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| 1 | Distribution of pericellular matrix molecules in the temporomandibular joint and their chondroprotective effects against inflammation显示文摘The objectives of this study were to(1) determine the distribution and synthesis of pericellular matrix(PCM) molecules(collagen VI, collagen IV and laminin) in rat temporomandibular joint(TMJ) and(2) investigate the effects of PCM molecules on chondrocytes against inflammation in osteoarthritis. Four zones(fibrous, proliferating, mature and hypertrophic) of condylar cartilage and three bands(anterior, intermediate and posterior) of disc were analysed by immunohistochemistry for the presence of PCM molecules in rat TMJs. Isolated chondrocytes were pre-treated with PCM molecules before being subjected to interleukin(IL)-1β treatment to stimulate inflammation. The responses of the chondrocytes were analysed using gene expression, nitric oxide release and matrix metalloproteinase(MMP)-13 production measures. Histomorphometric analyses revealed that the highest areal deposition of collagen VI(67.4%), collagen IV(45.7%) and laminin(52.4%) was in the proliferating zone of TMJ condylar cartilage. No significant difference in the distribution of PCM molecules was noted among the three bands of the TMJ disc. All three PCM molecules were expressed intracellularly by chondrocytes cultured in the monolayer. Among the PCM molecules, pre-treatment with collagen VI enhanced cellular proliferation, ameliorated IL-1β-induced MMP-3, MMP-9, MMP-13 and inducible nitric oxide synthase gene expression, and attenuated the downregulation of cartilage matrix genes, including collagen I, aggrecan and cartilage oligomeric matrix protein(COMP). Concurrently, collagen VI pretreatment inhibited nitric oxide and MMP-13 production. Our study demonstrates for the first time the distribution and role of PCM molecules, particularly collagen VI, in the protection of chondrocytes against inflammation. | Wern Cui Chu Shipin Zhang Timothy J Sng Yu Jie Ong Wen-Li Tan Vivien Y Ang Casper B Foldager Wei Seong Toh | 2017 | International Journal of Oral Science2017，9，1： | 5 |
| 2 | MIWI2 Is Essential for Spermatogenesis and Repression of Transposons in the Mouse Male Germline显示文摘 | Michelle A. Carmell Angélique Girard Henk J.G. van de Kant Deborah Bourc’his Timothy H. Bestor Dirk G. de Rooij Gregory J. Hannon | 2007 | Developmental Cell2007，，4： | 1 |
| 3 | Wnt and Hedgehog Signaling Pathways in Bone Development显示文摘 | Timothy F Day BS Yingzi Y ang | 2008 | J Bone &Joint Surg2008，90，1： | 1 |
| 4 | Phase II study of CCI-779 in patients with recurrent glioblastoma multiforme显示文摘 | Susan M. Chang Patrick Wen Timothy Cloughesy Harry Greenberg David Schiff Charles Conrad Karen Fink H. Ian Robins Lisa Angelis Jeffrey Raizer Kenneth Hess Ken Aldape Kathleen R. Lamborn John Kuhn Janet Dancey Michael D. Prados | 2005 | Investigational New Drugs2005，，4： | 1 |
| 5 | Movable typing of full-lumen personalized Vein-Chips to model cerebral venous sinus thrombosis显示文摘Cerebral venous sinus thrombosis(CVST)is a type of stroke associated with COVID-19 vaccine-induced immune thrombotic thrombocytopenia.The precise etiology of CVST often remains elusive due to the highly heterogeneous nature of its governing mechanisms,specifically,Virchow’s triad that involves altered blood flow,endothelial dysfunction,and hypercoagulability,which varies substantially amongst individuals.Existing diagnostic and monitoring approaches lack the capability to reflect the combination of these patient-specific thrombotic determinants.In response to this challenge,we introduce a Vein-Chip platform that recapitulates the CVST vascular anatomy from magnetic resonance venography and the associated hemodynamic flow profile using the“Chinese Movable Type-like”soft stereolithography technique.The resultant full-lumen personalized Vein-Chips,functionalized with endothelial cells,enable in-vitro thrombosis assays that can elucidate distinct thrombogenic scenarios between normal vascular conditions and those of endothelial dysfunction.The former displayed minimal platelet aggregation and negligible fibrin deposition,while the latter presented significant fibrin extrusion from platelet aggregations.The low-cost movable typing technique further enhances the potential for commercialization and broader utilization of personalized Vein-Chips in surgical labs and at-home monitoring.Future research and development in this direction will pave the way for improved management and prevention of CVST,ultimately benefiting both patients and healthcare systems. | Yunduo Charles Zhao Yingqi Zhang Arian Nasser Tianbo Hong Zihao Wang Allan Sun Laura Moldovan Leon S Edwards Freda Passam Ken S Butcher Timothy Ang Lining Arnold Ju | 2023 | Aggregate2023，4，6： | 0 |
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