|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Intracellular HMGB1 as a novel tumor suppressor of pancreatic cancer显示文摘尽管有最近的进展, oncogenic K 地岬驾驶的胰腺的 ductal 腺癌(PDAC ) 在最致命的人的癌症之中留在现代医学。PDAC 的致病对内在的染色体不稳定性和外来的发炎激活部分可归因。然而,在在胰腺的 tumorigenesis 的这二个事件之间的分子的连接充分还没被建立了。这里,我们证明(HMGB1 ) 细胞内部的高活动性组盒子 1 显著地压制 oncogenic 由禁止染色体的 K-Ras-driven 胰腺的 tumorigenesis 调停不稳定性的支持 inflammatory nucleosome 版本。任何一个单身者的有条件的基因脱离或在胰的 HMGB1 的两等位基因在出生使老鼠变为极其敏感到先锋损害的 oncogenic K-Ras-driven 开始,包括胰腺的 intraepithelial 瘤, intraductal 乳突的 mucinous 瘤,和 mucinous 膀胱的瘤。在胰的 HMGB1 的损失与染色体重新整理和 telomere 畸形描绘的氧化 DNA 损坏和 chromosomal 不稳定性被联系。这些导致煽动性的 nucleosome 版本并且宣传 K-Ras-driven 胰腺的 tumorigenesis。细胞外的 nucleosomes 支持 interleukin 6 (IL-6 ) 由渗入 macrophages/neutrophils 的分泌物并且提高在胰腺的损害表明激活的 oncogenic K 地岬。到 IL-6 或 histone H3 或为先进 glycation 的受体的大美人的抵销的抗体结束产品都限制表明激活的 K 地岬,阻止癌症开发和转移 / 侵略,并且延长在 Pdx1-Cre 的动物幸存; K 地岬 G12D/+;Hmgb1/ 鼠标。由 glycyrrhizin 的 HMGB1 损失的药理学抑制在煽动性的条件下面在老鼠限制 oncogenic K-Ras-driven tumorigenesis。减少在 PDAC 病人的 HMGB1 的原子、全部的细胞的表示与差的全面幸存相关,在 PDAC 与预示、治疗学的关联作为新奇肿瘤 suppressor 支持细胞内部的 HMGB1。 | Rui Kang Yangchun Xie Qiuhong Zhang Wen Hou Qingping Jiang Shan Zhu Jinbao Liu Dexing Zeng Haichao Wang David L Bartlet Timothy R Billiar Herbert J Zeh III Michael T Lotze Daolin Tang | 2017 | Cell Research2017，27，7： | 22 |
| 2 | Colorectal cancer and dysplasia in inflammatory bowel disease显示文摘Both ulcerative colitis and Crohn’s disease carry an increased risk of developing colorectal cancer. Established risk factors for cancer among patients with inflammatory bowel disease (IBD) include the younger age at diagnosis, greater extent and duration of disease, increased severity of inflammation, family history of colorectal cancer and coexisting primary sclerosing cholangitis. Recent evidence suggests that current medical therapies and surgical techniques for inflammatory bowel disease may be reducing the incidence of this complication. Nonetheless heightened vigilance and a careful, comprehensive approach to prevent or minimize the complications of invasive cancer are warranted in this unique cohort of patients. Current guidelines for the prevention and early detection of cancer in this high risk population are grounded in the concept of an inflammation-dysplasia- carcinoma sequence. A thorough understanding of the definition and natural history of dysplasia in IBD, as well as the challenges associated with detection and interpretation of dysplasia are fundamental to developing an effective strategy for surveillance and prevention, and understanding the limitations of the current approach to prevention. This article reviews the current consensus guidelines for screening and surveillance of cancer in IBD, as well as presenting the evidence and rationale for chemoprevention of cancer and a discussion of emerging technologies for the detection of dysplasia. | Timothy L Zisman David T Rubin | 2008 | World Journal of Gastroenterology2008，14，17： | 13 |
| 3 | Growing interest in gas hydrates显示文摘 | Timothy S C Rick L Uchida T | 2000 | Oilfield Review2000，12，： | 1 |
| 4 | Tea Polyphenols Overrides Inhibition of PDH during Exercise after a Low-carbohydrate Diet 显示文摘 | TIMOTHY A S T AMAND LAWRENCE L SPRIET NORMAN L JONES | 2000 | Am J Physiol Endocrinol Metab2000，279，2： | 1 |
| 5 | Descriptive fade slope statistics on INTELSAT Ku-band communi- cation link显示文摘 | TIMOTHY K I ONGJ T CHOO E B L | | Electron Lett0，36，16： | 1 |
| 6 | Return on Quality ( ROQ ) : Making Service Quality Financially Accountable 显示文摘 | Rust Roland T Anthony J Zahorik Timothy L Keiningham | 1995 | Journal of Marketing1995，59，2： | 1 |
