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| 1 | Therapeutic and prophylactic thalidomide in TNBS-induced colitis: Synergistic effects on TNF-α, IL-12 and VEGF production显示文摘AIM: To evaluated the therapeutic and prophylactic effect of thalidomide on 2, 4, 6-trinitrobenzene sulfonic acid (TNBS)-induced colitis. Thalidomide has been reported to downregulate the expression of tumor necrosis factor a (TNF-α), IL-12, and vascular endothelial growth factor (VEGF), hallmarks of intestinal inflammation in Crohn's disease (CD). METHODS: Male Wistar rats were divided in five groups of ten animals each. Four groups received a rectal infusion of TNBS in ethanol. The first group was sacrificed 7 d after colitis induction. The second and third groups received either thalidomide or placebo by gavage and were sacrificed at 14 d. The fourth group received thalidomide 6 h before TNBS administration, and was sacrificed 7 d after induction. The fifth group acted as the control group and colitis was not induced. Histological inflammatory scores of the colon were performed and lamina propria CD4+ T cells, macrophages, and VEGF+ cells were detected by immunohistochemistry. TNF-a and IL-12 were quantified in the supernatant of organ cultures by ELISA. RESULTS: Significant reduction in the inflammatory score and in the percentage of VEGF+ cells was observed in the group treated with thalidomide compared with animals not treated with thalidomide. Both TNF-αand IL-12 levels were significantly reduced among TNBS induced colitis animals treated with thalidomide compared with animals that did not receive thalidomide. TNF-αlevels were also significantly reduced among the animals receiving thalidomide prophylaxis compared with untreated animals with TNBS-induced colitis. Intestinal levels of TNF-αand IL-12 were significantly correlated with the inflammatory score and the number of VEGF+ cells. CONCLUSION: Thalidomide significantly attenuates TNBS-induced colitis by inhibiting the intestinal production of TNF-α, IL-12, and VEGF. This effect may support the use of thalidomide as an alternate approach in selected patients with CD. | Ana Teresa Carvalho Heitor Souza Antonio Jose Carneiro Morgana Castelo-Branco Kalil Madi Alberto Schanaider Flavia Silva Fernando Antonio Pereira Júnior Márcia G Pereira Cláudio Tortori Ilana Dines Jane Carvalho Eduardo Rocha Celeste Elia | 2007 | World Journal of Gastroenterology2007，13，15： | 6 |
| 2 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 3 | Distribution and expression pattern of claudins 6,7, and 9 in diffuse-and intestinal-type gastric adenocarcinomas 显示文摘 | RENDON-HUERTA E TERESA F TERESA G M | 2010 | J Gastrointest Cancer2010，41，1： | 1 |
| 4 | Distribution and expression pattern of Claudins 6, 7, and 9 in diffuse-and intesti- nal-type gastric adenocarcinomas 显示文摘 | Rend6n-I-Iuerta E Teresa F Teresa G M | 2010 | J Gastrointest Cancer2010，41，1： | 1 |
| 5 | Transparent conducting Nnc oxide thin films doped with aluminum and molybdenum显示文摘 | JOEL N D TIMOTHY A G DAVID M W TERESA M B MATTHEW Y BOBBY T TIMOTHY J C | 2007 | Journal V-acuum Society Technology2007，25，4： | 1 |
| 6 | An observational study in 4 hospitals before and after implementation of a 10-page educational sell-study modular educational program on best practice for prevention of ventilator-associated pneumoni显示文摘 | Hilary M Jeanne E Teresa G | 2004 | Chest2004，125，： | 1 |
| 7 | The role of the entrepreneur in identifying international expansion as a strategic opportunity显示文摘 | Valle S A and Teresa G M | 2010 | International Journal of Information Management2010，30，6： | 1 |
