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| 1 | Angiotensinogen g-ene promoter region variant modifies body size-ambulatory blood pressure relations in hypertension显示文摘 | TIAGO A D SAMANI N J CANDY G P | 2002 | Circulation2002，106，12： | 1 |
| 2 | Study of Ball Bearing Torque under Elastohydrodynamic Lubrication 显示文摘 | Tiago C Beatriz G Armando C | 2011 | TribologyInternational2011，44，： | 1 |
| 3 | Angiotensinogen gene promoter region variant modifies body size-ambulatory blood pressure relations in hypertension 显示文摘 | Tiago A D Samani N J Candy G P | 2002 | Circulation2002，106，12： | 1 |
| 4 | Friction torque in grease lubricated thrust ball bearings 显示文摘 | Tiago C Beatriz G Armando C | 2011 | Tribology In- ternational2011，44，： | 1 |
| 5 | Chitosan-coated solid lipid nanoparticles enhance the oral absorption of insulin 显示文摘 | PEDRO F TIAGO N CHRISTIANE G | 2011 | Drug Deliv Transl Res2011，1，4： | 1 |
| 6 | Angiotensinogen gene promoter region variant modifies body size-ambulatory blood pressure relations in hypertension显示文摘 | TIAGO A D SAMANI N J CANDY G P | 2002 | Circulation2002，106，： | 1 |
| 7 | Lactobacillus paracasei isolated from grape sourdough:acid,bile,salt,and heat tolerance after spray drying with skim milk and cheese whey显示文摘 | EUNICE C I TIAGO S JULIANAU G L | 2015 | European Food Research Technology2015，240，： | 1 |
| 8 | Association between an atrial natriuretic peptide gene polymorphism and normal blood pressure in subjects of African ancestry显示文摘 | Nkeh B Tiago A Candy G P | 2002 | Cardiovasc J S Aft2002，13，3： | 1 |
| 9 | Direct-acting antivirals for chronic hepatitis C treatment: The experience of two tertiary university centers in Brazil显示文摘BACKGROUND Hepatitis C virus(HCV)treatment has undergone major changes in recent years.Previous interferon-based therapies have been replaced by oral direct-acting antivirals(DAA)regimens,with high sustained virologic response(SVR)rates,and a lower incidence of adverse events(AEs).AIM To evaluate the efficacy and safety of DAAs for HCV treatment in subjects from two tertiary university centers in Brazil.METHODS This is a multicenter retrospective cohort study of 532 patients with chronic hepatitis C(CHC),undergoing treatment with interferon-free regimens from November 2015 to November 2019.The therapeutic regimen was defined by the current Brazilian guidelines for HCV management at the time of treatment.Demographic,anthropometric,clinical,and laboratory variables were evaluated.SVRs were assessed at 12 to 24 wk after therapy by intention-to-treat(ITT),and modified ITT(m-ITT)analysis.AEs and serious adverse events(SAEs)were registered.In the statistical analysis,a P value of<0.05 was considered significant.RESULTS The mean age was 56.88 years,with 415(78.5%)being HCV genotype 1,followed by genotype 3(20.1%).Moreover,306(57.5%)subjects had cirrhosis,and a third of them had decompensated cirrhosis.Sofosbuvir(SOF)plus daclatasvir±ribavirin was the most frequently used treatment(66.9%),followed by SOF plus simeprevir(21.2%).The overall ITT SVR was 92.6%(493/532),while the m-ITT SVR was 96.8%(493/509).Variables associated with treatment failure via ITT evaluation were hepatic encephalopathy(OR:4.320;95%CI:1.920-9.721,P=0.0004),presence of esophageal varices(OR:2.381;95%CI:1.137-4.988,P=0.0215),previous portal hypertensive bleeding(OR:2.756;95%CI:1.173-6.471,P=0.02),higher model for end-stage liver disease scores(OR:1.143,95%CI:1.060–1.233,P=0.0005),lower serum albumin levels(OR:0.528,95%CI:0.322-0.867,P=0.0115),higher serum creatinine(OR:1.117,95%CI:1.056-1.312,P=0.0033),and international