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| 1 | In vivo radiometric analysis of glucose uptake and distribution in mouse bone显示文摘Bone formation and remodeling occurs throughout life and requires the sustained activity of osteoblasts and osteoclasts,particularly during periods of rapid bone growth.Despite increasing evidence linking bone cell activity to global energy homeostasis,little is known about the relative energy requirements or substrate utilization of bone cells.In these studies,we measured the uptake and distribution of glucose in the skeleton in vivo using positron-emitting^(18)F-fluorodeoxyglucose([^(18)F]-FDG) and non-invasive,high-resolution positron emission tomography/computed tomography(PET/CT) imaging and ex vivo autoradiography.Assessment of [^(18)F]-FDG uptake demonstrated that relative to other tissues bone accumulated a significant fraction of the total dose of the glucose analog.Skeletal accumulation was greatest in young mice undergoing the rapid bone formation that characterizes early development.PET/CT imaging revealed that [^(18)F]-FDG uptake was greatest in the epiphyseal and metaphyseal regions of long bones,which accords with the increased osteoblast numbers and activity at this skeletal site.Insulin administration significantly increased skeletal accumulation of [^(18)F]-FDG,while uptake was reduced in mice lacking the insulin receptor specifically in osteoblasts or fed a high-fat diet.Our results indicated that the skeleton is a site of significant glucose uptake and that its consumption by bone cells is subject to regulation by insulin and disturbances in whole-body metabolism. | Meredith L Zoch Diane S Abou Thomas L Clemens Daniel LJ Thorek Ryan C Riddle | 2016 | Bone Research2016，4，1： | 9 |
| 2 | The hypoxia-inducible factor-1α activates ectopic production of fibroblast growth factor 23 in tumor-induced osteomalacia显示文摘Tumor-induced osteomalacia(TIO) is a rare paraneoplastic syndrome in which ectopic production of fibroblast growth factor 23(FGF23) by non-malignant mesenchymal tumors causes phosphate wasting and bone fractures. Recent studies have implicated the hypoxia-inducible factor-1α(HIF-1α) in other phosphate wasting disorders caused by elevated FGF23, including X-linked hypophosphatemic rickets and autosomal dominant hypophosphatemia. Here we provide evidence that HIF-1α mediates aberrant FGF23 in TIO by transcriptionally activating its promoter. Immunohistochemical studies in phosphaturic mesenchymal tumors resected from patients with documented TIO showed that HIF-1α and FGF23 were co-localized in spindleshaped cells adjacent to blood vessels. Cultured tumor tissue produced high levels of intact FGF23 and demonstrated increased expression of HIF-1α protein. Transfection of MC3T3-E1 and Saos-2 cells with a HIF-1α expression construct induced the activity of a FGF23 reporter construct. Prior treatment of tumor organ cultures with HIF-1α inhibitors decreased HIF-1α and FGF23 protein accumulation and inhibited HIF-1α-induced luciferase reporter activity in transfected cells. Chromatin immunoprecipitation assays confirmed binding to a HIF-1α consensus sequence within the proximal FGF23 promoter, which was eliminated by treatment with a HIF-1α inhibitor. These results show for the first time that HIF-1α is a direct transcriptional activator of FGF23 and suggest that upregulation of HIF-1α activity in TIO contributes to the aberrant FGF23 production in these patients. | Qian Zhang Michele Doucet Ryan E Tomlinson Xiaobin Han L Darryl Quarles Michael T Collins Thomas L Clemens | 2016 | Bone Research2016，4，2： | 6 |
