reduction Key Laboratory of Gansu Province, College of Atmospheric Sciences, Lanzhou University, Lanzhou 730000, China | 2009 | Progress in Natural Science:Materials International2009，19，6： | 13 |
| 5 | Recent Progress in Studies of the Variabilities and Mechanisms of the East Asian Monsoon in a Changing Climate显示文摘Located in a monsoon domain,East Asia suffers devastating natural hazards induced by anomalous monsoon behaviors.East Asian monsoon(EAM)research has traditionally been a high priority for the Chinese climate community and is particularly challenging in a changing climate where the global mean temperature has been rising.Recent advances in studies of the variabilities and mechanisms of the EAM are reviewed in this paper,focusing on the interannual to interdecadal time scales.Some new results have been achieved in understanding the behaviors of the EAM,such as the evolution of the East Asian summer monsoon(EASM),including both its onset and withdrawal over the South China Sea,the changes in the northern boundary activity of the EASM,or the transitional climate zone in East Asia,and the cycle of the EASM and the East Asian winter monsoon and their linkages.In addition,understanding of the mechanism of the EAM variability has improved in several aspects,including the impacts of different types of ENSO on the EAM,the impacts from the Indian Ocean and Atlantic Ocean,and the roles of mid-to high-latitude processes.Finally,some scientific issues regarding our understanding of the EAM are proposed for future investigation. | Wen CHEN Lin WANG Juan FENG Zhiping WEN Tiaojiao MA Xiuqun YANG Chenghai WANG | 2019 | Advances in Atmospheric Sciences2019，36，9： | 13 |
| 6 | Evidence for a recent warming and wetting in the source area of the Yellow River (SAYR) and its hydrological impacts显示文摘在分水岭规模的气候变化调查在在分水岭揭示历史的进化和流量变化的未来趋势起一个重要作用。这研究从 1961 ~ 2012 在黄河(SAYR ) 的来源区域上检验 multisource 水文学和气象学的变量并且在这个区域的未来气候情形在 20062100 期间基于 CMIP5 设计数据。它在 SAYR 认出最近的气候变化的重要特征并且在这个区域预言未来流动的变化趋势。(1 ) 自从 2000 年代初,在 SAYR 的气候经历了一个重要温暖湿的变化,这被发现,自从 1980 年代末,它与先前的温暖干燥的趋势很不同;(2 ) 在西北的 SAYR 的温暖湿的趋势(黄河(HAYR ) 的 headwater 区域,在整个 SAYR 是比那更明显的;(3 ) 与降水增加,自从 2006,在这个区域的流量也经历了一个增加的过程。在这个区域的流量变化对降水,宠物和最大的空气温度的变化敏感,然而并非对在吝啬、最小的空气温度的变化很敏感;(4 ) 基于 CMIP5 设计数据,如果认为三不同,在 SAYR 的温暖湿的气候趋势是可能的继续直到 2049 (即 RCP2.6, RCP4.5 和 RCP8.5 ) 在 SAYR 的温室气体排放情形,和降水不是不到在 2100 前的当前的水平;然而, SAYR 的最近的流动增加是可能的是十的变化,它将至多继续直到 2020 年代,这被估计;(5 ) 东方亚洲冬季季风的内部年度的变化被发现是仔细与在这个区域的年度降水的变化有关。同时,增加的降水以及是远的潜在的土壤水分蒸发蒸腾损失总量(宠物) 的增加不到在最近的时期的降水的是为这个区域的流动增加的主要气候原因。 | TIAN Hui LAN Yongchao WEN Jun JIN Huijun WANG Chenghai WANG Xin KANG Yue | 2015 | Journal of Geographical Sciences2015，25，6： | 12 |
| 7 | Land-surface processes and summer-cloud-precipitation characteristics in the Tibetan Plateau and their effects on downstream weather:a review and perspective显示文摘Correct understanding of the land-surface processes and cloud-precipitation processes in the Tibetan Plateau(TP)is an important prerequisite for the study and forecast of the downstream activities of weather systems and one of the key points for understanding the global atmospheric movement.In order to show the achievements that have been made,this paper reviews the progress on the observations for the atmospheric boundary layer,land-surface heat fluxes,cloud-precipitation distributions and vertical structures by using ground-and space-based multiplatform,multisensor instruments and the effect of the cloud system in the TP on the downstream weather.The results show that the form drag related to the topography,land-atmosphere momentum and scalar fluxes is an important part of the parameterization process.The sensible heat flux decreased especially in the central and northern TP caused by the decrease in wind speeds and the differences in the ground-air temperatures.Observations show that the cloud and precipitation over the TP have a strong diurnal variation.Studies also show the compressed-air column in the troposphere by the higher-altitude terrain of the TP makes particles inside clouds vary at a shorter distance in the vertical direction than those in the non-plateau area so that precipitation intensity over the TP is usually small with