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| 1 | 重组脊髓灰质炎病毒用于治疗复发胶质母细胞瘤(英文)显示文摘Background The prognosis of patients with recurrent World Health Organization(WHO)grade IV malignant glioma is dismal,and there is currently no effective therapy.We conducted a dose-finding and toxicity study in this population of patients,evaluating convection-enhanced,intratumoral delivery of the recombinant nonpathogenic polio-rhinovirus chimera(PVSRIPO).PVSRIPO recognizes the poliovirus receptor CD155,which is widely expressed in neoplastic cells of solid tumors and in major components of the tumor microenvironment.Methods We enrolled consecutive adult patients who had recurrent supratentorial WHO grade IV malignant glioma,confirmed on histopathological testing,with measurable disease(contrast-enhancing tumor of≥1 cm and≤5.5 cm in the greatest dimension).The study evaluated seven doses,ranging between 107 and 1010 50%tissue-culture infectious doses(TCID50),first in a dose-escalation phase and then in a dose-expansion phase.Results From May 2012 through May 2017,a total of 61 patients were enrolled and received a dose of PVSRIPO.Dose level-1(5.0×107TCID50)was identified as the phase 2 dose.One dose-limiting toxic effect was observed;a patient in whom dose level 5(1010TCID50)was administered had a grade 4 intracranial hemorrhage immediately after the catheter was removed.To mitigate locoregional inflammation of the infused tumor with prolonged glucocorticoid use,dose level 5 was deescalated to reach the phase 2 dose.In the dose-expansion phase,19%of the patients had a PVSRIPO-related adverse event of grade 3 or higher.Overall survival among the patients who received PVSRIPO reached a plateau of 21%(95%confidence interval,11 to 33)at 24 months that was sustained at 36 months.Conclusions Intratumoral infusion of PVSRIPO in patients with recurrent WHO grade IV malignant glioma confirmed the absence of neurovirulent potential.The survival rate among patients who receivedPVSRIPO immunotherapy was higher at 24 and 36 months than the rate among historical controls. | Desjardins A Gromeier M Herndon JE 2nd Beaubier N Bolognesi DP Friedman AH Friedman HS McSherry F Muscat AM Nair S Peters KB Randazzo D Sampson JH Vlahovic G Harrison WT McLendon RE Ashley D Bigner DD | 2018 | 中华神经外科疾病研究杂志2018，17，4： | 2 |
| 2 | Association be-tween injection practices and duration of injection among re-cently initiated injection drug users显示文摘 | Becker Buxton M Vlahov D Strathdee SA | 2004 | Drug Alcohol Depend2004，75，2： | 1 |
| 3 | DNA methylation as a regulatory mechanism for gene expression in mammals显示文摘 | Serman A Vlahovic M Serman L | 2006 | Coll Antropol2006，30，3： | 1 |
| 4 | Micro RNA-31 controls hair cycle-associated changes in gene expression pro- grams of the skin and hair follicle显示文摘 | Mardaryev A N Ahmed M I Vlahov N V | 2010 | The FASEB Journal2010，24，10： | 1 |
| 5 | The epidemiology of post-traumatic Stress disorder after disasters 显示文摘 | Galea S Nandi A Vlahov D | 2005 | Epidemiol Rev2005，27，： | 1 |
| 6 | Of mice and men: teratomas and teratocarcinomas显示文摘 | Bulic-Jakus F Ulamec M Vlahovic M | 2006 | Coll Antropol2006，30，4： | 1 |
| 7 | Activation of tyrosine kinases in cancer显示文摘 | Vlahovic G Crawford J | 2003 | Oncologist2003，8，6： | 1 |
| 8 | Oxidative stress parameters as possible urine markers in patients with diabetic nephropathy 显示文摘 | Cvetkovic T Mitic B Lazarevic G Vlahovic P Antic S Stefanovic V | 2009 | J Diabetes Complications2009，23，： | 1 |
| 9 | The effect of piracetam on the local cortical cerebral blood flow in cats显示文摘 | Vlahov V Nikolova M Nikolov R | 1980 | Arch Int Pharmacodyn1980，243，： | 1 |
| 10 | Synthesis and biological evaluation of EC20:a new folate-derived,^99mTc-based radiopharmaceutical显示文摘 | Leamon CP Parker MA Vlahov IR | 2002 | Bioconjug Chem2002，13，6： | 1 |
| 11 | Urbanization, urbanicity, and health显示文摘 | David Vlahov Sandro Galea | 2002 | Journal of Urban Health2002，，1： | 1 |
| 12 | Attitudes Toward Hrq Treatments Influence Unsafe Sexual and Injection Practices among Injecting Drug Users 显示文摘 | Tun W Celentano DD Vlahov D | 2003 | AIDS2003，17，13： | 1 |
| 13 | Significance of opening the medullar canal in surgical treatment of simple bone cyst显示文摘 | Bumci I Vlahovic T | 2002 | J Pediatr Orthop2002，22，： | 1 |
| 14 | Synthesis and biological evaluation of EC140:a no- vel folate-targeted vinca alkaloid conjugate 显示文摘 | LEAMON C P REDDY J A VLAHOV I R | 2006 | Bio- conjug Chem2006，17，5： | 1 |
| 15 | A new synthesis of roxatidine acetate 显示文摘 | Tarpanob V Vlahov R Penkov M | 1999 | SyntheticCommunications1999，29，1： | 1 |
| 16 | Evaluation of disulfide reduction during receptor-mediated endocytosis by using FRET imaging显示文摘 | Yang J Chen H Vlahov I R | 2006 | Proc Natl Acad Sci USA2006，103，13： | 1 |
| 17 | Correlates of enrollment in methadone maintenance treatment programs differ by HIVserostatus显示文摘 | Shah NG Celentano DD Vlahov D | 2000 | AIDS2000，14，13： | 1 |
| 18 | Urban health:evidence,challenge,and directions显示文摘 | Galea S Vlahov D | | 0，，： | 1 |
| 19 | Adjunctive effect of hyperbaric oxygen treatment after thrombolysis on left ventricular function in patients with acute myocardial infarction显示文摘 | Dekleva M Neskovic A Vlahovic A | | 0，，： | 1 |
| 20 | Re- gioselective synthesis of folate receptor-targeted agents derived from epothilone analogs and folic acid 显示文摘 | VLAHOV I R VITE G D KLEINDL P J | 2010 | Bioorg Med Chem Lett2010，20，15： | 1 |
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