|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Effect of extracorporeal bioartificial liver support system on fulminant hepatic failure rabbits显示文摘AIM To evaluate the possibility of usingcultured human hepatocytes as a bridge betweenbioartificial liver and liver transplantation.METHODS In this experiment,the efficacy ofextracorporeal bioartificial liver support system(EBLSS)consisting of spheriodal human livercells and cultured hepatocytes supernatant wasassessed in vivo using galactosamine inducedrabbit model of fulminant hepatic failure.RESULTS There was no difference of survivalbetween the two groups of rabbits,but in thesupported rabbits serum alanineaminotransferase,total bilirubin and creatininewere significantly lower and hepatocyte necrosiswas markedly milder than those in controlanimals.In addition,a good viability of humanliver cells was noted after the experiment.CONCLUSION EBLSS plays a biologic role inmaintaining and compensating the function ofthe liver. | Wang YJ Li MD Wang YM Chen GZ Lu GD Tan ZX | 2000 | World Journal of Gastroenterology2000，6，2： | 17 |
| 2 | Drug resistance mechanisms and novel drug targets for tuberculosis therapy显示文摘Drug-resistant tuberculosis(TB) poses a significant challenge to the successful treatment and control of TB worldwide.Resistance to anti-TB drugs has existed since the beginning of the chemotherapy era.New insights into the resistant mechanisms of anti-TB drugs have been provided.Better understanding of drug resistance mechanisms helps in the development of new tools for the rapid diagnosis of drugresistant TB.There is also a pressing need in the development of new drugs with novel targets to improve the current treatment of TB and to prevent the emergence of drug resistance in Mycobacterium tuberculosis.This review summarizes the anti-TB drug resistance mechanisms,furnishes some possible novel drug targets in the development of new agents for TB therapy and discusses the usefulness using known targets to develop new anti-TB drugs.Whole genome sequencing is currently an advanced technology to uncover drug resistance mechanisms in M.tuberculosis.However,further research is required to unravel the significance of some newly discovered gene mutations in their contribution to drug resistance. | Md Mahmudul Islam H.M. Adnan Hameed Julius Mugweru Chiranjibi Chhotaray Changwei Wang Yaoju Tan Jianxiong Liu Xinjie Li Shouyong Tan Iwao Ojima Wing Wai Yew Eric Nuermberger Gyanu Lamichhane Tianyu Zhang | 2017 | Journal of Genetics and Genomics2017，44，1： | 15 |
| 3 | Unexpected complication of arteriovenous fistula of the left common carotid to internal jugular vein following central venous catheterization显示文摘Incidence of inadvertent arterial puncture secondary to central venous catheter insertion is not common with an arterial puncture rate of<1%.This is due to the advancements and wide availability of ultrasound to guide its insertion.Formation of arteriovenous fistula after arterial puncture is an unexpected complication.Till date,only five cases(including this case)of acquired arteriovenous fistula formation has been described due to inadvertent common carotid puncture.The present case is a 26-year-old man sustained traumatic brain injuries,chest injuries and multiple bony fractures.During resuscitative phase,attempts at left central venous catheter via left internal jugular vein under ultrasound guidance resulted in inadvertent puncture into the left common carotid artery.Surgical neck exploration revealed that the catheter had punctured through the left internal jugular vein into the common carotid artery with formation of arteriovenous fistula.The catheter was removed successfully and common carotid artery was repaired.Postoperatively,the patient recovered and clinic visits revealed no neurological deficits.From our literature review,the safest method for removal is via endovascular and open surgical removal.The pull/push technique(direct removal with compression)is not recommended due to the high risk for stroke,bleeding and hematoma formation. | Tan Chor Lip Henry Tan Jih Huei Mohamad Yuzaidi Lenny Suryani Safri K.Krishna Imran Alwi Rizal Md Idris Mohamad Azim Hanafiah Harunarashid | 2020 | Chinese Journal of Traumatology2020，23，1： | 5 |
