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| 1 | Current status and perspectives of immune-based therapiesfor hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC)is a frequent cancer with a high mortality.For early stage cancer there are potentially curative treatments including local ablation,resection and liver transplantation.However,for more advanced stage disease,there is no optimal treatment available.Even in the case of a'curative'treatment,recurrence or development of a new cancer in the precancerous liver is common.Thus,there is an urgent need for novel and effective(adjuvant)therapies to treat HCC and to prevent recurrence after local treatment in patients with HCC.The unique immune response in the liver favors tolerance,which remains a genuine challenge for conventional immunotherapy in patients with HCC.However,even in this'immunotolerant'organ,spontaneous immune responses against tumor antigens have been detected,although they are insufficient to achieve significant tumor death.Local ablation therapy leads to immunogenic tumor cell death by inducing the release of massive amounts of antigens,which enhances spontaneous immune response.New immune therapies such as dendritic cell vaccination and immune checkpoint inhibition are under investigation.Immunotherapy for cancer has made huge progress in the last few years and clinical trials examining the use of immunotherapy to treat hepatocellular carcinoma have shown some success.In this review,we discuss the current status of and offer some perspectives on immunotherapy for hepatocellular carcinoma,which could change disease progression in the near future. | Maridi Aerts DaphnéBenteyn Hans Van Vlierberghe Kris Thielemans Hendrik Reynaert | 2016 | World Journal of Gastroenterology2016，22，1： | 24 |
| 2 | Quality of life after liver transplantation:State of the art显示文摘Quality of life(QoL) after deceased donor liver transplantation is increasingly recognized as a major outcome parameter. We reviewed recent publications in this rapidly evolving field in order to summarize recent achievements in the field and to define opportunities and perspectives for research and improvement of patient care. QoL does improve after liver transplantation according to a typical pattern. During the first year, there is a significant improvement in QoL. After one year, the improvement does stabilise and tends to decline slightly. In addition to the physical condition, different psychological parameters(such as depression, anxiety, sexual function) and sociodemographic elements(professional state, sex, marital state) seem to impact QoL. Opportunities for further research are the use of dedicated questionnaires and identification of influencing factors for QoL. | Louis Onghena Wouter Develtere Carine Poppe Anja Geerts Roberto Troisi Aude Vanlander Frederik Berrevoet Xavier Rogiers Hans Van Vlierberghe Xavier Verhelst | 2016 | World Journal of Hepatology2016，8，18： | 3 |
| 3 | Angiogenesis in chronic liver disease and its complications显示文摘 | StephanieCoulon FemkeHeindryckx AnjaGeerts ChristopheVan Steenkiste IsabelleColle HansVan Vlierberghe | 2011 | Liver International2011，，2： | 3 |
| 4 | Hepatopulmonary syndrome and portopulmonary hypertension: recent knowledge in pathogenesis and overview of clinical assessment显示文摘 | Sarah Raevens Anja Geerts Christophe Van Steenkiste Xavier Verhelst Hans Van Vlierberghe Isabelle Colle | 2015 | Liver Int2015，，6： | 2 |