| 3 | Modelling Regional Land Change Scenarios to Assess Land Abandonment and Reforestation Dynamics in the Pyrenees(France)显示文摘Over the last decades and centuries,European mountain landscapes have experienced substantial transformations.Natural and anthropogenic LULC changes(land use and land cover changes), especially agro-pastoral activities,have directly influenced the spatial organization and composition of European mountain landscapes.For the past sixty years, natural reforestation has been occurring due to a decline in both agricultural production activities and rural population.Stakeholders, to better anticipate future changes,need spatially and temporally explicit models to identify areas at risk of land change and possible abandonment.This paper presents an integrated approach combining forecasting scenarios and a LULC changes simulation model to assess where LULC changes may occur in the Pyrenees Mountains,based on historical LULC trends and a range of future socio-economic drivers.The proposed methodologyconsiders local specificities of the Pyrenean valleys,sub-regional climate and topographical properties,and regional economic policies.Results indicate that some regions are projected to face strong abandonment, regardless of the scenario conditions.Overall, high rates of change are associated with administrative regions where land productivity is highly dependent on socio-economic drivers and climatic and environmental conditions limit intensive(agricultural and/or pastoral) production and profitability.The combination of the results for the four scenarios allows assessments of where encroachment(e.g.colonization by shrublands) and reforestation are the most probable.This assessment intends to provide insight into the potential future development of the Pyrenees to help identify areas that are the most sensitive to change and to guide decision makers to help their management decisions. | Laure A.VACQUIE Thomas HOUET Terry L.SOHL Ryan REKER Kristi L.SAYLER | 2015 | Journal of Mountain Science2015，12，4： | 3 |
| 4 | Effect of interface on mid-infrared photothermal response of MoS2 thin film grown by pulsed laser deposition显示文摘这研究报导在上中间红外线(中间 -- 红外) 多层的瞬间 2 的 photothermal 反应在上成年的薄电影水晶(p 类型硅和 c-axis-oriented 单身者水晶蓝宝石) 并且非结晶(Si/SiO 2 和 Si/SiN ) 由搏动的激光免职(PLD ) 的底层。当照耀与时,瞬间 2 电影的 photothermal 反应在瞬间 2 电影的抵抗作为变化被测量一中间 -- 红外(7 ~ 8.2 m ) 来源。我们显示出那提高瞬间 2 的抵抗(TCR ) 的温度系数薄电影由通过底层和生长条件的一种合适的选择控制电影底层接口是可能的。PLD 种的薄电影用 X 光检查衍射,拉曼,原子力量显微镜学, X 光检查光电子显微镜学,和传播电子被描绘显微镜学。高分辨率的传播电子显微镜学(HRTEM ) 图象证明瞬间 2 电影与不合身的衣服脱臼以一种 layer-by-layer 方式在蓝宝石底层上成长。当这些电影在有一颗钻石的底层上是成年的时,层生长形态学被破坏立方的结构(例如,硅) 因为成双的生长形成。非结晶的底层上的生长形态学例如 Si/SiO 2 或 Si/SiN,是很不同的。硅上的 PLD-grown 瞬间 2 电影显示出更高的 TCR (在 296 K 的 2.9% K 1) ,更高中间 -- 红外敏感(R/R =5.2%) ,并且更高的 responsivity (8.7 V 湡杯湥牥瑡牯吗?? | Ankur Goswami Priyesh Dhandaria Soupitak Pal Ryan McGee Faheem Khan Zeljka Antic Ravi Gaikwad Kovur Prashanthi Thomas Thundat | 2017 | Nano Research2017，10，10： | 2 |
| 5 | Standardized Myocardial Segmentation and Nomenclature for Tomographic Imaging of the Heart: A Statement for Healthcare Professionals From the Cardiac Imaging Committee of the Council on Clinical Cardiology of the American Heart Association显示文摘 | Manuel D. Cerqueira Neil J. Weissman Vasken Dilsizian Alice K. Jacobs Sanjiv Kaul Warren K. Laskey Dudley J. Pennell John A. Rumberger Thomas Ryan Mario S. Verani | 2002 | Circulation: Journal of the American Heart Association2002，，： | 2 |
| 6 | Systemic inflammation and ammonia in hepatic encephalopathy显示文摘 | Thomas H. Tranah Godhev K. Manakkat Vijay Jennifer M. Ryan Debbie L. Shawcross | 2013 | Metabolic Brain Disease2013，，1： | 2 |
| 7 | A Cost-Utility Analysis of Ablative Therapy for Barrett’s Esophagus显示文摘 | John M. Inadomi Ma Somsouk Ryan D. Madanick Jennifer P. Thomas Nicholas J. Shaheen | 2009 | Gastroenterology2009，，7： | 2 |
| 8 | Endoscopic and Radiographic Evaluation of the Small Bowel in 2012显示文摘 | Charles E. Dye Ryan R. Gaffney Thomas M. Dykes Matthew T. Moyer | 2012 | The American Journal of Medicine2012，，12： | 2 |
| 9 | The Role of Rifaximin in the Primary Prophylaxis of Spontaneous Bacterial Peritonitis in Patients With Liver Cirrhosis显示文摘 | Mohamad A. Hanouneh Ibrahim A. Hanouneh Jana G. Hashash Ryan Law Jamak Modaresi Esfeh Rocio Lopez Nyla Hazratjee Thomas Smith Nizar N. Zein | 2012 | Journal of Clinical Gastroenterology2012，，8： | 2 |
