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| 1 | Management of postoperative spinal infections显示文摘Postoperative surgical site infection(SSI) is a common complication after posterior lumbar spine surgery. This review details an approach to the prevention,diagnosis and treatment of SSIs. Factors contributing to the development of a SSI can be split into three categories:(1) microbiological factors;(2) factors related to the patient and their spinal pathology; and(3) factors relating to the surgical procedure. SSI is most commonly caused by Staphylococcus aureus. The virulence of the organism causing the SSI can affect its presentation. SSI can be prevented by careful adherence to aseptic technique,prophylactic antibiotics,avoiding myonecrosis by frequently releasing retractors and preoperatively optimizing modifiable patient factors. Increasing pain is commonly the only symptom of a SSI and can lead to a delay in diagnosis. C-reactive protein and magnetic resonance imaging can help establish the diagnosis. Treatment requires acquiring intra-operative cultures to guide future antibiotic therapy and surgical debridement of all necrotic tissue. A SSI can usually be adequately treated without removing spinalinstrumentation. A multidisciplinary approach to SSIs is important. It is useful to involve an infectious disease specialist and use minimum serial bactericidal titers to enhance the effectiveness of antibiotic therapy. A plastic surgeon should also be involved in those cases of severe infection that require repeat debridement and delayed closure. | Vishal Hegde Dennis S Meredith Christopher K Kepler Russel C Huang | 2012 | World Journal of Orthopedics2012，3，11： | 17 |
| 2 | Coagonist of glucagon-like peptide-1 and glucagon receptors ameliorates kidney injury in murine models of obesity and diabetes mellitus显示文摘AIM To investigate the role of glucagon-like peptide-1(GLP-1)/glucagon receptors coagonist on renal dysfunction associated with diabetes and obesity. METHODS Chronic high-fat diet fed C57 BL/6 J mice, streptozotocintreated high-fat diet fed C57 BL/6 J mice and diabeticC57 BLKS/J db/db mice were used as models of diabetes-induced renal dysfunction. The streptozotocintreated high-fat diet fed mice and db/db mice were treated with the GLP-1 and glucagon receptors coagonist(Aib2 C24 Chimera2, 150 μg/kg, sc) for twelve weeks, while in chronic high-fat diet fed mice, coagonist(Aib2 C24 Chimera2, 150 μg/kg, sc) treatment was continued for forty weeks. Kidney function, histology, fibrosis, inflammation, and plasma biochemistry were assessed at the end of the treatment. RESULTS Coagonist treatment decreased body weight, plasma lipids, insulin resistance, creatinine, blood urea nitrogen, urinary albumin excretion rate and renal lipids. In kidney, expression of lipogenic genes(SREBP-1 C, FAS, and SCD-1) was decreased, and expression of genes involved in β-oxidation(CPT-1 and PPAR-α) was increased due to coagonist treatment. In plasma, coagonist treatment increased adiponectin and FGF21 and decreased IL-6 and TNF-?. Coagonist treatment reduced expression of inflammatory(TNF-α, MCP-1, and MMP-9) and pro-fibrotic(TGF-β, COL1 A1, and α-SMA) genes and also improved histological derangement in renal tissue.CONCLUSION Coagonist of GLP-1 and glucagon receptors alleviated diabetes and obesity-induced renal dysfunction by reducing glucose intolerance, obesity, and hyperlipidemia. | Vishal J Patel Amit A Joharapurkar Samadhan G Kshirsagar Brijesh K Sutariya Maulik S Patel Hiren M Patel Dheerendra K Pandey Rajesh H Bahekar Mukul R Jain | 2018 | World Journal of Diabetes2018，9，6： | 5 |
| 3 | Endoscopic ultrasound guided interventional procedures显示文摘Endoscopic ultrasound(EUS) has emerged as an important diagnostic and therapeutic modality in the field of gastrointestinal endoscopy. EUS provides access to many organs and lesions which are in proximity to the gastrointestinal tract and thus giving an opportunity to target them for therapeutic and diagnostic purposes. This modality also provides a real time opportunityto target the required area while avoiding adjacent vascular and other structures. Therapeutic EUS has found role in management of pancreatic fluid collections, biliary and pancreatic duct drainage in cases of failed endoscopic retrograde cholangiopancreatography, drainage of gallbladder, celiac plexus neurolysis/blockage, drainage of mediastinal and intra-abdominal abscesses and collections and in targeted cancer chemotherapy and radiotherapy. Infact, therapeutic EUS has emerged as the therapy of choice for management of pancreatic pseudocysts and recent innovations like fully covered removable metallic stents have improved results in patients with organised necrosis. Similarly, EUS guided drainage of biliary tract and pancreatic duct helps drainage of these systems in patients with failed cannulation, inaccessible papilla as with duodenal/gastric obstruction or surgically altered anatomy. EUS guided gall bladder drainage is a useful emergent procedure in patients with acute cholecystitis who are not fit for surgery. EUS guided celiac plexus neurolysis and blockage is more effective and less morbid vis-à-vis the percutaneous technique. The field of interventional EUS is rapidly advancing and many more interventions are being continuously added. This review focuses on the current status of evidence vis-à-vis the established indications of therapeutic EUS. | Vishal Sharma Surinder S Rana Deepak K Bhasin | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，6： | 2 |
