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| 1 | Oxidative stress, cardiolipin and mitochondrial dysfunction in nonalcoholic fatty liver disease显示文摘Nonalcoholic fatty liver disease(NAFLD) is today considered the most common form of chronic liver disease, affecting a high proportion of the population worldwide. NAFLD encompasses a large spectrum of liver damage, ranging from simple steatosis to steatohepatitis, advanced fibrosis and cirrhosis. Obesity, hyperglycemia, type 2 diabetes and hypertriglyceridemia are the most important risk factors. The pathogenesis of NAFLD and its progression to fibrosis and chronic liver disease is still unknown. Accumulating evidence indicates that mitochondrial dysfunction plays a key role in the physiopathology of NAFLD, although the mechanisms underlying this dysfunction are still unclear. Oxidative stress is considered an important factor in producing lethal hepatocyte injury associated with NAFLD. Mitochondrial respiratory chain is the main subcellular source of reactive oxygen species(ROS), which may damage mitochondrial proteins, lipids and mitochondrial DNA. Cardiolipin, a phospholipid located at the level of the inner mitochondrial membrane, plays an important role in several reactions and processes involved in mitochondrial bioenergetics as well as in mitochondrial dependent steps of apoptosis. This phospholipid is particularly susceptible to ROS attack. Cardiolipin peroxidation has been associated with mitochondrial dysfunction in multiple tissues in several physiopathological conditions, including NAFLD. In this review, we focus on the potential roles played by oxidative stress and cardiolipin alterations in mitochondrial dysfunction associated with NAFLD. | Giuseppe Paradies Valeria Paradies Francesca M Ruggiero Giuseppe Petrosillo | 2014 | World Journal of Gastroenterology2014，20，39： | 50 |
| 2 | It is safe to use transdermal glyceryl trinitrate to lower blood pressure in patients with acute ischaemic stroke with carotid stenosis显示文摘Background There is concern that blood pressure(BP)lowering in acute stroke may compromise cerebral perfusion and worsen outcome in the presence of carotid stenosis.We assessed the effect of glyceryl trinitrate(GTN)in patients with carotid stenosis using data from the Efficacy of Nitric Oxide in Stroke(ENOS)Trial.Methods ENOS randomised 4011 patients with acute stroke and raised systolic BP(140-220 mm Hg)to transdermal GTN or no GTN within 48 hours of onset.Those on prestroke antihypertensives were also randomised to stop or continue their medication for 7 days.The primary outcome was the modified Rankin Scale(mRS)at day 90.Ipsilateral carotid stenosis was split:<30%;30-<50%;50-<70%;≥70%.Data are ORs with 95%CIs adjusted for baseline prognostic factors.results 2023(60.5%)ischaemic stroke participants had carotid imaging.As compared with<30%,≥70%ipsilateral stenosis was associated with an unfavourable shift in mRS(worse outcome)at 90 days(OR 1.88,95%CI 1.44 to 2.44,p<0.001).Those with≥70%stenosis who received GTN versus no GTN had a favourable shift in mRS(OR 0.56,95%CI 0.34 to 0.93,p=0.024).In those with 50-<70%stenosis,continuing versus stopping prestroke antihypertensives was associated with worse disability,mood,quality of life and cognition at 90 days.Clinical outcomes did not differ across bilateral stenosis groups.Conclusions Following ischaemic stroke,severe ipsilateral carotid stenosis is associated with worse functional outcome at 90 days.GTN appears safe in ipsilateral or bilateral carotid stenosis,and might improve outcome in severe ipsilateral carotid stenosis. | Jason P Appleton Lisa J Woodhouse Andrew Belcher Daniel Bereczki Eivind Berge Valeria Caso Hui Meng Chang Hanne K Christensen Ronan Collins John Gommans Ann C Laska George Ntaios Serefnur Ozturk Gillian M Sare Szabolcs Szatmari Yongjun Wang Joanna M Wardlaw Nikola Sprigg Philip M Bath for the ENOS investigators | 2019 | Stroke & Vascular Neurology2019，4，1： | 6 |
