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| 1 | Second-generation direct-acting-antiviral hepatitis C virus treatment: Efficacy, safety, and predictors of SVR12显示文摘AIM To gather data on the antiviral efficacy and safety of second generation direct acting antiviral(DAA) treatment with respect to sustained virological response(SVR) 12 wk after conclusion of treatment, and to determine predictors of SVR12 in this setting.METHODS Two hundred and sixty patients treated with SOF combination partners PR(n = 51), R(n = 10), SMV(n = 30), DCV(n = 81), LDV(n = 73), or 3D(n = 15).144/260 were pre-treated, 89/260 had liver cirrhosis, 56/260 had portal hypertension with platelets < 100/nL, 25/260 had a MELD score ≥ 10 and 17/260 were postliver transplantation patients. 194/260 had HCV GT1, 44/260 HCV GT3.RESULTS Two hundred and forty/256(93.7%) patients achieved SVR12(m ITT); 4/260 were lost to follow-up. SVR12 rates for subgroups were: 92% for SOF/DCV, 93% for each SOF/SMV, SOF/PR, 94% for SOF/LDV, 100% for 3D, 94% for pretreated, 87% for liver cirrhosis, 82% for patients with platelets < 100/n L, 88% post-liver transplantation, 95% for GT1 a, 93% for GT1 b, 90% for GT3, 100% for GT2, 4, and 6. 12 patients suffered from relapse, 6 prematurely discontinued treatment, of which 4 died. Negative predictors of SVR12 were a platelet count < 100/nL, MELD score ≥ 10(P < 0.0001), liver cirrhosis(P = 0.005) at baseline. In Interferonfree treatment GT3 had significantly lower SVR rates than GT1(P = 0.016). Side effects were mild. CONCLUSION Excellent SVR12 rates and the favorable side-effect profile of DAA-combination therapy can be well translated into 'real-world'. Patients with advanced liver disease, signs of portal hypertension, especially with platelets < 100/n L and patients with GT3 are in special need for further research efforts to overcome comparatively higher rates of virological failure. | Christoph R Werner Julia M Schwarz Daniel P Egetemeyr Robert Beck Nisar P Malek Ulrich M Lauer Christoph P Berg | 2016 | World Journal of Gastroenterology2016，22，35： | 2 |
| 2 | Bifunctional chimeric SuperCD suicide gene -YCD: YUPRT fusion is highly effective in a rat hepatoma model显示文摘AIM: To investigate the effects of catalytically superior gene-directed enzyme prodrug therapy systems on a rat hepatoma model.METHODS: To increase hepatoma cell chemosensitivity for the prodrug 5-fluorocytosine (5-FC), we generated a chimeric bifunctional SuperCD suicide gene, a fusion of the yeast cytosine deaminase (YCD) and the yeast uracil phosphoribosyltransferase (YUPRT) gene.RESULTS: In vitro stably transduced Morris rat hepatoma cells (MH) expressing the bifunctional SuperCD suicide gene (MH SuperCD) showed a clearly marked enhancement in cell killing when incubated with 5-FC as compared with MH ceils stably expressing YCD solely (MH YCD) or the cytosine deaminase gene of bacterial origin(MH BCD), respectively. In vivo, MH SuperCD tumors implanted both subcutaneously as well as orthotopically into the livers of syngeneic ACI rats demonstrated significant tumor regressions (P<0.01) under both high dose as well as low dose systemic 5-FC application,whereas MH tumors without transgene expression (MH naive) showed rapid progression. For the first time, an order of in vivo suicide gene effectiveness (SuperCD>>YCD > > BCD > > > negative control) was defi ned as a result of a directin vivo comparison of all three suicide genes.CONCLUSION: Bifunctional SuperCD suicide gene expression is highly effective in a rat hepatoma model,thereby significantly improving both the therapeutic index and the efficacy of hepatocellular carcinoma killing by fluorocytosine. | Florian Graepler Marie-Luise Lemken Wolfgang A Wybranietz Ulrike Schmidt Irina Smirnow Christine D GroB Martin Spiegel Andrea Schenk Schenk Hansj(o|¨)rg Graf Ulrike A Lauer Reinhard Vonthein Michael Gregor Sorin Armeanu Michael Bitzer Ulrich M.Lauer | 2005 | World Journal of Gastroenterology2005，11，44： | 2 |
| 3 | Angiotensin Type 2 Receptor Stimulation Ameliorates Left Ventricular Fibrosis and Dysfunction via Regulation of Tissue Inhibitor of Matrix Metalloproteinase 1/Matrix Metalloproteinase 9 Axis and Transforming Growth Factor β1 in the Rat Heart显示文摘 | Dilyara Lauer Svetlana Slavic Manuela Sommerfeld Christa Th?ne-Reineke Yuliya Sharkovska Anders Hallberg Bjorn Dahl?f Ulrich Kintscher Thomas Unger Ulrike Muscha Steckelings Elena Kaschina | 2014 | Hypertension2014，，3： | 1 |
