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| 1 | 基于IMRT时代的第八版AJCC/UICC鼻咽癌临床分期建议显示文摘目的准确的分期系统对癌症的治疗至关重要。随着癌症分期和治疗方法的演变,需要不断评价分期的适用性和改进性。方法基于第7版AJCC/UICC分期回顾性分析香港和中国大陆2个肿瘤中心收治的1609例接受调强放射治疗的首诊无转移鼻咽癌患者临床资料,所有患者治疗前均行核磁共振分期评估。结果无其他T3、T4期解剖结构受侵患者中,伴有咀嚼肌间隙(翼内肌和/或翼外肌)侵犯、椎前肌侵犯及咽旁间隙侵犯的三组患者之间0s相近。伴广泛软组织(上述侵犯结构以外的软组织)受侵患者OS与伴有颅内侵犯或颅神经侵犯相似。仅2%患者锁骨上窝以上淋巴结转移者直径〉6cm,其0s率与下颈淋巴结转移者类似。用下颈(环状软骨尾侧缘水平以下)代替锁骨上窝并不影响N分期之间的风险差异性。采用推荐的T、N分期,T。N。、T。N,期0s相近。结论经AJCC/UICC分期筹备委员会审阅后,建议第8版分期应将翼内肌/翼外肌从T。降到T:期,增加椎前肌为L期,用下颈取代锁骨上窝,将淋巴结最大直径〉6cm合并归为N,期,将T。、N,期统一归为Ⅳ。期。这些改变不仅使得相邻分期间风险差异性更好,而且使得临床实践性与全球适用性之间达到最佳平衡。 | 潘建基 Wai Tong Ng 宗井凤 Lucy L.K.Chan Brian O' Sullivan 林少俊 Henry C.K.Sze 陈韵彬 Horace C.W.Choi 郭巧娟 Wai Kuen Kan 肖友平 Xu Wei Quynh Thu Le Christine M.Glastonbury A.Dimtrios Colevas Randal S.Weber Jatin P.Shah Anne W.M.Lee | 2016 | 中华放射肿瘤学杂志2016，25，3： | 65 |
| 2 | Clinicopathological and prognostic analysis of 429 patients with intrahepatic cholangiocarcinoma显示文摘AIM:To understand the clinicopathological characteristics and treatment selections and improve survival and provide valuable information for patients with intrahepatic cholangiocarcinoma(ICC). METHODS:We retrospectively evaluated 5311 liver cancer patients who received resection between October 1999 and December 2003.Of these,429(8.1%)patients were diagnosed with ICC,and their clinicopathological, surgical,and survival characteristics were analyzed. RESULTS:Upper abdominal discomfort or pain(65.0%), no symptoms(12.1%),and hypodynamia(8.2%)were the major causes for medical attention.Laboratory tests showed 198(46.4%)patients were HBsAg positive, 90(21.3%)hadα-fetoprotein>20μg/L,50(11.9%) carcinoembryonic antigen>10μg/L,and 242(57.5%) carbohydrate antigen 19-9(CA19-9)>37 U/mL.Survival data was available for 329(76.7%)patients and their mean survival time was 12.4 mo.The overall survival of the patients with R0,R1 resection and punching exploration were 18.3,6.6 and 5.6 mo,respectively. Additionally,CA19-9>37 U/mL was associated with lymph node metastases,but inversely associated withcirrhosis.Multivariate analysis indicated that radical resection,lymph node metastases,macroscopic tumor thrombi and size,and CA19-9 were associated with prognosis. CONCLUSION:Surgical radical resection is still the most effective means to cure ICC.Certain laboratory tests(such as CA19-9)can effectively predict the survival of the patients with ICC. | Wei-Feng Shen Wei Zhong Feng Xu Tong Kan Li Geng Feng Xie Cheng-Jun Sui Jia-Mei Yang | 2009 | World Journal of Gastroenterology2009，15，47： | 39 |
| 3 | Risk factors for early recurrence of small hepatocellular carcinoma after curative resection显示文摘BACKGROUND:Poorer prognosis is seen in patients with hepatocellular carcinoma (HCC) after curative hepatic resection with early recurrence (≤1 year) than in those with late recurrence (>1 year).This study aimed to identify risk factors for postoperative early recurrence of small HCC (≤3 cm in diameter).METHODS:The study population consisted of 158 patients who underwent curative resection for small HCC between January 2002 and July 2004.Risk factors for early recurrence were analyzed.RESULTS:Thirty-three (20.8%) patients developed early recurrence after surgery.Univariate analysis showed the following significant risk factors for early recurrence in small HCC:serum alpha-fetoprotein (AFP) level >100 ng/ml,lack of tumor capsule formation,microscopic vascular invasion,high Edmonson-Steiner grades,and cytokeratin-19 (CK-19) expression (P<0.05).Multivariate stepwise logistic regression analysis showed that serum AFP level >100 ng/ml (odds ratio 2.561,95% confidence interval 1.057 to 6.206,P=0.037) and microscopic vascular invasion (odds ratio 4.549,95% confidence interval 1.865 to 11.097,P=0.001) were independent factors.CONCLUSIONS:Postoperative early recurrence is related to serum AFP level >100 ng/ml and microscopic vascular invasion in patients with small HCC.Adjuvant therapy and careful follow-up are required for patients with these risk factors. | Zhou, Yan-Ming Yang, Jia-Mei Li, Bin Yin, Zheng-Feng Xu, Feng Wang, Bin Xu, Wen Kan, Tong | 2010 | Hepatobiliary & Pancreatic Diseases International2010，9，1： | 24 |
