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| 1 | Empagliflozin alleviates podocytopathy and enhances glomerular nephrin expression in db/db diabetic mice显示文摘BACKGROUND Modern guidelines recommend sodium-glucose cotransporter-2(SGLT2)inhibitors as the preferred antihyperglycemic agents for patients with type 2 diabetes and chronic kidney disease.However,the mechanisms underlying the renal protective effect of SGLT2 inhibitors are not fully understood.structure of podocytes and nephrin expression in glomeruli in db/db diabetic mice.METHODS We treated 8-wk-old male db/db mice with EMPA(10 mg/kg/d)or vehicle for 8 wk.Age-matched male db/+mice were included as non-diabetic controls.Parameters of body composition,glycemic and lipid control,and plasma concentrations of leptin,insulin and glucagon were assessed.We evaluated renal hypertrophy as kidney weight adjusted to lean mass,renal function as plasma levels of creatinine,and albuminuria as the urinary albumin-to-creatinine ratio(UACR).Renal structures were studied by light and transmission electron microscopy with a focus on mesangial volume and podocyte structure,respectively.Glomerular nephrin and transforming growth factor beta(TGF-β)were assessed by immunohistochemistry.RESULTS Severe obesity and hyperglycemia developed in db/db mice prior to the start of the experiment;increased plasma concentrations of fructosamine,glycated albumin,cholesterol,leptin,and insulin,and elevated UACR were detected.Mesangial expansion,glomerular basement membrane thickening,and increased area of TGF-βstaining in glomeruli were revealed in vehicle-treated mice.Podocytopathy was manifested by effacement of foot processes;nephrin-positive areas in glomeruli were reduced.EMPA decreased the levels of glucose,fructosamine and glycated albumin,UACR,kidney hypertrophy,mesangial expansion,glomerular basement membrane thickening,and glomerular TGF-βstaining,alleviated podocytopathy and restored glomerular staining of nephrin.CONCLUSION These data indicate that EMPA attenuates podocytopathy in experimental diabetic kidney disease.The anti-albuminuric effect of EMPA could be attributed to mitigation of podocyte injury and enhancement of nephrin expression. | Vadim V Klimontov Anton I Korbut Iuliia S Taskaeva Nataliya P Bgatova Maksim V Dashkin Nikolai BOrlov Anna S Khotskina Evgenii L Zavyalov Thomas Klein | 2020 | World Journal of Diabetes2020，11，12： | 2 |
| 2 | The Influence of Shock Bifurcations on Shock-Flame Interactions and DDT 显示文摘 | VADIM N GAMEZO ALEXEI M KHOKHLOV and ELAINE S ORAN | 2001 | 126 :1810 - 18262001，126，： | 1 |
| 3 | Current-indcued metal-insulator transition in VOx thin film prepared by rapid-thermalannealing显示文摘 | Cho C R Cho S Vadim S | 2006 | Thin Solid Films2006，495，12： | 1 |
| 4 | Spectral beam combining of fiber lasers with increased channel density显示文摘 | OLEKSIY A IGOR C VADIM S | 2007 | SPIE2007，6453，： | 1 |
| 5 | Multiracial characteristics of matrix cracking in laminates under T-fatigue显示文摘 | Vadim V S | 1998 | Computational materials science1998，13，： | 1 |
| 6 | Release of gold-bear- ing fluids in convergent margin magmas prompted by magnetite crystallization 显示文摘 | Sun W D Richard J A Vadim S K | 2004 | Nature2004，，4： | 1 |
| 7 | Current-induced metal-insulator transition in VOx thin film prepared by rapid-thermal-annealing显示文摘 | Cho C R Cho S Vadim S | 2006 | Thin Solid Films2006，495，12： | 1 |
| 8 | Network signatures of nuclear and cytoplasmic density alterations in a model of pre and postmetastatie colorectal cancer显示文摘 | Dhwanil D Hariharan S Vadim B | 2014 | J Biomed 0pt2014，19，16： | 1 |
| 9 | A critical look at Lo's modified R/S statistic 显示文摘 | Vadim Teverovsky Murad S Taqqu Walter Willingex | 1999 | Journal of Statistical Planning and Inference1999，80，： | 1 |
| 10 | Localized Rac activation dynamics visualized in living cells显示文摘 | Chester C Gary M B | 2000 | Science2000，290，： | 1 |
| 11 | Asymmetric michael addition reactions of chiral Ni(Ⅱ)-c-omplex of glycine with (N-trans-enoyl)oxazolidines:improved reactivity and stereochemical outcome显示文摘 | Vadim A S Chaozhong C Victor J H | 1999 | Tetrahedron:Asymmetry1999，，10： | 1 |
| 12 | Tailoring pore properties of MCM-48silica for selective adsorption of CO2显示文摘 | Kim S Ida J Vadim V G | 2005 | Journal of Physical Chemistry B2005，109，13： | 1 |
| 13 | Quality-aware service-oriented data integration: requirements, state of the art and open challenges显示文摘 | SCHAHRAM D REINHARD P VADIM S | 2012 | ACM SIGMOD Record2012，41，1： | 1 |
| 14 | Analysis of anisotropic viscoelastoplastic properties of cortical bone tissues 显示文摘 | Adel A A Khurshid A Vadim V S | 2011 | Journal of the Mechanical Behavior of Biomedical Materials2011，，4： | 1 |
| 15 | 显示文摘 | Joseph O Rich Vadim V Mozhaev Jonathan S Dordick | 2002 | J Am Chem Soc2002，124，： | 1 |
| 16 | Strategies for preventing calcium oxalate stones显示文摘 | VADIM A F DAVID S G | 2006 | CMAJ2006，174，10： | 1 |
| 17 | Temperature stratification in a cryogenic fuel tank 显示文摘 | Matthew J D Vadim N S Jacob B | 2013 | Journal of Thermophysics and Heat transfer2013，1，： | 1 |
| 18 | A critical look at Lo's modified R/S statistic显示文摘 | Vadim Teverovsky Murad S Taqqu Walter Willinger | 1999 | Journal of Statistical Planning and Inference1999，80，： | 1 |
| 19 | Consideration of a spread-out source in problems of near-infrared optical tomography 显示文摘 | Vadim Y S Lada V K | 2006 | Applied Optics2006，45，19： | 1 |
| 20 | Polycyclic aromatic hydro- carbons in meat smoked with different types of wood显示文摘 | ILZE S V VADIMS B AGNESE K | 2008 | Food Chemistry2008，110，3： | 1 |
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