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| 1 | Oxidative stress:New insights on the association of nonalcoholic fatty liver disease and atherosclerosis显示文摘Non-alcoholic fatty liver disease(NAFLD) represents the most common and emerging chronic liver disease worldwide. It includes a wide spectrum of liver diseasesranging from simple fatty liver to non-alcoholic steatohepatitis(NASH),which may progress to fibrosis and more severe liver complications such as cirrhosis,hepatocellular carcinoma and liver mortality. NAFLD is strongly associated with obesity,insulin resistance,hypertension,and dyslipidaemia,and is now regarded as the liver manifestation of the metabolic syndrome. The increased mortality of patients with NAFLD is primarily a result of cardiovascular disease and,to a lesser extent,to liver related diseases. Increased oxidative stress has been reported in both patients with NAFLD and patient with cardiovascular risk factors. Thus,oxidative stress represents a shared pathophysiological disorder between the two conditions. Several therapeutic strategies targeting oxidative stress reduction in patients with NAFLD have been proposed,with conflicting results. In particular,vitamin E supplementation has been suggested for the treatment of non-diabetic,non-cirrhotic adults with active NASH,although this recommendation is based only on the results of a single randomized controlled trial. Other antioxidant treatments suggested are resveratrol,silybin,L-carnitine and pentoxiphylline. No trial so far,has evaluated the cardiovascular effects of antioxidant treatment in patients with NAFLD. New,large-scale studies including as end-point also the assessment of the atherosclerosis markers are needed. | Licia Polimeni Maria Del Ben Francesco Baratta Ludovica Perri Fabiana Albanese Daniele Pastori Francesco Violi Francesco Angelico | 2015 | World Journal of Hepatology2015，7，10： | 23 |
| 2 | palliative care and end-stage colorectal cancer management:The surgeon meets the oncologist显示文摘Colorectal cancer(CRC)is a common neoplasia in the Western countries,with considerable morbidity and mortality.Every fifth patient with CRC presents with metastatic disease,which is not curable with radical intent in roughly 80%of cases.Traditionally approached surgically,by resection of the primitive tumor or stoma,the management to incurable stageⅣCRC patients has significantly changed over the last three decades and is nowadays multidisciplinary,with a pivotal role played by chemotherapy(CHT).This latter have allowed for a dramatic increase in survival,whereas the role of colonic and liver surgery is nowadays matter of debate.Although any generalization is difficult,two main situations are considered,asymptomatic(or minimally symptomatic)and severely symptomatic patients needing aggressive management,including emergency cases.In asymptomatic patients,new CHT regimens allow today long survival in selected patients,also exceeding two years.The role of colonic resection in this group has been challenged in recent years,as it is not clear whether the resection of primary CRC may imply a further increase in survival,thus justifying surgeryrelated morbidity/mortality in such a class of shortliving patients.Secondary surgery of liver metastasis is gaining acceptance since,under new generation CHT regimens,an increasing amount of patients with distant metastasis initially considered non resectable become resectable,with a significant increase in long term survival.The management of CRC emergency patients still represents a major issue in Western countries,and is associated to high morbidity/mortality.Obstruction is traditionally approached surgically by colonic resection,stoma or internal by-pass,although nowadays CRC stenting is a feasible option.Nevertheless,CRC stent has peculiar contraindications and complications,and its long-term cost-effectiveness is questionable,especially in the light of recently increased survival.Perforation is associated with the highest mortality and remains mostly matter for surgeons,by abdominal lavage/drainage,colonic resection and/or stoma.Bleeding and other CRC-related symptoms(pain,tenesmus,etc.)may be managed by several mini-invasive approaches,including radiotherapy,laser therapy and other transanal procedures. | Renato Costi Francesco Leonardi Daniele Zanoni Vincenzo Violi Luigi Roncoroni | 2014 | World Journal of Gastroenterology2014，20，24： | 6 |
| 3 | 肠道衍生的血清脂多糖与心房颤动患者主要不良心血管事件的风险增加相关:地中海膳食的影响显示文摘肠道微生物群正在成为动脉粥样硬化血栓形成的新型危险因素,但肠道衍生的脂多糖的预测作用尚不清楚。来自意大利罗马Sapienza大学的Pastori等进行了一项前瞻性单中心研究,分析了脂多糖与心房颤动中主要不良心血管事件(major adverse cardiovascular events,MACE)之间的关系,以及坚持地中海膳食(Mediterranean diet,Med-diet)对上述关系的影响。 | 刘莉 叶鹏 Pastori D Carnevale R Nocella C Novo M Santulli M Cammisotto V Menichelli D Pignatelli P Violi F | 2017 | 中华高血压杂志2017，25，9： | 5 |
