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| 1 | Fatty liver disease,an emerging etiology of hepatocellular carcinoma in Argentina显示文摘AIM To investigate any changing trends in the etiologies of hepatocellular carcinoma(HCC) in Argentina during the last years. METHODS A longitudinal cohort study was conducted by 14 regional hospitals starting in 2009 through 2016. All adult patients with newly diagnosed HCC either with pathology or imaging criteria were included. Patients were classified as presenting non-alcoholic fatty liver disease(NAFLD) either by histology or clinically, provided that all other etiologies of liver disease were ruled out, fatty liver was present on abdominal ultrasound and alcohol consumption was excluded. Complete follow-up was assessed in all included subjects since the date of HCC diagnosis until death or last medical visit.RESULTS A total of 708 consecutive adults with HCC were included. Six out of 14 hospitals were liver transplant centers(n = 484). The prevalence of diabetes mellitus was 27.7%. Overall, HCV was the main cause of liver disease related with HCC(37%) including cirrhotic and non-cirrhotic patients, followed by alcoholic liver disease 20.8%, NAFLD 11.4%, cryptogenic 9.6%, HBV 5.4% infection, cholestatic disease and autoimmune hepatitis 2.2%, and other causes 9.9%. A 6-fold increase in the percentage corresponding to NAFLDHCC was detected when the starting year, i.e., 2009 was compared to the last one, i.e., 2015(4.3% vs 25.6%; P < 0.0001). Accordingly, a higher prevalence of diabetes mellitus was present in NAFLD-HCC group 61.7% when compared to other than NAFLD-HCC 23.3%(P < 0.0001). Lower median AFP values at HCC diagnosis were observed between NAFLD-HCC and non-NAFLD groups(6.6 ng/m L vs 26 ng/m L; P = 0.02). Neither NAFLD nor other HCC etiologies were associated with higher mortality.CONCLUSION The growing incidence of NAFLD-HCC documented in the United States and Europe is also observed in Argentina, a confirmation with important Public Health implications. | Federico Pinero Josefina Pages Sebastián Marciano Nora Fernández Jorge Silva Margarita Anders Alina Zerega Ezequiel Ridruejo Beatriz Ameigeiras Claudia D’Amico Luis Gaite Carla Bermúdez Manuel Cobos Carlos Rosales Gustavo Romero Lucas McCormack Virginia Reggiardo Luis Colombato Adrián Gadano Marcelo Silva | 2018 | World Journal of Hepatology2018，10，1： | 4 |
| 2 | 3D additive-manufactured nanocomposite magnetic scaffolds: Effect of the application mode of a time-dependent magnetic field on hMSCs behavior显示文摘Over the past few years,the influence of static or dynamic magnetic fields on biological systems has become a topic of considerable interest.Magnetism has recently been implicated to play significant roles in the regulation of cell responses and,for this reason,it is revolutionizing many aspects of healthcare,also suggesting new opportunities in tissue engineering.The aim of the present study was to analyze the effect of the application mode of a time-dependent magnetic field on the behavior of human mesenchymal stem cells(hMSCs)seeded on 3D additivemanufactured poly(3-caprolactone)/iron-doped hydroxyapatite(PCL/FeHA)nanocomposite scaffolds. | Ugo D'Amora Teresa Russo Antonio Gloria Virginia Rivieccio Vincenzo D'Anto Giacomo Negri Luigi Ambrosio Roberto De Santis | 2017 | Bioactive Materials2017，2，3： | 3 |
| 3 | Intermediate-advanced hepatocellular carcinoma in Argentina:Treatment and survival analysis显示文摘BACKGROUND Hepatocellular carcinoma(HCC) represents the sixteenth most frequent cancer in Argentina. The rise of new therapeutic modalities in intermediate-advanced HCC opens up a new paradigm for the treatment of HCC.AIM To describe real-life treatments performed in patients with intermediateadvanced HCC before the approval of new systemic options.METHODS This longitudinal observational cohort study was conducted between 2009 and2016 in 14 different regional hospitals from Argentina. Included subjects had intermediate-advanced Barcelona Clinic Liver Cancer(BCLC) HCC stages(BCLC B to D). Primary end point analyzed was survival, which was assessed for each BCLC stage from the date of treatment until last patient follow-up or death.Kaplan Meier survival curves and Cox regression analysis were performed, with hazard ratios(HR) calculations and 95% confidence intervals(95%CI).RESULTS From 327 HCC patients, 41% were BCLC stage B, 20% stage C and 39% stage D.Corresponding median survival were 15 mo(IQR 5-26 mo), 5 mo(IQR 2-13 