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| 1 | Value of adipokines in predicting the severity of acute pancreatitis:Comprehensive review显示文摘AIM:To analyze the prognostic value of adipokines in predicting the course,complications and fatal outcome of acute pancreatitis(AP).METHODS:We performed the search of PubMed database and the systemic analysis of the literature for both experimental and human studies on prognostic value of adipokines in AP for period 2002-2012.Only the papers that described the use of adipokines for prediction of severity and/or complications of AP were selected for further analysis.Each article had to contain information about the levels of measured adipokines,diagnosis and verification of AP,to specify presence of pancreatic necrosis,organ dysfunction and/or mortality rates.From the very beginning,study was carried out adhering to the PRISMA checklist and flowchart for systemic reviews.To assess quality of all included human studies,the Quality Assessment of Diagnostic Accuracy Studies tool was used.Because of the high heterogeneity between the studies,it was decided to refrain from the statistical processing or meta-analysis of the available data.RESULTS:Nine human and three experimental studies were included into review.In experimental studies significant differences between leptin concentrations at 24 and 48 h in control,acute edematous and acute necrotizing pancreatitis groups were found(P = 0.027 and P < 0.001).In human studies significant differences between leptin and resitin concentrations in control and acute pancreatitis groups were found.1-3 d serum adiponectin threshold of 4.5 μg/mL correctly classified the severity of 81% of patients with AP.This threshold yielded a sensitivity of 70%,specificity 85%,positive predictive value 64%,negative predictive value88%(area under curve 0.75).Resistin and visfatin concentrations differ significantly between mild and severe acute pancreatitis groups,they correlate with severity of disease,need for interventions and outcome.Both adipokines are good markers for parapancreatic necrosis and the cut-off values of 11.9 ng/mL and 1.8 ng/mL respectively predict the high ranges of radiological scores.However,the review revealed that all nine human studies with adipokines are very different in terms of methodology and objectives,so it is difficult to generalize their results.It seems that concentrations of the leptin and resistin increases significantly in patients with acute pancreatitis compared with controls.Serum levels of adiponectin,visfatin and especially resitin(positive correlation with Acute Physiology and Chronic Health Evaluation Ⅱ,Ranson and C-reactive protein) are significantly different in mild acute pancreatitis and severe acute pancreatitis patients,so,they can serve as a markers for the disease severity prediction.Resistin and visfatin can also be used for pancreatic and parapancreatic necrosis prediction,interventions needs and possible,outcome.CONCLUSION:High levels of adipokines could allow for prediction of a severe disease course and outcome even in small pancreatic lesions on computed tomography scans. | Andrius Karpavicius Zilvinas Dambrauskas Audrius Sileikis Dalius Vitkus Kestutis Strupas | 2012 | World Journal of Gastroenterology2012，18，45： | 20 |
| 2 | Efficiency of arthroscopic treatment in the knee osteoarthritis 显示文摘 | Belickas J Vitkus L Fiodorovas M | 2003 | Medicina ( Kaunas)2003，11，： | 1 |
| 3 | The toxicity of Tau in Alzheimer disease: turnover, targets and potential therapeutics显示文摘 | Pritchard SM Dolan PJ Vitkus A | 2011 | J Cell Mol Med2011，15，： | 1 |
| 4 | Efficiency of arthroscopic treatment in the knee osteoarthritis显示文摘 | Belickas J Vitkus L Fiodomvas M | 2003 | Medicina (Kaunas)2003，39，11： | 1 |
| 5 | Microsurgical reconstruction of shotgun-blast wounds to the face显示文摘 | Vitkus K Vitkus M | 1990 | J Reconstr Microsurg1990，6，3： | 1 |
| 6 | Madness and Misogyny in Ken Kesey's One Flew Over the Cuckoo's Nest 显示文摘 | Vitkus Daniel J | 1994 | Alif: Journal of Comparative Poetics1994，，14： | 1 |
| 7 | Morphological criteria of oocyte quality 显示文摘 | Lasiene K Vitkus A Valanciute A | 2009 | Medicina ( Kaunas)2009，45，7： | 1 |
| 8 | Morphological criteria ofoocyte quality显示文摘 | LasieneK Vitkus A Valanciute A | 2009 | Medicina(Kaunas)2009，45，7： | 1 |
| 9 | The toxicity of tau in Alzheimer disease: turnover, targets and potential therapeutics显示文摘 | Pritchard SM Dolan P J Vitkus A | 2011 | J Cell Mol Med2011，15，8： | 1 |
| 10 | Development and validation of LC–MS/MS method for quantification of bisphenol A and estrogens in human plasma and seminal fluid显示文摘 | Jana Vitku Tereza Chlupacova Lucie Sosvorova Richard Hampl Martin Hill Jiri Heracek Marie Bicikova Luboslav Starka | 2015 | Talanta2015，，： | 1 |
| 11 | Morphological criteria of oocyte quality显示文摘 | Lasiene K Vitkus A Valanciūte A | 2009 | Medicina(Kaunas)2009，45，： | 1 |
| 12 | Efficiency of arthroscopic treatment in the knee osteoarthritis显示文摘 | Belickas J Vitkus L Fiodorovas M | | 0，，： | 1 |
| 13 | Efficiency of arthroscopic treatment in the knee osteoarthritis 显示文摘 | BELICKAS J VITKUS L FIODOROVAS M | 2003 | Medicina Kaunas2003，39，11： | 1 |
| 14 | Efficiency of ar- throseopie treatment in the knee osteoarthritis显示文摘 | Belickas J Vitkus L Fiodorovas M | 2003 | Medicina (Kaunas)2003，39，11： | 1 |
| 15 | The toxicity of tau in Alzheimer disease:turnover, targets and potential therapeutics显示文摘 | PRITCHARD S M DOLAN P J VITKUS A | 2011 | Cell Mol Med2011，15，： | 1 |
| 16 | The toxieity of Tau in Alzheimer disease: turnover, targets and potential therapeutics 显示文摘 | Pritehard S M Dolan P J Vitkus A | 2011 | J Cell Mol Med2011，15，8： | 1 |
| 17 | The toxicity of tau in Alzheimer disease:turnover,targets and potential therapeutics显示文摘 | Pritchard SM Dolan PJ Vitkus A | | 0，，08： | 1 |
| 18 | Morphologocalcriteria of oocyte quality显示文摘 | Lasiene K Vitkus A Valanciute A | 2009 | Medicina(Kaunas)2009，45，7： | 1 |
| 19 | Morphological criteria of oocyte quality显示文摘 | Lasiene K Vitkus A Valanciute A | 2009 | Medicina (Kaunas)2009，45，7： | 1 |
| 20 | Morphological criteria of oocyte quality 显示文摘 | LASIENE K VITKUS A VALANCIUTE A | 2009 | Medicina ( Kaunas )2009，45，7： | 1 |
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