| 4 | Prognostic factors in the surgical treatment of caudate lobe hepatocellular carcinoma显示文摘AIM:To evaluate the short-and long-term outcomes of liver resection for caudate lobe hepatocellular carcinoma (HCC).METHODS:We retrospectively analyzed 114 consecutive patients with HCC,originating from the caudate lobe,who underwent resection between January 2001 and January 2007.Univariate and multivariate analyses were performed on several clinicopathologic variables to determine the factors affecting long-term outcome and intrahepatic recurrence.RESULTS:Overall mortality and morbidity were 0% and 18%,respectively.After a median follow-up of 31 mo (interquartile range,11-66 mo),tumor recurrence had occurred in 76 patients (66.7%).The 1-,3-,and 5-year disease-free survival rates were 65.7%,38.1%,and 18.4%,respectively.The 1-,3-,and 5-year overall survival rates were 76.1%,54.7%,and 31.8%,respectively.Univariate analysis showed that subsegmental location of the tumor (45.7% vs 16.2%,P=0.01),liver cirrhosis (12.3% vs 47.9%,P=0.03),surgical margin (18.5% vs 54.6%,P=0.04),vascular invasion (37.9% vs 23.2%,P=0.04) and extended caudate resection (42.1% vs 15.4%,P=0.04) were related to poorer long-term survival.Multivariate analysis showed that only subsegmental location of the tumor,liver cirrhosis and surgical margin were significant independent prognostic factors.CONCLUSION:Hepatectomy was an effective treatment for HCC in the caudate lobe.The subsegmental location of the tumor,liver cirrhosis and surgical margin affected long-term survival. | Peng Liu,Jia-Mei Yang,Wen-Yang Niu,Tong Kan,Feng Xie,Dian-Qi Li,Ye Wang,Yan-Ming Zhou,Department of Special Treatment and Liver Transplantation,Eastern Hepatobiliary Surgery Hospital,Second Military Medical University,Shanghai 200438,China Peng Liu,Department of Hepatobiliary Surgery,Navy General Hospital,Beijing 100037,China | 2010 | World Journal of Gastroenterology2010，16，9： | 15 |
| 5 | One-pot hydrothermal fabrication of α-Fe_2O_3@C nanocomposites for electrochemical energy storage显示文摘A facile hydrothermal method was developed for the preparation of Fe_2O_3@C nanocomposites using FeCl_3·6H_2O as iron source and glucose as carbon source under alkaline condition. The morphology and structure of the as-prepared product were identified by transmission electron microscopy(TEM), high resolution transmission electron microscopy(HRTEM), field-emission scanning electron microscopy(FESEM),X-ray diffraction(XRD), Raman spectroscopy, Fourier Transform infrared spectroscopy(FTIR), and thermogravimetric analysis(TGA). The as-prepare α-Fe_2O_3@C nanocomposites were employed for supercapacitor electrode material. The synergistic combination of carbon electrical double-layer capacitance and α-Fe_2O_3 pseudo-capacitance established such nanocomposites as versatile platform for high performance supercapacitors. The synthesis method developed here is expected to obtain other metal oxide/carbon composite. | Maiyong Zhu Jiarui Kan Jianmei Pan Wenjie Tong Qi Chen Jiacheng Wang Songjun Li | 2019 | Journal of Energy Chemistry2019，28，1： | 9 |
