|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | The Reference Genome Sequence of Scutellaria baicalensis Provides Insights into the Evolution of Wogonin Biosynthesis显示文摘Scutellaria baicalensis Georgi is important in Chinese traditional medicine where preparations of dried roots,'Huang Qin,' are used for liver and lung complaints and as complementary cancer treatments. We report a high-quality reference genome sequence for S. baicalensis where 93% of the 408.14-Mb genome has been assembled into nine pseudochromosomes with a super-N50 of 33.2 Mb. Comparison of this sequence with those of closely related species in the order Lamiales, sesamum indicum and Salvia splendens,revealed that a specialized metabolic pathway for the synthesis of 4'-deoxyflavone bioactives evolved in the genus Scu-tellaria. We found that the gene encoding a specific cinnamate coenzyme A ligase likely obtained its newfunc- tion following recent mutations, and that four genes encoding enzymes in the 4'-deoxyflavone pathway are present as tandem repeats in the genome of S. baicalensis. Further analyses revealed that gene duplications, segmental duplication, gene amplification, and point mutations coupled to gene neo- and subfunctionaliza-tions were involved in the evolution of 4'-deoxyflavone synthesis in the genus Scutellaria. Our study not only provides significant insight into the evolution of specific flavone biosynthetic pathways in the mint family, Lamiaceae, but also will facilitate the development of tools for enhancing bioactive productivity by metabolic engineering in microbes or by molecular breeding in plants. The reference genome of S. baicalensis is also useful for improving the genome assemblies for other members of the mint family and offers an important foundation for decoding the synthetic pathways of bioactive compounds in medicinal plants. | Qing Zhao Jun Yang Meng-Ying Cui Jie Liu Yumin Fang Mengxiao Yan Wenqing Qiu Huiwen Shang Zhicheng Xu Reheman Yidiresi Jing-Ke Weng Tomas Pluskal Marielle Vigouroux Burkhard Steuernagel Yukun Wei Lei Yang Yonghong Hu Xiao-Ya Chen Cathie Martin | 2019 | Molecular Plant2019，12，7： | 23 |
| 2 | Antigen induced regulatory T cells显示文摘 | Vigouroux S Yvon E Biagi E | 2004 | Blood2004，104，1： | 1 |
| 3 | Simultaneous determination of five systemic azoles in plasma by high-performance liquid chromatography with ultraviolet detec- tion 显示文摘 | Jean-Baptiste Gordien Arnaud Pigneux Vigouroux S | 2009 | J pharm Biomed Anal2009，50，5： | 1 |
| 4 | A single domestica- tion for maize shown by muhilocus microsatellite genotyping显示文摘 | Matsuoka Y Vigouroux Y Goodman M M | 2002 | Pro- ceedings of the National Academy of Sciences2002，99，9： | 1 |
| 5 | Efficacy of pioglitazone in familial partial lipodystrophy of the Dunni- gan type: a case report显示文摘 | Moreau F Boullu-Sanchis S Vigouroux C | 2007 | Diabetes Metab2007，33，5： | 1 |
| 6 | The origin of the naked grains of maize显示文摘 | Wang H Waglar TN Li BL Zhao Q Vigouroux Y Faller M Bomblies K Lukens L Doebley JF | | 0，，7051： | 1 |
| 7 | Rate and pattem of mutation at microsatellite loci in maize 显示文摘 | Vigouroux Y Jaqueth J S Matsuoka Y | 2002 | Moleculla Biology and Evolution2002，19，8： | 1 |
| 8 | Antigen-induced regulatory T cells显示文摘 | Vigouroux S Yvon E Biagi E | 2004 | Blood2004，104，1： | 1 |
| 9 | Rate and pattern of muta- tion at microsatellite loci in maize 显示文摘 | Vigouroux Y Jaqueth S Matsuoka Y | 2002 | Mol Biol Evol2002，19，： | 1 |
| 10 | Induction of antigen-specific regulatory T cells following overexpression of a Notch ligand by human B lymphocytes显示文摘 | Vigouroux S Yvon E Wagner H | 2003 | J Virol2003，77，10： | 1 |
| 11 | Nuclear envelope disorganization in fibroblasts from lipodystrophic patients with heterozygous R482Q/W mutations in the lamin A/C gene 显示文摘 | Vigouroux C Auclair M Dubosclard E | 2001 | J Cell Sci2001，114，24： | 1 |
| 12 | Overexpression of the Notch ligand, Jagged-1, induces alloantigen-specific human regulatory T cells显示文摘 | Yvon ES Vigouroux S Rousseau RF | 2003 | Blood2003，102，10： | 1 |
| 13 | A nanalysisofgenetic diversity acrossthe maize genom e using m icrosatellites显示文摘 | Vigouroux Y Mitchell S M atsuoka Y | 2005 | Genet- ics2005，169，： | 1 |
| 14 | Surface processes occurring during breakdown of HV devices显示文摘 | Vigouroux J P Lee-Deacon O Le Gressus C | 1983 | IEEE Trans on Electr Insul1983，18，3： | 1 |
| 15 | Isolation and partial characterization of feruloylated oligosaccharides from maize bran显示文摘 | Saulnier L Vigouroux J Thibault J F | 1995 | Carbohydrate Research1995，272，： | 1 |
| 16 | Rate and pattern of mutation at microsatellite loci in maize显示文摘 | Vigouroux Y Jaqueth J S Matsuoka Y | 2002 | Mol Biol Evol2002，19，： | 1 |
| 17 | Induction of antigen-specific regulatory T cells following overexpression of a Notch ligand by human B lymphocytes显示文摘 | Vigouroux S Yvon E Wagner H J | 2003 | J Virol2003，77，10： | 1 |
| 18 | Genetic diversity and population structure of teosinte 显示文摘 | Fukunaga K Hill J Vigouroux Y | 2005 | Genetics2005，169，4： | 1 |
| 19 | Arabidopsis cell wall proteome defined using multidimensional protein identification technology显示文摘 | Bayer E M Bottrill A R Vigouroux M | 2006 | Proteomics2006，6，1： | 1 |
| 20 | ,Morphological image analysis for the detection of water stress in potted Forsythia显示文摘 | Foucher P Revollon P Vigouroux B | 2004 | Biosystems Engineering2004，89，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员