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| 1 | The increased severity of acute pancreatitis in the elderly is mainly related to intestinal barrier dysfunction显示文摘To the Editor:Severe acute pancreatitis in the elderly is characterized by significant morbidity and mortality rates,with a higher financial impact when compared to the same disease in younger patients[1].There are some obvious differences between these two populations.The most glaring one is the presence of multiple comorbidities in elderly patients. | Marcel Cerqueira Cesar Machado Heraldo Possolo Souza | 2018 | Hepatobiliary & Pancreatic Diseases International2018，17，6： | 3 |
| 2 | Pentoxifylline 通过 TNF- 合成和 TGF-1 基因表示的下面规定改进肝新生显示文摘 AIM:To investigate the mechanism of pentoxifylline(PTX)improvement in liver regeneration.RESULTS:Rats were randomized into 4 groups:Control rats;Sham-sham-operation rats;Saline-70% hepatectomy plus saline solution;PTX-70%hepatectomy plus PTX.At 2 and 6 h after hepatectomy,aspartate aminotransferase,alanine aminotransferase,tumor necrosis factor(TNF)-α and interleukin-6(IL-6)serum and hepatic tissue levels were determined.Tumor growth factor(TGF)-β1 gene expression in liver tissue was evaluated 24 h after hepatectomy by quantitative reverse transcriptase polymerase chain reaction analysis.Proliferation was analyzed by mitotic index and proliferating cell nuclear antigen(PCNA)staining 48 h after hepatectomy.RESULTS:TNF-α and IL-6 serum levels increased at 2 and 6 h after hepatectomy.At 2 h after hepatectomy serum PTX was reduced but not hepatic levels of TNF-α and IL-6.A decrease in liver TGF-β1 gene expression and an increase in mitotic index and PCNA after hepatectomy were observed in the PTX treatment group in comparison to the saline group.CONCLUSION:PTX improves liver regeneration by a mechanism related to down regulation of TNF-α production and TGF-β1 gene expression. | Rodrigo Bronze Martino Ana Maria Mendona Coelho Márcia Saldanha Kubrusly Regina Leito Sandra Nassa Sampietre Marcel Cerqueira Cesar Machado Telesforo Bacchella Luiz Augusto Carneiro D’Albuquerque | 2012 | World Journal of Gastrointestinal Surgery2012，4，6： | 2 |
| 3 | Beneficial effects of adenosine triphosphate-sensitive K^+ channel opener on liver ischemia/reperfusion injury显示文摘AIM:To investigate the effect of diazoxide administration on liver ischemia/reperfusion injury.METHODS:Wistar male rats underwent partial liver ischemia performed by clamping the pedicle from the medium and left anterior lateral segments for 1 h under mechanical ventilation.They were divided into 3 groups:Control Group,rats submitted to liver manipulation,Saline Group,rats received saline,and Diazoxide Group,rats received intravenous injection diazoxide(3.5 mg/kg) 15 min before liver reperfusion.4 h and 24 h after reperfusion,blood was collected for determination of aspartate transaminase(AST),alanine transaminase(ALT),tumor necrosis factor(TNF-α),interleukin-6(IL-6),interleukin-10(IL-10),nitrite/nitrate,creatinine and tumor growth factor-β1(TGF-β1).Liver tissues were assembled for mitochondrial oxidation and phosphorylation,malondialdehyde(MDA) content,and histologic analysis.Pulmonary vascular permeability and myeloperoxidase(MPO) were also determined.RESULTS:Four hours after reperfusion the diazoxide group presented with significant reduction of AST(2009 ± 257 U/L vs 3523 ± 424 U/L,P = 0.005); ALT(1794 ± 295 U/L vs 3316 ± 413 U/L,P = 0.005); TNF-α(17 ± 9 pg/mL vs 152 ± 43 pg/mL,P = 0.013; IL-6(62 ± 18 pg/mL vs 281 ± 92 pg/mL); IL-10(40 ± 9 pg/mL vs 78 ± 10 pg/mL P = 0.03),and nitrite/nitrate(3.8 ± 0.9 μmol/L vs 10.2 ± 2.4 μmol/L,P = 0.025) when compared to the saline group.A significant reduction in liver mitochondrial dysfunction was observed in the diazoxide group compared to the saline group(P < 0.05).No differences in liver MDA content,serum creatinine,pulmonary vascular permeability and MPO activity were observed between groups.Twenty four hours after reperfusion the diazoxide group showed a reduction of AST(495 ± 78 U/L vs 978 ± 192 U/L,P = 0.032); ALT(335 ± 59 U/L vs 742 ± 182 U/L,P = 0.048),and TGF-β1(11 ± 1 ng/mL vs 17 ± 0.5 ng/mL,P = 0.004) serum levels when compared to the saline group.The control group did not present alterations when compared to the diazoxide and saline groups.CONCLUSION:Diazoxide maintains liver mitochondrial function,increases liver tolerance to ischemia/reperfusion injury,and reduces the systemic inflammatory response.These effects require further evaluation for using in a clinical setting. | Mateus Antunes Nogueira Ana Maria Mendona Coelho Sandra Nassa Sampietre Rosely Antunes Patzina Fabiano Pinheiro da Silva Luiz Augusto Carneiro D'Albuquerque Marcel Cerqueira Cesar Machado | 2014 | World Journal of Gastroenterology2014，20，41： | 2 |
