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| 1 | Diffusion-weighted magnetic resonance imaging and micro-RNA in the diagnosis of hepatic fibrosis in chronic hepatitis C virus显示文摘BACKGROUND Diffusion-weighted magnetic resonance imaging has shown promise in the detection and quantification of hepatic fibrosis. In addition, the liver has numerous endogenous micro-RNAs(miRs) that play important roles in the regulation of biological processes such as cell proliferation and hepatic fibrosis.AIM To assess diffusion-weighted magnetic resonance imaging and miRs in diagnosing and staging hepatic fibrosis in patients with chronic hepatitis C.METHODS This prospective study included 208 patients and 82 age-and sex-matched controls who underwent diffusion-weighted magnetic resonance imaging of the abdomen, miR profiling, and liver biopsy. Pathological scoring was classified according to the METAVIR scoring system. The apparent diffusion coefficient (ADC) and miR were calculated and correlated with pathological scoring.RESULTS The ADC value decreased significantly with the progression of fibrosis, from controls(F0) to patients with early fibrosis(F1 and F2) to those with late fibrosis(F3 and F4)(median 1.92, 1.53, and 1.25 × 10^(-3) mm^2/s, respectively)(P = 0.001).The cut-off ADC value used to differentiate patients from controls was 1.83 × 10^(-3) mm^2/s with an area under the curve(AUC) of 0.992. Combining ADC and miR-200 b revealed the highest AUC(0.995) for differentiating patients from controls with an accuracy of 96.9%. The cut-off ADC used to differentiate early fibrosis from late fibrosis was 1.54 × 10^(-3) mm^2/s with an AUC of 0.866. The combination of ADC and miR-200 b revealed the best AUC(0.925) for differentiating early fibrosis from late fibrosis with an accuracy of 80.2%. The ADC correlated with miR-200 b(r =-0.61, P = 0.001), miR-21(r =-0.62, P = 0.001), and miR-29(r = 0.52,P = 0.001).CONCLUSION Combining ADC and miRs offers an alternative surrogate non-invasive diagnostic tool for diagnosing and staging hepatic fibrosis in patients with chronic hepatitis C. | Tarek Besheer Hatem Elalfy Mohamed Abd El-Maksoud Ahmed Abd El-Razek Saher Taman Khaled Zalata Wagdy Elkashef Hossam Zaghloul Heba Elshahawy Doaa Raafat Wafaa Elemshaty Eman Elsayed Abdel-Hady El-Gilany Mahmoud El-Bendary | 2019 | World Journal of Gastroenterology2019，25，11： | 9 |
| 2 | Circulating adrenocorticotropic hormone (ACTH) and cortisol concentrations in normal, appropriate-for-gestational-age newborns versus those with sepsis and respiratory distress: cortisol response to low-dose and standard-dose ACTH tests 显示文摘 | Soliman AT Taman KH Rizk MM | 2004 | Metabolism2004，53，2： | 1 |
| 3 | Transestefification of vegetable oil to biodiesel fuel using alkaline catalyst显示文摘 | KEERA S T SABAGH S M TAMAN A R | 2011 | Fuel2011，90，1： | 1 |
| 4 | Selective serotonin reuptake inhibitor discontinuation syndrome 显示文摘 | Taman L Ozpoyraz N | 2002 | Adv Ther2002，19，1： | 1 |
| 5 | In vivo effect of single oral dose of artemether against early iu- venile stages of Schistosomamansoni Egyptian strain显示文摘 | El-Beshbishi SN Taman A E1-Malky M | 2013 | Exp Parasitol2013，135，2： | 1 |
| 6 | Circulating adrenocorticotro-pic hormone (ACTH) and cortisol concentrations in normal,propriate-for-gestational-age newborns versus those with sepsis and respiratory distress:Cortisol response to low-dose and standard-dose ACTH tests显示文摘 | Soliman AT Taman KH Rizk MM | 2004 | Metabolism2004，53，2： | 1 |
| 7 | Thrombolysis for the management of massive pulmonary embolism in pregnancy显示文摘 | M.M. Tawfik M.E. Taman A.A. Motawea E. Abdel-Hady | 2013 | International Journal of Obstetric Anesthesia2013，，2： | 1 |
| 8 | Increase urinary HGF excretion in human acute renal failure显示文摘 | Taman M Liu Y Tolbert E | 1997 | Clin Nephrol1997，48，： | 1 |
| 9 | Osteoarthritis: aggravation factors and therapeu- tic measures显示文摘 | taman R D | 1986 | Postgrad Med1986，80，： | 1 |
| 10 | Transesterification of vegetable oil to biodiesel fuel using alkaline catalyst显示文摘 | S T Keera S M E1 Sabagh A R Taman | 2011 | Fuel2011，90，1： | 1 |
| 11 | Influence of acidic surface oxides of activated carbon on gas adsorption characteristics 显示文摘 | Taman H Okazaki M | 1996 | CAR- BON1996，34，6： | 1 |
| 12 | Circulating adrenocorti- cotropic hormone (ACTH) and cortisol concentrations in normal, appropriate-for-gestational-age newborns versus those with sepsis and respiratory distress: cortisol response to low-dose and standard-dose ACTH tests 显示文摘 | Sotiman AT Taman KH Rizk MM | 2004 | Metabolism2004，53，2： | 1 |
| 13 | Corrosion inhibition of copper and carbon steel in white petroleum oil显示文摘 | Sanad S H Taman A R | 1984 | Surface Technology1984，23，2： | 1 |
| 14 | Anti-DNA antibodies kinetics during in vivo apheresis in systemic lupus erythematosus patients and in an in vitro apheresis model显示文摘 | Suzuki K Taman J Matsuki Y | 1996 | J Clin apheresis1996，11，4： | 1 |
| 15 | lncrease urinary hepatocyte growth factor excretion in human acute renal failure 显示文摘 | Taman M Liu Y Tolbert E | 1997 | Clin Nephrol1997，48，4： | 1 |
| 16 | Thrombolysis for the management of massive pulmonary embolism in pregnancy显示文摘 | M.M. Tawfik M.E. Taman A.A. Motawea E. Abdel-Hady | 2013 | International Journal of Obstetric Anesthesia2013，，2： | 1 |
| 17 | Atrial natriuretic pep- tide as a marker of heart failure in children with left ventricular volume overload 显示文摘 | Kotby AA Taman KH Sedky HT | 2013 | J Paediatr Child Health2013，49，1： | 1 |
| 18 | Circulating adrenocorti- cotropic hormone (ACTH) and cortisol concentrations in normal, appropriate for gestational age newborns versos those with sepsis and respiratory distress: cortisol response to low-dose and standard- dose ACTH tests 显示文摘 | Soliman AT Taman KH Rizk MM | 2004 | Metabolism2004，53，2： | 1 |
| 19 | Circulating adrenocorticotropic honnone(ACTH) and cortisol concentrations in normal, appropriate-forgestational-age newboms versus those with sepsis and respiratory distress:Cortisol response to low-dose and standard-dose ACTH tests 显示文摘 | Soliman AT Taman KH Rizk MM | 2004 | Metablism2004，53，2： | 1 |
| 20 | Recovery of waste lubricating oil by solvent extraction 显示文摘 | E1 - Din O I S Hasan S J Taman A R | 1988 | Chemical Age of India1988，39，8： | 1 |
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