| 4 | Cannabinoid receptor 1 inhibition improves cardiac function and remodelling after myocardial infarction and in experimental metabolic syndrome显示文摘 | Svetlana Slavic Dilyara Lauer Manuela Sommerfeld Ulrich Rudolf Kemnitz Aleksandra Grzesiak Manuela Trappiel Christa Th?ne-Reineke Johannes Baulmann Ludovit Paulis Kai Kappert Ulrich Kintscher Thomas Unger Elena Kaschina | 2013 | Journal of Molecular Medicine2013，，7： | 1 |
| 5 | Growth characteristics and imaging properties of the morris hepatoma 3924a in ACI rats: A suitable model for transarterial chemoembolization显示文摘 | Jochen Trübenbach Florian Graepler Philippe L Pereira Peter Ruck Ulrich Lauer Michael Gregor Claus-D. Claussen Peter E. Huppert | 2000 | Cardiovascular and Interventional Radiology2000，，3： | 1 |
| 6 | Apoptosis on hepatoma cells but not on primary hepatocytes by histone deacetylase inhibitors valproate and ITF2357显示文摘 | Sorin Armeanu Anita Pathil Sascha Venturelli Paolo Mascagni Thomas S. Weiss Martin G?ttlicher Michael Gregor Ulrich M. Lauer Michael Bitzer | 2004 | Journal of Hepatology2004，，2： | 1 |
| 7 | Cardiac catheterisation in nonagenarians: Single center experience显示文摘ObjectiveTo 探索治疗,过程比回顾地经历心脏的 catheterization.MethodsWe 的 90 岁学习 32 病人 ≥ 的联系了老的病人的风险,和结果;90 年(93.0 ±1.2 年) 在一所第三级的专家医院里经历了心脏的 catheterisation (14,892 过程中的 0.2% 个在三年期间) 。结果比 90 年 age.ResultsBaseline 特征揭示糖尿病的更高的流行的与年轻的一个耐心的队相比(P <0.001 ) ,长期的妨碍的肺的疾病(P <0.04 ) ,以前的心肌的梗塞(P <0.02 ) ,并且在九十至九十九岁的人的复杂冠的解剖(句法分数 33 对 19 ) 。病人 <90 岁显示出更多的 hyperlipidemia (P <0.01 ) 并且以前的经皮的冠的干预(P <0.015 ) 。九十至九十九岁的人为急性冠的症候群(交流) 更经常经历了冠的 angiography (P <0.003 ) ,在心脏性的吃惊更经常被介绍(P <0.003 ) ,并且在交流的情况下更快被转移到冠的 angiography (P <0.0001 ) 。观察在里面医院死亡率(13% 学习组对 1% 控制组;P <0.003 ) 在九十至九十九岁的人是比在心肌的梗塞(TIMI ) 和尖锐心脏的事件(优雅) 的全球登记的 thrombolysis 的计算的率低的死亡并且强烈由临床的表示的严厉和 co-morbidities.ConclusionDespite 的存在影响了心脏的 catheterisation 暴露的普通怀疑论病人 ≥90 年到未经授权的风险,我们的数据在这组病人表明复杂并发症和死亡的可接受的发生。 | Marc-Alexander Ohlow Aly Hassan Ulrich Lotze Bemward Lauer | 2012 | Journal of Geriatric Cardiology2012，9，2： | 0 |
| 8 | Correlation of magnetic resonance signal characteristics and perfusion parameters assessed by volume perfusion computed tomography in hepatocellular carcinoma:Impact on lesion characterization显示文摘AIM: To find out if magnetic resonance(MR)-signal characteristics of hepatocellular carcinomas(HCC) correlate with perfusion parameters assessed by volume perfusion computed tomography(VPCT).METHODS: From October 2009 to January 2014, 26(mean age, 69.3 years) patients with 36 HCC lesions who underwent both VPCT and MR liver imaging were analysed. We compared signal intensity in the T1 wand T2w-images and wash-in/wash-out kinetics on postcontrast MR images with mean values of blood flow(BF, mL/100 mL per minute), blood volume(BV, mL/100 mL), k-trans(mL/100 mL per minute), arterial liver perfusion(mL/100 mL per minute), portal venous perfusion and hepatic perfusion index(HPI, %) obtained by VPCT. Signal intensity on magnetic resonance imaging(MRI) was classified hyper/iso/hypointense compared with surrounding liver parenchyma. RESULTS: Signal intensity on native T1w- and T2 wimages was hyper/iso/hypo in 4/16/16 and 21/14/1 lesions, respectively. Wash-in and wash-out contrast kinetics were found on MRI in 33 of 36 lesions(91.7%) and 25 of 36 lesions(69.4%), respectively. The latter was observed significantly more often in higher graded lesions(P < 0.005). HPI was 94.7% ± 6.5%. There was no significant relationship between lesion's MRsignal intensity, MR signal combinations, size and any of the VPCT-perfusion parameters. However HPI was constantly high in all HCC lesions.CONCLUSION: VPCT parameters add limited value to MR-lesion characterization. However in HCC lesions with atypical MR signal characteristics HPI can add a parameter to ensure HCC diagnosis. | Gerd Grozinger Michael Bitzer Roland Syha Dominik Ketelsen Konstantin Nikolaou Ulrich Lauer Marius Horger | 2016 | World Journal of Radiology2016，8，7： | 0 |
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