| 4 | Catalytic steam reforming of tar for enhancing hydrogen production from biomass gasification:a review显示文摘Presently,the global search for alternative renewable energy sources is rising due to the depletion of fossil fuel and rising greenhouse gas(GHG)emissions.Among alternatives,hydrogen(H2)produced from biomass gasification is considered a green energy sector,due to its environmentally friendly,sustainable,and renewable characteristics.However,tar formation along with syngas is a severe impediment to biomass conversion efficiency,which results in process-related problems.Typically,tar consists of various hydrocarbons(HCs),which are also sources for syngas.Hence,catalytic steam reforming is an effective technique to address tar formation and improve H2 production from biomass gasification.Of the various classes in existence,supported metal catalysts are considered the most promising.This paper focuses on the current researching status,prospects,and challenges of steam reforming of gasified biomass tar.Besides,it includes recent developments in tar compositional analysis,supported metal catalysts,along with the reactions and process conditions for catalytic steam reforming.Moreover,it discusses alternatives such as dry and autothermal reforming of tar. | Ru Shien TAN Tuan Amran TUAN ABDULLAH Anwar JOHARI Khairuddin MD ISA | 2020 | Frontiers in Energy2020，14，3： | 4 |
| 5 | A Review of Mucinous Cystic Neoplasms of the Pancreas Defined by Ovarian-type Stroma: Clinicopathological Features of 344 Patients显示文摘 | Brian K. P. Goh MBBS MMed (Surgery) MRCS Yu-Meng Tan BSc (Hons) MBBS FRCS Yaw-Fui A. Chung MBBS FRCS Pierce K. H. Chow MBBS FRCS PhD Peng-Chung Cheow MBBS FRCS Wai-Keong Wong MBBS FRCS London L. P. J. Ooi MBBS FRCS MD | 2006 | World Journal of Surgery2006，，12： | 2 |
| 6 | Advances in the development of molecular genetic tools for Mycobacterium tuberculosis显示文摘Mycobacterium tuberculosis, a Gram-positive bacterium of great clinical relevance, is a lethal pathogen owing to its complex physiological characteristics and development of drug resistance. Several molecular genetic tools have been developed in the past few decades to study this microorganism. These tools have been instrumental in understanding how M. tuberculosis became a successful pathogen. Advanced molecular genetic tools have played a significant role in exploring the complex pathways involved in M. tuberculosis pathogenesis. Here, we review various molecular genetic tools used in the study of M. tuberculosis. Further, we discuss the applications of clustered regularly interspaced short palindromic repeat interference(CRISPRi), a novel technology recently applied in M. tuberculosis research to study target gene functions. Finally, prospective outcomes of the applications of molecular techniques in the field of M. tuberculosis genetic research are also discussed. | Chiranjibi Chhotaray Yaoju Tan Julius Mugweru Md Mahmudul Islam H.M.Adnan Hameed Shuai Wang Zhili Lu Changwei Wang Xinjie Li Shouyong Tan Jianxiong Liu Tianyu Zhang | 2018 | Journal of Genetics and Genomics2018，45，6： | 2 |
