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| 1 | Increasing the frequency of CIK cells adoptive immunotherapy may decrease risk of death in gastric cancer patients显示文摘AIM: To analyze the correlation between cytokineinduced killer (CIK) cells adoptive immunotherapy and cancer-related death in gastric cancer patients. METHODS: One hundred and fifty-six gastric cancer patients after operation at the Third Affiliated Hospital of Soochow University were enrolled in this study. Their clinical data including demographic characteristics, operation time, tumor size, pathological type and staging, tumor metastasis, outcome of chemotherapy or CIK cells adoptive immunotherapy, survival time or time of death were collected with a standard structured questionnaire. Kaplan-Meier method was used to estimate the median survival time, and the 2- and 5- year survival rates. Hazard risk (HR) and 95% confidence interval (95% CI) of CIK cells adoptive immunotherapy for gastric cancer were calculated using the two-stage time-dependent covariates Cox model. RESULTS: The survival time of gastric cancer patients was longer after CIK cells adoptive immunotherapy than after chemotherapy (χ 2 = 10.907, P = 0.001). The median survival time of gastric cancer patients was also longer after CIK cells adoptive immunotherapy than after chemotherapy (49 mo vs 27 mo, P < 0.05). The 2- and 5-year survival rates of gastric cancer patients were significantly higher after CIK cells adoptive immunotherapy than after chemotherapy (73.5% vs 52.6%, 40.4% vs 23.9%, P < 0.05). A significant difference was observed in the survival curve for patients who received CIK cells adoptive immunotherapy (0, 1-10, 11-25, and over 25 frequencies) (χ 2 = 14.534, P = 0.002). The frequencies of CIK cells adoptive immunotherapy were significantly related with the decreasing risk of death in gastric cancer patients after adjustment for sex and age of the patients, tumor stage and relapse (HR = 0.54, 95% CI: 0.36-0.80) when the first stage Cox model was used to define the subjects who remained alive beyond 36 mo as survivors. However, no correlation was observed between the frequencies of death in CIK cells adoptive immunotherapy and the risk of gastric cancer patients (HR = 1.09, 95% CI: 0.63-0.89) when the second stage Cox model was used to define the subjects who survived for more than 36 mo as survivors. CONCLUSION: The survival time of the gastric cancer patients treated with chemotherapy combined with CIK cells adoptive immunotherapy is significantly longer than that of the patients treated with chemotherapy alone and increasing the frequency of CIK cells adoptive immunotherapy seems to benefit patients more. | Jing-Ting Jiang, Chang-Ping Wu, Lu-Jun Chen, Xiao Zheng, Department of Tumor Biological Treatment, Third Affiliated Hospital of Soochow University, Changzhou 213003, Jiangsu Province, China Yi-Bei Zhu, Jing Sun, Xue-Guang Zhang, Key Laboratory of Stem Cell of Jiangsu Province, Institute of Biotechnology, Key Laboratory of Clinical Immunology of Jiangsu Province, Soochow University, Suzhou 215123, Jiangsu Province, China Yue-Ping Shen, Wen-Xiang Wei, Department of Medicine, Soochow University, Suzhou 215123, Jiangsu Province, China Bin-Feng Lu, Department of Immunology, University of Pitts- burgh School of Medicine, Pittsburgh, PA 15261, United States | 2010 | World Journal of Gastroenterology2010，16，48： | 82 |
| 2 | Endoscopic ultrasonography guided biliary drainage: Summary of consortium meeting, May 7^(th) , 2011, Chicago显示文摘Endoscopic retrograde cholangiopancreatography (ERCP) has become the preferred procedure for biliary or pancreatic drainage in various pancreatico-biliary disorders. With a success rate of more than 90%, ERCP may not achieve biliary or pancreatic drainage in cases with altered anatomy or with tumors obstructing access to the duodenum. In the past those failures were typically managed exclusively by percutaneous approaches by interventional radiologists or surgical intervention. The morbidity associated was significant especially in those patients with advanced malignancy, seeking minimally invasive interventions and improved quality of life. With the advent of biliary drainage via endoscopic ultrasound (EUS) guidance, EUS guided biliary drainage has been used more frequently within the last decade in different countries. As with any novel advanced endoscopic procedure that encompasses various approaches, advanced endoscopists