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| 1 | Peat record reflecting Holo-cene climatic change in the Zoige Plateau and AMS radiocarbon dating显示文摘Through the use of reliable AMS dating of high resolution (15-30 years) peat and the establishment of monsoon climate proxies sequence, we have been able to recognize several cold, dry events in the Tibetan Plateau during the Holocene. The more obvious ones occurred around 12800, 11300, 10200, 9580, 8900, 6400, 4400, 3700, 2800 and 1500 cal. aBP. These events correlate well with both ice rafting events recorded in high latitude North Atlantic Ocean sediment cores and cooling events in the low latitude SST. Spectral analysis indicates high frequency climate variation on centennial-millennial time scale during the Holocene. This further reflects Holocene climate instability and the existence of centennial-millenium scale rhythm in mid latitude areas as well. | ZHOU Weijian LU Xuefeng WU Zhengkun DENG Lin A.J.T.Jull D.Donahue W.Beck | 2002 | Chinese Science Bulletin2002，47，1： | 68 |
| 2 | Metal and phosgene-free synthesis of 1 H-quinazolin-2,4-diones by selenium-catalyzed carbon- ylation of o-nitrobenzamides显示文摘 | Wu Xiaowei Yu Zhengkun | 2010 | Tetrahedron Lett2010，51，11： | 1 |
| 3 | Structural revolution of atomically dispersed Mn sites dictates oxygen reduction performance显示文摘An efficient preparation and local coordination environment regulation of isolated single-atom sites catalysts(ISASC)for improved activity is still challenging.Herein,we develop a solid phase thermal diffusion strategy to synthesize Mn ISASC on highly uniform nitrogen-doped carbon nanotubes by employing MnO_(2) nanowires@ZIF-8 core-shell structure.Under high-temperature,the Mn species break free from core-MnO_(2) lattice,which will be trapped by carbon defects derived from shell-ZIF-8 carbonization,and immobilized within carbon substrate.Furthermore,the poly-dispersed Mn sites with two nitrogen-coordinated centers can be controllably renovated into four-nitrogen-coordinated Mn sites using NH3 treatment technology.Both experimental and computational investigations indicate that the symmetric coordinated Mn sites manifest outstanding oxygen reduction activity and superior stability in alkaline and acidic solutions.This work not only provides efficient way to regulate the coordination structure of ISASC to improve catalytic performance but also paves the way to reveal its significant promise for commercial application. | Zhengkun Yang Xiaolin Wang Mengzhao Zhu Xinyan Leng Wenxing Chen Wenyu Wang Qian Xu Li-Ming Yang Yuen Wu | 2021 | Nano Research2021，14，12： | 1 |
| 4 | Upregulation of long non-coding RNA urothelial carcinoma associated1 by CCAAT/enhancer binding protein α contributes to bladder cancer cell growthand reduced apoptosis显示文摘 | Mei Xue Xu Li Wenjing Wu Shuwan Zhang Shouzhen Wu Zhengkun Li Wei Chen | 2014 | Oncology Reports2014，，5： | 1 |
| 5 | Efficient Transformation of indica Rice Mediated by Agrobacterium and Generation of NcGDH Transgenic Genic Male-Sterile Rice with High Nitrogen Use Efficiency显示文摘Although some indica rice varieties have already been transformed by Agrobacterium,there is still great demand of developing transformation system for economically important indica varieties.Here,a fast and efficient method of Agrobacterium-mediated transformation for indica rice was developed,and an NcGDH transgenic genic male-sterile(GMS)indica rice 628S was generated using this method.The regenerated transgenic plantlets can be obtained within three months,and the transformation efficiency achieved about 17%.NcGDH transgenic 628S exhibited an enhanced capacity of ammonium assimilation and more effective panicles under low nitrogen conditions.Moreover the hybrid rice lines generated by NcGDH transgenic 628S showed 8%-27%yield advantage than those by the non-transgenic 628S.Taken together,these results provide an efficient transfbnnation method for indica rice and an opportunity to improve nitrogen use efficiency(NUE)and the heterosis of hybrid rice. | LIU Cong TANGg Dongying ZHOU Zhengkun ZENG Hui HU Xiaochun TAN Vanning QIN Peng DENG Yong WU Jicai WANG Yan YANG Yuanzhu YUAN Dingyang LIU Xuanming LIN Jianzhong | 2021 | Rice science2021，28，6： | 0 |
