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| 1 | 非甾体抗炎药应用中,环氧合酶2、不对称二甲基精氨酸与心血管危害的关系显示文摘已有大规模、安慰剂对照试验确定了非甾体类抗炎药(nonsteroidal anti—inflammatory drugs,NSAIDs)具有心血管危害性:这归因于环氧合酶2(cyclooxygenase,COX-2)的心脏保护产物受到抑制,尤其是前列环素(prostacyclin,PG12)。NSAID降低心脏保护作用的另一种机制可能是通过增强肾脏中甲基精氨酸的形成来限制一氧化氮在整个脉管系统中的作用。 | Ricciotti E Castro C Tang SY Briggs WTE West JA Malik D Rhoades SD Meng H Li X Lahens NF Sparks JA Karlson EW Weljie AM Griffin JL FitzGerald GA6 刘青 叶鹏 | 2018 | 中华高血压杂志2018，26，9： | 3 |
| 2 | Magnetic resonance imaging of hepatocellular carcinoma induced by diethylnitrosamine in Sprague-Dawley rats显示文摘Diethylnitrosamine (DENA) is able to induce various benign and malignant liver lesions in rats with a high success rate and a low mortality rate. It provides a more appropriate model that better simulates the various lesions occurring in humans than the usual model of tumor implantations. The aim of the present study was to evaluate MRI liver examination in Sprague-Dawley(SD) rats as a routine method to detect hepatocellular carcinoma (HCC) nodules induced by DENA and to follow up their growth. METHODS:Hepatic carcinogenesis was induced in 80 male SD rats using oral DENA solution. All animals were imaged for liver tumor detection with a 1.5 Tesla magnet (Siemens Sonata,Erlangen, Germany) using correspondence scan parameters and a radio-frequency knee coil. Macroscopic examinations were performed along the axial MRI sections to evaluate magnetic resonance imaging (MRI) findings, and histopathological assessment was also performed. RESULTS:No false negative results were obtained on MR images. Hepatic tumors in 72 rats were confirmed macro-scopically and 68 rats were detected by MRI till the 20th week. The smallest and the largest nodules detected by MRI were 2 mm and 37 mm in diameter respectively. The agreement rate of MRI with macroscopic observation was 39. 1% and 97. 4% respectively for 2 mm to 5 mm and more than 5 mm nodules. CONCLUSIONS:The hepatic tumor induced by DENA provides a more representative range of tumors for imaging diagnosis and interventional treatment. MRI is the best approach for scrutinizing pathological changes of rat livers in the period of observation. | Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, China (Li X, Zhou XP and Guan YS) Department of Radiology, Ruijin Hospieal. Shanghai Second Medical University, Shanghai 200025 , China. Current address:Astra Zeneca R & D Alderley, Macclesfield SK 10 4 TG U. K. (Wang YX) | 2005 | Hepatobiliary & Pancreatic Diseases International2005，4，3： | 3 |
| 3 | Structural, spectral and thermal studies of N-2 - (4-picolyl) -and N-2 - (6-picolyl) -N' - (2-chlorophenyl) thioureas and N-2 - (6-picolyl) -N' - (2-bromophenyl) thiourea 显示文摘 | ACKERMAN L J SWEARINGEN J K WEST D X | 2002 | J Mol Struct2002，610，13： | 1 |
| 4 | Effects of pH and concentration of citric, malic and lactic acids on en- amel, in vitro 显示文摘 | HUGHES J A WEST N X PARKER D M | 2000 | Journal of Dentistry2000，28，2： | 1 |
| 5 | Effect of the presence of bacterial surfaces during the synthesis of Fe-oxides by oxidation of ferrous ions显示文摘 | Chatellier X Fortin D West M | 2001 | European Journal of Mineralogy2001，13，： | 1 |
| 6 | Spectral studies of semicarbazones derived from 3-and 4-formylpyridine and 3-and 4-acetylpyridine:Crystal and molecular structure of 3-formylpyridine semicarbazone显示文摘 | Beraldo H Nacif W F West D X | 2001 | Spectrochimica Acta Part A2001，57，： | 1 |
| 7 | Effects of gossypol on phorbol ester-calcimycin-induced prostagl and in synthesis by macrophages显示文摘 | XIAO D M WEST X L ZHANG J B | | 0，，： | 1 |
| 8 | J Mol Struct显示文摘 | Mendes I C Teixeira L R Lima R Beraldo H Speziali N L West D X | 2001 | 559:3552001，559，： | 1 |
| 9 | Polyhedron 显示文摘 | West D X Swearingen J K Valdes-Martinez J Hernandez-Ortega S El-Sawaf A K Meurs F V Castitieiras A Garcia I Bennejo E | 1999 | 18:2 9191999，18，： | 1 |
| 10 | Antifungal and antltumor activity of heterocyclic thiosemicarbazones and their metal complexes 显示文摘 | Liberta A E West D X | 1992 | Biometals1992，5，2： | 1 |
| 11 | 显示文摘 | Kaminslay W Goldberg K I West D X | 2002 | J Mol Strut2002，605，： | 1 |
| 12 | The chemical and antifungal properties of the copper ( Ⅱ ) complexes of 2-Acetylpyrazine显示文摘 | West D X Carlson C S | 1990 | Transition Met Chem1990，15，2： | 1 |
| 13 | Transition metal ions of a thiosemicarbazone derived from 2-Acetylpyridine: Part 6显示文摘 | West D X Carlson C S Galloway C P | 1990 | Transition Met Chem1990，15，1： | 1 |
| 14 | Thiosemicarbone complexes of copper( Ⅱ ); structural and biological studies显示文摘 | West D X Liberta A E | 1993 | Coord Chem Rev1993，125，3： | 1 |
| 15 | Transition metalions of a thiomsemicarbazone derived from 6-methyl-2-actylpyridine显示文摘 | West D X Ertem G Makever R M | 1985 | Transition Met Chem1985，5，10： | 1 |
| 16 | Structural properties of fluorinated amorphous carbon films 显示文摘 | WANG X HARRIS H R BOULDIN K GANGOPADHYA Y S TEM H STRATHMAN D D WEST M | 2000 | J Appl Phys2000，87，1： | 1 |
| 17 | Spectral studies of semicarbazones derived from 3-and 4-formylpyridine and 3-and 4-acetylpyridine:crystal and molecular structure of 3-formylpyridine semicarbazone显示文摘 | Beraldo H Nacif W F West D X | 2001 | Spectrochim Acta A2001，57，9： | 1 |
| 18 | 显示文摘 | West D X Swearingen J K Valdes-Martinez J | 1999 | Polyhedron1999，18，： | 1 |
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