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| 1 | Measurement of prostaglandin metabolites is useful in diagnosis of small bowel ulcerations显示文摘BACKGROUND We recently reported on a hereditary enteropathy associated with a gene encoding a prostaglandin transporter and referred to as chronic enteropathy associated with SLCO2 A1 gene(CEAS). Crohn's disease(CD) is a major differential diagnosis of CEAS, because these diseases share some clinical features. Therefore, there is a need to develop a convenient screening test to distinguish CEAS from CD.AIM To examine whether prostaglandin E major urinary metabolites(PGE-MUM) can serve as a biomarker to distinguish CEAS from CD.METHODS This was a transactional study of 20 patients with CEAS and 98 patients with CD.CEAS was diagnosed by the confirmation of homozygous or compound heterozygous mutation of SLCO2 A1. We measured the concentration of PGEMUM in spot urine by radioimmunoassay, and the concentration was compared between the two groups of patients. We also determined the optimal cut-off value of PGE-MUM to distinguish CEAS from CD by receiver operating characteristic(ROC) curve analysis.RESULTS Twenty Japanese patients with CEAS and 98 patients with CD were enrolled.PGE-MUM concentration in patients with CEAS was significantly higher than that in patients with CD(median 102.7 vs 27.9 μg/g × Cre, P < 0.0001). One log unit increase in PGE-MUM contributed to 7.3 increase in the likelihood for the diagnosis of CEAS [95% confidence interval(CI) 3.2-16.7]. A logistic regression analysis revealed that the association was significant even after adjusting confounding factors(adjusted odds ratio 29.6, 95%CI 4.7-185.7). ROC curve analysis revealed the optimal PGE-MUM cut-off value for the distinction of CEAS from CD to be 48.9 μg/g × Cre with 95.0% sensitivity and 79.6% specificity.CONCLUSION PGE-MUM measurement is a convenient, non-invasive and useful test for the distinction of CEAS from CD. | Yuichi Matsuno Junji Umeno Motohiro Esaki Yoichiro Hirakawa Yuta Fuyuno Yasuharu Okamoto Atsushi Hirano Shigeyoshi Yasukawa Fumihito Hirai Toshiyuki Matsui Shuhei Hosomi Kenji Watanabe Naoki Hosoe Haruhiko Ogata Tadakazu Hisamatsu Shunichi Yanai Shuji Kochi Koichi Kurahara Tsuneyoshi Yao Takehiro Torisu Takanari Kitazono Takayuki Matsumoto | 2019 | World Journal of Gastroenterology2019，25，14： | 5 |
| 2 | Genetic analysis is helpful for the diagnosis of small bowel ulceration显示文摘The widespread use of capsule endoscopy and balloonassisted endoscopy has provided easy access for detailed mucosal assessment of the small intestine. However, the diagnosis of rare small bowel diseases, such as cryptogenic multifocal ulcerous stenosing enteritis(CMUSE), remains difficult because clinical and morphological features of these diseases are obscure even for gastroenterologists. In an issue of this journal in 2017, Hwang et al reviewed and summarized clinical and radiographic features of 20 patients with an established diagnosis of CMUSE. Recently, recessive mutations in the PLA2G4A and SLCO2A1 genes have been shown to cause small intestinal diseases. The small bowel ulcers in each disease mimic those in the other and furthermore those found in nonsteroidal anti-inflammatory drug-induced enteropathy. These recent and novel findings suggest that a clinical diagnosis exclusively based on the characteristics of small bowel lesions is possibly imprecise. Genetic analyses seem to be inevitable for the diagnosis of rare small bowel disorders such as CMUSE. | Junji Umeno Takayuki Matsumoto Atsushi Hirano Yuta Fuyuno Motohiro Esaki | 2018 | World Journal of Gastroenterology2018，24，28： | 2 |
