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| 1 | Pancreatic neuroendocrine tumor and solid-pseudopapillary neoplasm: Key immunohistochemical profiles for differential diagnosis显示文摘AIM To reveal better diagnostic markers for differentiating neuroendocrine tumor(NET) from solid-pseudopapillary neoplasm(SPN), focusing primarily on immunohistochemical analysis.METHODS We reviewed 30 pancreatic surgical specimens of NET(24 cases) and SPN(6 cases). We carried out comprehensive immunohistochemical profiling using 9 markers: Synaptophysin, chromogranin A, pancytokeratin, E-cadherin, progesterone receptor,vimentin, α-1-antitrypsin, CD10, and β-catenin.RESULTS E-cadherin staining in NETs, and nuclear labeling of β-catenin in SPNs were the most sensitive and specific markers. Dot-like staining of chromogranin A might indicate the possibility of SPNs rather than NETs. The other six markers were not useful because their expression overlapped widely between NETs and SPNs. Moreover, two cases that had been initially diagnosed as NETs on the basis of their morphological features, demonstrated SPN-like immunohistochemical profiles. Careful diagnosis is crucial as we actually found two confusing cases showing disagreement between the tumor morphology and immunohistochemical profiles.CONCLUSION E-cadherin, chromogranin A, and β-catenin were the most useful markers which should be employed for differentiating between NET and SPN. | Yusuke Ohara Tatsuya Oda Shinji Hashimoto Yoshimasa Akashi Ryoichi Miyamoto Tsuyoshi Enomoto Kaishi Satomi Yukio Morishita Nobuhiro Ohkohchi | 2016 | World Journal of Gastroenterology2016，22，38： | 19 |
| 2 | Variants of dopamine and serotonin candidate genes as predictors of response to risperidone treatment in first-episode schizophrenia显示文摘 | Masashi Ikeda Yoshio Yamanouchi Yoko Kinoshita Tsuyoshi Kitajima Reiji Yoshimura Shuji Hashimoto Michael C O&rsquor Donovan Jun Nakamura Norio Ozaki Nakao Iwata | 2008 | Pharmacogenomics2008，，10： | 1 |
| 3 | Reliability,resiliency,and vulnerability criteria for water resource system performance evaluation显示文摘 | Tsuyoshi Hashimoto Jerry R Stedinger Daniel P Loucks | 1982 | Water resources research1982，，1： | 1 |
| 4 | Personality of seasonal affective disorder analyzed by Tri-dimensional Personality Questionnaire显示文摘 | Nobuhisa Maeno Kazunori Kusunoki Tsuyoshi Kitajima Nakao Iwata Yuichiro Ono Shuji Hashimoto Makoto Imai Lan Li Yuhei Kayukawa Tatsuro Ohta Norio Ozaki | 2004 | Journal of Affective Disorders2004，，： | 1 |
| 5 | Administration of Ex Vivo-expanded Bone Marrow-derived Endothelial Progenitor Cells Attenuates Focal Cerebral Ischemia-reperfusion Injury in Rats显示文摘 | Tsuyoshi Ohta Ken-ichiro Kikuta Hirotoshi Imamura Yasushi Takagi Masaki Nishimura Yoshiki Arakawa Nobuo Hashimoto Kazuhiko Nozaki | 2006 | Neurosurgery2006，，3： | 1 |
| 6 | Development of Cold Rolling Mill Rolls of High Speed Steel Type by Using Continuous Pouring Process for Cladding显示文摘 | Taku Tanaka Tsuyoshi Inoue | 2002 | ISIJ International2002，42，9： | 1 |
| 7 | Measuring hepatic functional reserve using low temporal resolution Gd-EOB-DTPA dynamic contrast-enhanced MRI: a preliminary study comparing galactosyl human serum albumin scintigraphy with indocyanine green retention显示文摘 | Kazuhiro Saito Joseph Ledsam Steven Sourbron Tsuyoshi Hashimoto Yoichi Araki Soichi Akata Koichi Tokuuye | 2014 | European Radiology2014，，1： | 1 |
