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| 1 | Development and evaluation of a one-step SYBR Green Ⅰ based real-time RT-PCR assay for the detection and quantification of Chikungunya virus in human,monkey and mosquito samples显示文摘 | Ali U H Vasan S S Thayan R | 2010 | Tropical Biomed2010，27，3： | 1 |
| 2 | Infliximab modifies mesenteric adipose tissue alterations and intestinal inflammation in rats with TNBS-induced colitis显示文摘 | Thayane Rodrigues Leite Clemente Aline Noronha dos Santos José Narciso Sturaro érica Martins Ferreira Gotardo Caroline Candida de Oliveira Simone Coghetto Acedo Cintia Rabelo e Paiva Caria José Pedrazzoli Marcelo Lima Ribeiro Alessandra Gambero | 2012 | Scandinavian Journal of Gastroenterology (-)2012，，8： | 1 |
| 3 | Sharing experiences from a reference laboratory in the public health response for Ebola viral disease, MERS-CoV and H7N9 influenza virus investigations显示文摘The International Health Regulations was enforced in June 2007,emphasizing the obligation of State Parties to detect,report,and respond to public health emergencies[1].An effective public health response requires a coordinated laboratory response in the Ministry of Health(MOH)network with credible laboratories capable of providing accurate and reliable results in a timely manner to enable effective public health measures | T.S.Saraswathy Subramaniam Ravindran Thayan Mohd Apandi Yusof Jeyanthi Suppiah Tengku Rogayah Tg Abd Rashid Zarina Mohd Zawawi Nor Aziyah Mat Rahim Fauziah Kassim Rozainanee Mohd Zain Zainah Saat | 2016 | Asian Pacific Journal of Tropical Medicine2016，9，2： | 1 |
| 4 | Rapid detection and serotyping of dengue virus by multiplex RT-PCR and real- time SYBR green RT-PCR显示文摘 | YONG Y K THAYAN R CHONG H T | 2007 | Singapore Medical Journal2007，48，7： | 1 |
| 5 | Rapid detection and serotyping of dengue virus by multiplex RT-PCR and real time SYBR Green RT-PCR 显示文摘 | Yong YK Thayan R Chong HT | 2007 | Singapore Med J2007，48，： | 1 |
| 6 | Hepcidin expression in colon during trinitrobenzene sulfonic acid-induced colitis in rats显示文摘AIM:To investigate hepcidin expression,interleukin-6(IL-6)production and iron levels in the rat colon in the presence of trinitrobenzene sulfonic acid(TNBS)-induced colitis.METHODS:In rats,we evaluated the severity of colitis induced by repeated TNBS administration using macroscopic and microscopic scoring systems and myeloperoxidase activity measurements.The colonic levels of hepcidin,tumor necrosis factor alpha(TNF-α),IL-10 and IL-6 were measured by Enzyme-Linked Immunosorbent Assay,and hepcidin-25 expression and iron deposition were analyzed by immunohistochemistry and the Prussian blue reaction,respectively.Stat-3 phosphorylation was assessed by Western blot analysis.Hematological parameters,iron and transferrin levels,and transferrin saturation were also measured.Additionally,the ability of iron,pathogen-derived molecules and IL-6 to induce hepcidin expression in HT-29 cells was evaluated.RESULTS:Repeated TNBS administration to rats resulted in macroscopically and microscopically detectable colon lesions and elevated colonic myeloperoxidase activity.Hepcidin-25 protein levels were increased in colonic surface epithelia in colitic rats(10.2±4.0pg/mg protein vs 71.0±8.4 pg/mg protein,P<0.01).Elevated IL-6 levels(8.2±1.7 pg/mg protein vs 14.7±0.7 pg/mg protein,P<0.05),TNF-αlevels(1.8±1.2pg/mg protein vs 7.4±2.1 pg/mg protein,P<0.05)and Stat-3 phosphorylation were also observed.Systemic alterations in iron homeostasis,hepcidin levels and anemia were not detected in colitic rats.Iron deposition in the colon was only observed during colitis.Hepcidin gene expression was increased in HT-29 cells after IL-6 and lipopolysaccharide[a toll-like receptor 4(TLR-4)ligand]treatment.Deferoxamine,ferric citrate and peptidoglycan(a TLR-2 ligand)were unable to alter the in vitro expression of hepcidin in HT-29 cells.CONCLUSION:Colitis increased local hepcidin-25 expression,which was associated with the IL-6/Stat-3 signaling pathway.An increase in local iron sequestration was also observed,but additional studies are needed to determine whether this sequestration is a defensive or pathological response to intestinal inflammation. | Erica Martins Ferreira Gotardo Gilberto de Almeida Ribeiro Thayane Rodrigues Leite Clemente Camila Henrique Moscato Renata Bortolin Guerra Tome Thalita Rocha Jose Pedrazzoli Jr Marcelo Lima Ribeiro Alessandra Gambero | 2014 | World Journal of Gastroenterology2014，20，15： | 1 |
