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| 1 | Japanese species of the Genus Stigmella(Nepticulidae;Lepidoptera)显示文摘 | | 1985 | Insecct Matsumura1985，32，： | 1 |
| 2 | Hypoxia-inducible factor induces local thyroid hormone inactivation during hypoxic-ischemic disease in rats显示文摘 | Simonides Warner S Mulcahey Michelle A Redout Everaldo M Muller Alice Zuidwijk Marian J Visser Theo J Wassen Frank W J S Crescenzi Alessandra da-Silva Wagner S Harney John Engel Felix B Obregon Maria-Jesús Larsen P Reed Bianco Antonio C Huan | 2008 | Journal of Clinical Investigation2008，，3： | 1 |
| 3 | Sustained efficacy of dialectical behaviour therapy for borderline personality disorder显示文摘 | Louisa M C van den Bosch Maarten W J Koeter Theo Stijnen | 2005 | Behavior Research and Therapy2005，，43： | 1 |
| 4 | Toxicological assessment of ambient and traffic-relat- ed particulate matter: A review of recent studies显示文摘 | Theo M C M de Kok Driece H A L Hogervorst J G F | 2006 | Mutation Research2006，613，： | 1 |
| 5 | Significance of Metal Exchange in EDDS-Flushing Column Experiments 显示文摘 | LO IRENE M C TSANG DANIEL C W YIP THEO C M | 2011 | Chemosphere2011，83，1： | 1 |
| 6 | The Boundary Element Method in the Forward and Inverse Problem ofElectrical Impedance Tomography 显示文摘 | Jan C de Munck Theo J C Faes Rob M Heethaar | 2000 | IEEE TransBioEng2000，47，6： | 1 |
| 7 | Verhallen Brand Confusion in Advertising 显示文摘 | Poiesz Theo B C Theo M M | 1989 | International Journal of Advertising1989，，8： | 1 |
| 8 | Evaluating Color Descriptors for Object and Scene Recognition 显示文摘 | Koen E A van de Sande Theo C evers CeesG M Snoek | 2010 | Pattern Analysis and Machine Intdligence2010，32，9： | 1 |
| 9 | Inhibition of trehalase activity enhances trehalose accumulation in transgenic plants显示文摘 | Oscar J M Goddijn Theo C Verwoerd Eline Voogd | 1997 | Plant Physiology1997，113，1： | 1 |
| 10 | An industry perspective on current and future state of the art in system-on-chip (Sot) technology显示文摘 | Theo A C M Claasen | 2006 | Proceedings of thelEEE2006，94，6： | 1 |
| 11 | The Boundary Element Method in the Forward and Inverse Problem of Electrical Impedance Tomography显示文摘 | Jan C de Munck Theo J C Faes Rob M Heethaar | 2000 | IEEE Trans Biomed Eng2000，47，6： | 1 |
| 12 | Color-based Object Recognition显示文摘 | Theo C evers Arnold W Smelders M | 1999 | Pattern Recognition1999，32，3： | 1 |
| 13 | Empiri- cal modeling of heavy metal extraction by EDDS from single-met- al and multi-metal contaminated soils显示文摘 | Theo C M Yip Daniel C W Tsang Kelvin T W Ng | 2009 | Chemosphere2009，74，2： | 1 |
| 14 | Influence ofEDDS-to-metal molar ratio, solution pH, and soid-to-solution ratio onmetal extraction under EDDS deficiency显示文摘 | Dickson Y S Yan Theo C M Yip Matthew M T Yui | 2010 | Journal of Hazardous Ma-terials2010，，178： | 1 |
| 15 | Inhibition of trehalase activity enhances trehalose accumulation in transgenic plants显示文摘 | Oscar J M Goddijin Theo C Verwoerd Eline Voogd | 1997 | Plant Physiol1997，113，： | 1 |
| 16 | Ophthalmic acid as a read-out for hepatic glutathione metabolism in humans显示文摘Background and Aim:Animal studies indicated that systemic ophthalmic acid(OPH)is a biomarker for hepatic glutathione(GSH)homeostasis,an important determinant of liver function.We aimed to clarify whether OPH levels can be used as a read-out for hepatic GSH homeostasis after paracetamol(APAP)challenges during pylorus-preserving pancreaticoduodenectomy(PPPD)or partial hepatectomy(PH).Methods:Nineteen patients undergoing PPPD(n=7,control group)or PH(n=12)were included.APAP(1000 mg)was administered intravenously before resection(first challenge),and six and twelve hours later,with sequential blood sampling during this period.Arterial,hepatic and portal venous blood samples and liver biopsies were taken on three occasions during the first APAP challenge.Plasma and hepatic OPH and GSH levels were quantified,and venous-arterial differences were calculated to study hepatic release.Results:Systemic GSH levels decreased during the course of the APAP challenge in both surgical groups,without notable change in OPH levels.Hepatic GSH and OPH content was not affected within^3 hours after administration of the first APAP dose in patients undergoing PPPD or PH.In this period,net release of OPH by the liver was observed only in patients undergoing PPPD.Conclusions:The drop in circulating GSH levels following APAP administrations,did not result in an increase in plasma OPH in both patients with an intact liver and in those undergoing liver resection.Hepatic content of GSH and OPH was not affected during the first APAP dose.It is uncertain whether hepatic GSH homeostasis was sufficiently challenged in the present study.Relevance for patients:In the present study,plasma OPH seemed not useful as a marker for GSH depletion because APAP administration during liver surgery did not lead to(immediate)GSH depletion or increased OPH levels.Based on stable levels of hepatic GSH,OPH and thiyl radicals during surgery,standard APAP administration seems to be safe in a postoperative care program with regards to GSH homeostasis in this specific population.However,no general statements can be made on the basis of the current experiment,since GSH homeostasis and susceptibility to xenobiotic toxicity are influenced by several metabolic and genetic factors. | Kim MC van Mierlo Simon AWG Dello Mechteld C de Jong Hans MH van Eijk Theo M de Kok Jacob J Briedé Frank G Schaap Steven WM Olde Damink Cornelius HC Dejong | 2017 | Journal of Clinical & Translational Research2017，3，4： | 0 |
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