| 4 | Osmotically controlled drug delivery显示文摘 | Vishal G Verma S Arun N | 2005 | Drug Deliv Tech2005，5，7： | 1 |
| 5 | Contact urticaria to glycolic acid peel显示文摘 | Vishal B Rao SS Pavithra S | 2012 | J Cutan Aesthet Surg2012，5，1： | 1 |
| 6 | Projectile i- dentification and impact point prediction 显示文摘 | VISHAL C R YAAKOV B S PETER W | 2010 | IEEE Transactions on Aerospace and Electronic Systems2010，46，4： | 1 |
| 7 | Small bowel bleeding:a comprehensive review显示文摘The small intestine is an uncommon site of gastro-intestinal(GI)bleeding;however it is the commonest cause of obscure GI bleeding.It may require multiple blood transfusions,diagnostic procedures and repeated hospitalizations.Angiodysplasia is the commonest cause of obscure GI bleeding,particularly in the elderly.Inflammatory lesions and tumours are the usual causes of small intestinal bleeding in younger patients.Capsule endoscopy and deep enteroscopy have improved our ability to investigate small bowel bleeds.Deep enteroscopy has also an added advantage of therapeutic potential.Computed tomography is helpful in identifying extra-intestinal lesions.In cases of difficult diagnosis,surgery and intra-operative enteroscopy can help with diagnosis and management.The treatment is dependent upon the aetiology of the bleed.An overt bleed requires aggressive resuscitation and immediate localisation of the lesion for institution of appropriate therapy.Small bowel bleeding can be managed by conservative,radiological,pharmacological,endoscopic and surgical methods,depending upon indications,expertise and availability.Some patients,especially those with multiple vascular lesions,can re-bleed even after appropriate treatment and pose difficult challenge to the treating physician. | Deepak Gunjan Vishal Sharma Surinder S Rana Deepak K Bhasin | 2014 | Gastroenterology Report2014，2，4： | 1 |
| 8 | Approximate approach to the Das model of fractional logistic population growth 显示文摘 | DAS S GUPTA P K VISHAL K | 2010 | Appl Appl Math2010，5，10： | 1 |
| 9 | Forecasting the effects of non- linear shipping and handling fees 显示文摘 | LEWIS M VISHAL S SCOTT F | 2003 | Journal of Marketing Re- search2003，18，3： | 1 |
| 10 | Intensity - modulated radi-ation therapy for inoperablenon - small cell caneer : the MemorialSloan - Kettering Cancer Center experience 显示文摘 | SONAL S VISHAL G ELLENY | 2008 | Radiother Oncol2008，87，1： | 1 |
| 11 | Low Reynolds number flow through nozzle-diffuser elements in valveless micropumps显示文摘 | VISHAL S SURESH V GARIMELLA J | 2004 | Sensors and Actuators A2004，113，2： | 1 |
| 12 | Informaiton sharing in a supply chain under ARMA demand显示文摘 | Avi G Sridhar S | 2005 | Management Science2005，51，6： | 1 |
| 13 | Sharma, In- fluence of Cutting Parameters on Tool Wear and Surface Roughness in Hard Turning of AISI H11 Tool Steel using Ceramic Tools 显示文摘 | Sanjeev Saini Inderpreet Singh Ahuja and Vishal S | 2012 | International Journal of Precision Engineering and Manufacturing2012，13，8： | 1 |
| 14 | Towards an integrated generative design framework Origina4 Research Article显示文摘 | Vishal S Ning G | 2012 | Design Studies2012，33，2： | 1 |
| 15 | Drug carriertransfersomes: a novel tool for transdermal drug deliverysystem 显示文摘 | Roopesh S Tarun P Vishal S | 2013 | IntJ2013，2，2： | 1 |
| 16 | Osmotically controlled drug delivery显示文摘 | Vishal G Verma S Arun N | 2005 | Drug Deliv Tech2005，5，7： | 1 |
| 17 | Cardiac tissue enriched factors serum response factor and GATA-4 are mutual coregulators显示文摘 | JORGE L Ssepulveda VISHAL Nigam | 2000 | Mol Cell Biol2000，20，： | 1 |
| 18 | Mixture design as a first step for optimization of fermentation medium for cutinase production from Colletotrichum lindemuthianum 显示文摘 | FRED J R VISHAL S | 2007 | Journal of Industrial Microbiology & Biotechnology2007，34，5： | 1 |
| 19 | Urinary biomarkers for sensitive and specific detection of acute kidney injury in humans显示文摘 | Vishal S Vaidya Sushrut S Waikar Michael A Ferguson | 2008 | Clin Transl Sci2008，1，3： | 1 |
| 20 | Contact urticaria to glycolic acid peel显示文摘 | Vishal B Rao SS Pavithra S | 2012 | J Cutan Aesthet Surg2012，5，1： | 1 |
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