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| 1 | Reciprocal association of C-reactive protein with adiponectin in blood Stream and adipose tissue显示文摘 | NORIYUKI O SHINJI K TOHRU F | 2003 | Circulation2003，107，5： | 1 |
| 2 | Combination of wood and silicate (Ⅰ):Impregnation by water glass and application of aluminum sulfate and calcium chloride as reactants显示文摘 | TAKESHI F TOHRU U SUSUMU J | 1991 | Mokuzai Gakkaishi1991，37，5： | 1 |
| 3 | Synthesis of secondary arylamines through copper-mediated intermolecular aryl amination 显示文摘 | Kentaro O Hidetoshi T Tohru F | 2003 | Org Lett2003，26，5： | 1 |
| 4 | Combination of wood and silicate (Ⅱ):Wood-mineral composites using water glass and reactants of barirum chloride,boric acid,and borax,and their properties显示文摘 | TAKESHI F KWNTA S TOHRU U | 1992 | Mokuzai Gakkaishi1992，38，5： | 1 |
| 5 | Combination of wood and silicate (Ⅲ):Some properties of wood-mineral composites using the water glassboron compound system显示文摘 | TAKESHI F TOHRU U | 1993 | Moku zai Gakkaishi1993，39，5： | 1 |
| 6 | Adiponectin down-regulates acyl-coenzyme A: cholesterol acyltransferase-1 in cultured human monocyte-derived macrophages显示文摘 | Furukawa K Hori M Ouchi N Shinji K Tohru F Yuji M | 2004 | Biochemical Biophysical Research Communications2004，317，3： | 1 |
| 7 | Levels of the adipocyte-derivedplasma protein, adiponectin, have a close relation-ship with theroma显示文摘 | Sunao K Tohru F Hidetomo M | 2005 | Thrombosis Research2005，115，6： | 1 |
| 8 | Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemia显示文摘 | Christian W Tohru F Sachiyo T | 2001 | J Clin Endocrinol Metab2001，86，： | 1 |
| 9 | Levels of the adipocyte-derived plasma protein, adiponectin, have a close relationship with atheroma显示文摘 | Sunao K Tohru F Hidetomo M Osamu H Seigo S Hiroaki K | 2005 | Thrombosis Research2005，115，6： | 1 |
| 10 | Adiponectin and metabolic syn- drome 显示文摘 | Yuji M Tohru F Shinji K | 2004 | Arterioscler Thremb Vasc Biol2004，24，： | 1 |
| 11 | 显示文摘 | Martin A Andrzej W Tohru F | 2003 | Am J Hypertens2003，16，1： | 1 |
| 12 | Decreased plasma adiponectin concentration in patients with essential hypertension 显示文摘 | MARCIN A ANDRZEJ W TOHRU F | 2003 | Am J Hypertens2003，16，： | 1 |
| 13 | Design of an optimal preview servomechanism for discrete- time systems in a multirate setting显示文摘 | Liao F C Kiyotsugu Takabai Tohru Katayama | 2003 | Dynamics of Continuous Discrete and Impulsive Systems Series B: Applications and Algorithms2003，10，5： | 1 |
| 14 | Fecal alphal-antitrypsin concen- trations as a measure of enteric protein loss after modified fontan operations 显示文摘 | Tohru F Toshiaki S Ken T | 2003 | J Pediatr Gastroenterol Nutr2003，37，5： | 1 |
| 15 | Weight reduction increases plasma levels of an adipose-derived anti-inflammatory protein : Adiponectin 显示文摘 | Wei S Y Wei J L Tohru F | 2001 | J Clin Endocrinol Metab2001，86，： | 1 |
| 16 | Effect of bamboo vinegar on regulation of germination and radicle growth of seed plants显示文摘 | Jun M Tohru U Takeshi F | 2003 | The Japan Wood Research Society2003，49，： | 1 |
| 17 | Analysis of cell arrangement in softwoods using two-dimensional fast fourier transforms 显示文摘 | DIAO X M TAKESHI F TOHRU U | 1996 | Mokuzai Gakkaishi1996，42，7： | 1 |
| 18 | Immunohistochemical expression of sialyl Lex antigen in relation to survival of patients with colorectal carcinoma 显示文摘 | Tohru N Kiyoyasu F Masaki H | 1993 | Cancer1993，72，8： | 1 |
| 19 | Development of rotary shaft seals for primary coolant pumps for nuclear reactors显示文摘 | TAKUYA F TOHRU S TAKANORI T | 1989 | Tribology Transactions1989，32，1： | 1 |
| 20 | A specific gene-expression signature quantifies the degree of hepatic fibrosis in patients with chronic liver disease显示文摘AIM: To study a more accurate quantification of hepatic fibrosis which would provide clinically useful information for monitoring the progression of chronic liver disease. METHODS: Using a cDNA microarray containing over 22 000 clones, we analyzed the gene-expression profiles of non-cancerous liver in 74 patients who underwent hepatic resection. We calculated the ratio of azan- stained: total area, and determined the morphologic fibrosis index (MFI), as a mean of 9 section-images. We used the MFI as a reference standard to evaluate our method for assessing liver fibrosis. RESULTS: We identified 39 genes that collectively showed a good correlation (r > 0.50) between gene-expression and the severity of liver fibrosis. Many of the identified genes were involved in immune responses and cell signaling. To quantify the extent of liver fibrosis, we developed a new genetic fibrosis index (GFI) based on gene-expression profiling of 4 clones using a linear support vector regression analysis. This technique, based on a supervised learning analysis, correctly quantified the various degrees of fibrosis in both 74 training samples (r = 0.76, 2.2% vs 2.8%, P < 0.0001) and 12 independent additional test samples (r = 0.75, 9.8% vs 8.6%, P < 0.005). It was far better in assessing liver fibrosis than blood markers such as prothrombin time (r = -0.53), type Ⅳ collagen 7s (r = 0.48), hyaluronic acid (r = 0.41), and aspartate aminotransferase to platelets ratio index (APRI) (r = 0.38). CONCLUSION: Our cDNA microarray-based strategy may help clinicians to precisely and objectively monitor the severity of liver fibrosis. | Tohru Utsunomiya Masahiro Okamoto Shigeki Wakiyama Masaji Hashimoto Kengo Fukuzawa Takahiro Ezaki Shinichi Aishima Yasuji Yoshikawa Taizo Hanai Hiroshi Inoue Graham F Barnard Masaki Mori | 2007 | World Journal of Gastroenterology2007，13，3： | 1 |
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