short duration,and the vertical structure of the convective precipitation over the TP is obviously different from that in other regions.In addition,the influence of the TP on severe weather downstream is preliminarily understood from the mechanism.It is necessary to use model simulations and observation techniques to reveal the difference between cloud precipitation in the TP and non-plateau areas in order to understand the cloud microphysical parameters over the TP and the processes of the land boundary layer affecting cloud,precipitation and weather in the downstream regions. | Yunfei Fu Yaoming Ma Lei Zhong Yuanjian Yang Xueliang Guo Chenghai Wang Xiaofeng Xu Kun Yang Xiangde Xu Liping Liu Guangzhou Fan Yueqing Li Donghai Wang | 2020 | National Science Review2020，7，3： | 10 |
| 8 | Spatial distributions and interannual variations of snow cover over China in the last 40 years显示文摘By using the observational snow data of more than 700 weather stations,the interannual temporal and spatial characteristics of seasonal snow cover in China were analyzed.The results show that northern Xinjiang,northeastern China-Inner Mongolia,and the southwestern and southern portions of Tibetan Plateau are three regions in China with high seasonal snow cover and also an interannual anomaly of snow cover.According to the trend of both the snow depth and snow cover days,there are three changing patterns for the seasonal snow cover:The first type is that both snow depth and snow cover days simultaneously increase or decrease;this includes northern Xinjiang,middle and eastern Inner Mongolia,and so on.The second is that snow depth increases but snow cover days decrease;this type mainly locates in the eastern parts of the northeastern plain of China and the upper reaches of the Yangtze River.The last type is that snow depth decreases but snow cover days increase at the same time such as that in middle parts of Tibetan Plateau.Snow cover in China appears to have been having a slow increasing trend during the last 40 years.On the decadal scale,snow depth and snow cover days slightly increased in the 1960s and then decreased in the 1970s;they again turn to increasing in the 1980s and persist into 1990s. | ChengHai Wang ZhiLan Wang Yang Cui | 2009 | Research in Cold and Arid Regions2009，1，6： | 8 |
| 9 | Oscillation propagation features of the atmosphere around the Qinghai-Xizang Plateau during the spring season of typical strong and weak monsoon years显示文摘The interaction between the low-frequency atmospheric oscillation(Madden-Julian Oscillation,MJO) and the diabatic heating over the Qinghai-Xizang Plateau(QXP) from March to June is analyzed.The results show that there are respectively two and one wave trains around the QXP during the onset of the South China Sea monsoon in strong and weak monsoon years.The locations and strength of the wave train propagation differ between the strong and weak monsoon years.Because diabatic heating of the QXP prevents the low-frequency oscillation,the wave train of interaction between the diabatic heating and the zonal wind MJO propagates along the west and east of the QXP in the strong monsoon years.The distribution of the wave train interaction between the diabatic heating and the zonal wind MJO traverses the QXP and coincides with the location of the southern and northern upper-level jet streams,showing that they are remarkably correlated.An interesting and notable phenomenon is that the interaction between diabatic heating and the zonal wind MJO over the QXP suddenly disappears during the monsoon onset in weak monsoon years. | WANG ChengHai CUI Yang JIN ShuangLong | 2011 | Science China Earth Sciences2011，54，2： | 7 |