| 6 | 15-Deoxy-△12,14 -prostaglandtn J2 alleviates hepatic ischemia-reperfusion injury in mice via inducing antioxidant response and inhibiting apoptosis and autophagy显示文摘肝的 ischemia-reperfusion (I/R ) 损害是在许多情形发生并且导致差的预后的一个普通临床的缺陷。apoptosis 和 autophagy 被显示了在肝的 I/R 损害贡献房间死亡。15-Deoxy-12,14-prostaglandin J 2(15d-PGJ2 ) 是学习最好的反煽动性的前列腺素之一,它被验证了在细胞和动物模型的各种各样的类型施加反煽动性、房间保护的功能。在这研究,我们在老鼠在 apoptosis 和 autophagy 上探索了 15d-PGJ2 的效果肝的 I/R 损害和它的可能的机制。一个模型部分(70%)肝的温暖的局部缺血在 Balb/c 老鼠被建立,并且在浆液的病理学的变化和肝纸巾在 6 , 12 ,和 24 h 被检测外科以后 15d-PGJ2 ( 2.5 , 7.5 , 15 g , iv )被管理 30 min 优先外科。有 15d-PGJ2 的预告的处理(7.5, 15 g ) 浆液中高音和著名计算机生产厂商层次的剂量依赖者减小象减轻的织物一样证实的显著地改善的 I/R-induced 肝的损害损坏。15d-PGJ2 预告的处理显著地减少了浆液 TNF-1 和 IL-1 层次和 F4/80 的肝的表示,巨噬细胞的主要 biomarker。15d-PGJ2 预告的处理 upregulated Bcl-2/Bax 比率,因此在肝减少 apoptotic 房间的数字。15d-PGJ2 预告的处理更加压制了 Beclin-1 和 LC3 的表示,因此减少在肝的 autophagosomes 的数字。而且, 15d-PGJ2 预告的处理激活 Nrf2 并且在肝禁止了一条 ROS/HIF1/BNIP3 小径。有 PPAR 受体 blocker GW9662 的预告的处理(2 g, ip ) 部分在肝的 I/R 损害上颠倒了 15d-PGJ2 的保护的效果。在结论,我们的结果在肝的 I/R 损害,可以在 Kupffer 房间并且在 Nrf2 小径的激活上的激活依靠减小的效果,它导致 ROS 产生的抑制, apoptosis,和 autophagy 上证实 15d-PGJ2 的保护的效果。 | Kan CHEN Jing-jing LI Sai-nan LI Jiao FENG Tong LIU Fan WANG Wei-qi DAI Yu-jing XIA Jie LU Ying-qun ZHOU Chuan-yong GUO | 2017 | Acta Pharmacologica Sinica2017，38，5： | 8 |
| 7 | Hepatectomy in the treatment of very big primary liver cancer: report of 86 cases显示文摘Objective: To study the indications for resection ofvery big primary liver cancer and the operative re-sults.Methods: From January 1985 to June 1996, 86 pa-tients with very big primary liver cancer (≥15cm indiameter) underwent hepatectomy in our hospital.The volume of bleeding and blood transfusion wasrecorded during the operation. After the operation,the draining quantity from their abdominal cavities,and the days of transfusion and hospitalization wererecorded. The occurrence of complications and sur-vival time of the patient were followed up.Results: The postoperative mortality was 3.48% andthe occurrence rate of complications was 31.40%, whichwas significantly correlated with preoperative lowerlevel of serum albumin or the elevated γ-globulin lev-el and the amount of resected liver tissue. But their liverfunction before operation was fairly good, the 1-, 3-and 5-year survival rates after hepatectomy were58.2%, 35.7% and 17.64%.Conclusions: Patients with very big primary liver can-cer, should be subjected to hepatectomy if their liverfunction before operation are normal and the marginsare distinct between the tumor and liver tissues. Afterthe operation, other treatments are suitable for goodeffects. | Jia-Mei Yang Tong Kan Han Chen Meng-Chao Wu From the Eastern Hospital of Hepatobiliary Surgery, Second Military Medical University, Shanghai 200433 China | 2002 | Hepatobiliary & Pancreatic Diseases International2002，1，1： | 7 |
| 8 | Excessive gestational weight gain in early pregnancy and insufficient gestational weight gain in middle pregnancy increased risk of gestational diabetes mellitus显示文摘Background:Gestational weight gain(GWG)is associated with the risk of gestational diabetes mellitus(GDM).However,the effect of weight gain in different trimesters on the risk of GDM is unclear.This study aimed to evaluate the effect of GWG on GDM during different trimesters.Methods:A birth cohort study was conducted from 2017 to 2020 in Shenzhen,China.In total,51,205 participants were included comprising two models(early pregnancy model and middle pregnancy model).Gestational weight(kg)was measured at each prenatal clinical visit using a standardized weight scale.Logistic regression analysis was used to assess the risk of GDM.Interaction analysis and mediation effect analysis were performed in the middle pregnancy model.Results:In the early pregnancy model,the risk of GDM was 0.858 times lower(95%confidence interval[CI]:0.786,0.937)with insufficient GWG(iGWG)and 1.201 times higher(95%CI:1.097,1.316)with excessive GWG after adjustment.In the middle pregnancy model,the risk of GDM associated with iGWG increased 1.595 times(95%CI:1.418,1.794)after adjustment;for excessive GWG,no significant difference was found(P=0.223).Interaction analysis showed no interaction between GWG in early pregnancy(GWG-E)and GWG in middle pregnancy(GWG-M)(F=1.268;P=0.280).The mediation effect analysis indicated that GWG-M plays a partial mediating role,with an effect proportion of 14.9%.Conclusions:eGWG-E and iGWG-M are associated with an increased risk of GDM.Strict control of weight gain in early pregnancy is needed,and sufficient nutrition should be provided in middle pregnancy. | Aiqi Yin Fuying Tian Xiaoxia Wu Yixuan Chen Kan Liu Jianing Tong Xiaonian Guan Huafan Zhang Linlin Wu Jianmin Niu | 2022 | Chinese Medical Journal2022，，9： | 5 |
