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| 1 | Pegylated interferon-alpha plus taurine in treatment of rat liver fibrosis显示文摘AIM: To investigate the antif ibrotic effects of peginterferon- alpha 2b and taurine on oxidative stress markers and hepatocellular apoptosis. METHODS: Sixty rats with CCl4-induced liver fibrosis were divided into 4 groups (n = 15). Group 1 was left for spontaneous recovery (SR). Groups 2-4 received peginterferon-alpha 2b, taurine, and their combination, respectively, for four weeks. Histological f ibrosis scores, histomorphometric analysis, tissue hydroxyproline, tissue MDA, GPx and SOD activities were determined. Activated stellate cells and hepatocellular apoptosis were also evaluated. RESULTS: The degree of f ibrosis decreased in all treatment groups compared to spontaneous recovery group. Taurine alone and in combination with peginterferon-alpha 2b reduced oxidative stress markers, but peginterferon-alpha 2b alone did not. Apoptotic hepatocytes and activated stellate cells were higher in groups 2-4 than in group 1. Combined taurine and peginterferon-alpha 2b further reduced fibrosis and increased activated stellate cell apoptosis, but could not improve oxidative stress more than taurine alone.CONCLUSION: Peginterferon-alpha 2b exerts anti- f ibrotic effects on rat liver fibrosis. It seems ineffective against oxidative stress in vivo. Peginterferon-alpha 2b in combination with taurine seems to be an antif ibrotic strategy. | Ilker Tasci Mehmet Refik Mas Sevil Atalay Vural Salih Deveci Bilgin Comert Gunay Alcigir Nuket Mas Cemal Akay Mithat Bozdayi Cihan Yurdaydin Hakan Bozkaya Ozden Uzunalimoglu Ahmet Turan Isik Harun M Said | 2007 | World Journal of Gastroenterology2007，13，23： | 7 |
| 2 | The scores of Hamilton depresion,anxiety,and panic agoraphobiarating scales in patients with acute coronary syndrome显示文摘 | Vural M Acer M Akbas B | 2008 | Anadolu Kardiyol Derg2008，8，1： | 1 |
| 3 | Oxidative stress in polycystic ovary syndrome and its contribution to the risk of cardiovascular disease显示文摘 | Sabuncu T Vural H Harma M | 2001 | Clin Biochem2001，34，5： | 1 |
| 4 | Off-pump,in situ internal thoracic artery grafting:a durable treatment for singlevessel coronary artery disease显示文摘 | Vural K M Iscan Z H Kunt A | 2005 | Ann Thorac Surg2005，79，3： | 1 |
| 5 | The effect of melatonin bleo-mycin-induced pulmonary fibrosis in rats显示文摘 | Arslan SO’Zerin M Vural H eJ al | 2002 | J Pineal Res2002，32，1： | 1 |
| 6 | The scores of Hamilton depression,anxiety,and panic agoraphobia rating scales in patients with acute coronary syndrome显示文摘 | Vural M Acer M Akbas B | 2008 | Anadolu Kardiyol Derg2008，8，1： | 1 |
| 7 | Use of cyanoacrylate glue for the closure of uterine incisions显示文摘 | Basaran M Vural M Irkorucu O | 2009 | Minimally Invasive Therapy&Allied Technologies2009，18，4： | 1 |
| 8 | High-resolution multispectral satellite image matching using scale invariant feature transform and speeded up robust features显示文摘 | TEKE M VURAL M F TEMIZEL A | 2011 | Journal of Applied Remote Sensing2011，5，53： | 1 |
| 9 | Power quality assessment of wind turbines and comparison with conventional legal regulations:a case study in Turkey显示文摘 | Tascikaraoglu A Uzunoglu M Vural B | 2011 | Applied Energy2011，，88： | 1 |
| 10 | The scores of Hailton depression,anxiety,andpanic agoraphobia rating scales in patients with acute coronarysundrom显示文摘 | Vural M Acer M Akbas B | 2008 | Anadolu Kardiyol Derg2008，8，1： | 1 |
| 11 | Central corneal thickness and Diaton transpalpebral tonometry显示文摘 | TOKER M VURAL A ERDOGAN H | 2008 | Graefes Arch Clin Exp Ophthalmol2008，246，6： | 1 |
| 12 | Hemangiomas of the head and neck with phleboliths: Clinical features, diagnostic imaging, and treatment of 3 cases显示文摘 | Hasan A Vural B Kemal M | 2007 | OralSurgery Oral Medicine Oral Pathology Oral Radiology & Endodontics2007，103，3： | 1 |
| 13 | The scores of Hamilton depression,anxiety,and panic agoraphobia rating scales in patients with acute coronary syndrome显示文摘 | VURAL M ACER M AKBAS B | 2008 | Anadolu Kardiyol Derg2008，8，1： | 1 |
| 14 | What to expect after tricuspid valve replacement long-term results 显示文摘 | Iscan Z H Vural K M Bahar I | 2007 | Eur J Cardio Thorac Surg2007，32，2： | 1 |
| 15 | Power quality assessment of' wind turbines and comparison with conventional legal regulations: A case study in Turkey显示文摘 | A Tascikaraoglu M Uzunoglu B Vural | 2011 | Applied Energy2011，，88： | 1 |
| 16 | The scores of hamilton depression,anxiety,and panic agoraphobia rating scales in patients with acute coronary syndrome显示文摘 | Vural M Aeer M Akbas B | 2008 | Anadolu Kardiyol Derg2008，8，1： | 1 |
| 17 | The association be- tween COX-2 expression and survival in myeloma patients 显示文摘 | Vural F Soyer N Hekimgil M | 2014 | Eur Rev Med Pharmacol Sci2014，18，15： | 1 |
| 18 | The Scores of Hamilton Depression,Anxiety,and Panic Agoraphobia Rating Scales in Patients with Acute Coronary Syndrome显示文摘 | Vural M Acer M Akbas B | 2008 | Anadolu Kardiyol Derg2008，8，1： | 1 |
| 19 | Use of cyanoacrylate glue for the closure of uterine incisions显示文摘 | Basaran M Vural M Irkorucu O | 2009 | Minim Invasive Ther Allied Technol2009，18，4： | 1 |
| 20 | Off-pump, in situ internal thoracic artery grafting: a durable treatment for single-vessel coronary artery disease显示文摘 | Vural K M Iscan Z H Kunt A | 2005 | Ann Thorac Surg2005，79，3： | 1 |
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