| 10 | Influence of bactibilia after preoperative biliary stenting on postoperative infectious complications显示文摘 | Thomas J. Howard M.D. Jian Yu M.S. Ryan B. Greene M.D. Virgilio George M.D. George M. Wairiuko M.D. Seth A. Moore M.S. James A. Madura M.D | 2006 | Journal of Gastrointestinal Surgery2006，，4： | 2 |
| 11 | A Cost-Utility Analysis of Ablative Therapy for Barrett’s Esophagus显示文摘 | John M. Inadomi Ma Somsouk Ryan D. Madanick Jennifer P. Thomas Nicholas J. Shaheen | 2009 | Gastroenterology2009，，： | 2 |
| 12 | Sphingosine analogue drug FTY720 targets I2PP2A/SET and mediates lung tumour suppression via activation of PP2A‐RIPK1‐dependent necroptosis显示文摘 | Sahar A. Saddoughi Salih Gencer Yuri K. Peterson Katherine E. Ward Archana Mukhopadhyay Joshua Oaks Jacek Bielawski Zdzislaw M. Szulc Raquela J. Thomas Shanmugam P. Selvam Can E. Senkal Elizabeth Garrett‐Mayer Ryan M. De Palma Dzmitry Fedarovich Angen Liu | 2012 | EMBO Mol Med2012，，1： | 2 |
| 13 | Appendectomy and Clostridium difficile colitis:Relationships revealed by clinical observations and immunology显示文摘Advances in understanding the interaction between the human immune system and the microbiome have led to an improved understanding of the function of the vermiform appendix as a safe-house for beneficial bacteria in the colon.These advances have been made despite long standing clinical observations that the appendectomy is a safe and effective procedure.However,more recent clinical data show that an appendectomy puts patients at increased risk for recurrent Clostridium difficile(C.difficile)-associated colitis,and probably other diseases associated with an altered microbiome.At the same time,appendectomy does not apparently put patients at risk for an initial onset of C.difficile-associated colitis.These clinical observations point toward the idea that the vermiform appendix might not effectively protect the microbiome in the face of broad spectrum antibiotics,the use of which precedes the initial onset of C.difficile-associated colitis.Further,these observations point to the idea that historically important threats to the microbiome such as infectious gastrointestinal pathogens have been supplanted by other threats,particularly the use of broad spectrum antibiotics. | Nathan L Sanders R Randal Bollinger Ryan Lee Steven Thomas William Parker | 2013 | World Journal of Gastroenterology2013，19，34： | 2 |
| 14 | Clinical predic- tions of human blastocyst formation and pregnancy after ex- tended embryo culture and transfer 显示文摘 | Thomas MR Sparks AE Ryan GL | 2010 | Fertil Steril2010，94，2： | 1 |
| 15 | Cetane numbers of branched and straight-chain fatty esters determined in an ignition quality tester显示文摘 | Knothe Gerhard Matheaus Andrew C Ryan Thomas W | 2003 | Fuel2003，82，8： | 1 |
| 16 | Stable co-transformation of maize protoplasts with gusA and neo genes显示文摘 | Leszek A. Lyznik Randy D. Ryan Steven W. Ritchie Thomas K. Hodges | 1989 | Plant Molecular Biology1989，，2： | 1 |
| 17 | Informality, Uncertainty and the Manage- ment ef Street Vending in New York City显示文摘 | Ryan Thomas Devlin | 2011 | Planning Theory2011，，10： | 1 |
| 18 | Mitochondria‐targeted antioxidant (MitoQ) ameliorates age‐related arterial endothelial dysfunction in mice显示文摘 | Rachel A. Gioscia‐Ryan Thomas J. LaRocca Amy L. Sindler Melanie C. Zigler Michael P. Murphy Douglas R. Seals | 2014 | J Physiol2014，，12： | 1 |
| 19 | NCCN Clinical Practice Guidelines in Oncology:rectal cancer 显示文摘 | Engstrom PF Arnoletti JP Benson AB 3rd Chen YJ Choti MA Cooper HS Covey A Dilawari RA Early DS Enzinger PC Fakih MG Fleshman J Jr Fuchs C Greta JL Kiel K Knol JA Leong LA Lin E Mulcahy MF Rao S Ryan DP Saltz L Shibata D Skibber JM Sofocleous C Thomas J Venook AP Willett C | 2009 | J Natl Compr Canc Netw2009，7，： | 1 |
| 20 | Isolation of Angiopoietin-1, a Ligand for the TIE2 Receptor, by Secretion-Trap Expression Cloning显示文摘 | Samuel Davis Thomas H Aldrich Pamela F Jones Ann Acheson Debra L Compton Vivek Jain Terence E Ryan Joanne Bruno Czeslaw Radziejewski Peter C Maisonpierre George D Yancopoulos | 1996 | Cell1996，，7： | 1 |
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