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| 1 | Refining pathological evaluation of neoadjuvant therapy for adenocarcinoma of the esophagus显示文摘AIM:To assess tumour regression grade(TRG)and lymph node downstaging to help define patients who benefit from neoadjuvant chemotherapy.METHODS:Two hundred and eighteen consecutive patients with adenocarcinoma of the esophagus or gastro-esophageal junction treated with surgery alone or neoadjuvant chemotherapy and surgery between 2005and 2011 at a single institution were reviewed.Triplet neoadjuvant chemotherapy consisting of platinum,fluoropyrimidine and anthracycline was considered for operable patients(World Health Organization performance status≤2)with clinical stage T2-4 N0-1.Response to neoadjuvant chemotherapy(NAC)was assessed using TRG,as described by Mandard et al.In addition lymph node downstaging was also assessed.Lymph node downstaging was defined by cN1 at diagnosis:assessed radiologically(computed tomography,positron emission tomography,endoscopic ultrasonography),then pathologically recorded as N0 after surgery;ypN0 if NAC given prior to surgery,or pN0if surgery alone.Patients were followed up for 5 years post surgery.Recurrence was defined radiologically,with or without pathological confirmation.An association was examined between t TRG and lymph node downstaging with disease free survival(DFS)and a comprehensive range of clinicopathological characteristics.RESULTS:Two hundred and eighteen patients underwent esophageal resection during the study interval with a mean follow up of 3 years(median follow up:2.552,95%CI:2.022-3.081).There was a 1.8%(n=4)inpatient mortality rate.One hundred and thirty-six(62.4%)patients received NAC,with 74.3%(n=101)of patients demonstrating some signs of pathological tumour regression(TRG 1-4)and 5.9%(n=8)having a complete pathological response.Forty four point one percent(n=60)had downstaging of their nodal disease(cN1 to ypN0),compared to only 15.9%(n=13)that underwent surgery alone(pre-operatively overstaged:cN1 to pN0),(P<0.0001).Response to NAC was associated with significantly increased DFS(mean DFS;TRG 1-2:5.1years,95%CI:4.6-5.6 vs TRG 3-5:2.8 years,95%CI:2.2-3.3,P<0.0001).Nodal down-staging conferred a significant DFS advantage for those patients with a poor primary tumour response to NAC(median DFS;TRG 3-5 and nodal down-staging:5.533 years,95%CI:3.558-7.531 vs TRG 3-5 and no nodal down-staging:1.114 years,95%CI:0.961-1.267,P<0.0001).CONCLUSION:Response to NAC in the primary tumour and in the lymph nodes are both independently associated with improved DFS. | Fergus Noble Luke Nolan Adrian C Bateman James P Byrne Jamie J Kelly Ian S Bailey Donna M Sharland Charlotte N Rees Timothy J Iveson Tim J Underwood Andrew R Bateman | 2013 | World Journal of Gastroenterology2013，19，48： | 4 |
| 2 | Improving truck underhood thermal management through CFD显示文摘 | Timothy P N Sunil K J | 2002 | SAE Technical Paper Series2002，，： | 1 |
| 3 | Chemical in diesel exhaust particles generate reactive oxygen radicals and induce apoptosis in macrophages 显示文摘 | Timothy S Martin P Kaszubowski N | 1999 | J Immunol1999，163，10： | 1 |
| 4 | The Coevolution of New Organizational Forms 显示文摘 | LEWIN A Y LONG C P TIMOTHY N | 1999 | Organization Science1999，10，5： | 1 |
| 5 | What Influences IT Ethical Behavior Intentions-Planned Behavior, Reasoned Action, Perceived Importance, or Individual Characteristics?显示文摘 | Leonard L N K Timothy P C Kreiec J | 2004 | Information and Management2004，，1： | 1 |
| 6 | Photo polymerized thiolene systems as shape memorypolymers显示文摘 | DEVATHA P N CNEIL B TIMOTHY F S | 2010 | Polymer2010，9，51： | 1 |