all over the world have innovated and adopted diverse EUS guided biliary and pancreatic drainage techniques. This diversity has resulted in variations and improvements in EUS Guided biliary and pancreatic drainage; and over the years has led to an extensive nomenclature. The diversity of techniques, nomenclature and recent progress in our intrumentation has led to a dedicated meeting on May 7 th , 2011 during Digestive Disease Week 2011. More than 40 advanced endoscopists from United States, Brazil, Mexico, Venezuela, Colombia, Italy, France, Austria, Germany, Spain, Japan, China, South Korea and India attended this pivotal meeting. The meeting covered improved EUS guided biliary access and drainage procedures, terminology, nomenclature, training and credentialing; as well as emerging devices for EUS guided biliary drainage. This paper summarizes the meeting's agenda and the conclusions generated by the creation of this consortium group. | Michel Kahaleh Everson LA Artifon Manuel Perez-Miranda Kapil Gupta Takao Itoi Kenneth F Binmoeller California Pacific Medical Center San Francisco CA 94115 United States Marc Giovannini | 2013 | World Journal of Gastroenterology2013，19，9： | 15 |
| 3 | Environmental Implications of Excessive Selenium: A Review显示文摘Selenium is a naturally occurring trace element that is nutritionally required in smallamounts but it can become toxic at concentrations only twice those required. The narrow mar-gin between beneficial and harmful levels has important implications for human activities thatincrease the amount of selenium in the environment. Two of these activities, disposal of fbssilfuel wastes and agricultural irrigation of arid, seleniferous soils, have poisoned fish andwildlife, and threatened public health at several locations in the United States. Research stud-ies of these episodes have generated a data base that clearly illustrates the environmental hazardof excessive selenium. It is strongly bioaccumulated by aquatic organisms and even slight in-creases in waterborne concentrations can quickly result in toxic effects such as deformed em-bryos and reproductive failure in wildlife. The selenium data base has been very beneficial indeveloping hazard assessment procedures and establishing environmentally sound water qualitycriteria. The two faces of selenium, required nutrient and Potent toxin, make it a particularlyimportant trace element in the health of both animals and man. Because of this paradox, envi-ronmental selenium in relation to agriculture, fisheries, and wildlife wiIl continue to raise im-POrtant land and water management issues for decades to come. If these issues are dealt withusing prudence and the available environmental selenium data base, adverse irnpacts to naturalresources andspublic health can be | A. DENNIS LEMLY(United States Forest Service, Southern Research Station, Coldwater Fisheries Research Unit, Department of Fisheries and Wildlife Sciences, Virginia Tech University, Blacksburg, VA 24061-0321, USA) | 1997 | Biomedical and Environmental Sciences1997，10，4： | 10 |
| 4 | Role of autophagy in liver physiology and pathophysiology显示文摘Autophagy is a highly conserved intracellular degradation pathway by which bulk cytoplasm and superfluous or damaged organelles are enveloped by double membrane structures termed autophagosomes. The autophago-somes then fuse with lysosomes for degradation of their contents, and the resulting amino acids can then recycle back to the cytosol. Autophagy is normally activated in response to nutrient deprivation and other stressors and occurs in all eukaryotes. In addition to maintaining energy and nutrient balance in the liver, it is now clear that autophagy plays a role in liver protein aggregates related diseases, hepatocyte cell death, steatohepatitis, hepatitis virus infection and hepatocellular carcinoma. In this review, I discuss the recent findings of autophagy with a focus on its role in liver pathophysiology. | Wen-Xing Ding, Department of Pharmacology, Toxicology and Therapeutics, The University of Kansas Medical Center, MS 1018, 3901 Rainbow Blvd, Kansas City, Kansas, KS 66160, United States | 2010 | World Journal of Biological Chemistry2010，1，1： | 9 |