| 10 | Properties of Cloud and Precipitation over the Tibetan Plateau显示文摘The characteristics of seasonal precipitation over the Tibetan Plateau(TP) were investigated using TRMM(Tropical Rainfall Measuring Mission) precipitation data(3B43). Sensitive regions of summer precipitation interannual variation anomalies were investigated using EOF(empirical orthogonal function) analysis. Furthermore, the profiles of cloud water content(CWC) and precipitable water in different regions and seasons were analyzed using TRMM-3A12 data observed by the TRMM Microwave Imager. Good agreement was found between hydrometeors and precipitation over the eastern and southeastern TP, where water vapor is adequate, while the water vapor amount is not significant over the western and northern TP.Further analysis showed meridional and zonal anomalies of CWC centers in the ascending branch of the Hadley and Walker Circulation, especially over the south and east of the TP. The interannual variation of hydrometeors over the past decade showed a decrease over the southeastern and northwestern TP, along with a corresponding increase over other regions. | WANG Chenghai SHI Hongxia HU Haolin WANG Yi XI Baike | 2015 | Advances in Atmospheric Sciences2015，32，11： | 6 |
| 11 | Characteristics of GLDAS soil-moisture data on the Tibet Plateau显示文摘In this paper, the applicability of soil-moisture(SM) datasets of GLDAS(Global Land Data Assimilation System) in an alpine region(Tibet Plateau, TP) is investigated. The relations and discrepancies between the GLDAS-NOAH SM(0~10cm) and the observations are compared; the possible reasons for errors over the TP are explored. The results show that GLDAS SM biases mainly show up in errors of values in the nonfrozen period(April to October) and changes of SM along with the temperature, especially during the freezing-thawing process in the frozen period(November to March). The biases of GLDAS SM in the nonfrozen period are mainly caused by the GLDAS precipitation-forcing data. The errors of GLDAS SM in the frozen period are speculated to be induced by the freeze-thaw parameterization scheme in the land-surface model. | HongYan Bao Kai Yang ChengHai Wang | 2017 | Research in Cold and Arid Regions2017，9，2： | 4 |
| 12 | Optimization of microwave-assisted extraction of silymarin from milk thistle seeds显示文摘Microwave-assisted extraction(MAE)technology was used to extract silymarin from milk thistle seeds.The single factor experiments and quadratic orthogonal rotation regression combination design were adopted to study the effects of such factors as extraction time,extraction temperature,ethanol concentration and solid-liquid ratio on silymarin yield.Ultraviolet-Visible(UV-Vis)spectrophotometry method was employed to measure the silybin content.The optimal technological conditions for extracting silymarin from milk thistle seeds by MAE were determined,and then the extraction regression mathematical model was established.The importance orders of factors that influenced the extraction yield within the experimental model were as follows:ethanol concentration,the ratio of solid to liquid,extraction temperature and extraction time.The optimum extraction parameters were obtained as follows:extraction time 50 min,extraction temperature 130℃,ethanol concentration 85%(V/V),solid to liquid ratio 1∶40(g/mL),and under such conditions,experimental value of silymarin yield after being extracted three times is 59.33mg/g.The validation experiments verify that the established regression mathematical model can predict the extraction yield of silymarin accurately. | Wang Xin Zheng Xianzhe Liu Chenghai | 2008 | International Journal of Agricultural and Biological Engineering2008，1，1： | 3 |
| 13 | Simulation analysis on characteristics of land surface over western Qinghai-Xizang Plateau during freez-ing-thawing period显示文摘Using the Global Energy and Water Cycle Experiment-Asian Monsoon-Tibet Plateau Experiment (GAME-Tibet) observa-tional data-from October 2002 through September 2003-of Gaize in the western Qinghai-Xizang Plateau (QXP),the land-surface characteristics of the Qinghai-Xizang Plateau are simulated by the improved land-surface model Common Land Model (CoLM).The results show that CoLM can reproduce the land-surface characteristics of plateau areas well.In the sur-face-energy balance of the western QXP in the winter half year,the sensible heat (SH) flux constituted the dominant energy,and the latent heat (LH,here and after) flux is very small.Although the LH flux nearly equals zero in freezing season,it cannot be ig-nored during the period of freezing-thawing in QXP.In the transition season from midto late-May,the frequent phase change of soil water that is caused by the freezing-thawing process leads to the increase of LH flux and decrease of the Bowen ratio.The simulation results also indicate that the changes of surface effective heat fluxes (SH and LH flux) are associated with precipitation and the frequent change between freezing and thawing processes in soil surface. | ChengHai Wang,Rui Shi,Yang Cui,HongChao Zuo College of Atmospheric Sciences,Lanzhou University.No.222,South Tianshui Road,Lanzhou,Gansu 730000,China. | 2009 | Research in Cold and Arid Regions2009，1，4： | 3 |