| 9 | Review of Chinese atmospheric science research over the past 70 years: Atmospheric physics and atmospheric environment显示文摘Since the founding of the People’s Republic of China 70 years ago,the subject of atmospheric physics and atmospheric environment has developed rapidly in China,providing important support for the development of atmospheric science and guarantee for the development of national economy.In this paper,the general advancement of atmospheric physics and atmospheric environment in last 70 years was described.The main research progress of atmospheric physics and atmospheric environment in the past 40 years of reform and opening-up was reviewed,the outstanding research achievements since the 21 st century were summarized,the major problems and challenges are pointed out,and the key directions and suggestions for future development are put forward. | Tijian WANG Taichang GAO Hongsheng ZHANG Maofa GE Hengchi LEI Peichang ZHANG Peng ZHANG Chunsong LU Chao LIU Hua ZHANG Qiang ZHANG Hong LIAO Haidong KAN Zhaozhong FENG Yijun ZHANG Xiushu QIE Xuhui CAI Mengmeng LI Lei LIU Shengrui TONG | 2019 | Science China Earth Sciences2019，62，12： | 5 |
| 10 | New WHO global air quality guidelines help prevent premature deaths in China显示文摘The air quality guidelines (AQGs) issued by the World Health Organization (WHO) in 2005 are key references for the National Ambient Air Quality Standards (NAAQSs) in China.On 22September 2021,the WHO issued new AQGs (NAQGs)[1],which propose more stringent targets to control exposure to multiple air pollutants,including fine particulate matter (PM_(2.5)) and ozone (O_(3)),to which,in 2019,451 million premature deaths,globally,were attributable [2]. | Tao Xue Guannan Geng Xia Meng Qingyang Xiao Yixuan Zheng Jicheng Gong Jun Liu Wei Wan Qiang Zhang Haidong Kan Shiqiu Zhang Tong Zhu | 2022 | National Science Review2022，9，4： | 3 |
| 11 | CONSTANT AMPLITUDE FATIGUE STRENGTH AND P-S_a-S_m-N CAMBER FAMILY显示文摘CONSTANTAMPLITUDEFATIGUESTRENGTHANDP-S_a-S_m-NCAMBERFAMILYNiKan(DepartmentofNavalArchitectureandOceanEngineering,ShanghaiJiaoT... | Ni Kan(Department of Naval Architecture and Ocean Engineering,Shanghai Jiao Tong Universily, Shanghai, China, 200030)Gao Zentong(Department of Flight Vehicle Design and Applied Mechanics, Beijing University of Aeronautics and Astronautics,Beijing, China, | 1996 | Chinese Journal of Aeronautics1996，9，1： | 3 |
| 12 | Ambient air pollution, climate change, and population health in China显示文摘 | Haidong Kan Renjie Chen Shilu Tong | 2011 | Environment International2011，，： | 2 |
| 13 | Celastrol enhances transcription factor EB (TFEB)-mediated autophagy and mitigates Tau pathology:Implications for Alzheimer's disease therapy显示文摘Alzheimer's disease(AD),characterized by the accumulation of protein aggregates including phosphorylated Tau aggregates,is the most common neurodegenerative disorder with limited therapeutic agents.Autophagy plays a critical role in the degradation of phosphorylated Tau aggregates,and transcription factor EB(TFEB)is a master regulator of autophagy and lysosomal biogenesis.Thus,small-molecule autophagy enhancers targeting TFEB hold promise for AD therapy.Here,we found that celastrol,an active ingredient isolated from the root extracts of Tripterygium wilfordii(Lei Gong Teng in Chinese)enhanced TFEB-mediated autophagy and lysosomal biogenesis in vitro and in mouse brains.Importantly,celastrol reduced