normalized ratio(INR)levels(OR:5.542,95%CI:2.023-15.182,P=0.0009).AEs were reported in 41.1%(211/514)of patients,and SAEs in 3.7%.The female gender,higher body mass index,esophageal varices,higher INR values,and longer treatment duration were independently associated with AE occurrence.CONCLUSION Treatment with oral DAAs attains a high SVR rate,with fewer SAEs in a real-life cohort of subjects with CHC,from two tertiary university centers in Brazil. | Mariana Sandoval Lourenço Patricia Momoyo Y Zitelli Marlone Cunha-Silva Arthur Ivan N Oliveira Cláudia P Oliveira Tiago Sevá-Pereira Flair JoséCarrilho Mario G Pessoa Daniel F Mazo | 2022 | World Journal of Hepatology2022，14，1： | 1 |
| 10 | Quasiparticle Elec- tronic Structure of Bismuth Telluride in the GW Approx- imation 显示文摘 | Kioupakis E Tiago M L Louie S G | 2010 | Phys Rev B2010，82，24： | 1 |
| 11 | Surface Energetics and Growth of Pentacene 显示文摘 | Northrup J E Tiago M L Louie S G | 2002 | Phys Rev B2002，，： | 1 |
| 12 | Risk factors associated with inflammatory bowel disease: A multicenter case-control study in Brazil显示文摘BACKGROUND The etiology of inflammatory bowel disease(IBD)is unknown,but it is believed to be multifactorial.The hygiene hypothesis proposes that better hygiene conditions would lead to less infectious disease during childhood and favor the development of immune-mediated diseases.AIM To test the hygiene hypothesis in IBD by assessing the environmental risk factors associated with IBD development in different regions of Brazil with diverse socioeconomic development indices.METHODS A multicenter case-control study was carried out with 548 Crohn’s disease(CD)and 492 ulcerative colitis(UC)outpatients and 416 healthy controls,from six IBD centers within different Brazilian states at diverse socioeconomic development stages.A semi-structured questionnaire with 87 socioeconomic and environmental questions was applied.Logistic regression model was created to assess the odds ratio(OR)with P value and 95%confidence intervals(CI).RESULTS Predictive variables for both diseases(CD and UC)were women[odd ratios(OR)=1.31;OR=1.69],low monthly family income(OR=1.78;OR=1.57),lower number of cohabitants(OR=1.70;OR=1.60),absence of vaccination(OR=3.11;OR=2.51),previous history of bowel infections(OR=1.78;OR=1.49),and family history of IBD(OR=5.26;OR=3.33).Associated risk factors for CD were age(18-39 years)(OR=1.73),higher educational level(OR=2.22),absence of infectious childhood diseases(OR=1.99).The UC predictive variables were living in an urban area(OR=1.62),inadequate living conditions(OR=1.48)and former smokers(OR=3.36).Appendectomy was a risk factor for CD(OR=1.58)with inverse association with UC(OR=4.79).Consumption of treated and untreated water was associated with risk of CD(OR=1.38)and UC(OR=1.53),respectively.CONCLUSION This is the first examining environmental exposures as risk factors for inflammatory bowel disease in Brazil.Most of the variables associated with disease risk support the role of the hygiene hypothesis in IBD development. | Valéria Cristina Loureiro Salgado Ronir Raggio Luiz Neio Lucio Fernandes Boéchat Isabella Sued Leao Bianca do Carmo Schorr JoséMiguel Luz Parente Daniela Calado Lima Eduardo Santos Silveira Júnior Genoile Oliveira Santana Silva Neogélia Pereira Almeida Andrea Vieira Maria Luiza Queiroz de Bueno Júlio Maria Chebli érika Ruback Bertges Luísa Martins da Costa Brugnara Columbano Junqueira Neto Stefania Burjack Gabriel Campbell Luana Letiza Discacciati Joao Paulo Silva Cézar Tiago Nunes Gilaad G Kaplan Cyrla Zaltman | 2020 | World Journal of Gastroenterology2020，26，25： | 1 |