| 5 | Effect of Recql5 deficiency on the intestinal tumor susceptibility of Apc^(min) mice显示文摘AIM:To investigate whether Recql5,a DNA helicase that plays an important role in the maintenance of genome integrity,is a tumor suppressor in the gastrointestinal tract in mice.METHODS:We generated cohorts of both Recql5-proficient and Recql5-deficient Apcmin/+mice and compared the tumor susceptibility in their gastrointestinal tracts.RESULTS:Recql5 deficiency in Apcmin/+mice resulted in a significant increase in the tumor incidence in both the colon(P=0.0162)and the small intestine(P<0.01).These findings have provided the first genetic evidence for a tumor suppression role of Recql5 in the gastrointestinal tract of mice.Importantly,since mouse Recql5 and human RECQL5 are highly conserved,these findings also suggest that RECQL5 may be a tu-mor suppressor for human colon cancer.CONCLUSION:Recql5 has a tumor suppression role in the mouse gastrointestinal tract. | Yiduo Hu,Xincheng Lu,Guangbin Luo,Department of Genetics,Case Comprehensive Cancer Center and University Hospitals of Cleveland,Case Western Reserve University,Cleveland,OH 44106,United States Yiduo Hu,Department of Cancer Biology,Dana-Farber Cancer Institute,Boston,MA 02115,United States | 2010 | World Journal of Gastroenterology2010，16，12： | 6 |
| 6 | Biocompatibility evaluation in vitro. Part I: Morphology expression and proliferation of human and rat osteoblasts on the biomaterials显示文摘The biocompatibility evaluation of calcium phosphate based biomaterials is performed by tissue culture in vitro model. Three kinds of bioceramic materials which are potential to deal with bone trauma and/or conduct tissue growth are recommodated. The biological research results show that human and animal osteoblast cells anchor the materials surface in two hours in culture. Confocal laser scanning microscopy (CLSM) demonstrated the normal cell distribution and proliferation on both of dense and porous biomaterials. Hydroxyapatite and tricalcium phosphate stimulate cell proliferation. However, DNA and protein synthesis were considerably limited and the apoptosis phenomenon would be present on the hydroxyapatite (HA) materials by adding Al, Mg elements. Several important methods of biocompatibility evaluation of implant materials are described and the related biological molecular techniques such as tissue culture, cell transfection, cellular DNA stain, and Lowry assay are involved in the present research. | RUAN Jian ming 1,GRANT M. Helen 2 (1 Powder Metallurgy State Key Laboratory, Central South University, Changsha 410083, China 2 Bioengineering Unit, Strathclyde University, Glasgow, G4 0NW, UK) | 2001 | Journal of Central South University of Technology2001，8，1： | 5 |
| 7 | SEDIMENT DAMAGES AND RECENT TRENDSIN THE UNITED STATES显示文摘In the United States, cropland erosion has decreased by an estimated one billion tons or 42 Percent for the period 1982 to 1997 (USDA NRCS, 1998) through erosion reduction provisions of the Food Security Actof 1985 and the ongoing soil conservation programs administered by the United States Department ofAgriculture’s Soil Conservation Service (USDA-SCS), which became the Natural Resources ConservationService (USDA-NRCS) in 1997.The U.S. Geological Survey has measured suspended sediment loads at strearn gages from 198O through1989 and showed primarily decreases of from 1 to 12 percent for most regions and increases for only threeregions, ranging from 2 to l2 percent.A Reservoir Sediment Information System (RESIS) was created so that decades of dare on reservoir sediment deposits could be evaluated (Atwood, 1994, Steffen, 1994; Atwood and Steffen, 1994). Theresults of analyses show a major increase in unit-area sediment deposition rates during the period 1970through 1985, which may be attributable to increased cropland acreage, a switch from diversified farming tointensive monocultUred crops, with widespread adoption of soybeans. The most recent measured ratesshow that 25 percent of the United States reservoirs would be at least half-filled with sediment by 2O18,although there is a significant data gap since 1985. Relatively few reservoirs were surveyed since 1985 dueto lack of funding priority and increased survey labor costs. | Jerry M. Bernard (National Geologist) Thomas A. Iivari(Senior Hydrologist, United States Department of Agriculture-Natura ResourcesConservation Service, Washington, DC) | 2000 | International Journal of Sediment Research2000，15，2： | 3 |
