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| 1 | New approaches for patients with advanced radioiodine-refractory thyroid cancer显示文摘The cumulative evidence over the past decades has shown that the incidence of differentiated thyroid carcinoma(DTC)has exponentially increased.Approximately 10%of patients with DTC exhibit recurrent or metastatic disease,and about two-thirds of the latter will be defined as refractory to radioactive iodine(RAIR)treatment.Since this condition implies 10-year survival rates less than 10% after detection,using available treatments,such as systemic and targeted therapies,have become increasingly relevant.The initiation of these treatments aims to reach stabilization,tumor volume reduction,and/or symptom improvement and it should be decided by highly specialized endocrinologists/oncologists on the basis of patient’s features.Considering that despite enlarged progression-free survival was proven,multikinase inhibitors remain non-curative,their benefits last for a limited time and the side effects potentially cause harm and quality of life reduction.In this context,molecular testing of cancer cells provides a promising spectrum of targeted therapies that offer increased compatibility with individual patient needs by improving efficacy,progression free survival,overall survival and adverse events profile.This review article aims to provide a summary of the current therapeutic strategies in advanced RAIR-DTC,including approved target therapies as well as those for off-label use,RAI resensitization agents,and immunotherapy. | Fabian Pitoia Fernando Jerkovich Pierpaolo Trimboli Anabella Smulever | 2022 | World Journal of Clinical Oncology2022，13，1： | 2 |
| 2 | A mild Grave's ophthalmopathy during pregnancy显示文摘 | Abbouda A Trimboli P Bruscolini A | 2014 | Semin Ophthalmol2014，29，1： | 1 |
| 3 | Direct evidence for epithelial-mesenchymal transitions in breast cancer 显示文摘 | Trimboli A J Fukino K de Bruin A | 2008 | Cancer Res2008，68，3： | 1 |
| 4 | Direct evidence for epithe- lial-mesenchyanal transitions in breast cancer显示文摘 | Trimboli AJ Fukhlo K de Bruin A | 2008 | Cancer Res2008，68，3： | 1 |
| 5 | Assessing psychopa- thology from'a structural perspective: A psychodynamic model 显示文摘 | Trimboli F Marshall R L Keenan C W | 2013 | Bulletin of the Menninger Clinic2013，77，2： | 1 |
| 6 | Ultrasound features of medullary thyroid carcinoma correlate with cancer aggressiveness: a retrospective multicenter study 显示文摘 | TRIMBOLI P GIOVANELLA L VALABREGA S | 2014 | Journal of Experimental & Clinical Cancer Research2014，33，1： | 1 |
| 7 | Influence of coenzyme A-independent transacylase and cyclooxygenase inhibitors on the proliferation of breast cancer cells显示文摘 | Trimboli A J Waite M Atsumi G | 1999 | Cancer Res1999，59，： | 1 |
| 8 | Direct evidence for epithelial-mesenchymal transitions in breast cancer显示文摘 | Trimboli AJ Fukino K de Bruin A | | 0，，03： | 1 |
| 9 | Direct evidence for pithelial-mesenchymal transitions in breast cancer 显示文摘 | Trimboli A J Fukino K de Bruin A | 2008 | Cancer Res2008，68，3： | 1 |
| 10 | Direct evidence for epithelial-mesenchymal transitions in breast cancer 显示文摘 | Anthony J Trimboli Koichi F | 2008 | Cancer Res2008，68，3： | 1 |
| 11 | Pten in stromal fibro- blasts suppresses mammary epithelial tumours 显示文摘 | Trimboli AJ Cantemir-Stone CZ Li F | 2009 | Nature2009，461，7267： | 1 |
| 12 | Direct evidence for epithelial-mesenchymal transitions in breast cancer显示文摘 | TRIMBOLI A J FUKINO K DE BRUIN A | 2008 | Cancer Res2008，68，3： | 1 |
| 13 | Thyroglobulin levels and thyroglobulin doubling time independently predict a positive 18 F-FDG PET/CT scan in patients with biochemical recurrence of differentiated thyroid carcinoma显示文摘 | Luca Giovanella Pierpaolo Trimboli Frederik A. Verburg Giorgio Treglia Arnoldo Piccardo Luca Foppiani Luca Ceriani | 2013 | European Journal of Nuclear Medicine and Molecular Imaging2013，，6： | 1 |
| 14 | MRI of fat necrosis of he breast: the 'black hole' sign at short tau inversion recovery 显示文摘 | Trimboli R M Carbonaro L A Cartia F | 2012 | Eur J Radiol2012，81，4： | 1 |
| 15 | BRAF-mutated carcinomas among thyroid nodules with prior indeterminate FNA report:a systematic review and meta-analysis显示文摘 | Trimboli P Treglia G Condorelli E | 2016 | Clin Endocrinol(Oxf)2016，84，3： | 1 |
| 16 | The use of core needle biopsy as first-line in diagnosis of thyroid nodules reduces false negative and inconclusive data reported by fie-needle aspiration 显示文摘 | Trimboli P Nasrollah N Guidobaldi L | 2014 | World J Surg Oncol2014，12，： | 1 |
| 17 | Pten in stromal fibroblasts suppresses mammary epithelial tumours显示文摘 | Trimboli AJ Cantemir-Stone CZ Li F | 2009 | Nature2009，461，7267： | 1 |
| 18 | Direct evidence for epithelialmesenchymal transitions in breast cancer显示文摘 | Trimboli AJ Fukino K de Bruin A | | 0，，03： | 1 |
| 19 | PTEN in stromal fibroblasts suppresses mammary epithelial tumours显示文摘 | Trimboli AJ Cantemir-Stone CZ Trimbol I | 2009 | Nature2009，461，7267： | 1 |
| 20 | Direct evi-dence for epithelial-mesenchymal transitions in breast cancer显示文摘 | Trimboli AJ Fukino K de Bruin A | | 0，，03： | 1 |
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