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| 1 | Prognostic value of postoperative complication for early recurrence after curative resection of hepatocellular carcinoma显示文摘Background: Postoperative complications may adversely affect oncological outcomes. The aim of this study was to evaluate the impact of postoperative complications on early-phase recurrence after curative resection for hepatocellular carcinoma(HCC).Methods: We included 145 HCC patients who underwent initial and curative resection between January2004 and December 2013. Postoperative complications of grade III or higher based on Clavien–Dindo classification were defined as clinically relevant postoperative complications. Recurrence within two years after hepatectomy was defined as early-phase recurrence.Results: Thirty-eight patients(26%) developed postoperative complications. The only predictive factor for postoperative complication was longer operative duration(P = 0.037). The disease-specific survival rate of patients with complication was lower than that of patients without complications(P = 0.015). Earlyphase recurrence was observed in 20/38(53%) patients who suffered postoperative complications and36/107(34%) patients with no complications, which was statistically significant(P = 0.039). Multivariate analysis identified four factors contributing to early-phase recurrence: high serum AFP level(P = 0.042),multiple tumors(P < 0.001), poor differentiation(P = 0.036) and presence of postoperative complication(P = 0.039).Conclusions: Postoperative complication is an independent prognostic factor for early-phase recurrence after curative resection of HCC. Close observation of patients with postoperative complications may be a necessary treatment strategy for HCC. | Masataka Amisaki Hiroaki Saito Naruo Tokuyasu Teruhisa Sakamoto Soichiro Honjo Yoshiyuki Fujiwara | 2018 | Hepatobiliary & Pancreatic Diseases International2018，17，4： | 10 |
| 2 | Post-operative albumin-bilirubin grade predicts long-term outcomes among Child–Pugh grade A patients with hepatocellular carcinoma after curative resection显示文摘Background: Although Child–Pugh grade A patients with hepatocellular carcinoma(HCC) are candidates for curative resection, some may have a poor prognosis. The albumin-bilirubin(ALBI) grade, a measure of liver function based on albumin and bilirubin, has the potential to detect Child–Pugh grade A HCC patients with poor prognosis. Because components of the ALBI grade can be measured easily even after surgery, we explored the predictive values of ALBI in patient prognosis after HCC resection. Methods: In this retrospective case-control study, we included 136 HCC patients who underwent curative resection between January 2004 and December 2013 at our hospital. ALBI grade was calculated from laboratory data recorded the day before surgery and at post-operative day 5. Results: Pre-and post-operative ALBI grade predicted patients' long-term outcomes( P = 0.020 and P < 0.001, respectively, for overall survival, and P = 0.012 and P = 0.015, respectively, for recurrence-free survival). Post-operative ALBI grade was associated with patients' surgical factors of repeated hepatic resection( P = 0.012), intra-operative bleeding( P = 0.006), and surgery duration( P = 0.033). Furthermore, post-operative ALBI grade, rather than pre-operative ALBI grade, was an independent predictive factor of long-term outcome of Child–Pugh grade A patients with HCC. Conclusions: Post-operative ALBI grade is useful to predict the prognosis in patients after HCC resection. | Masataka Amisaki Ei Uchinaka Masaki Morimoto Naruo Tokuyasu Teruhisa Sakamoto Soichiro Honjo Hiroaki Saito Yoshiyuki Fujiwara | 2018 | Hepatobiliary & Pancreatic Diseases International2018，17，6： | 9 |
| 3 | Combined preoperative platelet-to-lymphocyte ratio and serum carbohydrate antigen 19–9 level as a prognostic factor in patients with resected pancreatic cancer显示文摘Background: Carbohydrate antigen 19–9(CA19-9) is the most frequently used tumor marker and serves as a prognostic indicator in patients with pancreatic cancer(PC). The platelet-to-lymphocyte ratio(PLR) is thought to be an inflammation-related serum marker. An elevated PLR represents increased inflammatory status and is associated with poor prognosis in patients with various cancers including PC. Methods: This study involved 103 patients with a histopathological diagnosis of pancreatic ductal adenocarcinoma who underwent pancreatectomy. The