| 8 | CARMA3: A novel scaffold protein in regulation of NF-κB activation and diseases显示文摘CARD recruited membrane associated protein 3 (CARMA3) is a novel scaffold protein. It belongs to the CARMA protein family, and is known to activate nuclear factor (NF)- κB. However, it is still unknown which receptor functions upstream of CARMA3 to trigger NF-κB activation. Recently, several studies have demonstrated that CARMA3 serves as an indispensable adaptor protein in NF-κB signaling under some G protein-coupled receptors (GP- CRs), such as lysophosphatidic acid (LPA) receptor and angiotensin (Ang) Ⅱ receptor. Mechanistically, CARMA3 recruits its essential downstream molecules Bcl10 and MALT1 to form the CBM (CARMA3-Bcl10-MALT1) signalosome whereby it triggers NF-κB activation. GPCRs and NF-κB play pivotal roles in the regulation of various cellular functions, therefore, aberrant regulation of the GPCR/NF-κB signaling axis leads to the development of many types of diseases, such as cancer and atherogenesis. Recently, the GPCR/CARMA3/NF-κB signaling axis has been confirmed in these specific diseases and it plays crucial roles in the pathogenesis of disease progression. In ovarian cancer cell lines, knockdown of CARMA3 abolishes LPA receptor-induced NF-κB activation, and reduces LPA-induced ovarian cancer invasion. In vascular smooth cells, downregulation of CARMA3 substantially impairs Ang-Ⅱ-receptor-induced NF-κB activation, and in vivo studies have confirmed that Bcl10- deficient mice are protected from developing Ang-Ⅱ-receptor-induced atherosclerosis and aortic aneurysms. In this review, we summarize the biology of CARMA3, describe the role of the GPCR/CARMA3/NF-κB signaling axis in ovarian cancer and atherogenesis, and speculate about the potential roles of this signaling axis in other types of cancer and diseases. With a significant increase in the identification of LPA- and Ang-Ⅱ-like ligands, such as endothelin-1, which also activates NF-κB via CARMA3 and contributes to the development of many diseases, CARMA3 is emerging as a novel therapeutic target for various types of cancer and other diseases. | Jiyuan Sun, Department of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, TX 77030, United States | 2010 | World Journal of Biological Chemistry2010，1，12： | 2 |
| 9 | Role of apoptosis resistance in immune evasion and metastasis of colorectal cancer显示文摘The host immune system functions as a guardian against tumor development. It has been demonstrated that cytotoxic T lymphocyte (CTL)-mediated cytotoxic pathways function to inhibit or delay human colorectal cancer development. However, the host anti-tumor immune responses also 'edit' the tumor and select for more aggressive variants, resulting in immune evasion and tumor escape. Fas is a death receptor that mediates one of the major cytotoxic effector mechanisms of the CTLs. Fas is highly expressed in normal human colon epithelial cells but is frequently silenced in colorectal carcinoma, especially in metastatic colorectal carcinoma, suggesting that loss of Fas expression and function may be an immune evasion and tumor escape mechanism. In addition, recent studies indicated that Fas also mediates cellular proliferation signaling pathways to promote tumor development. Therefore, the death receptor Fas may not only transduce death signals to suppress tumor development but also activate cellular proliferation and the migration process to promote tumor growth and progression. Thus, understanding the mechanisms by which the Fas receptor and its associated protein complex transduces the death and survival signals may identify molecular targets for the development of therapeutic strategy to enhance the Fas-mediated death signals to increase the efficacy of cancer immunotherapy. | Kebin Liu, Department of Biochemistry and Molecular Biology, Medical College of Georgia, Georgia Health Sciences University, Augusta, GA 30912, United States | 2010 | World Journal of Gastrointestinal Oncology2010，2，11： | 2 |
| 10 | Excerpts from the 2000 US renal data system annual data report:Atlas of end stage renal disease in the united states 显示文摘 | United States Renal Data System | 2000 | A m J Kidney Dis2000，36，1： | 1 |
| 11 | Fac- tor analysis of occupational aptitude tests 显示文摘 | UNITED STATES WAR MANPOWER COMMISSION | 1945 | Educational and Psychological Measurement1945，，2： | 1 |
| 12 | Statement on Government of Canada' s Bill on Limits of the Territorial Sea, Fishers and Pollu- tion 显示文摘 | United States of Department 1970 | 1970 | International Legal Materials1970，，3： | 1 |
| 13 | Nursing Outlook显示文摘 | A brief history of nursing informatics in the United States of America | 2008 | Creative nursing so far: a history2008，14，1： | 1 |
