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| 1 | Ionic and nonionic polymers can prevent surfactant inactivation显示文摘It is well known that treatment with exogenous surfactant works well in premature infants with lung surfactant deficiency. Effects of surfactant therapy are less dramatic when used to treat lung diseases associated with acute lung injury (ALI) and adult respiratory distress syndrome (ARDS). This less | Karen W LU H William TAEUSCH | 2003 | Acta Pharmacologica Sinica2003，24，12： | 2 |
| 2 | Nonoliguric acute renal failure显示文摘 | Linas SL Berns AS Taeusch HW | 2007 | N Engl J Med2007，29，624： | 1 |
| 3 | Surfactant replacement therapy for meconium aspiration syndrome显示文摘 | Findlay RD Taeusch HU Walther FJ | | 0，，01： | 1 |
| 4 | Reductions of phospholipase A (2) inhibition of pulmonary surfactant with hyaluronan 显示文摘 | Iwanicki JL Lu KW Taeusch HW | 2010 | Exp LungRes2010，36，3： | 1 |
| 5 | Lysis of red blood celia and alveolar epithelial toxicity by therapeutic pulmonary surfactanla显示文摘 | Findlay RD William Taeusch H David-cu R | 1995 | Pedialx Res1995，37，1： | 1 |
| 6 | Dextran or polyethylene glycol addedto curosurf for treatment of meconium lung injury in rats显示文摘 | Lu K W Robertson B Taeusch H W | 2005 | Biol Neonate2005，88，1： | 1 |
| 7 | Surfactant replacement therapy for meconium aspiration syndrome显示文摘 | Findlay RD Taeusch HW Walther FJ | 1996 | Pediatrics1996，97，： | 1 |
| 8 | Surfactnt replacement therapy for meconium aspiration syndrome显示文摘 | Findlay RD Taeusch HW Walther FJ | 1996 | Pediatrics1996，97，1： | 1 |
| 9 | Dextran or polyethylene glycol added to curosurf for treatment of meconium lung injury in rats显示文摘 | Lu KW Robertson B Taeusch HW | 2005 | Biol Neonate2005，88，1： | 1 |
| 10 | Treatment of acute(Adult) respiratory distress syndrome: the holy grail of surfactant therapy显示文摘 | Taeusch HW | 2000 | Biol Neonate2000，，： | 1 |
| 11 | Polyethylene glycol/surfactant mixtures improve lung function after HC1 and endotoxin lung injuries 显示文摘 | Karen W Lu H Willian Taeusch Bengt Robertson | 2001 | Am J Respir Crit Care Med2001，164，8： | 1 |
| 12 | Surfactant replacement therapy for meconium aspiration syndrome 显示文摘 | Findlay RD Taeusch HW Walther FJ | 1996 | Pediatrics1996，79，1： | 1 |
| 13 | Surfactant replacement therapy for meconium aspiration syndrome显示文摘 | Findtay RD Taeusch HW Walther FJ | 1996 | Pediatrics1996，97，1： | 1 |
| 14 | Surfactant replacement therapy for meconium aspiration syndrome显示文摘 | Findlay DR Taeusch WH Walther FJ | 1996 | Pediatr1996，97，1： | 1 |
| 15 | Polymer - surfactant treatment of meconium -induced acute lung injury显示文摘 | Lu KW William Taeusch H Robertson B | 2000 | Am J Respir Crit Care Med2000，162，2： | 1 |
| 16 | Suriactant replacement therapy for meconium aspiration syndrome显示文摘 | Findlay RD Taeusch HW Walther FJ | 1996 | Pediatrics1996，97，1： | 1 |
| 17 | Polymer-surfactant treatment of meconium-induced acute lung injury 显示文摘 | Lu KW William Taeusch H Robertson B | 2000 | Am J Respir Crit Care Med2000，162，2： | 1 |
| 18 | Polymer - surfactant treatment of meconium - induced acute lung injury 显示文摘 | Lu KW William Taeusch H Robertson B | 2000 | Am J Respir Crit Care Med2000，162，21： | 1 |
| 19 | 早产猪呼吸窘迫综合征模型的建立与治疗显示文摘目的建立早产猪呼吸窘迫综合征 (respiratory distress syndrome, RDS)模型并探讨猪肺表面活性物质(pulmonary surfactant, PS)制剂的治疗效果. 方法选择相当于足月孕期85%(94~97 d)的早产猪作RDS模型,随机分成4组(C组:对照组;C50组:PS 50 mg/kg;C100组:PS 100 mg/kg; N组:自主呼吸组).除N组外,其余早产猪气管切开插管,压力控制模式通气,吸入高浓度氧和标准潮气量通气.分别在治疗0~6 h测血气与呼吸力学参数,6 h后处死动物留取肺组织和肺泡灌洗液(bronchoalveolar lavage, BALF)进行形态学与生化分析. 结果 RDS动物BALF中总磷脂约10 mg/kg;电子显微镜下板层小体仅零星可见;光学显微镜下可见肺泡基本处于萎陷状态.C100组PaO2/FiO2由(92±37)上升到(235±137)mm Hg,肺顺应性由(0.48±0.08)上升到(0.76±0.29)ml/(cm H2O·kg),肺泡扩张均匀,少见损伤;C50组肺氧合及呼吸力学改善不明显. 结论早产猪RDS模型用于研究新生儿呼吸系统疾病具有一定价值,100 mg/kg的PS对肺氧合、呼吸力学及形态学的改善具有明显作用. | 王晓宁 孙波 郭春宝 孙中厚 钱莉玲 汪薇 喻文亮 Karen Lu William Taeusch | 2005 | 中华围产医学杂志2005，8，5： | 1 |
| 20 | Surfactant replacement therapy for meconium aspiration syndrome显示文摘 | Findlay RD Taeusch HW Walther FJ | 1996 | Pediatrics1996，97，： | 1 |
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