| 7 | Southern Ocean iron enrichment experiment: Carbon cycling in high-and low-Si waters 显示文摘 | Coale K H Johnson K S Chavez F P Buesseler K O Barber R T Brzezinski M A Cochlan W P Millero F J Falkowski P G Bauer J E Wanninkhof R H Kudela R M Altabet M A Hales B E Takahashi T Landry M R Bidigare R R Wang Xiujun Chase Z Strutton P G Friederich G E Gorbunov M Y Lance V P Hilting A K Hiscock M R Demarest M Hiscock W T Sullivan K F Tanner S J Gordon R M Hunter C N Elrod V A Fitzwater S E Jones J L Tozzi S Koblizek M Roberts A E Herndon J Brewster J Ladizinsky N Smith G Cooper D Timothy D Brown S L Selph K E Sheridan C C Twining B S Johnson Z I | 2004 | Science2004，304，5669： | 1 |
| 8 | Studies on Co-based catalysts supported on modified carbon substrates for PEMFC cathodes显示文摘 | Subramanian Nalini P Kumaraguru Swaminatha P Colo-Mercado Hector Kim Hansung Popov Branko N Black Timothy Chen Donna A | 2006 | Journal of Power Sources2006，57，： | 1 |
| 9 | Chemical in diesel exhaust particles generate reactive oxygen radicals and induce apoptosis in macrophages显示文摘 | Timothy S Martin P Kaszubowski N | 1999 | J Immunol1999，163，： | 1 |
| 10 | 显示文摘 | Devatha P N Neil B C Timothy F S | 2010 | Polymer2010，51，： | 1 |
| 11 | The Coevolution of New Organizational Forms 显示文摘 | ARIE Y LEWIN CHRIS P LONG TIMOTHY N CARROLL | 1999 | Organization Science1999，，5： | 1 |
| 12 | What influences IT ethical behavior intentions:planned behavior,reasoned action,perceived importance,or individual characteristics显示文摘 | Lori N K L Timothy P C Jennifer K | 2004 | Information & Management2004，，42： | 1 |
| 13 | The Brain Bench:Virtual Tools for Stereotactic Frame Neurosurgery显示文摘 | Luis S Wieslaw L N Timothy P | 1996 | Medical Image Analysis1996，1，4： | 1 |
| 14 | An evaluation of agriculturaldrought indices for the Canadian prairies 显示文摘 | Steven M Q Timothy N P | 2003 | Agricultural andForest Meteorology2003，118，： | 1 |
| 15 | Cancer‐associated fibroblasts predict poor outcome and promote periostin‐dependent invasion in oesophageal adenocarcinoma显示文摘 | Timothy J Underwood Annette L Hayden Mathieu Derouet Edwin Garcia Fergus Noble Michael J White Steve Thirdborough Abbie Mead Nicholas Clemons Massimiliano Mellone Chudy Uzoho John N Primrose Jeremy P Blaydes Gareth J Thomas | 2015 | Pathol2015，，3： | 1 |
| 16 | Microscopic colitis associated with exposure to lansoprazole显示文摘 | Timothy R H Robert P E | 2006 | J MJA2006，184，4： | 1 |
| 17 | Dietary manipulation and testosterone replacement therapy may explain changes in body composition after spinal cord injury: A retrospective case report显示文摘BACKGROUND Reduced level of physical activity,high-fat diet and skeletal muscle atrophy are key factors that are likely to contribute to deleterious changes in body composition and metabolic following spinal cord injury (SCI).Reduced caloric intake with lowering percentage macronutrients of fat and increasing protein intake may likely to improve body composition parameters and decrease ectopic adiposity after SCI.AIM To highlight the effects of dietary manipulation and testosterone replacement therapy (TRT) on body composition after SCI METHODS A 31-year-old male with T5 SCI was administered transdermal TRT daily for 16 wk.Caloric intake and percentage macronutrients were analyzed using dietary recalls.Magnetic resonance imaging and dual-energy x-ray absorptiometry were used to measure changes in body composition.RESULTS Caloric intake and fat percentage were reduced by 445 kcal/d and 6.5%,respectively.Total body weight decreased by 8%,body fat decreased by 29%,and lean mass increased by 7%.Thigh subcutaneous adipose tissue cross-sectional area was reduced by 31%.CONCLUSION Manipulation of caloric intake,fat percentage,and protein percentage may have influenced body composition after SCI. | Ashraf S Gorgey Robert M Lester Mina P Ghatas Sakita N Sistrun Timothy Lavis | 2019 | World Journal of Clinical Cases2019，7，17： | 0 |
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