| 13 | Trademarks as an indicator of innovation and industrial change显示文摘 | Sandro M Tiago S P Manuel M G | | 0，，33： | 1 |
| 14 | An integrated method for the determination of set-back lines for coastal erosion hazards on sandy shores 显示文摘 | oscar F Tiago G Ana M Rui T | 2006 | Continental Shelf Research2006，26，9： | 1 |
| 15 | Use of hybrid chitosan membranes and human mesenchymal stem cells from the Wharton jelly of umbilical cord for promoting nerve regeneration in an axonotmesis rat model显示文摘Many studies have been dedicated to the development of scaffolds for improving post-traumatic nerve regeneration. The goal of this study was to assess the effect on nerve regeneration, associating a hybrid chitosan membrane with non-differentiated human mesenchymal stem cells isolated from Wharton's jelly of umbilical cord, in peripheral nerve reconstruction after crush injury. Chromosome analysis on human mesenchymal stem cell line from Wharton's jelly was carried out and no structural alterations were found in metaphase. Chitosan membranes were previously tested in vitro, to assess their ability in supporting human mesenchymal stem cell survival, expansion, and differentiation. For the in vivo testing, Sasco Sprague adult rats were divided in 4 groups of 6 or 7 animals each:Group 1, sciatic axonotmesis injury without any other intervention (Group 1-Crush); Group 2, the axonotmesis lesion of 3 mm was infiltrated with a suspension of 1 250-1 500 human mesenchymal stem cells (total volume of 50 μL) (Group 2-CrushCell); Group 3, axonotmesis lesion of 3 mm was enwrapped with a chitosan type III membrane covered with a monolayer of non-differentiated human mesenchymal stem cells (Group 3-CrushChitIIICell) and Group 4, axonotmesis lesion of 3 mm was enwrapped with a chitosan type III membrane (Group 4-CrushChitIII). Motor and sensory functional recovery was evaluated throughout a healing period of 12 weeks using sciatic functional index, static sciatic index, extensor postural thrust, and withdrawal reflex latency. Stereological analysis was carried out on regenerated nerve fibers. Results showed that infiltration of human mesenchymal stem cells, or the combination of chitosan membrane enwrapment and human mesenchymal stem cell enrichment after nerve crush injury provide a slight advantage to post-traumatic nerve regeneration. Results obtained with chitosan type III membrane alone confirmed that they significantly improve post-traumatic axonal regrowth and may represent a very promising clinical tool in peripheral nerve reconstructive surgery. Yet, umbilical cord human mesenchymal stem cells, that can be expanded in culture and induced toform several different types of cells, may prove, in future experiments, to be a new source of cells for cell therapy, including targets such as peripheral nerve and muscle. | Andrea Gärtner Tiago Pereira Maria Joāo Simōes Paulo AS Armada-da-Silva Miguel L França Rosa Sousa Simone Bompasso Stefania Raimondo Yuki Shirosaki Yuri Nakamura Satoshi Hayakawa Akiyoshi Osakah Beatriz Porto Ana Lúcia Luís Artur SP Varejāo Ana Colette Maurício | 2012 | Neural Regeneration Research2012，7，29： | 1 |
| 16 | Influence of grease rheology on thrust ball bearings friction torque显示文摘 | TIAGO C BEATRIZ M G ARMANDO V C | | 0，，1： | 1 |
| 17 | Friction torque in grease lubricated thrust ball bearings 显示文摘 | Tiago C Beatriz G Armando C | 2011 | Tribology In- ternational2011，44，： | 1 |
| 18 | EFFECT OF CLIMATE CHANGE ON LONGEVITY AND REPRODUCTION OF SIPHA FLAVA (HEMIPTERA: APHIDIDAE)显示文摘 | Auad Alexander Machado Fonseca Marcy G Resende Tiago T Maddalena ítalo S C P | 2012 | EN2012，，： | 1 |
