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| 1 | Intravitreal dexamethasone implants for diabetic macular edema显示文摘AIM: To evaluate the safety and efficacy of a dexamethasone(DEX) intravitreal implant for diabetic macular edema(DME).METHODS: Totally 113 eyes of 84 patients were divided in three subgroups: naive patients(n=11), pseudophakic patients(n=72) and phakic patients(n=30). Inclusive criterion comprised adult diabetic patients with central fovea thickening and impaired visual acuity resulting from DME for whom previous standard treatments showed no improvement in both central macular thickness(CMT) and best corrected visual acuity(BCVA) after at least 3 mo of treatment. Outcome data were obtained from patient visits at baseline and at months 1, 3, 5, 9 and 12 after the first DEX implant injection. At each of these visits, patients underwent measurement of BCVA, a complete eye examination and measurement of CMT and macular volume(MV) carried out with optical coherence tomography(OCT) images. RESULTS: Seventy-three eyes(64.5%) received a single implant, 30(26.5%) received two implants and 10(9%) received three implants. At baseline, average in BCVA, CMT and MV were 43.5±20.8, 462.8±145 and 12.6±2.5 respectively. These values improved significantly at 1 mo(BCVA: 47.2±19.5, CMT: 339.6±120, MV: 11.11±1.4) and 3 mo(BCVA: 53.2±18.1, CMT: 353.8±141, MV: 11.3±1.3)(P≤0.05). At 5 mo(BCVA: 50.9±19.8, CMT: 425±150, MV: 12.27±2.3), 9 mo(BCVA: 48.4±17.6, CMT: 445.5±170, MV: 12.5±2.3) and 12 mo(BCVA: 47.7±18.8, CMT: 413.2±149, MV: 12.03±2.5), improvements in the three parameters were no longer statistically significant and decreased progressively but did not reach baseline values. There were no clinical differences between subgroups. Ocular complications were minimal.CONCLUSION: Patients with DEX implants show maximum efficacy at 3 mo which then declined progressively, but is still better than baseline values at the end of follow-up. | Alicia Pareja-Ríos Paloma Ruiz-de la Fuente-Rodríguez Sergio Bonaque-González Maribel López-Gálvez Virginia Lozano-López Pedro Romero-Aroca | 2018 | International Journal of Ophthalmology(English edition)2018，11，1： | 8 |
| 2 | Subclinical carotid atherosclerosis predicts all-cause mortality and cardiovascular events in obese patients with negative exercise echocardiography显示文摘BACKGROUND Obesity is a major health problem due to its high prevalence. The relationship between obesity and cardiovascular disease is unclear. Some studies agree that certain conditions associated with obesity, such as physical inactivity or cardiovascular risk factors, are responsible for cardiovascular risk excess among obese people. Carotid intima-media thickness and carotid plaques(CP) have been associated with cardiovascular adverse events in healthy populations, and recent data suggest a higher prevalence of subclinical carotid atherosclerosis in obese and metabolically unhealthy patients. However, there are no studies correlating subclinical atherosclerosis and adverse events(AE) in obese subjects.AIM To determine the association between carotid disease and AE in obese patients with negative exercise echocardiography(EE).METHODS From January 1, 2006 to December 31, 2010, 2000 consecutive patients with a suspicion of coronary artery disease were submitted for EE and carotid ultrasonography. Exclusion criteria included previous vascular disease, left ventricular ejection fraction < 50%, positive EE, significant valvular heart disease and inferior to submaximal EE. An AE was defined as all-cause mortality,myocardial infarction and cerebrovascular accident. Subclinical atherosclerosis was defined as CP presence according to Manheim and the American Society of Echocardiography Consensus.RESULTS Of the 652 patients who fulfilled the inclusion criteria, 226(34.7%) had body mass indexes ≥ 30 kg/m2, and 76 of them(33.6%) had CP. During a mean follow-up time of 8.2(2.1) years, 27 AE were found(11.9%). Mean event-free survival at 1, 5 and 10 years was 99.1%(0.6), 95.1%(1.4) and 86.5%(2.7), respectively. In univariate analysis, CP predicted AE [hazard ratio(HR) 2.52, 95% confidence interval(CI) 1.17-5.46; P = 0.019]. In multivariable analysis, the presence of CP remained a predictor of AE(HR 2.26, 95%CI 1.04-4.95, P = 0.041). Other predictors identified were glomerular filtration rate(HR 0.98, 95%CI 0.96-0.99; P= 0.023), peak metabolic equivalents(HR 0.83, 95%CI 0.70–0.99, P = 0.034) and moderate mitral regurgitation(HR 5.02, 95%CI 1.42–17.75, P = 0.012).CONCLUSION Subclinical atherosclerosis defined by CP predicts AE in obese patients with negative EE. These patients could benefit from aggressive prevention measures. | Rafael Vidal-Perez Raúl Franco-Gutiérrez Alberto J Pérez-Pérez Virginia Franco-Gutiérrez Alberto Gascón-Vázquez Andrea López-López Ana María Testa-Fernández Carlos González-Juanatey | 2019 | World Journal of Cardiology2019，11，1： | 7 |