| 7 | Bioengineered pseudovirus nanoparticles displaying the HA1 antigens of influenza viruses for enhanced immunogenicity显示文摘Even with implementation of current influenza vaccines,influenza still claims up to 500,000 lives worldwide annually,indicating a need for a better vaccine strategy.We have developed a technology to generate unique S_(60)-HA1 pseudovirus nanoparticles(PVNPs)that display the receptor-binding HA1 domains of influenza viruses.Each self-assembled S_(60)-HA1 PVNP consists of a T=1 icosahedral S_(60) nanoparticle that resembles the inner shell of norovirus capsid and 60 surface-displayed HA1 antigens that are excellent vaccine targets.Soluble S_(60)-HA1 PVNPs presenting HA1 antigens of H7N9 influenza virus subtypes have been produced efficiently in large amount.Their three-dimensional(3D)structures have been solved by cryogenic electron microscopy.The PVNP-displayed HA1 antigens react with HA-specific antibody,and retain authentic sialic acid binding specificity and hemagglutinate human erythrocytes.The PVNPs are highly immunogenic,eliciting high titers of HA1-specific antibodies in mice and the mouse sera strongly inhibited hemagglutinations of homologous and heterologous influenza virus HA proteins.Therefore,the S_(60)-HA1 PVNPs may provide useful reagents to study influenza viruses and offer a potential new vaccine tactic to fight the deadly influenza disease. | Ming Xia Md Rejaul Hoq Pengwei Huang Wen Jiang Xi Jiang Ming Tan | 2022 | Nano Research2022，15，5： | 2 |
| 8 | Pancreatic Serous Oligocystic Adenomas: Clinicopathologic Features and a Comparison with Serous Microcystic Adenomas and Mucinous Cystic Neoplasms显示文摘 | Brian K.P. Goh MBBS MMed Yu-Meng Tan BSc MBBS Wai-Ming Yap MBBS Peng-Chung Cheow MBBS Pierce K.H. Chow MBBS PhD Yaw-Fui Alexander Chung MBBS Wai-Keong Wong MBBS London L.P.J. Ooi MBBS MD | 2006 | World Journal of Surgery2006，，8： | 2 |
| 9 | Pre-emptive intraperito- neal local anaesthesia: an effective method in immediate post-operative pain management and metabolic stress response in laparoscopic appendicectomy, a randomized, double-blind- ed, placebo-controlled study 显示文摘 | Thanapal MR Tata MD Tan A J | 2014 | ANZ J Surg2014，84，1： | 1 |
| 10 | Regulation of platelet activating factor receptor gene expressionin vivo by endotoxin,platelet activating factor and endogenous tumor necrosisfacto显示文摘 | Wang H Tan MD Chang H | 2005 | Biochem2005，32，2： | 1 |
| 11 | The solitary pulmonary nodule显示文摘 | Tan BB Flaherty KR Kazerooni EA Iannettoni MD | 2003 | Chest2003，123，： | 1 |
| 12 | IRF5 polymorphism predicts prognosis in patients with systemic sclerosis显示文摘 | SHARIF R MAYES MD TAN FK | 2012 | Ann Rheum Dis2012，71，7： | 1 |
| 13 | Push off Tests on Pin Connected Shear Studs with Composite Steel Concrete Beams 显示文摘 | Mahmood Md Tahir Poi Nglan Shek Cher Slang Tan | 2009 | Construction and Building Materials2009，，： | 1 |
| 14 | Basic mechanisms involved in the anti-cancer effects of melatonin显示文摘 | Mediavilla MD Sanchez-Barcelo EJ Tan DX | 2010 | Curr Med Chem2010，17，36： | 1 |
| 15 | Voltage-gatedpotassium channel autoimmunity mimicking Creutzfeldt-Jakobdisease显示文摘 | Geschwind MD Tan KM Lennon VA | 2008 | Arch Neurol2008，65，： | 1 |
| 16 | Activated Akt and Erk Expression and Survival After Surgery in Pancreatic Carcinoma显示文摘 | Krishdeep S. Chadha MD Thaer Khoury MD Jihnhee Yu PhD Jennifer D. Black PhD John F. Gibbs MD Boris W. Kuvshinoff MD Dongfeng Tan MD Michael G. Brattain PhD Milind M. Javle MD | 2006 | Annals of Surgical Oncology2006，，7： | 1 |
| 17 | Enhanced internal search for iatrogenic retinal breaks in 20-gauge macular surgery 显示文摘 | Tan HS Lesnik Oberstein SY Mura M de Smet MD | 2010 | Br J Ophthalmol2010，94，11： | 1 |
| 18 | Placement of self-expanding metal stents for acute malignant large-bowel obstruction: A collective review显示文摘 | Christine E. Dauphine MD Patrick Tan MD Robert W. Beart MD Petar Vukasin MD Hartley Cohen MD Marvin L. Corman MD | 2002 | Annals of Surgical Oncology2002，，6： | 1 |
| 19 | Iatrogenic retinal breaks in 25- gauge macular surgery 显示文摘 | Tan HS Mura M de Smet MD | 2009 | Am J Ophthalmol2009，148，3： | 1 |
| 20 | Lower extremity cellulitis and bacteremia with Herbaspirillum seropedicae associated with aquatic exposure in a patient with cirrhosis显示文摘 | Michael J Tan MD Richard L | 2005 | Infect Dis Clin Pract2005，13，5： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员