| 7 | Return on Quality(ROQ) :Making Serv- ice Quality Financially Aceountable显示文摘 | RUST ROLAND T ANTHONY J ZAHORIK TIMOTHY L KEININGHAM | 1995 | Journal of Market- ing1995，，： | 1 |
| 8 | The gene for fragrance in rice显示文摘 | Louis M Bradbury T Timothy L | 2005 | Plant Biotechnology Journal2005，3，： | 1 |
| 9 | Persis- tent Colonization by HaeraopHilus influenzae in chronic obstructive pul- monary disease 显示文摘 | Timothy FMurphy Aimee L Brauer Andrew T Schiffmacher | 2004 | Am J Repir Crit Care Med2004，170，3： | 1 |
| 10 | The gene for fragrance in rice显示文摘 | LOUIS M T BRADBURY TIMOTHY L F | 2005 | Plant Biotechnology Journal2005，3，： | 1 |
| 11 | Development of ben- thic and fish assemblages on artificial reef materials compared to adjacent natural reef assemblages in Miami-Dade County, Florida 显示文摘 | SARA E T TIMOTHY L STEPHEN M B | 2006 | Bull Mar Sei2006，78，1： | 1 |
| 12 | Frequency dependence of antidepressant response to left prefrontal repetitive transcranial magnetic stimulation (rTMS) as a function of baseline cerebral glucose metabolism显示文摘 | Timothy A Kimbrell John T Little Robert T Dunn Mark A Frye Benjamin D Greenberg Eric M Wassermann Jennifer D Repella Aimee L Danielson Mark W Willis Brenda E Benson Andrew M Speer Elizabeth Osuch Mark S George Robert M Post | 1999 | Biological Psychiatry1999，，12： | 1 |
| 13 | Computational design of hypervelocity launchers 显示文摘 | Timothy G T Chhabildas L C | 1995 | Int J Impact Eng1995，17，456： | 1 |
| 14 | Monomer diffusion and the kinetics of methyl methacrylate radical polymerization at intermediate to high conversion显示文摘 | Alessandro F Matthew T Timothy P L | 1994 | Macromolecules1994，27，15： | 1 |
| 15 | The stochastic-hub center problem with service-level constraints 显示文摘 | SIM T L TIMOTHY J T BARRETT W | 2009 | Computers and Operations Research2009，36，12： | 1 |
| 16 | 5-hydroxytryptamine-receptor antagonists versus prochlorperazine for control of delayed nausea caused by doxorubicin: a URCC CCOP randomised controlled trial显示文摘 | Jane T Hickok Joseph A Roscoe Gary R Morrow Christopher W Bole Hongwei Zhao Karen L Hoelzer Shaker R Dakhil Timothy Moore Tom R Fitch | 2005 | Lancet Oncology2005，，： | 1 |
| 17 | Southern Ocean iron enrichment experiment: Carbon cycling in high-and low-Si waters 显示文摘 | Coale K H Johnson K S Chavez F P Buesseler K O Barber R T Brzezinski M A Cochlan W P Millero F J Falkowski P G Bauer J E Wanninkhof R H Kudela R M Altabet M A Hales B E Takahashi T Landry M R Bidigare R R Wang Xiujun Chase Z Strutton P G Friederich G E Gorbunov M Y Lance V P Hilting A K Hiscock M R Demarest M Hiscock W T Sullivan K F Tanner S J Gordon R M Hunter C N Elrod V A Fitzwater S E Jones J L Tozzi S Koblizek M Roberts A E Herndon J Brewster J Ladizinsky N Smith G Cooper D Timothy D Brown S L Selph K E Sheridan C C Twining B S Johnson Z I | 2004 | Science2004，304，5669： | 1 |
| 18 | Integration of Qater Quantity andQuality in Strategic River Basin Planning显示文摘 | L Gabriel T de Azevedo Timothy K Gates | 2000 | Journal of Water Resources Plan-ning and Management2000，，4： | 1 |
| 19 | In vitro assembly do Sindbis Virus core-like particles from cross-linked dimers of truncated and mutant caspid proteins显示文摘 | Timothy L T Rushika P Richard J K | 2001 | J Virol2001，75，6： | 1 |
| 20 | Size control,shape evolution,and silica coating of near-infrared emitting PbSe quantum dots显示文摘 | TIMOTHY T T TAMIL SELVAN S ZHAO L | 2007 | Chem Mater2007，19，13： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员