| 6 | Genetic Architecture of Childhood Kidney and Urological Diseases in China显示文摘Kidney disease is manifested in a wide variety of phenotypes,many of which have an important hereditary component.To delineate the genotypic and phenotypic spectrum of pediatric nephropathy,a multicenter registration system is being imple-mented based on the Chinese Children Genetic Kidney Disease Database(CCGKDD).In this study,all the patients with kidney and urological diseases were recruited from 2014 to 2020.Genetic analysis was conducted using exome sequencing for families with multiple affected individuals with nephropathy or clinical suspicion of a genetic kidney disease owing to early-onset or extrarenal features.The genetic diagnosis was confirmed in 883 of 2256(39.1%)patients from 23 provinces in China.Phenotypic profiles showed that the primary diagnosis included steroid-resistant nephrotic syndrome(SRNS,23.5%),glomerulonephritis(GN,32.2%),congenital anomalies of the kidney and urinary tract(CAKUT,21.2%),cystic renal disease(3.9%),renal calcinosis/stone(3.6%),tubulopathy(9.7%),and chronic kidney disease of unknown etiology(CKDu,5.8%).The pathogenic variants of 105 monogenetic disorders were identified.Ten distinct genomic disorders were identified as pathogenic copy number variants(CNVs)in 11 patients.The diagnostic yield differed by subgroups,and was highest in those with cystic renal disease(66.3%),followed by tubulopathy(58.4%),GN(57.7%),CKDu(43.5%),SRNS(29.2%),renal calcinosis/stone(29.3%)and CAKUT(8.6%).Reverse phenotyping permitted correct identification in 40 cases with clinical reassessment and unexpected genetic conditions.We present the results of the largest cohort of children with kidney disease in China where diagnostic exome sequencing was performed.Our data demonstrate the utility of family-based exome sequencing,and indicate that the combined analysis of genotype and phenotype based on the national patient registry is pivotal to the genetic diagnosis of kidney disease. | Ye Fang Hua Shi Tianchao Xiang Jiaojiao Liu Jialu Liu Xiaoshan Tang Xiaoyan Fang Jing Chen Yihui Zhai Qian Shen Guomin Li Li Sun Yunli Bi Xiang Wang Yanyan Qian Bingbing Wu Huijun Wang Wenhao Zhou Duan Ma Jianhua Mao Xiaoyun Jiang Shuzhen Sun Ying Shen Xiaorong Liu Aihua Zhang Xiaowen Wang Wenyan Huang Qiu Li Mo Wang Xiaojie Gao Yubin Wu Fang Deng Ruifeng Zhang Cuihua Liu Li Yu Jieqiu Zhuang Qing Sun Xiqiang Dang Haitao Bai Ying Zhu Siguang Lu Bili Zhang Xiaoshan Shao Xuemei Liu Mei Han Lijun Zhao Yuling Liu Jian Gao Ying Bao Dongfeng Zhang Qingshan Ma Liping Zhao Zhengkun Xia Biao Lu Yulong Wang Mengzhun Zhao Jianjiang Zhang Shan Jian Guohua He Huifeng Zhang Bo Zhao Xiaohua LI Feiyan Wang Yufeng Li Hongtao Zhu Xinhui Luo Jinghai Li Jia Rao Hong Xu | 2021 | Phenomics2021，1，3： | 0 |
| 7 | Fluoropyridine family:Bifunction as electrolyte solvent and additive to achieve dendrites-free lithium metal batteries显示文摘Electrolyte formulation with high stability towards both Li metal anode and high-voltage cathode is considered as one of key points for the high-energy density lithium metal batteries(LMBs).In our previous study,by adding only 2%of 2-fluoropyridine(2-FP)as the additive in the carbonate and ether-based electrolyte formulations effectively suppressed Li dendrite growth.In this study,we further found that the main fluoropyridine(FP)family members can serve as not only the effective additive but also the excellent electrolyte solvent in the electrolyte formulations to enhance the performance of LMBs.For the 2-FP,when it was also used the electrolyte solvent and paired with single-salt lithium bis(trifluoromethylsulfonyl)imide(Li TFSI),the obtained electrolyte formulation of 1 M Li TFSI in pure2-FP solvent not only allowed faster ion transport though solvation effect,but also possessed impressive oxidation stability window over 4.3 V.As a result,the high-voltage LiNi_(1/3)Mn1_(/3)Co_(1/3)O_(2)(1.5 mA h cm^(-2))|Li metal battery with it exhibited a capacity retention of more than 80%over a long-term cycle even at 0.45 m A cm^(-2)with a lean electrolyte(30μL).Meanwhile,for another FP family member(i.e.,3-FP)as the electrolyte additive,the 4.3 V LMBs with the carbonate-based electrolyte containing only 1%of 3-FP maintained 83.9%of initial capacity after 200 cycles at 0.75 m A cm^(-2).Density functional theory(DFT)calculations and experiments confirmed that three typical FPs,i.e.,2-FP,3-FP and 4-FP can not only regulate the initial Li nucleation process,but more importantly also induce a protective layer,leading to a uniform and dendrites-free Li deposition.This bifunction of the FP family member as either electrolyte solvent or additive in the electrolyte formulations should be promising for the achieving of dendrites-free high-energy density LMBs. | Zhengkun Xie Xiaowei An Zhijun Wu Xiyan Yue Jiajia Wang Xiaogang Hao Abuliti Abudula Guoqing Guan | 2021 | Journal of Materials Science & Technology2021，，15： | 0 |
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