phosphorylated Tau aggregates and attenuated memory dysfunction and cognitive deficits in P301S Tau and 3xTg mice,two commonly used AD animal models.Mechanistical studies suggest that TFEB-mediated autophagy-lysosomal pathway is responsible for phosphorylated Tau degradation in response to celastrol.Overall,our findings indicate that Celastrol is a novel TFEB activator that promotes the degradation of phosphorylated Tau aggregates and improves memory in AD animal models.Therefore,Celastrol shows potential as a novel agent for the treatment and/or prevention of AD and other tauopathies. | Chuanbin Yang Chengfu Su Ashok Iyaswamy Senthil Kumar Krishnamoorthi Zhou Zhu Sichang Yang Benjamin Chunkit Tong Jia Liu Sravan G.Sreenivasmurthy Xinjie Guan Yuxuan Kan Aston Jiaxi Wu Alexis Shiying Huang Jieqiong Tan Kingho Cheung Juxian Song Min Li | 2022 | Acta Pharmaceutica Sinica B2022，12，4： | 2 |
| 14 | Ambient air pollution,climate change,and population health in China显示文摘 | Kan H D Chen R J Tong S L | 2012 | Environment International2012，42，： | 1 |
| 15 | Corynoxine B derivative CB6 prevents Parkinsonian toxicity in mice by inducing PIK3C3 complex-dependent autophagy显示文摘Increasing evidence shows that autophagy impairment is involved in the pathogenesis and progression of neurodegenerative diseases including Parkinson’s disease(PD).We previously identified a natural alkaloid named corynoxine B(Cory B)as a neuronal autophagy inducer.However,its brain permeability is relatively low,which hinders its potential use in treating PD.Thus we synthesized various derivatives of Cory B to find more potent autophagy inducers with improved brain bioavailability.In this study,we evaluated the autophagy-enhancing effect of CB6 derivative and its neuroprotective action against PD in vitro and in vivo.We showed that CB6(5–40μM)dose-dependently accelerated autophagy flux in cultured N2a neural cells through activating the PIK3C3 complex and promoting PI3P production.In MPP^(+)-treated PC12 cells,CB6 inhibited cell apoptosis and increased cell viability by inducing autophagy.In MPTP-induced mouse model of PD,oral administration of CB6(10,20 mg·kg^(-1)·d^(-1),for 21 days)significantly improved motor dysfunction and prevented the loss of dopaminergic neurons in the striatum and substantia nigra pars compacta.Collectively,compound CB6 is a brain-permeable autophagy enhancer via PIK3C3 complex activation,which may help the prevention or treatment of PD. | Zhou Zhu Liang-feng Liu Cheng-fu Su Jia Liu Benjamin Chun-Kit Tong Ashok lyaswamy Senthilkumar Krishnamoorthi Sravan Gopalkrishnashetty Sreenivasmurthy Xin-jie Guan Yu-xuan Kan Wen-jian Xie Chen-liang Zhao King-ho Cheung Jia-hong Lu Jie-qiong Tan Hong-jie Zhang Ju-xian Song Min Li | 2022 | Acta Pharmacologica Sinica2022，43，10： | 1 |
| 16 | Bifunctional ultraviolet light-emitting/detecting device based on a SnO_(2) microwire/p-GaN heterojunction显示文摘SnO_(2)has attracted considerable attention due to its wide bandgap,large exciton binding energy,and outstanding electrical and optoelectronic features.Owing to the lack of reliable and reproducible p-type SnO_(2),many challenges on developing SnO_(2)-based optoelectronic devices and their practical applications still remain.Herein,single-crystal SnO_(2)microwires(MWs)are acquired via the self-catalyzed approach.As a strategic alternative,n-SnO_(2)MW/p-GaN heterojunction was constructed,which exhibited selectable dual-functionalities of light-emitting and photodetection when operated by applying an appropriate voltage.The device illustrated a distinct near-ultraviolet light-emission peaking at∼395.0 nm and a linewidth∼50 nm.Significantly,the device characteristics,in terms of the main peak positions and linewidth,are nearly invariant as functions of various injection current,suggesting that quantum-confined Stark effect is essentially