| 4 | Standardized Myocardial Segmentation and Nomenclature for Tomographic Imaging of the Heart: A Statement for Healthcare Professionals From the Cardiac Imaging Committee of the Council on Clinical Cardiology of the American Heart Association显示文摘 | Manuel D. Cerqueira Neil J. Weissman Vasken Dilsizian Alice K. Jacobs Sanjiv Kaul Warren K. Laskey Dudley J. Pennell John A. Rumberger Thomas Ryan Mario S. Verani | 2002 | Circulation: Journal of the American Heart Association2002，，： | 2 |
| 5 | β -Hydoxy- β -methylbutyrate supplementation affects Walker 256 tumor-bearing rats in a time-dependent manner显示文摘 | érico Chagas Caperuto Ronaldo Vagner Tomatieli Alison Colquhoun Marília Cerqueira Leite Seelaender Luis Fernando Bicudo Pereira Costa Rosa | 2006 | Clinical Nutrition2006，，1： | 2 |
| 6 | Impact of IFRS adoption on accounting quality in European firms显示文摘 | Cldudia Lopes Antonio Cerqueira Elisio Brandao | 2010 | Journal of Modern Accounting and Auditing2010，6，9： | 2 |
| 7 | Experimental and theoretical study of the ferroelectric and piezoelectric behavior of strontium-doped PZT显示文摘 | NASAR R S CERQUEIRA M LONGO E | 1999 | J Mater Sci1999，34，： | 2 |
| 8 | Standardized myocardial segmentation and nomenclature for tomographic imaging of the heart 显示文摘 | Cerqueira MD Weissman N J Dilsizian V | 2002 | Circulation2002，105，4： | 1 |
| 9 | Gaia: A Middleware In- frastructure to Enable Active Spaces显示文摘 | Roman M Hess C K Cerqueira R | 2002 | IEEE Pervasive Com- puting2002，1，4： | 1 |
| 10 | Standardized myocardial segmentation and nomenclature for tomographic imaging of the heart:a statement for healthcare professionals from the Cardiac Imaging Committee of the Council on Clinical Cardiology of the American Heart Association显示文摘 | Cerqueira MD Weissman N J Dilsizian V | 2002 | Int J Cardiovasc Imaging2002，18，1： | 1 |
| 11 | Dinamica-a stochastic cellular automata model designed to simulate the landscape dynamics in an Amazonian colonization frontier显示文摘 | Soares B S Cerqueira G C Pennachin C L | 2002 | Ecological Modelling2002，154，3： | 1 |
| 12 | Pulmonary involvement in ankylosing spondylitis 显示文摘 | Sampaio-Barros PD Cerqueira EM Rezende SM | 2007 | Clin Rheumatol2007，26，2： | 1 |
| 13 | Deactivation of FCC catalysts显示文摘 | Cerqueira H S Caeiro G Costa L | 2008 | Journal of Molecular Catalysis A: Chemical2008，292，12： | 1 |
| 14 | Carbapenem resist- ance in Acinetobacter baumannii: laboratop/ challenges, mecha- nistic insights and therapeutic strategies 显示文摘 | Abbott I Cerqueira GM Bhuiyan S | 2013 | Expert RevAnti In- fect Ther2013，11，4： | 1 |
| 15 | Corticosteroid receptors and neuroplasticity显示文摘 | Sousa N Cerqueira J J Almeida O F X | 2008 | Brain Research Reciews2008，57，2： | 1 |
| 16 | Large normal and reduced penetrance alleles in Huntington disease: instability in families and frequency at the laboratory, at the clinic and in the population 显示文摘 | Sequeiros J Ramos EM Cerqueira J | 2010 | Clin Genet2010，78，4： | 1 |
| 17 | Safety profile of adenosine stress perfusion imaging:results from the adeniscan multicenter trial registry显示文摘 | Cerqueira MD Verani MS Schwaiger M | 1994 | J Am Coll Cardiol1994，23，2： | 1 |
| 18 | Mechanical behaviour of polypropylene reinforced sugarcane bagasse fibers composites显示文摘 | Cerqueira E F Baptista C A R P Mulinari D R | 2011 | Procedia Engineering2011，10，： | 1 |
| 19 | Bio-oils upgrading for second generation biofuels显示文摘 | Graca I Lopes J M Cerqueira H S | | 0，，： | 1 |
| 20 | The utilization of diets containing high levels of fish protein hydrolysate by turbot ( Scophthalmus maximus) juveniles 显示文摘 | OLIVA-TELES A CERQUEIRA A L GONCALVES P | 1999 | Aquaculture1999，179，14： | 1 |
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