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| 1 | Significant decrease in prevalence ofHelicobacter pylori in the Czech Republic显示文摘AIM:To study possible decrease in prevalence of Helicobacter pylori(H.pylori) infection in the Czech Republic within a 10-year period.METHODS:A total of 22 centres entered the study.The catchment areas of these centres covered cities and towns with more than 20 000 inhabitants,smaller towns(≤ 20 000 inhabitants) with surrounding villages and rural areas,and were spread over the whole country,corresponding well to the geographical distribution of the Czech population.A total of 1 837 subjects(aged 5-98 years) took part in the study,randomly selected out of 38 147 people from the general population.H.pylori infection was investigated by means of a 13 C-urea breath test.Breath samples in duplicates were analysed using isotope ratio mass spectrometry.The cut-off point was 3.5.Social and demographic characteristics were based on data from self-completed questionnaires.RESULTS:The overall prevalence of H.pylori infection was 23.5%(430/1826),and 4.8%(20/420) in children aged 15 or less.There was no statistically significant difference in prevalence between males(24.3%;208/857) and females(22.9%,222/969,P = 0.494).H.pylori infection was strongly associated with higher age,among subjects aged 55+ years,prevalence of H.pylori infection was 39.8%(252/633,P < 0.001).The highest prevalence of H.pylori infection was found among persons aged 55-64 years(43.9%,97/221) and 75+ years(37.9%,58/153).Among study subjects aged 15+ years,prevalence of H.pylori infection was significantly increased in those with lowest education(odds risk 3.19,95% CI 1.87-5.47).Compared to never married(14.1%),the prevalence of H.pylori infection was statistically significantly higher among married(35.4%,246/694,P < 0.001),divorced(36.8%,49/133,P < 0.001) and widowed study subjects(40.2%,45/112,P < 0.001),both in minimally and fully adjusted analysis.There was no significant difference in the prevalence of H.pylori infection between married and widowed subjects(35.4%,246/694 vs 40.2%,45/112,P = 0.389).There was little variation in smoking prevalence across categories of smoking and there was no evidence of an increased risk ofH.pylori infection among current or past smokers in our data(odds risk 1.04 with 95% CI 0.78-1.40 for current smokers;odds ratio 0.83 with 95% CI 0.60-1.16 for former smokers).The current prevalence of H.pylori in 2011 was significantly lower compared to the prevalence reported from identical geographical areas in 2001(23.5%vs 41.7%,P < 0.001).CONCLUSION:The overall prevalence of H.pylori infection in the general population has fallen substantially in the Czech Republic over the past 10 years. | Jan Bure Marcela Kopáová Ilona Koupil Bohumil Seifert Miluka kodová Fendrichová Jana pirková Viktor Voíek Stanislav Rejchrt TomáDouda Norbert Král Ilja Tachecí | 2012 | World Journal of Gastroenterology2012，18，32： | 8 |
| 2 | Investigation of the effects of peppermint oil and valerian on rat liver and cultured human liver cells显示文摘 | Vo L T Chan D King R G | 2003 | Clin Exp Pharmacol Physiol2003，30，10： | 1 |
| 3 | Regulation of purine biosynthesis by a eukaryotic-type kinase in Streptococcus agalactiae显示文摘 | Rajagopal L Vo A Silvestroni A Rubens C E | | 0，，05： | 1 |
| 4 | Design of novel Pt-structured catalyst on anodic aluminum support for VOCs catalytic combustion 显示文摘 | Wang L F Tran T P Vo D V | 2008 | Applied Catalysis A : General2008，350，2： | 1 |
| 5 | Protein kinase C- fdeltaf regulates the subcellular localization of Shc in H202-treated cardiomyocytes显示文摘 | Guo J Cong L Rybin VO | 2010 | Am J Physiol Cell Physiol2010，299，77： | 1 |
| 6 | Lifetime and 12-month prevalence of mental disorders in the Nigerian Survey of Mental Health and Well-Being显示文摘 | Gureje O Lasebikan VO Kola L | 2006 | Br J Psychiatry2006，188，： | 1 |
| 7 | Biogenic Methane Potential for Surat Basin, Queensland Coal Seams 显示文摘 | Papendick S L Downs K R Vo K D | 2011 | International Journal of Coal Geology2011，88，23： | 1 |
| 8 | Enhancements of Authenticated Multiple Key Exchange Protocol Based on Bilinear Pairings显示文摘 | Vo D L Lee H Yeun C Y | 2010 | Computers and Electrical Engineering2010，36，1： | 1 |
| 9 | Use of coaxial gas jackets to stabilize taylor cones of volatile solutions and to induce particle-to- fiber transitions 显示文摘 | Gustavo L Ruben S Raffet VO | 2004 | Advanced Materials2004，16，2： | 1 |
| 10 | Accuracy enhancement of digital image correlation with B^spline interpolation显示文摘 | Luu L Wang Z Vo M | 2011 | Optics Letters2011，36，： | 1 |
| 11 | The ATM gene is a target for epigenetic silencing in locally advanced breast cancer显示文摘 | Vo UN Kim WJ Cvitanovic L | 2005 | On- cogene2005，24，11： | 1 |
| 12 | The oncology drug elesclomol selectively transports copper to the mitochondria to induce oxidative stress in cancer cells显示文摘 | NAGAI M VO NH SHIN OGAWA L et ol | 2012 | Free Radical Bio Med2012，52，10： | 1 |
| 13 | Texture heterogeneities induced by subtransus processing of near α titanium alloys显示文摘 | GERMAIN L GEY N HUMBERT M VO P JAHAZI M BOCHER P | 2008 | Acta Materialia2008，56，16： | 1 |
| 14 | Nitrogen adsorption isotherms for zeo- lite and activated carbon显示文摘 | Yang L C Vo T D Burris H H | 1982 | Cryogenics1982，，： | 1 |
| 15 | The effect of rabeprazole on regional gastric acidity and the postpandial cardia/ gastroesophageal junction acid lower in normal subjects: a randomized double blind, placebo controlled study显示文摘 | Vo L Simniom H Doma S | 2005 | A liment Pharmacol Ther2005，21，： | 1 |
| 16 | Fixed-dose combination of extended-re- lease niacin plus simvastatin for lipid disorders显示文摘 | Vo A N Kashyap M L | 2008 | Expert Rev Cardiovase Ther2008，6，10： | 1 |
| 17 | Studies on the stereoselective metabolism of citalopram by human liver microsomes and cDNA-expressed cytochrome P450 enzymes显示文摘 | OLE VO KRISTIAN L | 1996 | Journal of Chromatography B1996，675，： | 1 |
| 18 | An expanded genome-scale model of Escherichia coli K-12 (iJR904GSM/GPR)显示文摘 | Jennifer L Reed Thuy D Vo Christophe H Schilling | 2003 | Genome Biology2003，4，9： | 1 |
| 19 | The ATM gene is a target for epigenetic silencing in locally advanced breast cancer 显示文摘 | Vo QN Kim WJ Cvitanovie L | 2004 | Oncogene2004，23，58： | 1 |
| 20 | Durable remission of mantle cell lymphoma relapsing a third time after allogeneie hematopoietic stem cell transplantation treated with rituximab, bortezomib, donor lymphocytes, and pegylated interferon 显示文摘 | Vo P Jaffe ES Cook L | 2013 | Clin Lymphoma Myeloma Leuk2013，13，6： | 1 |
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