| 8 | Determination of neutral and cationic herbicides in water by micellar electrokinetic capillary chromatography显示文摘 | ACEDO -VALENZUELA M I TERESA G D NIELENE M D ANTONIO S R | 2004 | Anal Chim Acta2004，519，： | 1 |
| 9 | Determination of odorous mixed chloro-bromoanisoles in water by solid-phase micro- exction and gas chromatography-mass detection 显示文摘 | Alfredo D Francesc V M Teresa G | 2005 | Journal of Chromatography A2005，1064，： | 1 |
| 10 | Adenine nucleotide translocase 3(ANT3) overexpression induces apoptosis in cultured cells显示文摘 | Monica Z Meritxell G Teresa M | 2004 | FEBS Letters2004，563，： | 1 |
| 11 | Pollen biology in four Mediterranean Quercus species显示文摘 | Teresa Gómez-Casero M T Hidalgo P J García-Mozo H Dominguez E Galán C | | 0，，： | 1 |
| 12 | Determination of odorous mixed chloro-bromoanisoles in water by solid-phase micro-extraction and gas chromatography-mass detection 显示文摘 | ALFREDO D FRANCESC V M TERESA G | 2005 | Journal of Chromatography A2005，，97： | 1 |
| 13 | Treatment review of sight threatening circumscribed choroidal haemangioma显示文摘AIM:To describe our clinical experience in treating circumscribed choroidal haemangioma(CCH)in a tertiary referral centre over a fifteen year period prior to photodynamic therapy. METHODS:The departmental database and photographic records of a tertiary referral center were used to identify patients who were treated for CCH between 1992 and 2007. Their case records were reviewed. RESULTS:Visual acuity improved(>2 Snellen lines)in eleven patients(69%)remained stable in one patient(6%) and deteriorated in four patients(25%).Six of the seven treated with brachytherapy and three of the four treated with transpupillary thermotherapy achieved better visual acuity after treatment.86%of patients treated within six months of onset of symptoms and 50%of patients treated after six months of onset of symptoms noted an improvement in visual acuity.Only one patient in our series had a final VA of 6/60 or worse.Mean follow-up was thirty-five months. CONCLUSION:Visual outcome is better when treatment is performed within 6 months of symptoms.The majority of patients achieved an improvement in visual acuity without any adverse effect following treatment. | James FT Li Yim Teresa Sandinha Jan M Kerr Diana Ritchie Ewan G Kemp | 2010 | International Journal of Ophthalmology(English edition)2010，3，2： | 1 |
| 14 | Determination of odorous mixed chloro-bromoanisoles in water by solid-phase micro-extraction and gas chromatography-mass detection 显示文摘 | Alfredo D Francesc V M Teresa G | 2005 | Journal of Chromatography A2005，1064，： | 1 |
| 15 | German demand for tourism in Spain显示文摘 | Teresa G M | 2007 | Tourism Man- agement2007，28，1： | 1 |
| 16 | Response surface methodology in the development of a stacking - sensitive capillary electrophoresis method for the analysis of tricyclic antidepressantsin human serum显示文摘 | Teresa G D Maria Isabel A V Nielene M D | 2005 | Eleetrophoresis2005，26，： | 1 |
| 17 | Enzymatic assays for xylanase and β-glucanase feed enzymes 显示文摘 | Cossona T Vendrellb A M Teresa B G | 1999 | Animal Feed Science and Technology1999，77，： | 1 |
| 18 | Preparation of hydrolysates from tobacco stalks and ethanolic fermentation by Saccharomyces cerevisiae 显示文摘 | Carlos M Teresa F Ram6n G | 2002 | World Journal of Microbiology and Biotechnology2002，18，9： | 1 |
| 19 | Prearation of hyfrolysates from tobacco stalks and ethanolic fermentation by Saccharomyces cerevisiae显示文摘 | Carlos M Teresa F Ramon G | 2002 | World J Microbiol Biotechnol2002，，18： | 1 |
| 20 | The contribution of publicly provided inputs to states ' economies 显示文摘 | Teresa G Therese J M | 1992 | Regional Science and Urban Economics1992，22，2： | 1 |
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