| 5 | Modulation of Portal Graft Inflow: A Necessity in Adult Living-Donor Liver Transplantation?显示文摘 | Roberto Troisi Guy Cammu Giuseppe Militerno Luc De Baerdemaeker Johan Decruyenaere Eric Hoste Peter Smeets Isabelle Colle Hans Van Vlierberghe Mirko Petrovic Dirk Voet Eric Mortier Uwe J. Hesse Bernard de Hemptinne | 2003 | Annals of Surgery2003，，3： | 2 |
| 6 | CT and MR imaging findings in f ocal nodular hyperplasia of the liver:radiologic-pathologic correlation显示文摘 | Mortele KJ Praet M Van Vlierberghe | 2000 | AJR2000，179，3： | 1 |
| 7 | PHF6 muta- tions in adult acute myeloid leukemia 显示文摘 | Van Vlierberghe P Patel J Abdel-Wahab O | 2011 | Leukemia2011，25，1： | 1 |
| 8 | Monoalletic or biallelic LMO2 expression in relation to the LMO2 rearrangement status in pediatric T-cell acute lymphoblastic leukemia显示文摘 | Van Vlierberghe P Beverloo HB Buijs-Gladdines J | 2008 | Leukemia2008，22，7： | 1 |
| 9 | Experimental mouse models for hepatocellular carcinoma research显示文摘 | Heindryckx F Colle I Van Vlierberghe H | 2009 | Int J Exp Pathol2009，90，4： | 1 |
| 10 | Biopolymer-based hydrogels as scaffolds for tissue engineering applications: a review 显示文摘 | Van Vlierberghe S Dubruel P Schacht E | 2011 | Biomaeromoleeules2011，12，5： | 1 |
| 11 | Duplication of the MYB oncogene in T cell acute lymphoblastic leukemia 显示文摘 | Lahortiga I De Keersmaecker K Van Vlierberghe P | 2007 | Nat Genet2007，39，5： | 1 |
| 12 | Early Arterial Revascularization After Hepatic Artery Thrombosis May Avoid Graft Loss and Improve Outcomes in Adult Liver Transplantation显示文摘 | A. Scarinci M. Sainz-Barriga F. Berrevoet B. van den Bossche I. Colle A. Geerts X. Rogiers H. van Vlierberghe B. de Hemptinne R. Troisi | 2010 | Transplantation Proceedings2010，，10： | 1 |
| 13 | CT and MR imaging findings in focal nodular hyperplasia of the liver:radiologic-pathologic correlation显示文摘 | Mortele KJ Praet M Vlierberghe V | 2000 | AJR2000，175，： | 1 |
| 14 | The recurren t SET-NUP214 fusion as a new HOXA activation mechanism in pediatric T-cell acute lymphoblastic leukemia显示文摘 | Van Vlierberghe P Van Grotel M Tch inda J | 2008 | Blood2008，111，： | 1 |
| 15 | Entecavir is superior to lamivudine in reducing hepatitis B virus DNA in patients with chronic hepatitis B infection显示文摘 | Ching–Lung Lai Mohamed Rosmawati Judy Lao Hans Van Vlierberghe Frank H. Anderson Neal Thomas Deborah Dehertogh | 2002 | Gastroenterology2002，，6： | 1 |
| 16 | Campylobaeter- associated Guillain-Barr syndrome after orthotopie liver transplantation for hepatitis C cirrhosis: a case report显示文摘 | Colle I Van Vlierberghe H Troisi R | 2002 | Hepatol Res2002，24，2： | 1 |
| 17 | The recurrentSET-NUP214 fusion as a new HOXA activation mechanism in pedia-tric T-cell acute lymphoblastic leukemia显示文摘 | van Vlierberghe P van Grotel M Tchinda J | 2008 | Blood2008，111，9： | 1 |
| 18 | Evaluation of inflammatory and angiogenic factors in patients with non-alcoholic fatty liver disease显示文摘 | Stephanie Coulon Sven Francque Isabelle Colle An Verrijken Bram Blomme Femke Heindryckx Steffi De Munter Janne Prawitt Sandrine Caron Bart Staels Hans Van Vlierberghe Luc Van Gaal Anja Geerts | 2012 | Cytokine2012，，： | 1 |
| 19 | Deposition of HMDSO-based coatings on PET substrates using an atmospheric pressure dielectric barrier discharge显示文摘 | Morent R Geyter N D Vlierberghe S V Dubruel P | 2009 | Progress in Organic Coatings2009，69，23： | 1 |
| 20 | Noninvasive diagnosis of liver cirrhosis using DNA sequencer-based total serum protein glycomics显示文摘 | Callewaert N Vlierberghe HV Hecke AV | 2004 | Nat Med2004，10，4： | 1 |
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