| 7 | Rapid detection and serotyping of dengue virus by multiplex RT-PCR and real time SYBR Green RT- PCR 显示文摘 | Yong YK Thayan R Chong HT | 2007 | Singapore Med J2007，48，： | 1 |
| 8 | Human adenovirus type 7 outbreak in Police Training Center, Malaysia, 2011显示文摘 | Yusof MA Rashid TR Thayan R | 2012 | Emerg Infect Dis2012，18，5： | 1 |
| 9 | Rapid detection and serotyping of dengue virus by multiplex RT-PCR and re- al-time SYBR green RT-PCR显示文摘 | Yong Y K Thayan R Chong H T | 2007 | Singapore Med J2007，48，7： | 1 |
| 10 | Type-3 dengue virusesresponsible for the dengue epidemic in Malaysia during 1993-1994显示文摘 | Kobayashi N Thayan R Sugimoto C | 1999 | Am J Trop Med Hyg1999，60，6： | 1 |
| 11 | Reviewing perovskite oxide sites influence on electrocatalytic reactions for high energy density devices显示文摘Batteries,fuel cells,and supercapacitors are electrochemical devices already on the market and still need a boost in kinetics to match the high energy density demand of applications.Perovskites have attracted the scientific community's attention in the last decade due to their electrocatalytic activity,chemical and structural properties,tunability,low cost,and scalability.Efforts have been made to understand the active sites and the operational mechanisms in perovskite oxides to shape them as an electrocatalyst in advanced energy devices.Understanding the role of perovskites is the key to engineering more controlled and efficient electrocatalysts via chemical synthesis,and there is still much to do.This review highlights the use of perovskites in different energy storage and conversion systems.The A,B,and A&B doping-site effects are analyzed to understand the opportunities and challenges related to this class of materials.In addition,the synthesis methods and the properties related to the doping site are described and summarized. | Lorrane C.C.B.Oliveira Raissa Venâncio Paulo V.F.de Azevedo Chayene G.Anchieta Thayane C.M.Nepel Cristiane B.Rodella Hudson Zanin Gustavo Doubek | 2023 | Journal of Energy Chemistry2023，，6： | 1 |
| 12 | Identifications of drug resistance mutations among antiretroviral treatment naive HIV-1 patients in Peninsular Malaysia显示文摘Objective: To determine drug resistance mutations and the HIV-1 subtypes among antiretroviral treatment naive HIV-1 patients in Peninsular Malaysia,Methods: A total of 45 samples from four hospitals that provide HIV viral load services were subjected to the amplification of the protease and two third of reverse transcriptase regions of the pol gene by RT-PCR and Sanger sequencing,Drug resistance mutation(DRM) interpretation reports the presence of mutations related to protease inhibitors(PIs),Nucleoside reverse-transcriptase inhibitors(NRTI) and Non-nucleoside reverse-transcriptase inhibitors(NNRTI) based on analysis using Stanford HIV database program,Results: DRMs were identified in 35% of patients,among which 46.7% of them showed minor resistance to protease inhibitor with A71 V and L10 l were the commonest DRMs detected,About 21.4% and 50.0% of patients had mutations to NRTIs and NNRTIs,respectively,CRF01_AE was found to be the predominant HIV-1 subtype,Conclusions: These findings have served as an initial crucial data in determining the prevalence of transmitted HIV-1 drug resistance for the country,However,more samples from various parts of the country need to be accumulated and analyzed to provide overall HIV-1 drug resistance in the country. | Rozainanee Mohd Zain Nabila Ibrahim Suriani Ismail Jeyanthi Suppiah Nor Aziyah Mat Rahim Ravindran Thayan | 2017 | Asian Pacific Journal of Tropical Medicine2017，10，1： | 0 |
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