| 14 | A shadow- eliminated vegetation index (SEVI) for removal of self and cast shadow effects on vegetation in rugged terrains显示文摘The effect of terrain shadow, including the self and cast shadows, is one ofthe main obstacles for accurate retrieval of vegetation parameters byremote sensing in rugged terrains. A shadow- eliminated vegetation index(SEVI) was developed, which was computed from only red and nearinfrared top-of-atmosphere reflectance without other heterogeneous dataand topographic correction. After introduction of the conceptual modeland feature analysis of conventional wavebands, the SEVI was constructedby ratio vegetation index (RVI), shadow vegetation index (SVI) andadjustment factor (f (Δ)). Then three methods were used to validate theSEVI accuracy in elimination of terrain shadow effects, including relativeerror analysis, correlation analysis between the cosine of solar incidenceangle (cosi) and vegetation indices, and comparison analysis between SEVIand conventional vegetation indices with topographic correction. Thevalidation results based on 532 samples showed that the SEVI relativeerrors for self and cast shadows were 4.32% and 1.51% respectively. Thecoefficient of determination between cosi and SEVI was only 0.032 and thecoefficient of variation (std/mean) for SEVI was 12.59%. The results indicatethat the proposed SEVI effectively eliminated the effect of terrain shadowsand achieved similar or better results than conventional vegetation indiceswith topographic correction. | Hong Jiang Sen Wang Xiaojie Cao Chenghai Yang Zhaoming Zhang Xiaoqin Wang | 2019 | International Journal of Digital Earth2019，12，9： | 3 |
| 15 | A Similitude Method and the Corresponding Blade Design of a Low-Speed Large-Scale Axial Compressor Rotor显示文摘A similitude method to model the tip clearance flow in a high-speed compressor with a low-speed model is presented in this paper.The first step of this method is the derivation of similarity criteria for tip clearance flow,on the basis of an inviscid model of tip clearance flow.The aerodynamic parameters needed for the model design are then obtained from a numerical simulation of the target high-speed compressor rotor.According to the aerodynamic and geometric parameters of the target compressor rotor,a large-scale low-speed rotor blade is designed with an inverse blade design program.In order to validate the similitude method,the features of tip clearance flow in the low-speed model compressor are compared with the ones in the high-speed compressor at both design and small flow rate points.It is found that not only the trajectory of the tip leakage vortex but also the interface between the tip leakage flow and the incoming main flow in the high-speed compressor match well with that of its low speed model.These results validate the effectiveness of the similitude method for the tip clearance flow proposed in this paper. | YU Chenghai MA Ning WANG Kai DU Juan Van den Braembussche R.A. LIN Feng | 2014 | Journal of Thermal Science2014，23，2： | 3 |
| 16 | A piecewise-integration method for simulating the influence of external forcing on climate显示文摘气候飘移由于复杂气候系统的不完全的物理、数字的表示发生在很一般的发行量模型(GCM ) ,它可以在在外部强迫评估气候反应到变化的敏感实验引起大不确定性。解决这个问题,我们建议一个 piecewise 集成方法在气候敏感研究减少系统的错误。观察被使用动态松驰技术放松到空气的当前的状态第一吸收进一个数字模型,然后吸收领域连续地被用来重新初始化减少气候的错误的模拟模拟。当数字模型与改变的外部强迫是综合的时,结果能被分成二部分,背景和不安地,和背景在外部强迫被改变以前,是状态。piecewise 集成方法被用来连续地重新初始化有吸收领域的模型,而不是背景。因此,有外部强迫的模型的模拟错误能被减少。这样,气候敏感实验的精确性极大地被改进。测试与一简单低顺序光谱这条途径能显著地减少的模型表演气候敏感实验的不确定性。 | Zhifu Zhang Chongjian Qiu Chenghai Wang | 2008 | Progress in Natural Science:Materials International2008，18，10： | 2 |