absent.Meanwhile,the identical n-SnO_(2)MW/p-GaN heterojunction can also achieve photovoltaic-type light detection.The device can steadily feature ultraviolet photodetecting ability,including the ultraviolet/visible rejection ratio(R_(360 nm)/R_(400 nm))∼1.5×10^(3),high photodark current ratio of 105,fast response speed of 9.2/51 ms,maximum responsivity of 1.5 A/W,and detectivity of 1.3×10^(13)Jones under 360 nm light at−3 V bias.Therefore,the bifunctional device not only displays distinct near-ultraviolet light emission,but also has the ability of high-sensitive ultraviolet photodetection.The novel design of n-SnO_(2)MW/p-GaN heterojunction bifunctional systems is expected to open doors to practical application of SnO_(2)microstructures/nanostructures for large-scale device miniaturization,integration and multifunction in next-generation high-performance photoelectronic devices. | TONG XU MINGMING JIANG PENG WAN KAI TANG DANING SHI CAIXIA KAN | 2021 | Photonics Research2021，9，12： | 1 |
| 17 | Aerodynamic characteristics of morphing wing withflexible leading-edge显示文摘The morphing wing can improve the flight performance during different phases.However,research has been subject to limitations in aerodynamic characteristics of the morphing wing with a flexible leading-edge.The computational fluid dynamic method and dynamic mesh were used to simulate the continuous morphing of the flexible leading-edge.After comparing the steady aerodynamic characteristics of morphing and conventional wings,this study examined the unsteady aerodynamic characteristics of morphing wings with upward and downward deflections of the leading-edge at different frequencies.The numerical results show that for the steady aerodynamic,the leading-edge deflection mainly affects the stall characteristic.The downward deflection of the leading-edge increases the stall angle of attack and nose-down pitching moment.The results are opposite for the upward deflection.For the unsteady aerodynamic,at a small angle of attack,the transient lift coefficient of the upward deflection,growing with the increase of deflection frequency,is larger than that of the static case.The transient lift coefficient of the downward deflection,decreasing with the increase of deflection frequency,is smaller than that of the static case.However,at a large angle of attack,an opposite effect of deflection frequency on the transient lift coefficient was demonstrated.The transient lift coefficient is larger than that of the static case when the leading edge is in the nose-up stage,and lower than that of the static one in the nose-down stage. | Zi KAN Daochun LI Tong SHEN Jinwu XIANG Lu ZHANG | 2020 | Chinese Journal of Aeronautics2020，33，10： | 1 |
| 18 | 腹腔化疗或联合其他方法综合治疗晚期原发性肝癌72例的疗效观察(英文)显示文摘Objective: To evaluate the effect of intraperitoneal chemotherapy or in combination with other therapies in pa- tients with advanced primary liver cancer. Methods: 72 patients with advanced primary liver cancer with no indication for surgery received intraperitoneal chemotherapy in combination with other therapies including transcatheter arterial chemoem- bolization (TACE), radiofrequency catheter ablation (RFA), percutaneous ethanol injection therapy (PEIT) and radiotherapy. Of them, 29 cases were complicated with hilar or retroperitoneal multiple lymph node metastases, 14 with portal vein em- bolus, 15 with intraperitoneal and diaphragmatic metastases, 6 with chylous ascites, one with cancerous ascites, and 7 with suspected cancerous ascites (referring to large amounts of ascites without hypoproteinemia while exfoliative cytology of the ascites was positive). The mean maximum tumor size was 8.2 cm in diameter. Liver function at the initial treatment was Child A in 53 cases, and Child B in 19 cases. Intraperitoneal chemotherapy was performed in all these patients. The