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| 1 | In vitro effect of pantoprazole on lower esophageal sphincter tone in rats显示文摘AIM:To investigate the in vitro effects of pantoprazole on rat lower esophageal sphincter(LES)tone.METHODS:Rats weighing 250-300 g,provided by the Yeditepe University Experimental Research Center(Yü-DETAM),were used throughout the study.They were anesthetized before decapitation.LES tissues whose mucosal lining were removed were placed in a stan-dard 30-mL organ bath with a modif ied Krebs solution and continuously aerated with 95% oxygen-5% carbon dioxide gas mixture and kept at room temperature.The tissues were allowed to stabilize for 60 min.Sub-sequently,the contractile response to 10-6 mol/L carba-chol was obtained.Different concentrations of freshly prepared pantoprazole were added directly to the tis-sue bath to generate cumulative concentrations of 5×10-6 mol/L,5×10-5 mol/L,and 1.5×10-4 mol/L.Activi-ties were recorded on an online computer via a 4-channeltransducer data acquisition system using the software BSL PRO v 3.7,which also analyzed the data.RESULTS:Pantoprazole at 5×10-6 mol/L caused a small,but statistically insignif icant,relaxation in the car-bachol-contracted LES(2.23% vs 3.95%).The 5×10-5 mol/L concentration,however,caused a signif icant relax-ation of 10.47% compared with the control.1.5×10-4 mol/L concentration of pantoprazol caused a 19.89% relaxation in the carbachol contracted LES(P<0.001).CONCLUSION:This is the fi rst study to demonstrate that pantoprazole has a relaxing effect in isolated LESs.These results might have signif icant clinical implications for the subset of patients using proton pump inhibitors who do not receive full symptomatic alleviation from gastroesophageal reflux disease. | Mustafa Duman Mahmut zer Enver Rean Yeliz Demirci Ali E Atιcι Tahsin Dalgι Erdal B Bostancι Ece Gen | 2011 | World Journal of Gastroenterology2011，17，46： | 3 |
| 2 | Performance of immobilized glucoamylase in a magnetically stabilized fluidized bed reactor(MSFBR) 显示文摘 | TAHSIN B SERDAR S C | 2000 | Enzyme and Microbial Technology2000，26，： | 1 |
| 3 | Highly Efficient Red Fluorescent Days for Organic Light-Emitting Diodes 显示文摘 | Yuan J C Tahsin J C | 2011 | J Mater Chem2011，21，： | 1 |
| 4 | Database support for data-driven scientific applications in the grid显示文摘 | SIVARAMAKRISHNAN N TAHSIN K UMIT C | 2003 | Parallel Processing Letters2003，13，2： | 1 |
| 5 | An analytic hierarchy process and two-sided matching based decision support system for military personnel assignment显示文摘 | I rahim K Hadi G Tahsin C | 2008 | Information Sciences2008，178，14： | 1 |
| 6 | Modeling and testing of a field-controllable magnetorheological fluid damper显示文摘 | SEVKI C TAHSIN E | 2010 | International Journal of Mechanical Sciences2010，52，8： | 1 |
| 7 | Modeling and testing of a field-controllable magnetorheological fluid damper 显示文摘 | Sevki C Tahsin E | 2010 | International Journal of Mechanical Sciences2010，5，： | 1 |
| 8 | Immobilization of glucoamylase on magnetic polystyrene particles显示文摘 | Tahsin B Serdar S C | 1999 | J Appl Polym Sci1999，72，： | 1 |
| 9 | Modeling and testing of a field- controllable magnetorheological fluid damper显示文摘 | Sevki C Tahsin E | 2010 | International Joumal of Mechanical Sciences2010，52，8： | 1 |
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