patients were assessed to determine the prognostic significance of the combination of the PLR and CA19-9 level. Results: Based on the receiver operating characteristic analysis results, the patients were divided into PLR H igh(PLR ≥ 129.1) andPLRLow(PLR < 129.1) groups and into CA19-9High(CA19-9 ≥ 74.0 U/mL) and CA19-9Low(CA19-9 < 74.0 U/mL) groups. The cumulative 5-year overall survival(OS) and disease-specific survival(DSS) rates significantly differed by both the PLR(PLR H igh group: 19.5% and 22.9%;PLRLow group: 39.1% and 45.9%) and CA19-9(CA19-9 H igh group: 19.1% and 25.6%;CA19-9Low group: 41.0% and 41.0%). We then divided the patients into Groups A(PLR L ow/CA19-9Low), B(PLR Low/CA19-9High or PLRHigh/CA19-9Low), and C(PLR H igh/CA19-9High). The cumulative 5-year OS rates in Groups A, B, and C were 44.0%, 31.9%, and 11.9%, respectively( P = 0.002). The cumulative 5-year DSS rates in Groups A, B, and C were 47.7%, 36.4%, and 16.8%, respectively( P = 0.002). Multivariate analysis revealed that the combination of the PLR and CA19-9 was an independent prognostic factor in patients with resected PC. Conclusions: The combination of the PLR and CA19-9 is useful for predicting the prognosis of patients with resected PC. | Teruhisa Sakamoto Hiroaki Saito Masataka Amisaki Naruo Tokuyasu Soichiro Honjo Yoshiyuki Fujiwara | 2019 | Hepatobiliary & Pancreatic Diseases International2019，18，3： | 3 |
| 4 | Minichromosome maintenance 2 ( MCM2 ) immunoreactivity in stage Ill human gastric carcinoma: clinicopatbological significance 显示文摘 | Tokuyasu N Shomori K Nishihara K | 2008 | Gastric Cancer2008，，1： | 1 |
| 5 | Three Cases of ResectedPleomorphic Carcinoma显示文摘 | Kikuchi R Isowa N Tokuyasu H | 2010 | Ann Thorac Cardiovasc Surg2010，16，4： | 1 |
| 6 | Sjogren's syndrome with multiple bullae caused by lymphocytic interstitial pneumonia显示文摘 | Tokuyasu H Watanabe E Okazaki R | | 0，，03： | 1 |
| 7 | Enzymatic hydrolysis of cellulose I is greatly accelerated via its conversion to the cellulose II hydrate form显示文摘 | Masahisa Wada Masakazu Ike Ken Tokuyasu | 2010 | Polymer Degradation and Stability2010，，4： | 1 |
| 8 | Three eases of re sected pleomorphic carcinoma 显示文摘 | Kikuchi R lsowa N Tokuyasu H | 2010 | Ann Thorac Cardiovasc Surg2010，16，4： | 1 |
| 9 | Enzymatic hydrolysis of celluloseI is greatly accelerated via its conversion to the cellulose II hydrate form显示文摘 | Wada M Ike M Tokuyasu K | 2010 | Polymer Degradation and Stability2010，95，4： | 1 |
| 10 | Minichromosome main- tenance 2 (MCM2) immunoreactivity in stage Ill human gastric carci- noma: clinicopathological significance 显示文摘 | Tokuyasu N Shomori K Nishihara K | 2008 | Gastric Cancer2008，11，： | 1 |
| 11 | Improved procedures for immunoferritin labeling of ultrathin frozen sections显示文摘 | Tokuyasu KT Singer SJ | | 0，，03： | 1 |
| 12 | Immunochemistry on ultrathin frozen sections显示文摘 | Tokuyasu KT | | 0，，04： | 1 |
| 13 | Large cell neuroendocrine carcinoma arising from the left main bronchus 显示文摘 | Tokuyasu H Sakaguchi Y Isowa N | 2011 | Intern Med2011，50，18： | 1 |
| 14 | Effectiveness of meropenem for the treatment of aspiration pneumonia in elderly patients 显示文摘 | Tokuyasu H Harada T Watanabe E | 2009 | Intern Med2009，48，3： | 1 |
| 15 | Fully automatic quantification of microarray image data显示文摘 | Jain AN Tokuyasu TA Snijders AM | 2002 | Genome Res2002，12，2： | 1 |
| 16 | Effectiveness of meropenem for the treatment of aspiration pneumonia in elderly patients显示文摘 | Tokuyasu H lqarada T Watanabe E etal | 2009 | Intern Med2009，48，3： | 1 |
| 17 | Vineulin, an intraeellular protein localized at specialized sites where mierofilament bundles terminate at cell membranes 显示文摘 | Geiger B Tokuyasu K T Dutton A H | 1980 | Proc Natl Acad Sci U S A1980，77，7： | 1 |
| 18 | Immunoelectron microscopic studies of desmin (skeleton) localization and intermediate filament organization in chicken skeletal muscle显示文摘 | Tokuyasu KT Dutton AH and Singer SJ | 1982 | J Cell Biol1982，96，： | 1 |
| 19 | CoCl2-induced HIF- 1alpha expression correlates with proliferation and apoptosis in MKN- 1 cells: a possible role for the P13K/Akt pathway显示文摘 | Ardyanto TD Osaki M Tokuyasu N | 2006 | Int JmOncol2006，29，3： | 1 |
| 20 | Recognition of Chitoohgosaccharides and Their N-acetyl Groups by Putative Subsites of Chitin Deacetylase from a Deuteromycete, Colletotrichum lindemuthianum 显示文摘 | Tokuyasu K Mitsutomi M Yamaguchi I | 2000 | Biochemistry2000，39，30： | 1 |
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