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| 1 | Studies on Hypokalemia Induced by Trimethyltin Chloride显示文摘Objectives To determine the possible relationship between plasma potassiumconcentration and severity of acute trimethyltin chloride (TMT) poisoning and to assess themechanism of TMT induced hypokalemia. Methods SD rats were treated with variousdosages of TMT (ip). All the indices were measured and analysed for determing theirpossible relations with plasma K+. Results With increase of dosage, the plasma K+ leveldropped rapidly, and deaths appeared more quickly. The LD50 of TMT (ip) was 14.7 mg/kgbw. In the low dosage group (10 mg/kgbw), the plasma K+ level dropped slowly with thelowest dosage on day 6 (4.85 mmol/L). It rose again on day 11 (5.06 mmol/L), and recoverdon day 28. The poisoning signs corresponded with decline of the span of K+ level. The plasmaNa+ level dropped half an hour after TMT treatment, but recovered 24 h later. In the highdosage group (46.4 mg/kgbw), the levels of plasma K+ and Na+ fell rapidly within half anhour (P<0.05), the intracellular potassium concentration of RBC did not decrerase obviously(P>0.05), the activities of Na+-K+-ATPase and Mg2+-ATPase in RBC membrane weredepressed remarkably (P<0.01, P<0.05, respectively), the plasma aldosterone concentrationsrose as high as tenfold (P<0.01), the arterial blood pH fell from 7.434 to 7.258 (P<0.01),pCO2 was raised from 29.62 to 45.33 mmHg (P<0.01). In the 24 h urine test, when rats weretreated with TMT (21.5 mg/kgbw, ip), urine volume, urinary potassium, sodium and chlorideincreased significantly in comparison with those in the controls (P<0.01). Conclusion TMTcould induce hypokalemia in SD rats. The available evidence suggests that TMT can induceacute renal leakage of potassium. At the same time, a significant rise of plasma aldosteronemay play an important role in promoting potassium leakage from kidney to result in severehypokalemia with inhaling acid-base abnormalities produced, which aggravate the poisoningsymptoms. In the end the rats would die of respiratory failure. | TangXJ LaiGC | 2002 | Biomedical and Environmental Sciences2002，15，1： | 14 |
| 2 | Guinea Pig Maximization Test for Trichloroethylene and Its Metabolites显示文摘Objectives To study the contact allergenic activities of trichloroethylene (TCE) and its three metabolites trichloroacetic acid, trichloroethanol and chloral hydrate. Methods A modified guinea pig maximization test (GPMT) was adopted. The skin sensitization (edema and erythema) was observed in trichloroethylene, trichloroacetic acid, trichloroethanol, chloral hydrate and 2,4-dinitrochlorobenzene. Results The allergenic rate of TCE, trichloroacetic acid and 2,4-dinitrochlorobenzene was 71.4%, 58.3% and 100.0% respectively, and that of trichloroethanol and chloral hydrate was 0%. The mean response score of TCE, trichloroacetic acid and 2,4-dinitrochlorobenzene was 2.3, 1.1, 6.0 respectively. The histopathological analysis also showed an induction of allergenic transfomation in guinea pig skin by both TCE and trichloroacetic acid. Conclusion TCE appears to be a strong allergen while trichloroacetic acid a moderate one. On the other hand, both trichloroethanol and chloral hydrate are weak sensitization potentials. Immunologic reaction induced by TCE might be postulated as the pathological process of this illness. Consequently, it is suggested that in the mechanism of Occupational Dermatitis Medicamentose-Like (ODML) induced by TCE, the chemical itself might be the main cause of allergy. As one of its metabolic products, trichloroacetic acid might be a subordinate factor. | TangXJ LiaLY 等 | 2002 | Biomedical and Environmental Sciences2002，15，2： | 10 |
| 3 | Mediumoptimizationfor theproductionofthermalstablel3-glucanaseby Raeillussubtilis ZJ F- 1 AS usingresponses ur facemethodologyl显示文摘 | TangXJ HeGQ ChenQH etal | 2004 | Bioresouree Technology2004，，93： | 1 |
| 4 | Hypokalemia as an early index in trimethyltin chloride poisoning显示文摘Nowdays,dimethyltin(DMT) is widely used as plastic stabilizers.Trimethyltin chloride(TMT) is the main byproduct of DMT.Our study on SD rats had shown that hypokalemia played a very inportant role in TMT poisoning.The purpose of this paper was to clarify if hypokalemia can be used as an early index of diagnosis,therapy and prevention in TMT intoxication.We analyzed the serum potassium of 169 cases exposed to TMT,from which 123 cases were measured in 24h after the disease was complained.The serum potassium of 96 cases(78%) were below 3.5mmol·L^-1.Four cases died with very serious hypokalemia(<2.5mmol·L^-1).The lower the serum potassium was,the more serious of symptom would be found.In the recent 3 accidents,we measured the serum potassium as early as possible,and treat with KCl(iv or po) rightly.All of the 95 cases recovered within 1 month.No sequela was found.The available evidence suggested that hypokalemia could be the early clinical signs of TMT intoxication.Injection of KCl early should be the first selected treatment. | TangXJ LiLY | 2002 | 中国药理学与毒理学杂志2002，16，6： | 0 |
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