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| 1 | Colorectal cancer in patients under 50 years of age:A retrospective analysis of two institutions' experience显示文摘AIM:To investigate the epidemiological characteristics of colorectal cancer(CRC)in patients under 50 years of age across two institutions.METHODS:Records of patients under age 50 years of age who had CRC surgery over a 16 year period were assessed at two institutions.The following documents where reviewed:admission notes,operative notes,and discharge summaries.The main study variables included:age,presenting symptoms,family history,tumor location,operation,stage/differentiation of disease,and post operative complications.Stage of disease was classified according to the American Joint Committee on Cancer TNM staging system:tumor depth;node status;and metastases.RESULTS:CRC was found in 180 patients under age50 years(87 females,93 males;mean age 41.4±6.2years).Young patients accounted for 11.2%of cases during a 6 year period for which the full data set wasavailable.Eight percent had a 1stdegree and 12%a 2nd degree family CRC history.Almost all patients(94%)were symptomatic at diagnosis;common symptoms included:bleeding(59%),obstruction(9%),and abdominal/rectal pain(35%).Evaluation was often delayed and bleeding frequently attributed to hemorrhoids.Advanced stage CRC(Stage 3 or 4)was noted in 53%of patients.Most tumors were distal to the splenic flexure(77%)and 39%involved the rectum.Most patients(95%)had segmental resections;6 patients had subtotal/total colectomy.Poorly differentiated tumors were noted in 12%and mucinous lesions in 19%of patients of which most had Stage 3 or 4 disease.Twenty-two patients(13%)developed recurrence and/or progression of disease to date.Three patients(ages 42,42and 49 years)went on to develop metachronous primary colon cancers within 3 to 4 years of their initial resection.CONCLUSION:CRC was common in young patients with no family history.Young patients with symptoms merit a timely evaluation to avoid presentation with late stage CRC. | Elizabeth A Myers Daniel L Feingold Kenneth A Forde Tracey Arnell Joon Ho Jang Richard L Whelan | 2013 | World Journal of Gastroenterology2013，19，34： | 9 |
| 2 | Bcl-2 expression in endometrial hyperplasia and carcinoma显示文摘 | Theodorf H Niemannn MD Tracey L | 1996 | Gynecol Oncol1996，63，： | 1 |
| 3 | Noxious hot and cold stimulation produce common patterns of brain activation in humans: A functional magnetic resonance imaging study显示文摘 | Tracey I Becerra L Chang I | 2000 | Neurosci Lett2000，288，2： | 1 |
| 4 | MicroRNA- 34a is a potent tumor suppressor molecule in vivo in neuroblastoma 显示文摘 | Tivnan A Tracey L Buckley PG | 2011 | BMC Cancer2011，11，： | 1 |
| 5 | The 'cytokine profile': a code for sepsis 显示文摘 | Ulloa L Tracey KJ | 2005 | Trends Mol Med2005，11，2： | 1 |
| 6 | CrystallisationKinetics of Novel Branched Poly(ethylene terephthalate) : a Small-angle X-ray Scattering Study显示文摘 | Tracey L H John S F David S | 2006 | Polymer Interna- tional2006，55，： | 1 |
| 7 | A Reexamination of the Effects of Just-In-Time on Inbound Logistics显示文摘 | TRACEY M TAN C L VONDEREMBSE M | 1995 | International Journal of Logistics Management1995，，2： | 1 |
| 8 | Adaptive disk spin-down for mobile computers显示文摘 | David P Helmbold Darrell D E Long Tracey L Sconyers Bruce Sherrod | 2000 | Mobile Networks and Applications2000，5，4： | 1 |
| 9 | Updating the study of punishment 显示文摘 | Tracey L Meares | 2004 | Stanford Law Review2004，24，11： | 1 |
| 10 | Expression of the NF-kappa B targets BCL2 and BIRC5/Survivin characterizes small B-cell and aggressive B-cell lymphomas, respectively 显示文摘 | Tracey L Perez-Rosado A Artiga M J | 2005 | J Pathol2005，206，2： | 1 |
| 11 | Tumor necrosis factor antagonist mechanisms of action: a comprehensive review 显示文摘 | Tracey D Klareskog L Sasso EH | 2008 | Pharmacol Ther2008，117，2： | 1 |
| 12 | The 'cytokine profile': a code for sepsis显示文摘 | Ulloa L Tracey KJ | 2005 | Trends Mol Med2005，11，2： | 1 |
| 13 | Emotional states of athletes prior to performance-induced injury显示文摘 | TRACEY J D ANDREW M L YURI L H | 2005 | J Sports Sci Med2005，4，： | 1 |
| 14 | The 'cytokine profile' : a code for sepsis 显示文摘 | Ulloa L Tracey K J | 2005 | Trends Mol Med2005，11，： | 1 |
| 15 | MicroRNA-184-mediated inhibition of tumour growth in an orthotopic murine model of neuroblastoma显示文摘 | Tivnan A Foley NH Tracey L | 2010 | Anticancer Res2010，30，11： | 1 |
| 16 | The role of endogenous heme synthesis and degradation domain cysteines in cellular iron-dependent degradation of IRP2显示文摘 | Emmanuel Bourdon Dae-Kyung Kang Manik C Ghosh Steven K Drake Jane Wey Rodney L Levine Tracey A Rouault | 2003 | Blood Cells, Molecules and Diseases2003，，2： | 1 |
| 17 | Alliances, networks and competitive strategy: rethinking cluster of innovation 显示文摘 | Tracey P & G L Clark | 2003 | Growth and Change2003，34，1： | 1 |
| 18 | MicroRNA-34a is a potent tumor suppressor molecule in vivo in neuroblastoma显示文摘 | Tivnan A Tracey L Buckley PG | 2011 | BMC Cancer2011，11，1： | 1 |
| 19 | Perspective-Alliances,Networks and Competitive Strategy,Rethinking Cluster of Innovation显示文摘 | Paul Tracey Gordon L Clark | 2003 | Growth and Change2003，34，8： | 1 |
| 20 | MicroRNA-34a is a potent tumor suppressor molecule in vivo in neuroblastoma显示文摘 | Tivnan A Tracey L Buckley P G | 2011 | BMC Cancer2011，11，33： | 1 |
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