| 4 | Cholecystocolonic fistula: facts and myths. A review of the 231 published cases显示文摘 | Renato Costi Bruto Randone Vincenzo Violi Olivier Scatton Leopoldo Sarli Olivier Soubrane Bertrand Dousset Thierry Montariol | 2009 | Journal of Hepato - Biliary - Pancreatic Surgery2009，，1： | 2 |
| 5 | Patients with liver cirrhosis suffer from primary haemostatic defects? Fact or fiction?显示文摘 | F. Violi S. Basili V. Raparelli P. Chowdary A. Gatt A.K. Burroughs | 2011 | Journal of Hepatology2011，，6： | 2 |
| 6 | Functional outcome of total anorectal reconstruction:incontinence or constipation?显示文摘 | Boselli AS Bernardinis M | 2003 | Acta Bio Medica2003，74，2： | 1 |
| 7 | Obstructive sleep apnoea syndrome and the metabolic syndrome in an internal medicine setting显示文摘 | Francesco Angelico Maria del Ben Teresa Augelletti Rosanna de Vita Rocco Roma Francesco Violi Mario Fabiani | 2010 | European Journal of Internal Medicine2010，，3： | 1 |
| 8 | Association between low-grade disseminated intravascular coagulation and endotoxemia in patients with liver cirrhosis显示文摘 | Violi F Ferro D Basili S | 1995 | Gastroenterology1995，109，2： | 1 |
| 9 | Treatment of a patient with congenital analbuminemia with atorvastatin and albumin infusion显示文摘Congenital analbuminemia is a rare autosomic recessive inherited disorder characterized by low plasma albumin and hypercholesterolemia, which may increase cardiovascular risk. Patients are essentially asymptomatic, apart from ease of fatigue, minimal ankle oedema and hypotension. There is no accepted strategy for safely treating both hypercholesterolemia and analbuminemia in order to eventually decrease the atherosclerotic risk. We report a case of congenital analbuminemia(1.0 g/dL) in a 38-year-old male with hypercholesterolemia(range: 406-475 mg/dL) and severe arterial dysfunction [no brachial artery flow-mediated dilation(FMD)]. Long-term, cholesterol-lowering treatment with atorvastatin was associated with the appearance of peripheral edema. Twomonths of infusion with albumin improved FMD(7%) and reduced serum cholesterol(273 mg/dL), supporting the hypothesis of a compensatory role of hypercholesterolemia. Statin treatment, together with periodical albumin infusions, may contribute to the safe reduction of cardiovascular risk. | Maria Del Ben Francesco Angelico Lorenzo Loffredo Francesco Violi | 2013 | World Journal of Clinical Cases2013，1，1： | 1 |
| 10 | Antiolatelet treatment with ticlopidine in unstable augina: a controlled multicenter clinical tria 显示文摘 | Balsano F Rizzon P Violi F | 1996 | the Studio della Ticlopidina nell'' Augina Instabile Group Circulation1996，82，： | 1 |
| 11 | Hyperfibrinolysis increases the risk of gastrointestinal hemorrhage in patients with advanced cirrhosis显示文摘 | Violi F Ferro D Basili S | 1992 | Hepatology1992，15，4： | 1 |
| 12 | The association between fibrillation显示文摘 | Loffredo L Violi F Fimognari FL | | 0，，07： | 1 |
| 13 | Improvement of blood gas levels after calcium heparin treatment in patients with chronic obstructive pulmonary disease显示文摘 | Cordova C Violi F Alessandri C | | 0，，03： | 1 |
| 14 | Kinetics of hydrogen abstraction reactions from polycyclic aromatic hydrocarbons by H atoms显示文摘 | Violi A Truong T N Sarofim A F | 2004 | J Phys Chem A2004，108，22： | 1 |
| 15 | Rapid conversion to sirolimus for chronic progressive deterioration of the renal function in kidney allograft recipients显示文摘 | Citterlo F Scata MC Violi P | 2003 | Transpl Proc2003，35，4： | 1 |
| 16 | Insulin Resistance, the Metabolic Syndrome, and Nonalcoholic Fatty Liver Disease显示文摘 | F Angelico M Del Ben R Conti S Francioso K Feole S Fiorello M G. Cavallo B Zalunardo F Lirussi C Alessandri F Violi | 2005 | The Journal of Clinical Endocrinology & Metabolism2005，，3： | 1 |
| 17 | Association between low-grade disseminated intravascular coagulation and endotoxemia in patients with liver cirrhosis显示文摘 | VIOLI F FERRO D BASILI S | 1995 | Thromb Res1995，77，3： | 1 |
| 18 | Hyperfibrinolysis resulting from clotting activation in patients with different degrees of cirrhosis显示文摘 | Violi F Ferro D Basili S | 1993 | Hepatology1993，17，1： | 1 |
| 19 | Small gallstones, acute pancreatitis, and prophylactic cholecystectomy 显示文摘 | Costi R Violi V Roncoroni L | 2006 | Am J Gastroenterol2006，101，7： | 1 |
| 20 | Rapid conversion to sirolimus for chronic progressive deterioration of the renal function in kidney allograft recipients显示文摘 | Citterlo F Scata MC Violi P | | 0，，： | 1 |
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