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1Foveal avascular zone area and parafoveal vessel density measurements in different stages of diabetic retinopathy by optical coherence tomography angiography显示文摘AIM:To investigate foveal avascular zone(FAZ) and parafoveal vessel densities(PRVD) by means of optical coherence tomography angiography(OCTA) in diabetic patients with or without diabetic retinopathy(DR) and to assess the reproducibility of FAZ and PRVD measurements.METHODS:Sixty diabetic patients(60 eyes) with different stage of DR(graded according to the International Clinical Severity Scale for DR) and 20 healthy subjects underwent FAZ area and PRVD measurements using OCTA by two experienced examiners.FAZ area in all patients was also assessed using fluorescein angiography(FA).RESULTS:In subject with proliferative DR and with moderate-severe non proliferative DR,FAZ area was significantly increased compared to healthy controls(P=0.025 and P=0.050 respectively measured with OCTA and P=0.025 and P=0.048 respectively measured with FA).OCTA showed significantly less inter-observer variability compared to FA.Concordance correlation coefficient(CCC) for FAZ area measurements was 0.829(95%CI:0.736-0.891) P<0.001 with FA and 1.000(95%CI:0.999-1.000) P<0.001 with OCTA.CCC was 0.834(95%CI:0.746-0.893) P<0.001 and 0.890(95%CI:0.828-0.930) P<0.001 for parafoveal superficial and deep vessel density measurements,respectively.CONCLUSION:OCTA shows progressive increase of FAZ area and reduction of PRVD in both superficial and deep plexus at increasing DR severity.FAZ area and PRVD measurements using OCTA are highly reproducible.Rodolfo Mastropasqua Lisa Toto Alessandra Mastropasqua Raffaella Aloia Chiara De Nicola Peter A Mattei Guido Di Marzio Marta Di Nicola Luca Di Antonio 2017International Journal of Ophthalmology(English edition)2017,10,10:26
2Anterior capsule contraction syndrome: a successful multimodal therapeutic approach显示文摘Dear Editor,I am Dr. Lisa Toto, from Department of Medicine and Science of Ageing, University G. D’Annunzio ChietiPescara, Chieti, Italy. I write to present a case report of anterior capsule contraction syndrome(ACCS).Lisa Toto Pasquale Viggiano Luca Vecchiarino Federica Evangelista Enrico Borrelli Leonardo Mastropasqua 2019International Journal of Ophthalmology(English edition)2019,12,8:4
3Retinal image quality with multifocal,EDoF,and accommodative intraocular lenses as studied by pyramidal aberrometry显示文摘Background:To study and compare the clinical optical image quality following implantation with different premium IOLs by analysing the point spread function(PSF)Strehl ratio using a pyramidal wavefront sensor(PWS)-based aberrometer.Methods:This study included 194 eyes implanted with:(a)19 AcrySof SA60AT(control group);(b)19 Miniwell;(c)24 LENTIS Mplus LS-313 MF30;(d)33 LENTIS Mplus LS-313 MF15;(e)17 AkkoLens Lumina;(f)31 AT LISA Tri 839MP;(g)20 Precizon Presbyopic;(h)20 AcrySof IQ PanOptix;(i)11 Tecnis Eyhance.Main outcome measures were PSF Strehl ratio,PSF Strehl ratio excluding second-order aberrations(PSFw2),total root mean square(RMS),low-order aberration(LOA)and high-order aberration(HOA)RMS measured by PWS aberrometer.Results:AT LISA Tri had the highest PSFw2 Strehl ratio at both 3.0-and 4.0-mm pupil size(0.52±0.14 and 0.31±0.10;P<0.05),followed by SA60AT(0.41±0.11 and 0.28±0.07)and PanOptix(0.4±0.07 and 0.26±0.04).AT LISA Tri was found to provide a significantly better retinal image quality than PanOptix at both 3.0 mm(P<0.0001)and 4.0 mm(P=0.004).Mplus MF15 was found to be significantly better than Mplus MF30 at both 3.0 mm(P<0.0001)and 4.0 mm(P=0.002).Total RMS,LOA RMS,HOA RMS,PSF Strehl ratio and PSFw2 varied significantly between the studied groups(P<0.001).Conclusions:Far distance clinical image quality parameters measured by PWS aberrometer differed significantly according to the technology of the implanted lens.AT LISA Tri,SA60AT and PanOptix showed the highest values of far distance retinal image quality,while the lowest PSFw2 Strehl ratios were displayed by Miniwell,Mplus MF30 and Precizon Presbyopic.Jorge L.Alio Francesco D’Oria Francesca Toto Joan Balgos Antonio Palazon Francesco Versaci Jorge L.Alio del Barrio 2021Eye and Vision2021,8,1:3
