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| 1 | A full periodic table force field for molecular mechanics and molecular dynamics simulations 显示文摘 | Rappe A K Casewit C J UFF K S | 1992 | J Am Chem Soc1992，11，4： | 1 |
| 2 | CD44 exhibits a cell type dependent interaction with triton X-100 insoluble, lipid rich, slasma membrane domains显示文摘 | Neame S J Uff CR Sheikh H | 1995 | J Cell Sci1995，108，9： | 1 |
| 3 | Crystal structure of the platelet glycoprotein Ⅰ bα N-terminal domain reveals an unmasking mechanism for receptor activation显示文摘 | Uff S Clemetson JM Harrison T | 2002 | J Biol Chem2002，277，35： | 1 |
| 4 | Mutated Desmoglein‐2 Proteins are Incorporated into Desmosomes and Exhibit Dominant‐Negative Effects in Arrhythmogenic Right Ventricular Cardiomyopathy显示文摘 | Torsten B. Rasmussen Johan Palmfeldt Peter H. Nissen Raffaela Magnoni S?ren Dalager Uffe B. Jensen Won Y. Kim Lene Heickendorff Henning M?lgaard Henrik K. Jensen Ulrik T. Baandrup Peter Bross Jens Mogensen | 2013 | Human Mutation2013，，5： | 1 |
| 5 | Periprocedural complications and one-year outcomes after catheter ablation for treatment of atrial fibrillation in elderly patients:a nationwide Danish cohort study显示文摘OBJECTIVES To investigate complications within 30-days following first-time ablation for atrial fibrillation(AF),including a composite of cardiac tamponade,hematoma requiring intervention,stroke or death,in patients≥75 years of age,compared to pa-tients aged 65−74 years.In addition,one-year all-cause mortality and AF relapse were compared.METHODS&RESULTS All patients receiving their first catheter ablation for AF between 2012 and 2016 were identified us-ing Danish nationwide registries.Patients aged 65−74 years served as the reference group for patients≥75 years.Relapse of AF within one year was defined as cardioversion following a three-month blanking period,re-ablation or confirmed relapse within follow-up.The composite complication outcome did not differ between the two age groups,with 39/1554(2.8%)in patients 65−74 years of age,versus 5/199(2.5%)in older patients(adjusted HR=0.94),95%CI:0.37−2.39,P=0.896).Patients≥75 years or older had no increased hazard of death within 30 days after the procedure,with an incidence of 3/1554(0.2%)in younger pa-tients and 2/199(1.0%)in patients≥75 years of age(adjusted HR=4.71,95%CI:0.78−28.40,P=0.091).There was no difference in relapse of AF after one year between age groups(≥75 years adjusted HR=1.00,95%CI:0.78-1.26,P=0.969).CONCLUSION In patients≥75 years of age selected for catheter ablation for AF,the incidence of periprocedural complica-tions,as well as one-year freedom from AF showed no statistical difference,when compared to patients 65−74 years of age. | Jesper Nielsen Kristian Hay Kragholm Sofie Brix Christensen Arne Johannessen Christian Torp-Pedersen Steen Buus Kristiansen Peter Karl Jacobsen Peter Steen Hansen Mogens Stig Djurhus Christoffer Polcwiartek Peter Søgaard Anna Margrethe Thøgersen Uffe Jakob Ortved Gang Ole Dan Jørgensen Filip Lyng Lindgren Sam Riahi | 2021 | Journal of Geriatric Cardiology2021，18，11： | 1 |
| 6 | Effect of capsulation of opportunistic pathogenic bacteria on binding of the pattern recognition molecules mannan-binding lectin, L-ficolin, and H-ficolin显示文摘 | Krarup A Uffe BS Rensen S | 2005 | Infection and Immunity2005，73，2： | 1 |
| 7 | Conversion of methanol to hydrocarbons over conventional and meso- porous H-ZSM-5 and H-Ga-MFI: major differences in de- activation behavior 显示文摘 | UFFE V KAREN T MARTIN S | 2012 | Applied Catalysis A : General2012，，： | 1 |
| 8 | Somatic alterations of the NF1 gene in an NF1 individual with multiple benign turnours (internal and external) and malignant turnour types显示文摘 | GRIFFITHS S UFF J | 2007 | Fam Cancer2007，6，4： | 1 |
| 9 | Genome sequence of the palaeopolyp|oid soybean 显示文摘 | Jeremy S Steven B C Jessica S Ma J X Therese M William N David L H Qijian S Jay J T Cheng J L Xu D Uffe H Gregory D M Yeisoo Y Tetsuya S Taishi U Madan K B Devinder S Babu V Erika L Myron P David G Shu S Q David G Kerrie B Montona F Brian A Du J C Tian Z Zhu L Navdeep G Trupti J Marc L Anand S Zhang X C Kazuo S Henry T N Rod A Perry C James S Jane G Dan R Gary S Randy C S Scott A J | 2010 | Nature2010，463，： | 1 |