| 3 | Heart Disease and Stroke Statistics—2009 Update: A Report From the American Heart Association Statistics Committee and Stroke Statistics Subcommittee显示文摘 | Donald Lloyd-Jones Robert Adams Mercedes Carnethon Giovanni De Simone T Bruce Ferguson Katherine Flegal Earl Ford Karen Furie Alan Go Kurt Greenlund Nancy Haase Susan Hailpern Michael Ho Virginia Howard Brett Kissela Steven Kittner Daniel Lackland Lynda L | 2009 | Circulation2009，，3： | 4 |
| 4 | Soil Microbial Diversity : Present and future considerations显示文摘 | AnnC Kennydy and Virginia L Gewin | 1997 | Soil Microbial Diversity1997，162，9： | 2 |
| 5 | A comparative evaluation of microalgae for the degradation of piggery wastewater under photosynthetic oxygenation显示文摘 | Ignacio de Godos Virginia A. Vargas Saúl Blanco María C. García González Roberto Soto Pedro A. García-Encina Eloy Becares Raúl Mu?oz | 2010 | Bioresource Technology2010，，14： | 2 |
| 6 | Haploinsufficiency of p18INK4c sensitizes mice to carcinogen-induced tumorigenesis显示文摘 | BAI F PEI X H VIRGINIA L G | 2003 | Molecular and Cellular2003，23，4： | 1 |
| 7 | CEO Attributes Associated with Attitude Toward Change: The Direct and Moderating Effects of CEO Tenure 显示文摘 | Martina Musteen Vincent L Barker Ⅲ Virginia L B | 2006 | Journal of Business Research2006，59，5： | 1 |
| 8 | Optimization by direct search: new perspectives on some classical and modern methods 显示文摘 | Kolda T G Robert M L Virginia T | 2003 | SIAM Review2003，45，3： | 1 |
| 9 | Growth response of selected vegetable crops to spent mushroom compost appli- cation in a controlled environment显示文摘 | SHERRY I-I W VIRGINIA I L DAVID L C | 1984 | Plant and Soi11984，82，1： | 1 |
| 10 | Carbon Isotopes Reveal Soil Organic Matter Dynamics Following arid Land Shrub Expansion显示文摘 | Connin S L Virginia R A Chamberlain C P | 1997 | Oecologia1997，110，： | 1 |
| 11 | Temsirolimus with or without Megestrol Acetate and Tamoxifen for endometrial cancer:a gyneco- logic oncology group study 显示文摘 | Gini F Leming F Virginia L | 2014 | Gynecol Oncol2014，132，3： | 1 |
| 12 | Growth response of selected vegetable crops to spent mushroom compost application in a controlled environment显示文摘 | SHERRY HSIAO L W VIRGINIA I | 1984 | Plant and Soil1984，82，： | 1 |
| 13 | Neurotoxic effects and biomarkers of lead exposure显示文摘 | Talia S Yiming L Virginia B | 2009 | Rev Environ Health2009，24，1： | 1 |
| 14 | Spatial distribution of nematodes in polar desert soils of Antarctica显示文摘 | POWERS L E FRECKMAN D W VIRGINIA R A | 1995 | Polar Biology1995，15，： | 1 |
| 15 | 1-Pentene isomerization over SAPO-11,BEA and AlMCM-41 molecular sieves显示文摘 | CARMEN M L LEYDA R VIRGINIA S | | 0，，： | 1 |
| 16 | Effect of high-dose simvastatin on brain atrophy and disability in secondary progressive multiple sclerosis (MS-STAT): a randomised, placebo-controlled, phase 2 trial显示文摘 | Jeremy Chataway Nadine Schuerer Ali Alsanousi Dennis Chan David MacManus Kelvin Hunter Val Anderson Charles R M Bangham Shona Clegg Casper Nielsen Nick C Fox David Wilkie Jennifer M Nicholas Virginia L Calder John Greenwood Chris Frost Richard Nicholas | 2014 | The Lancet2014，，： | 1 |
| 17 | Floral development of Nelumbo nucifera (Nelumbonaceae)显示文摘 | Hayes Virginia Schneider Edward L Carlquist Sherwin | 2000 | International Journal of Plant Sciences2000，，： | 1 |
| 18 | Nutrient limitation and algal blooms in urbanizing tidal creeks显示文摘 | MICHAEL A M DOUGLAS C P VIRGINIA L J | 2004 | Journal of Experimental Marine Biology and Ecology2004，298，： | 1 |
| 19 | Accuracy of neural network approximator in simulation-optimization显示文摘 | Virginia M J Leah L R | 2000 | Journal of Water Resources Planning and Management ASCE2000，126，2： | 1 |
| 20 | Comparative impacts of stormwater runoff on water quality of an urban,a suburban,and a rural stream显示文摘 | Michael AM Virginia L J Scott HE | | 0，，： | 1 |
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