| 19 | 西57号街公寓显示文摘西57号街公寓结合了欧洲庭院建筑和传统曼哈顿高层的特点,并兼具两者的优点:通透的院落建筑的紧凑与高效性以及摩天楼拥有的广阔视野。通过让建筑三个角保持较低姿态而仅将东北角提升至450英尺(约137.2米),使得庭院面向哈德逊河的视野开阔,让较低的夕阳也能照进街区深处,并优雅地为一旁的Helena Tower保留河景。建筑的形式随着观察者的位置而不断变换。从西侧的高速公路上看. | David Brown Aleksander Tokarz Alessandro Ronfini Alessio Valmori Alvaro Mendive Benjamin Schulte Birk Daugaard Celine Jeanne Christoffer Gotfredsen Daniel Sundlin Dominyka Mineikyte Eivor Davidsen Felicia Guldberg Florian Oberschneider Soren Grunert Gabrielle Nadeau Gül Ertekin Ho Kyung Lee Hongyi Jin Julian Liang Julianne Gola Laura Youf Lucian Racovitan Marcella Martinez Maria Nikolova Maya Shopova Mitesh Dixit Nicklas A.Rasch Ola Hariri Riccardo Mariano Steffan Heath Stanley Lung Tara Hagan Thilani Rajarathna Tyler Polich Valentina Mele Valerie Lechene Xu Li Yi Li Aaron Hales Alessandro Ronfini Brian Foster Christoffer Gotfredsen Francesca Portesine Ho Kyung Lee Hongyi Jin Ivy Hume Jenny Chang Lauren Turner Mina Rafiee Rakel Karlsdottir Tara Hagan Thomas Fagan Tiago Barros Valentina Mele Iwan Baan 朱翰林(译) | 2019 | 城市环境设计2019，0，2： | 0 |
| 20 | Lithic soils in the semi-arid region of Brazil:edaphic characterization and susceptibility to erosion显示文摘Soils(Leptosols or Epileptic Regosols)with lithic contact at a depth of 50 cm occupy almost 20%of the Brazilian semi-arid region.These lithic soils are susceptible to erosion due to faster saturation of water-holding capacity during rainfall,which accelerates the beginning of runoff.However,erosion traits of lithic soils in the semi-arid region of Brazil are less studied.The aim of this study was to characterize the soil and landscape attributes in areas with Neossolos Litólicos(Entisols)in the Caatinga biome to identify region of high susceptibility to erosion.Results showed that the soils were characterized by a sandy texture,soil structure with poor development and low content of organic carbon.These attributes increase susceptibility to erosion and reduce water storage capacity,especially in the states of Cearáand Sergipe.In these states,the content of rock fragments in the soil reaches 790 g/kg.High contents of silt and fine sand,high silt/clay ratio,predominance of Leptosols and strong rainfall erosivity were observed in Piauíand northwestern Ceará.A very high degree of water erosion was observed in the states of Pernambuco and Paraíba.Despite the low degree of erosion observed in the state of Bahia,it is highly susceptible to erosion due to the predominance of very shallow soils,rugged relief and high values of rainfall erosivity.Lower vulnerability was observed in the state of Alagoas because of its more smoothed relief,greater effective soil depth,thicker A horizon of soil and lower rainfall erosivity.In general,the characteristics that intensify the susceptibility to erosion in the Caatinga biome are those soil structures with poor development or without aggregation,low contents of organic carbon,high contents of silt and fine sand,high values of silt/clay ratio and rugged relief in some regions.This study collected information contributing to a better characterization of soils with lithic contact in the semi-arid region of Brazil.In addition,regions with a higher susceptibility to erosion were identified,revealing insights that could help develop strategies for environmental risk mitigation. | Carlos R PINHEIRO JUNIOR Conan A SALVADOR Tiago R TAVARES Marcel C ABREU Hugo S FAGUNDES Wilk S ALMEIDA Eduardo C SILVA NETO Lúcia H C ANJOS Marcos G PEREIRA | 2022 | Journal of Arid Land2022，14，1： | 0 |
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