| 3 | Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: a randomised, open-label, phase III study显示文摘 | Pierre Fenaux Ghulam J Mufti Eva Hellstrom-Lindberg Valeria Santini Carlo Finelli Aristoteles Giagounidis Robert Schoch Norbert Gattermann Guillermo Sanz Alan List Steven D Gore John F Seymour John M Bennett John Byrd Jay Backstrom Linda Zimmerman David M | 2009 | Lancet Oncology2009，，： | 2 |
| 4 | Cervical artery dissection: Trauma and other potential mechanical trigger events显示文摘 | Stefan T. Engelter Caspar Grond-Ginsbach Tiina M. Metso Antti J. Metso Manja Kloss Stephanie Debette Didier Leys Armin Grau Jean Dallongeville Marie Bodenant Yves Samson Valeria Caso Alessandro Pezzini Leo H. Bonati Vincent Thijs Henrik Gensicke Juan J. M | 2013 | Neurology2013，，21： | 2 |
| 5 | Hydrotherapy Versus Conventional Land-Based Exercise for the Management of Patients With Osteoarthritis of the Knee: A Randomized Clinical Trial显示文摘 | Silva Luciana E Valim Valeria Pessanha Ana Paula C Oliveira Leda M Myamoto Samira Jones Anamaria Natour Jamil | 2008 | Physical Therapy2008，，1： | 2 |
| 6 | Price discovery and informational efficiency of international shares funds显示文摘 | Yiuman T Valeria M | 2007 | Global Finance Journal2007，18，1： | 1 |
| 7 | Spatially-resolved EELS analysis of antibody distribution on biofunctionalized magnetic nanoparticles显示文摘 | Raul A Laura D M Laura C Alvaro M Marcel T Valeria G Jesus M D L F Clara M Ricardo 1 | 2013 | ACS Nano2013，7，5： | 1 |
| 8 | Effect of calcium dips and chitosan coatings on postharvest life of strawberries (Fragaria x ananassa) 显示文摘 | Pilaf H M Eva A Valeria D V | 2008 | Food Chemistry2008，，110： | 1 |
| 9 | Chemokines in neuroectodermal mmour progression and metastasis 显示文摘 | Raffaghello L Cocco C Valeria M | | Semin Cancer Biol0，19，： | 1 |
| 10 | Anion recognition by hy- drogen bonding: urea-based receptors 显示文摘 | Valeria A Luigi F Lorenzo M | 2010 | Chem Soc Rev2010，39，： | 1 |
| 11 | Degradation of mierocystin-RR by sphingomonas sp CBA4 isolated from San Roque reservoir (Co' rdoba - Argentina)显示文摘 | VALERIA A M ECHENIQUE J R PFLUGMACHER S | 2006 | Biodegradation2006，，17： | 1 |
| 12 | On the green and innovative side of trade competitiveness? The impact of environmental policies and innovation on EU exports显示文摘 | Valeria C Massimiliano M | 2012 | Research Policy2012，41，1： | 1 |
| 13 | Conservative surgi- cal management of stage IA endometrial carcinoma for fertility preservation 显示文摘 | Ivan M Giacomo C Valeria M | 2010 | Fertil Steril2010，93，4： | 1 |
| 14 | Assays of physical stability and antioxidant activity of a topical formulation added with different plant extracts 显示文摘 | Di Mambro Valeria M Fonseca Maria J V | 2005 | Journal of Pharmaceutical and Biomedical Analysis2005，37，2： | 1 |
| 15 | Evaluation of the antioxidant activity of different flavonoids by the chemiluminescence method 显示文摘 | GEORGETTI SANDRA R CASAGRAND RUBIA MAMBRO VALERIA M D | 2003 | AAPS Pharm Sci2003，5，2： | 1 |
| 16 | A study of the effect of setup errors and organ motion on prostate cancer with IMRT显示文摘 | Valeria L Biance S Simona M | 2006 | Int J Radiat Oncol Biol Phys2006，65，： | 1 |
| 17 | Argon plasma coagulation for prevention of recurrent bleeding from GI angiadysplasias显示文摘 | JORGE AO MARIANO M VALERIA P | 2004 | Gastrointestinal Endoscopy2004，60，6： | 1 |
| 18 | Influence of recycled aggregates on mechanical properties of HS/HPC显示文摘 | Valeria C Giacomo M | 2002 | Cement and ConcreteComposites2002，24，2： | 1 |
| 19 | Hydrolysis of oligosaccharides in soybean flour by soybean a-galactosidase显示文摘 | Simone D F V Valeria M G Ines C J | 2005 | Food Chemistry2005，93，： | 1 |
| 20 | Lactoferrin inhibits early steps of human BK polyomavirus infection显示文摘 | Giovanna L Valeria P Monica M | 2006 | Antiviral Res2006，72，： | 1 |
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