| 8 | Detection of genetic and chromosomal aberrations in medulloblastomas and primitive neuroectodermal tumors with DNA microarrays显示文摘 | Naoki Kagawa Motohiko Maruno Tsuyoshi Suzuki Tetsuo Hashiba Naoya Hashimoto Shuichi Izumoto Toshiki Yoshimine | 2006 | Brain Tumor Pathology2006，，1： | 1 |
| 9 | Effects of Silicon and Manganese Addition on Mechanical Properties of High-strength Hot-rolled Sheet Steel Containing Retained Austenite 显示文摘 | Ichiro Tsukatani Shun'ichi Hashimoto Tsuyoshi Inoue | 1991 | ISIJ International1991，31，9： | 1 |
| 10 | 显示文摘 | Yoshihara Mutsuda Tsuyoshi Fukushima Himyuki Hashimoto and Ryuichi Arakania | 2002 | J Electrochem Soc2002，149，10： | 1 |
| 11 | Prevalence of Cryptosporidium oocysts and Giardia cysts in the drinking water supply in Japan显示文摘 | Atsushi Hashimoto Shoichi Kunikane Tsuyoshi Hirata | 2002 | Water Res2002，36，： | 1 |
| 12 | Development of Cold Rolling Mill Rolls of High Speed Steel Type by Using Continuous Pouring Process for Cladding显示文摘 | Mitsuo Hashimoto Taku Tanaka Tsuyoshi Inoue | 2002 | ISIJ International2002，42，9： | 1 |
| 13 | Effects of silicon and manganese addition on mechanical properties of high-strength hot-rolled sheet steel containing retained austenite显示文摘 | Ichiro Tsukatani Shun'ichi Hashimoto Tsuyoshi Inoue | 1991 | ISIJ International1991，31，99： | 1 |
| 14 | Reliability,resiliency,and vulnerability criteria for water resource system performance evaluation显示文摘 | Tsuyoshi Hashimoto Jerry R Stedinger Daniel P Loucks | 1982 | Water resources research1982，，1： | 1 |
| 15 | Development of cold rolling mill rolls of high speed steel type by using continuous pouting process for cladding 显示文摘 | Mitsuo Hashimoto Taku Tanaka Tsuyoshi Inoue | 2002 | ISU International2002，42，9： | 1 |
| 16 | C5 palsy following anterior decompression and spinal fusion for cervical degenerative diseases显示文摘 | Mitsuhiro Hashimoto Macondo Mochizuki Atsuomi Aiba Akihiko Okawa Koichi Hayashi Tsuyoshi Sakuma Hiroshi Takahashi Masao Koda Kazuhisa Takahashi Masashi Yamazaki | 2010 | European Spine Journal2010，，10： | 1 |
| 17 | Prevalence of Crytosporidium oocysts and Giardia cysts in the drinking water supply in Japan显示文摘 | Hashimoto Atsushi Kunikane Shoichi Hirata Tsuyoshi | 2002 | Wat Res2002，36，3： | 1 |
| 18 | Solvation of lithium ions in mixed organic electrolyte solutions by electrospray ionization mass spectroscopy显示文摘 | YoshiharuMatsuda Tsuyoshi Fukushima Hiroyuki Hashimoto | 2002 | J Electrochem Soc2002，149，： | 1 |
| 19 | Histological and prognostic importance of CD 44+/ CD 24+/ E p CAM + expression in clinical pancreatic cancer显示文摘 | Yusuke Ohara Tatsuya Oda Masato Sugano Shinji Hashimoto Tsuyoshi Enomoto Keiichi Yamada Yoshimasa Akashi Ryoichi Miyamoto Akihiko Kobayashi Kiyoshi Fukunaga Yukio Morishita Nobuhiro Ohkohchi | 2013 | Cancer Sci2013，，8： | 1 |
| 20 | Effects of Silicon and Manganese Addition on Mech,mical Properties of High - strength Hot-rolledSheet Steel Containing Retained Austenite 显示文摘 | Ichiro Tsukatani Shun ichi Hashimoto Tsuyoshi Inoue | 1991 | ISIJ Intermational1991，31，9： | 1 |
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