| 14 | 显示文摘 | Office of the United States Trade Representative Statement by Ambassador Ron KirkoonTFPP | 2009 | Novemberl32009，，： | 1 |
| 15 | Rui Liao's work on patient-specific 3-D model guidance for interventional and hybrid-operating-room applications显示文摘Compared to surgery,interventional and hybrid-operating-room(OR) approaches diagnose or treat pathology with the most minimally invasive techniques possible.By minimizing the physical trauma to the patient,peripheral or hybrid approaches can reduce infection rates and recovery time as well as shorten hospital stays.Minimally invasive approaches therefore are the trend and often the preferred choice,and may even be the only option for the patients associated with high surgery risks.Common interventional imaging modalities include 2-D X-ray fluoroscopy and ultrasound.However,fluoroscopic images do not display the anatomic structures without a contrast agent,which on the other hand,needs to be minimized for patients' safety.Ultrasound images suffer from relatively low image quality and tissue contrast problems.To augment the doctor's view of the patient's anatomy and help doctors navigate the devices to the targeted area with more confidence and a higher accuracy,high-resolution pre-operative volumetric data such as computed tomography and/or magnetic resonance can be fused with intra-operative 2-D images during interventions.A seamless workflow and accurate 2-D/3-D registrationas well as cardiac and/or respiratory motion compensation are the key components for a successful image guidance system using a patient-specific 3-D model.Dr.Liao's research has been focused on developing methods and systems of 3-D model guidance for various interventions and hybrid-OR applications.Dr.Liao' s work has led to several Siemens products with high clinical and/or market impact and a good number of scientific publications in leading journals/conferences on medical imaging. | Rui Liao,Siemens Corporate Research,755 College Road East,Princeton,NJ 08540,United States | 2011 | World Journal of Radiology2011，3，6： | 1 |
| 16 | The USRDS Dialysis Morbidity and Mortality Study:Wave 2显示文摘 | United States Renal Data System(USRDS) | 1997 | Am J Kidney Dis1997，30，： | 1 |
| 17 | Responsibilities of awardee and applicant institutions for dealing with and reporting possible misconduct in science:final rule,42 CFR Part 50,Subpart A显示文摘 | Department of Health and Human Services United States Public Health Service | | 0，，： | 1 |
| 18 | National Council focuses on coordinating error reduction efforts显示文摘 | The United States Pharmacopeial convention | 1997 | Qual Rev ( Newsletter )1997，57，2： | 1 |
| 19 | Biocompatibility evaluation in vitro. Part III: Cytotoxicity expression of human and animal osteoblasts on the biomaterials显示文摘Exclusion and inflammation in the clinic are observe d for various reas ons including material che- mical composition, physical properties as well a s macr o- and micro-structure of the implants, surface condition of the implants, and also patient dependent factors. Cytotoxicity expression of cells is a central issue i n current biocompatibility to screen the potential implant materials and drugs. This study was aimed at investigation reaction between the potential implant mat erials and surround tissue. Cytotoxicity of human and rat osteoblast in the mate rial extracts was determinated by testing standards such as GHS assay, MTT assay , alkaline phosphatase activity assay, LDH assay, and Lowry assay. Research resu lts demonstrated that compared with the control condition polystyrene culture pl a te both human and rat osteoblast cells have normal phenotypic expression in hydr oxyapatite extract, and this expression was statistically restricted in hydroxya patite-spinel extract. How- ever, this restrict, e.g. cytotoxicity could be partially eliminated by immersion treatment of the materials in culture medium. | RUAN Jian-ming 1,M.H. Grant 2 (1. State Key Laboratory for Powder Metallurgy, Central South University, Changs ha 410083, China 2. Bioengineering Unit, Strathclyde University, Glasgow, G4 0NW, UK) | 2001 | Journal of Central South University2001，13，3： | 1 |
| 20 | CB TRUS statistical report:pimary brain and central nervous system tu- mors diagnosed in the United States in 2004-2006显示文摘 | Central Brain Tumor Registy of the United States(CBTRUS) | 2010 | Hinsdale:CB- TRUS2010，，： | 1 |
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