| 3 | Robust speed control of DC servomotors using modem two degrees-of-freedom controller design显示文摘 | UMENO T HORI Y | 1991 | IEEE Transactions on Industrial Electronics1991，38，5： | 1 |
| 4 | A genome-wide association study identifies three new susceptibility loci for ulcerative colitis in the Japanese population 显示文摘 | Asano K Matsushita T Umeno J | 2009 | Nat Genet2009，41，12： | 1 |
| 5 | FPGA implementation of EA- SI algorithm 显示文摘 | Kim S J Ken Umeno Ryo Takahashi | 2007 | IHCE HectrorL Express2007，22，： | 1 |
| 6 | Planer nano-gra-phenes from camphor by CVD 显示文摘 | Somani P R Somani S P Umeno M | 2006 | Chem Phys Lett2006，430，13： | 1 |
| 7 | Autonomic responses during inhalation of natural fragrance of 'cedrol' in humans显示文摘 | Dayawansa S Umeno K | 2003 | Auton Neurosci2003，108，： | 1 |
| 8 | Metallic-semiconducting transition of single-walled carbon nanotube under high axial strain显示文摘 | Umeno Y Kitamura T Kushima A | 2004 | Computational Materials Science2004，31，12： | 1 |
| 9 | Correlations between homocysteine levels and atherosclerosis in japanese type 2 diabetic patients显示文摘 | Anan F Masaki T Umeno Y | 2007 | Metabolism2007，56，10： | 1 |
| 10 | A rapid and simple system of detecting deletions on the Y chromosome related with male infertility using muhiplex PCR显示文摘 | Umeno M Shinka T Sato Y | 2006 | J Med Invest2006，53，1： | 1 |
| 11 | Molecular breeding of carotenoid biosynthetic pathways显示文摘 | Schmidt- Dannert C Umeno D Arnold F H | 2000 | Nat Biotechno2000，18，7： | 1 |
| 12 | A Hereditary Enteropathy Caused by Mutations in the SLCO2A1 Gene, Encoding a Prostaglandin Transporter 显示文摘 | Umeno J Hisamatsu T Esaki M | 2015 | PLoS Genet2015，11，00： | 1 |
| 13 | Coating of DLC film by pulsed discharge plasma CVD 显示文摘 | Noda M Umeno M | 2005 | Diamond and Related Materials2005，14，1112： | 1 |
| 14 | Hypertensive intracerebral hemorrhage in isolated islands in Nagasaki prefecture:a remote teleradiology and helicopter transportation system显示文摘 | Kawahara I Motokawa T Umeno T | | 0，，10： | 1 |
| 15 | Hypertensive intracerebral hemorrhage in isolated islands in Nagasaki Prefecture: a remote teleradiology and helicopter transportation system 显示文摘 | Kawahara I Motokawa T Umeno T | 2011 | No Shinkei Geka2011，39，10： | 1 |
| 16 | Correlations be- tween homocysteine levels and atherosclerosis in Japanese type 2 dia- betic patients 显示文摘 | Anan F Masaki T Umeno Y Yonemoehi H | 2007 | Metabolism2007，56，10： | 1 |
| 17 | Observer Based Estimation of Parameter Variations and Its Application to Tyre Pressure Diagnosis 显示文摘 | TAKAJI UMENO | 2001 | Control Engineering Practice2001，9，6： | 1 |
| 18 | High-performance liquid chromatographic determination of proglumide in plasma 显示文摘 | Marunaka T Minami Y Umeno Y | 1982 | J Pharm Sci1982，71，8： | 1 |
| 19 | Specific acupunctu sensa- tion correlates with EEGs and autonomic changes in human sub- jects 显示文摘 | Sakai S Hori E Umeno K | 2007 | Auton Neurosci2007，133，2： | 1 |
| 20 | Asymmetric reduction of acetone by knockout mutants of a cyanobacterium显示文摘 | Takemura T Akiyama K Umeno N | 2009 | Journal of Molecular Catalysis B:Enzymatic2009，60，12： | 1 |
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