mo)and 3 mo(IQR 1-13 mo)(P < 0.0001), respectively. Among BCLC-B patients(n =135), 57% received TACE with a median number of 2 sessions(IQR 1-3 sessions).Survival was significantly better in BCLC-B patients treated with TACE HR =0.29(CI: 0.21-0.40) than those without TACE. After tumor reassessment by RECIST 1.1 criteria following the first TACE, patients with complete response achieved longer survival (HR = 0.15(CI: 0.04-0.56, P = 0.005))Eighty-two patients were treated with sorafenib, mostly BCLC-B and C(87.8%). However,12.2% were BCLC-D. Median survival with sorafenib was 4.5 mo(IQR 2.3-11.7 mo);which was lower among BCLC-D patients 3.2 mo(IQR 2.0-14.1 mo). A total of 36 BCLC-B patients presented tumor progression after TACE. In these patients,treatment with sorafenib presented better survival when compared to those patients who received sorafenib without prior TACE [HR = 0.26(CI: 0.09-0.71);P= 0.013].CONCLUSION In this real setting, our results were lower than expected. This highlights unmet needs in Argentina, prior to the introduction of new treatments for HCC. | Federico Pinero Sebastián Marciano Nora Fernández Jorge Silva Margarita Anders Alina Zerega Ezequiel Ridruejo Gustavo Romero Beatriz Ameigeiras Claudia D’Amico Luis Gaite Carla Bermúdez Virginia Reggiardo Luis Colombato Adrián Gadano Marcelo Silva | 2019 | World Journal of Gastroenterology2019，25，27： | 3 |
| 4 | Neonatal polycythemina and hyperviscosity显示文摘 | Virginia D | 1982 | Pedi Cli Nor Am1982，29，： | 2 |
| 5 | Dynamics of the yeast transcriptome dur- ing wine fermentation reveals a novel fermentation stress response 显示文摘 | Virginia D M | 2008 | Research Article2008，，8： | 1 |
| 6 | Trial of complete weaning from immunosuppression for liver transplant recipients: Factors predictive of tolerance显示文摘 | Rocío García Garza Pablo Sarobe Juana Merino Juan J. Lasarte Delia D’Avola Virginia Belsue José A. Delgado Leyre Silva Mercedes I?arrairaegui Bruno Sangro Jesus J. Sola Fernando Pardo Jorge Quiroga J. Ignacio Herrero | 2013 | Liver Transpl2013，，9： | 1 |
| 7 | Studies on acetate ester production by non-Saccharomyces wine yeasts 显示文摘 | Virginia Rojas Jose V Gil Francisco Pinaga et (d | 2001 | International Journal of Food Microbiology2001，70，： | 1 |
| 8 | Decline in a dominant invertebrate species contributes to altered carbon cy- cling in a low- diversity soil ecosystem 显示文摘 | Barrett J E Virginia R A Wall D H | 2008 | Global Change Biology2008，14，： | 1 |
| 9 | Spatial distribution of nematodes in polar desert soils of Antarctica显示文摘 | POWERS L E FRECKMAN D W VIRGINIA R A | 1995 | Polar Biology1995，15，： | 1 |
| 10 | Congruence of pain assessment betweennurses and emergency department patients : A replication显示文摘 | Martin D Virginia D | 2008 | Inter-national Emergency Nursing2008，16，： | 1 |
| 11 | The interplay between climate change, forests, and disturbances显示文摘 | VIRGINIA H D LINDA A J STEVE M | 2000 | Science of the Total Environment2000，262，： | 1 |
| 12 | Challenges in the development and use of ecological indicators显示文摘 | VIRGINIA H D SUZANNE C B | 2001 | Ecological Indicators2001，1，： | 1 |
| 13 | Low-diversity Antarctic soil nematode communities : distribution and response to disturbance显示文摘 | FRECKMAN D W VIRGINIA R A | 1997 | Ecology1997，78，： | 1 |
| 14 | Leukoregulin induction of prostaglandin-endoperoxide H synthesis-Z in human orbital fibroblasts显示文摘 | Wang HS James HC Virginia D | | 0，，： | 1 |
| 15 | Congruence of pain assessment between nurses and emergency department patients:A replication显示文摘 | Martin D Virginia D | 2008 | International Emergency Nursing2008，16，： | 1 |
| 16 | Production of transgenic soybean lines expressing the bean pod mottle virus coat protein precursor gene显示文摘 | RONG D VIRGINIA P GLENN B C | 1996 | Plant Cell Reports1996，15，10： | 1 |
| 17 | Removal of As (Ⅲ ) and As ( Ⅴ ) from Water Using a Natural Fe and Mn Enriched Sample显示文摘 | Eleonora D Virginia S T C Wolfgang H H | 2005 | Water Res2005，39，： | 1 |
| 18 | Organizing multi-agent systems显示文摘 | Javier V S Virginia D Frank D | 2005 | Autonomous Agents and Multi-Agent System2005，3，： | 1 |
| 19 | Nuclear and mitocondrial DNA sequence diversity in Antarctic nematode Scottnema lindsayane显示文摘 | Courtright E M Wall D H Virginia R A | 2000 | J Nematol2000，32，： | 1 |
| 20 | Sequence variation in the ribosomal DNA internal transcribed spacer of Tridacna crocea 显示文摘 | Eizadora T Y Antonette J M Virginia D M | 2000 | Mar Biotechno12000，2，6： | 1 |
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