| 10 | CD44 expression in rejection rat small bowel allografts显示文摘 | Uff C R Reid S D Wood R F | 1995 | Transplantation1995，60，： | 1 |
| 11 | NMR spectra and stereochemistry of some 7-substituted 6,14-bridged thebaine derivatives显示文摘 | Uff B C Mallard A S Davis J A | 1985 | Magn Resort Chem1985，23，： | 1 |
| 12 | The homologue of mannose-binding lectin in the carp family Cyprinidae is expressed at high level in spleen, and the deduced primary structure predicts affinity for galactose显示文摘 | Lars Vitved Uffe Holmskov Claus Koch B?rge Teisner S?ren Hansen Karsten Skj?dt | 2000 | Immunogenetics2000，，11： | 1 |
| 13 | Influence of anastomoses on intestine ischemia and cefuroxime concentrations:Evaluated in the ileum and colon in a porcine model显示文摘BACKGROUND Anastomotic leakage is a serious complication following gastrointestinal surgery and is associated with increased morbidity and mortality.The incidence of anastomotic leakage is determined by anatomy and is reported to be between 4%-33%for colon anastomosis and 1%-3%for small intestine anastomosis.The etiology of anastomotic leakage of the intestine has been divided into three main factors:healing disturbances,communication between intra-and extra-luminal compartments,and infection.All three factors interact,and one factor will inevitably lead to the other two factors resulting in tissue ischemia,tissue necrosis,and anastomotic leakage.AIM To evaluate ischemic metabolites and cefuroxime concentrations in both anastomosis and non-anastomosis ileum and colon in a porcine model.METHODS Eight healthy female pigs(Danish Landrace breed,weight 58-62 kg)were included in this study.Microdialysis catheters were placed for sampling of ischemic metabolites(glucose,lactate,glycerol,and pyruvate)and cefuroxime concentrations in both anastomosis and non-anastomosis ileum and colon.Cefuroxime 1.5 g was administered as an intravenous infusion over 15 min.Subsequently,dialysates and blood samples were collected over 8 h and the ischemic metabolites and cefuroxime concentrations were quantified in all samples.The concentrations of glucose,lactate,glycerol and pyruvate were determined using the CMA 600 Microdialysis Analyzer with Reagent Set A(M Dialysis AB,Sweden),and the concentrations of cefuroxime and meropenem were quantified using a validated ultra-high-performance liquid chromatography assay.RESULTS Only the colon anastomosis induced mean ischemic lactate/pyruvate ratios above 25(ischemic cut-off)throughout the entire sampling interval,and simultaneously decreased glucose concentrations.The mean time for which cefuroxime concentrations were maintained above the clinical breakpoint minimal inhibitory concentration for Escherichia coli(8μg/mL)ranged between 116-128 min across all the investigated compartments,and was similar between the anastomosis and non-anastomosis ileum and colon.For all pigs and in all the investigated compartments,a cefuroxime concentration of 8μg/mL was reached within 10 min after administration.When comparing the pharmacokinetic parameters between the anastomosis and non-anastomosis sites for both ileum and colon,only colon Tmax and half-life differed between anastomosis and non-anastomosis(P<0.03).Incomplete tissue penetrations were found in all tissues except for the nonanastomosis colon.CONCLUSION Administering 1.5 g cefuroxime 10 min prior to intestine surgery seems sufficient,and effective concentrations are sustained for approximately 2 h.Only colon anastomosis was locally vulnerable to ischemia. | Pelle Hanberg Mats Bue Maja Thomassen Uffe Schou Løve Josephine Olsen Kipp Christina Harlev Elisabeth Petersen Kjeld Søballe Maiken Stilling | 2021 | World Journal of Gastrointestinal Pathophysiology2021，12，1： | 0 |
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