4Anatomical and functional changes after dexamethasone implant and ranibizumab in diabetic macular edema: a retrospective cohort study显示文摘AIM: To investigate the efficacy and safety of ranibizumab(RZB group) and dexamethasone implant(DEX group) intravitreal treatments in patients with treatment-na?ve center involved diabetic macular edema(DME) by means of functional and morphological assessments.METHODS: This retrospective cohort study included 50 eyes of 50 patients with DME treated either with RBZ or DEX. Best-corrected visual acuity(BCVA) and microperimetry were evaluated at baseline and during a 6-month follow-up. In addition, central macular thickness(CMT) by means of structural optical coherence tomography(OCT) and retinal capillary plexus density and choriocapillary density by means of OCT angiography were assessed in all cases.RESULTS: Functional and morphological parameters significantly improved during the study period in both groups. BCVA improved significantly in both groups witha greater increase in the DEX group compared to the RBZ group(P=0.030). Microperimetry significantly differed during follow-up between the two treatments(P=0.031). In both groups CMT significantly decreased(P<0.001) without statistically significant differences between the two groups. A statistically significant increase of deep capillary plexus density was detected in both groups at 30 d after therapy. The retreatment rate was 0.70±0.10 and 0.65±0.10 in the RBZ group and 0.65±0.10 and 0.50±0.11 in DEX group at 120 and 180 d respectively. Two out of 25 patients in DEX group showed intraocular pressure increase requiring hypotonic eye drops.CONCLUSION: Both treatments are very effective for DME treatment during 6 mo of follow-up with a lower retreatment rate in DEX group.Leonardo Mastropasqua Silvio Di Staso Rossella D’Aloisio Alessandra Mastropasqua Luca DiAntonio Alfonso Senatore Marco Ciancaglini Marta Di Nicola Giuseppe Di Martino DanieleTognetto Lisa Toto 2019International Journal of Ophthalmology(English edition)2019,12,10:2
5Design of Mach-Zehnder Interferometer and Ring Resonator for Biochemical Sensing显示文摘我们基于 Mach-Zehnder 干涉仪(MZI ) 建议了一个光生物化学的传感器的一个紧缩的图案,它被一个戒指共鸣器(RR ) 作为一个察觉到的工具联合。传感器敏感被力量差别在输出端口决定了。传感器改进被数字地评估 MZI 和 RR 的几何参数优化了。Fano 回声特征描绘的大传感器敏感从包含的高压力区域在 4eds 的范围作为双程票阶段的功能被表明了更多的全部的维生素 E (108rican 岩屑。post-500-MaDedi IRAWAN Toto SAKTIOTO Jalil ALI Preecha YUPAPIN 2015Photonic Sensors2015,5,1:2
6Photorefractive keratectomy with aspheric profile of ablation versus conventional photorefractive keratectomy for myopia correction:six - month controlled clinical trial 显示文摘MASTROPASQUA L TOTO L ZUPPARDI E 2006J Cataract Refract Sure2006,32,1:1
7Clinical study of the 1CU accommodatingintraocular lens显示文摘Mastropasqua L Toto L Nubile M 2003J Cataract Refract2003,29,7:1
8Association of blood pres- sure increases during hemodialysis with 2-year mortality in in- cident hemodialysis patients:a secondary analysis of the Dialy- sis Morbidity and Mortality Wave 2 Study显示文摘Inrig JK Patel UD Toto RD 2009Am J Kidney Dis2009,54,5:1
9Clinical study of the 1CU accommodating intraocular lens显示文摘Mastropasqua L Toto L Nubile M 2003J Cataract Refract Surg2003,29,:1
10Resistant Hypertension: Diagnosis, Evaluation, and Treatment: A Scientific Statement From the American Heart Association Professional Education Committee of the Council for High Blood Pressure Research显示文摘David A. Calhoun Daniel Jones Stephen Textor David C. Goff Timothy P. Murphy Robert D. Toto Anthony White William C. Cushman William White Domenic Sica Keith Ferdinand Thomas D. Giles Bonita Falkner Robert M. Carey 2008Hypertension2008,,6:1
11Efficacy and tolerability of losartan in hypertensive patients with renal impairment,collaborative group显示文摘 1998Hypertension1998,31,2:1
12Efficiency and tolerability of losratan in hypertensive patients with renal impairment显示文摘Toto R Shultz P Raij L 1998Hypertension1998,31,:1
13Efficacy and tolerability of losartan in hypertensive patients with renal impairment 显示文摘Toto R Shultz P Raij L 1998Hypertension1998,31,2:1
14Resistant Hypertension: Diagnosis, Evaluation, and Treatment: A Scientific Statement From the American Heart Association Professional Education Committee of the Council for High Blood Pressure Research显示文摘David A. Calhoun Daniel Jones Stephen Textor David C. Goff Timothy P. Murphy Robert D. Toto Anthony White William C. Cushman William White Domenic Sica Keith Ferdinand Thomas D. Giles Bonita Falkner Robert M. Carey 2008Hypertension2008,,6:1
15Longterm results of 1 CU accommodative intraocular lens implantation:2-year follow-up study显示文摘MASTROPASQUA L TOTO L FALCONIO G 2007Acta Ophthalmol Scand2007,85,4:1
16Long - term com- plications of bilateral posterior chamberphakic intraoeular lens implantation显示文摘Mastropasqua L Toto L Nubile M 2004J Cataract Refract Surg2004,30,:1
17Tumor lysis syndrome显示文摘ARRAMBIDE K TOTO D 1993Semin Nephrol1993,13,3:1
18The prevalence of per- sistent intradialytic hypertension in a hemodialysis population with extended follow-up 显示文摘Van Buren PN Kim C Toto RD 2012Int J Artif Organs2012,35,12:1
19Bardoxolone methyl and kidney function in CKD with type 2 diabetes 显示文摘Pergola PE Raskin P Toto RD 2011N Engl J Med2011,365,:1
20Bardoxolone methyl and kidney function in CKD with type 2 diabetes显示文摘Pergola PE Raskin P Toto RD 2011N Engl J Med2011,365,4:1
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