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| 1 | Cancer cachexia,mechanism and treatment显示文摘It is estimated that half of all patients with cancer eventually develop a syndrome of cachexia, with anorexia and a progressive loss of adipose tissue and skeletal muscle mass. Cancer cachexia is characterized by systemic inflammation, negative protein and energy balance, and an involuntary loss of lean body mass. It is an insidious syndrome that not only has a dramatic impact on patient quality of life, but also is associated with poor responsesto chemotherapy and decreased survival. Cachexia is still largely an underestimated and untreated condition, despite the fact that multiple mechanisms are reported to be involved in its development, with a number of cytokines postulated to play a role in the etiology of the persistent catabolic state. Existing therapies for cachexia, including orexigenic appetite stimulants, focus on palliation of symptoms and reduction of the distress of patients and families rather than prolongation of life. Recent therapies for the cachectic syndrome involve a multidisciplinary approach. Combination therapy with diet modification and/or exercise has been added to novel pharmaceutical agents, such as Megestrol acetate, medroxyprogesterone, ghrelin, omega-3-fatty acid among others. These agents are reported to have improved survival rates as well as quality of life. In this review, we will discuss the emerging understanding of the mechanisms of cancer cachexia, the current treatment options including multidisciplinary combination therapies, as well an update on new and ongoing clinical trials. | Tomoyoshi Aoyagi Krista P Terracina Ali Raza Hisahiro Matsubara Kazuaki Takabe | 2015 | World Journal of Gastrointestinal Oncology2015，7，4： | 20 |
| 2 | Current treatment options for colon cancer peritoneal carcinomatosis显示文摘Peritoneal carcinomatosis(PC),the dissemination of cancer cells throughout the lining of the abdominal cavity,is the second most common presentation of colon cancer distant metastasis.Despite remarkable advances in cytotoxic chemotherapy and targeted therapy for colon cancer over the last 15 years,it has been repeatedly shown that these therapies remain ineffective for colon cancer PC.Recently,there has been a rapid accumulation of reports that cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy(CRS-HIPEC) prolongs the life of colon cancer PC patients.Here,we will review the clinical presentation,the mechanisms of disease progression,and current treatment options for colon cancer PC,with a focus on the benefits and limitations of CRSHIPEC. | Tomoyoshi Aoyagi Krista P Terracina Ali Raza Kazuaki Takabe | 2014 | World Journal of Gastroenterology2014，20，35： | 15 |
| 3 | A MULTI-AGENT SYSTEM FOR MANAGING THE QUALITY OF SERVICE IN TELECOMMUNICATIONS NETWORKS显示文摘In this paper we propose X-MAQoS, a novel XML-based multi-agent system for the QoS management in telecommunications networks. This system is characterized by the following features: (i) it handles a user profile and exploits it jointly with suitable network resource management techniques to maximize user satisfaction; (ii) it is capable of operating in a large variety of telecommunications networks; (iii) it is semi-automatic; (iv) it exploits XML for guaranteeing a light, versatile and standard mechanism for information representation, storing and exchange. In this paper the basic features of the system are discussed in details. Furthermore, the main results of a performance evaluation study in UMTS environment, aiming at comparing X-MAQoS with alternative agent-based approaches for handling user access to telecommunications networks, are reported. | Pasquale DE MEO Antonio IERA Giorgio TERRACINA Domenico URSINO | 2005 | Journal of Systems Science and Systems Engineering2005，14，2： | 1 |
| 4 | Treatment of atrophic scars with Er: YAG laser: our experience显示文摘 | Mezzana P Sonnino M Madonna Terracina FS | 2001 | Acta Chir Plast2001，43，： | 1 |
| 5 | Personalizing learning programs with X-Learn,an XML-based,'user-device'adaptive muhi-agent system显示文摘 | Alfredo Garro Giorgio Terracina Domenico Ursino | | Sci-enceDirect0，2006，： | 1 |
| 6 | Identification ofpresenilin 1-selective 7-secretase inhibitors with reconstituted γ-seeretase complexes显示文摘 | Lee J Song L Terracina G | 2011 | Biochemistry2011，50，22： | 1 |
| 7 | Qualitative behavior of the two-phase en- tropy solution of a forward-backward parabolic problem 显示文摘 | TERRACINA A | 2011 | SIAM J Math Anal2011，43，： | 1 |
| 8 | Ethambutol in pregnancy:observations on embryogenesis显示文摘 | Lewit T Nebel L Terracina S | | 0，，01： | 1 |
| 9 | Response of a slotted orifice flow meter to an air/water mixture 显示文摘 | GERALD L Morrison DWAYNE Terracina CARL Brewer | 2001 | Flow Measurement and Instrumentation2001，12，3： | 1 |
| 10 | Uniform techniques for deriving similarities of objects and subschemes in heterogeneous databases 显示文摘 | Palopoli L Sacca D Terracina G | 2003 | Knowledge and Data Engineering IEEE Transactions2003，15，2： | 1 |
| 11 | Response of a slotted orifice flow meter to an air/water mixture显示文摘 | Morrison G L Terracina D Brewer C | 2001 | Flow Measurement and Instrumentation2001，12，3： | 1 |
| 12 | Response of a Slotted Orifice Flow Meter to an Air/Water Mixture显示文摘 | Morrison G L Terracina D Brewer C | 2001 | Flow Mearsurement and Instrumentation2001，12，： | 1 |
| 13 | Novel Oxidizing Breaker for High-Tempefature Fracturing显示文摘 | Terracina J M | | SPE0，，： | 1 |
| 14 | Uniform techniques for deriving similarities of objects and subschemes in heterogeneous databases显示文摘 | Palopoli L Sacca D Terracina G | 2003 | IEEE Transactions on Knowledge and Data Engineering2003，15，1： | 1 |
| 15 | An effective and economical mapping system for the monitoring of Psorphora columbiae in rice and fallow fields in southwestern Louisiana 显示文摘 | Fleetwood SC Chambers MD Terracina L | 1981 | Mosq News1981，，41： | 1 |
| 16 | Recommendation of similar users, resources and social net- works in a Social Intemetworking Scenario 显示文摘 | Pasquale De Meo Antonino Nocera Giorgio Terracina Domenico Ursino | 2011 | Information Sciences2011，181，： | 1 |
| 17 | Choline in- corporation into phospholipids in brain areas fromspontaneously hypertensive rats: effect of oxiracetam treatment显示文摘 | Nardella C Terracina L Brunetti M | 1991 | Farmaco1991，46，10： | 1 |
| 18 | Expression and function of neurotrophins and their receptors in euhured human keratinocytes 显示文摘 | Marconi A Terracina M Fila C | 2003 | J Invest Dermatol2003，121，6： | 1 |
| 19 | Class specific rheumatoid factors and antiphospholipid syndrome insystemic lupus erythematosus 显示文摘 | Spadaro A Riccieri V Terracina S | 2000 | Lupus2000，9，1： | 1 |
| 20 | Sphingosine-1- phosphate transporters as targets for cancer therapy 显示文摘 | Nagahashi M Takabe K Terracina KP | 2014 | Biomed Res lnt2014，2014，65： | 1 |
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