intraperitoneal chemotherapy protocols included: 5-FU 0.5-0.75 g/d for 10-15 consecutive days, with a total dosage of 5-12.5 g, and at the last day of chemotherapy 10 mg mitomycin (MMC) or 100 mg carboplatin was injected. For 7 cases of cholangiocarcinoma, Gemzar 800-1000 mg was administered additionally. A majority of all these patients received another one or two therapy methods followed by intraperitoneal chemotherapy. TACE was performed in the patients with multiple tumors or nodule more than 5 cm in diameter in the liver, RFA or PEIT with nodule fewer than 4 in number and 5 cm or less than 5 cm in diameter and radiotherapy, only for metastases, with metastatic lymph nodes, localized metastasis within the abdominal cavity or portal vein embolus. Interval time between two methods was one month or so. Two months after the sequential therapy, repeated treatment would be given if general medical condition and liver function were perfect at that time. Results: The median sur- vival time of the group was 13.97 ± 6.27 months. The 1- and 2-year survival rates were 59.7% and 30.6% respectively. The mean survival time of the patients with liver function Child A was 15.91 ± 5.49 months, and that of the patients with Child B was 8.55 ± 5.09 months. The difference was statistically significant (P < 0.05). Conclusion: Intraperitoneal chemotherapy or in combination with other therapies in patients with advanced primary liver cancer with metastases to abdominal cavity is an effective method. It can prolong the survival time and improve life quality for a certain percentage of patients with advanced primary liver cancer. | Weifeng Shen Jiamei Yang Feng Xu Tong Kan Ying Tong Feng Xie | 2008 | The Chinese-German Journal of Clinical Oncology2008，7，2： | 1 |
| 19 | High-mobility induced high-performance self-powered ultraviolet photodetector based on single ZnO microwire/PEDOT:PSS heterojunction via slight ga-doping显示文摘Semiconductor micro/nanostructures with broad bandgap can provide powerful candidates for fabricating ultraviolet photodetectors(PDs)due to their proper bandgap,unique optoelectronic properties,large surface-to-volume ratio and good integration.However,semiconducting micro/nanostructures suffer from low electron conductivity and abundant surface defects,which greatly limits their practical application in developing PDs.In this work,an ultraviolet PD consisting of single Ga-doped ZnO microwire(ZnO:Ga MW)and p-type poly(3,4 ethylenedioxythiophene):poly(styrenesulfonate)(PEDOT:PSS)was designed.When exposed to ultraviolet illumination,the PD exhibits excellent performance(responsivity~185 m A/W,detectivity~2.4×10^(11) Jones,and fast response speed of~212μs for rise time and~387μs for decay time)under self-driven conditions.Compared with that of an undoped Zn O MWbased PD,the responsivity and detectivity of ZnO:Ga MW/PEDOT:PSS PD are significantly enhanced over 400%and 600%,respectively.Due to the incorporation of Ga element,the charge transport properties of a ZnO:Ga MW,specifically for the mobility,are effectively enhanced,which can substantially facilitate the generation,separation,transport and harvest efficiency of photo-generated carriers in the asfabricated PD.Besides,the Ga-incorporation improves the crystalline quality of MWs and reduces surface state density,further suggesting a high-quality ZnO:Ga MW/PEDOT:PSS heterojunction.This work provides a potential approach for designing high-performance self-powered ultraviolet PDs from the aspect of enhancing carrier transport through fine doping. | Peng Wan Mingming Jiang Tong Xu Yang Liu Caixia Kan | 2021 | Journal of Materials Science & Technology2021，，34： | 1 |
| 20 | Ambient air pollution, climate change, and population health in China显示文摘 | Kan H Chen R Tong S | 2012 | Environ Int2012，42，： | 1 |
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