| 17 | EGFR tyrosine kinase inhibitor HS-10182 increases radiation sensitivity in non-small cell lung cancers with EGFR T790M mutation显示文摘Objective:To investigate the potential of HS-10182,a second-generation epidermal growth factor receptor tyrosine kinase inhibitor(EGFR-TKI),as a radiosensitizer in non-small cell lung cancer(NSCLC).Methods:Two cell lines of NSCLCs,A549 that possesses wild-type(WT)EGFRs and H1975 that possesses EGFR L858R/T790M double mutations,were treated with HS-10182 at various concentrations,and cell viabilities were determined using the MTS assay.The cells were tested by clonogenic survival assays to identify the radiosensitivity of both groups.Western blot was performed to analyze the expression of phosphorylated EGFR,AKT,DNA-dependent protein kinase,and catalytic subunit(DNA-PKcs)proteins.Immunofluorescence analyses were performed to examine the formation and changes in nuclearγ-H2AX foci.Cell apoptosis was examined by flow cytometry and Western blots for cleaved caspase-3,-8,-9,and cleaved poly ADP-ribose polymerase(PARP).Furthermore,we established xenograft models in mice and the effects of different treatments on tumor growth were then assessed.Results:Clonogenic survival assays revealed that HS-10182 significantly enhanced the radiosensitivity of H1975 cells but not A549cells[dose enhancement ratios(DERs)=2.36(P<0.05)vs.1.43(P>0.05)].Western blot results showed that HS-10182 increased the levels of cleaved caspase-3,-8,-9,and cleaved PARP in H1975 cells but not in A549 cells.In addition,flow cytometry analysis showed that HS-10182 enhanced irradiation-induced apoptosis in H1975.Immunofluorescence results found that HS-10182increased the average number ofγ-H2AX foci after irradiation in H1975 cells,but not in A549 cells.Combined radiation and HS-10182 treatment increased the expression of DNA-PKcs but this increase was more significant in H1975 cells than in A549 cells.Moreover,HS-10182 suppressed the increased expression of Rad50 in H1975 cells in response to irradiation.In vivo experiments found that the combined therapy significantly inhibited tumor growth.Conclusions:HS-10182 enhances the radiosensitivity of H1975 cells which is possibly because that HS-10182 could enhance irradiation-induced apoptosis,increase irradiation-induced DNA damage,and cause a delay in DNA damage repair.Our findings suggest that radiotherapy combined HS-10182 is a novel treatment for lung cancer cells which have acquired the T790M mutation.HS-10182 could be brought to the clinic as a radiosensitizer in NSCLCs with the EGFR T790M mutation. | Yang Chen Youyou Wang Lujun Zhao Ping Wang Jifeng Sun Rudi Bao Chenghai Li Ningbo Liu | 2018 | Cancer Biology & Medicine2018，15，1： | 2 |
| 18 | Adaptive lattice Boltzmanrt model for eom0ressible flows显示文摘 | SUN Chenghai WANG Baoguo SHEN Mengyu | 2000 | Tsinghua Science and Technology2000，5，1： | 1 |
| 19 | The new sideway of CNTF sig-nal transduction pathway显示文摘The action of ciliary neurotrophic factor (CNTF) on intercellular free Ca2+ concentrations [Ca2+]1 induced by glutamate (Glu) in primary cultured hippocampal neurons were detected with Fura2/AM, a Ca2+-sensitive fluorophore. and the morphological influence of G-protein on it was ob-jected. Glu could induce rapid increase of [Ca2+]1 in hippo-campal neurons. CNTF had no significant action on [Ca2+]1 in resting hippocampal neurons. However, after incubation of CNTF for 5 min, the increase of [Ca2+]1 in hippocampal neurons rapidly induced by Glu was inhibited. Pretussis toxin (PTX)-sensitive G protein could block the action. These results indicate that a new non-genomic rapid sideway might exist in the upper stream of CNTF signal transduction pathway, which was related to Ca2+ signal transduction. | YAN Jin HE Cheng LU Changlin WANG Chenghai BAO Xuan TANG Tieshan HUANG Xiuying SUN Fangzhen | 2001 | Chinese Science Bulletin2001，46，6： | 1 |
| 20 | Precipitable water conversion rates over the Qinghai-Xizang (Tibet) Plateau: changing characteris- tics with global warming显示文摘 | Wang Chenghai Guo Yipeng | 2012 | Hydrological Processes2012，26，10： | 1 |
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