|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Isolated limb infusion chemotherapy with or without hemofiltration for recurrent limb melanoma显示文摘AIM: To better define the efficacy and the safety of intra-arterial infusion performed with or without hemofiltration for recurrent limb melanoma. METHODS: Patients with the following characteristics were included in the study: recurrent limb melanoma not indicated for surgical resection, measurable disease in the extremity, > 18 years, performances status(Eastern Cooperative Oncology Group) was 0-1 and life expectancy of at least 6 mo. Twenty nine consecutive patients were enrolled in the study. Patients underwent fluoroscopic placement of angiographic arterial and venous catheters to infuse the drug in the artery [isolated limb infusion(ILI)], and to stop the out flow(venous). Melphalan was rapidly infused into the isolated limb via the arterial catheter after the inflation of venous balloon catheter. Then the circulation of the limb was completely blocked with a pneumatic cuff at the root of the limb. Haemofiltration(HF) was available only in the main center, and was performed with an extracorporeal perfusion system, in order to reduce high systemic toxic peaks of drug.RESULTS: Thirty seven ILI were done in 29 cases(31 ILI-HF and 6 ILI) between 2001 and 2014 at Ancona and Pesaro Hospitals, Italy. Clinical outcomes were monitored 30 d after treatment. Eleven patients(38%) received infusion of melphalan alone, 7(24%) melphalan associated to mitomicin C and 7(24%) melphalan associated to cisplatin, the remaining 4 were treated with cisplatin, melphalan and epirubicin or cisplatin and mitomicin C. The overall response rate was 66%, in particular, 3 patients(10%) were complete responders and 16(56%) were partial responders; whereas 7 patients(24%) had stable disease, and 3(10%) showed progressive disease. Limb toxicity was assessed adopting Wieberdink scale, with evidence of 90% of low grade(I and II) toxicity.CONCLUSION: ILI-HF and ILI are effective and safe treatments for recurrent non-resectable limb melanoma. They present evidence of favorable clinical benefit and is effective in delaying progression. | Sara Cecchini Donatella Sarti Stefano Ricci Ludovico Delle Vergini Manuela Sallei Stefano Serresi Giuseppe Ricotti Luca Mulazzani Fabrizia Lattanzio Giammaria Fiorentini | 2015 | World Journal of Clinical Oncology2015，6，4： | 2 |
| 2 | The scar mechanism revisited显示文摘 | Borondo F Wisniacki DA Vergini EG | 2008 | Europ Physi J2008，65，12： | 1 |
| 3 | Tolerogenie semimature dendritic cells suppress experimental autoimmune thyroiditis by activation of thyroglobulin-speeific CD4^+CD25^+ T cells 显示文摘 | Verginis P Li H S Carayanniotis G | 2005 | J Immuno2005，174，11： | 1 |
| 4 | Early diagnosis of vertebral fractures显示文摘 | Guglielmi G di Chio F Vergini MR | 2013 | Clin Cases Miner Bone Metab2013，10，1： | 1 |
| 5 | 显示文摘 | Verginis P Stanford MM Carayanniotis G | 2002 | J Immunol2002，169，9： | 1 |
| 6 | Tolerogenic semimature dendritic cells suppress experimental autoimmune thyroiditis by activation of thyroglobulin specific CD4+ CD25+ T cells显示文摘 | Verginis P Li HS Carayanniotis G | 2005 | J Immunol2005，174，11： | 1 |
| 7 | Delineation of five thyroglobulin T cell epitopes with pathogenic potential in experimental autoimmune thyroiditis 显示文摘 | Verginis P Stanford MM Carayanniotis G | 2002 | J Immunol2002，169，9： | 1 |
| 8 | Tolerogenic semimaturedendrit- ic ceils suppress experimental autoimmune thyroiditisby activation of thyroglobulin-specific CD^4+ CD^25+ T cells 显示文摘 | Verginis P Li HS Carayanniotis G | 2005 | J Immunol2005，174，11： | 1 |
| 9 | Tolerogenic semimature dendritic cells suppress experimental autoimmune thyroiditis by activation of thyroglobulin-specific CD4+CD25+ T cells显示文摘 | Li HS Carayanniotis G | 2005 | J Immunol2005，174，11： | 1 |
| 10 | Maturation of dendritic cells by necrotic thyrocytes facilitates induction of experimental autoimmune thyroiditis显示文摘 | Verginis P CarayanniotisG | 2006 | Clin Exp Immunol2006，144，3： | 1 |
| 11 | Delin- eation of Five Thyroglobulin T Cell Epitopes with Pathogenic Potential in Experimental Autoimmune Thy- roiditis显示文摘 | Verginis P Stanford MM Carayanniotis G | 2002 | J Immunol2002，169，9： | 1 |
| 12 | Tolerogenic semimature dendritic cells suppress experimental autoimmune thyroiditis by activation of thyroglobulin-specific CD4+ CD25+ T cells显示文摘 | Verginis P Li HS Carayanniotis G | 2005 | J Immunol2005，174，： | 1 |
| 13 | Peripherally Induced Treg: Mode, Stability, and Role in Specific Tolerance显示文摘 | Irina Apostolou Panos Verginis Karsten Kretschmer Julia Polansky Jochen Hühn Harald Boehmer | 2008 | Journal of Clinical Immunology2008，，6： | 1 |
| 14 | Delineation of five thyroglobulin T cell epitopes with pathogenic potential in experimental autoimmune thyroiditis显示文摘 | Verginis P Stanford MM Carayanniotis G | | 0，，09： | 1 |
| 15 | Tolerogenic semimature dendritic cellssuppress experimental autoimmune thyroiditis by activation of thyroglobulin-specific CD4 +CD25 +T cells显示文摘 | Verginis P Li HS Carayanniotis G | 2005 | J Immunol2005，174，11： | 1 |
| 16 | Identification of novel microRNA signatures linked to human lupus disease activicy and pathogenesis:miR-21 regulates aberrant T cell responses through regulation of PD CD4 expression显示文摘 | Stagakis E Bertsias G Verginis P | 2011 | Ann Rheum Dis2011，70，8： | 1 |
| 17 | Identifi-cation of novel microRNA signatures linked to human lu-pus disease activity and pathogenesis : miR-21 regulatesaberrant T cell responses through regulation of PDCD4 ex-pression 显示文摘 | STAGAKIS E BERTSIAS G’VERGINIS P | 2011 | Ann Rheum Dis2011，70，8： | 1 |
| 18 | Delineation of five thyroglobulin T cell epitopes with pathogenic potential in experimental autoimmune thyroiditis 显示文摘 | Verginis P Stanford MM Carayanniotis | 2002 | J Immunol2002，169，9： | 1 |
| 19 | Tolerogenic semimature dendritic cells suppress experimental autoimmune thyroiditis by activation of thyroglobulin-specific CD4 + CD25 + T cells 显示文摘 | Verginis P Li HS Carayanniotis G | 2005 | J Immunol2005，174，11： | 1 |
| 20 | Identification of novel microRNA signatures linked to human lupus disease activity and pathogenesis:miR-21 regulates aberrant T cell responses through regulation of PDCD4 expression显示文摘 | Stagakis E Bertsias G Verginis P | | 0，，08： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员