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104篇 您的检索式:作者名="TANAPAT P"
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1Notch signaling regulates expression of Mcl-1 andapoptosis in PPD-treated macrophages显示文摘巨噬细胞是为由细菌和病毒的感染的细胞的目标。感染的巨噬细胞的命运在决定主人免疫者反应的结果起一个关键作用。巨噬细胞的 Apoptotic 房间死亡被认为是消除病原体的保护的主人防卫并且感染房间。在这研究,我们调查了槽口在在与结核菌素对待的巨噬细胞调整 apoptosis 发信号的参与净化的蛋白质衍生物(PPD ) 。导出髓的巨噬细胞(BMM ) 与 PPD 对待或与 Mycobacterium bovis 杆菌 Calmette-Gué 感染了的鼠科的骨头; rin (BCG ) 导致了 Notch1 的 upregulation。这 upregulation 在 transcriptional 和翻译层次两个都与 anti-apoptotic 基因 mcl-1 的 upregulation 相关很好。Notch1 和 Mcl-1 的减少的层次在当一个 gamma secretase 禁止者(GSI ) 禁止处理槽口受体,被使用时,与 PPD 对待的 BMM 被观察。而且,在像巨噬细胞的房间线 RAW264.7 的 silencing Notch1 减少了 Mcl-1 蛋白质表示,建议那 Notch1 为在巨噬细胞的 Mcl-1 表示是批评的。apoptotic 房间的重要增加与车辆控制相比面对 GSI 与 PPD 在 BMM 的处理之上被观察对待的房间。最后,在人和老鼠的 mcl-1 倡导者的分析揭示了保存潜在的 CSL/RBP-Jκ有约束力的地点。与 mcl-1 倡导者一起的 Notch1 的协会被染色质 immunoprecipitation 证实。一起拿,这些结果显示 Notch1 禁止直接控制 mcl-1 倡导者与 PPD 刺激的巨噬细胞的 apoptosis。Tanapat P alaga Siriluk Ratanabunyong Thitiporn Pattarakankul Naunpun Sangphech Wipawee Wongchana Yukihiro Hadae Patipark Kueanjinda 2013Cellular & Molecular Immunology2013,10,5:4
2Sex differencesin dendritic atrophy of CA3 pyramidal neurons inresponse to chronic restraint stress显示文摘Galea LA McEwen BS Tanapat P 1997Neuroscience1997,81,:1
3Stress inhibits the proliferation of granule cell precursors in the developing dentate gyrus显示文摘 Galea Liisa AM Gould E 1998Int J Dev Neurosci1998,16,34:1
4Estrogen stimulates a transient increase in the number of new neurons in the dentate gyrus of the adult female rats显示文摘Tanapat P Nicholas B Hastings NB 1999J Neurosci1999,19,:1
5Learning enhances adult neurogenesis in the hippocampal formation 显示文摘Gould E Beylin A Tanapat P 1999Nat Neurosci1999,2,12:1
6Adrenal steroids and N-methyl-D-aspartate receptor activation regulate neurogenesis in the dentate gyrus of adult rats through a common pathway显示文摘Cameron HA Tanapat P Gould E 1998Neuroscience1998,82,2:1
7Lesion-induced proliferation of neuronal progenitors in the dentate gyrus of the adult rat显示文摘Gould E Tanapat P 1997Neuroscience1997,80,2:1
8Neurogenesis in the dentate gyrus of the adult tree shrew is regulated by psychosocial stress and NMDA receptor activation显示文摘 McEwen BS Tanapat P 1997J Neurosci1997,17,9:1
9Learning enhances adult neurogenesis in the adult hippocampal formation显示文摘Gouhl E Beylin A Tanapat P el al 1999Nat Neurosci1999,2,3:1
10Neurogenesis in adulthood: A possible role in learning 显示文摘Gould E Tanapat P Hastings NB 1999Trends Cogn Sci1999,3,:1
11Learning enhances adult neurgenesis in the hippocampal formation显示文摘 Beylin A Tanapat P 1999Nat Neurosci1999,2,:1
12Lesion-induced proliferation of neuronal progenitors in the dentate gyrus of adult rat 显示文摘Gould E Tanapat P 1997Neurosci1997,80,:1
13Sex diffe rences in dendritic atrophy of CA3 pyramidal neurons in response to chronic restraint stress 显示文摘Galea L A M McEwen B S Tanapat P 1997Neurosci1997,81,3:1
14Neurogenesis in thedentate gyrus of the adult tree shrew is regulated bypsychosocial stress and NMDA receptor activation 显示文摘Gould E McEwen BS Tanapat P 1997JNeurosci1997,17,7:1
15Estrogen stimulates a transient increase in the number of new neurons in the dentate gyms of the adult female rat 显示文摘Tanapat P Nicholas B Hastings NB 1999Neuro Sci1999,19,14:1
16Regulation of hippocampal neurogenesis in adulthood 显示文摘Gould E Tanapat P Rydel T 2000Biol Psychiatry2000,48,:1
17Neurogenesis in the Dentategyrus of the Adult Tree Shrew is Regulated by Psychosocial Stress and NMDA Receptor Activation显示文摘GOULD E MCEWEN BS TANAPAT P 1997J Neurosci(S0270-6474)1997,17,7:1
18Regulation of hippocampalneurogenesis in adulthood 显示文摘Gould E Tanapat P Rydel T 2000Biol Psychiatry2000,48,:1
19Learning enhances adult neuro- genesis in the hippocampal formation 显示文摘Gould E Beylin A Tanapat P et at 1999Nat Neurosci1999,2,3:1
20Learning enhances adult neurogenesis in the hippocampal formation 显示文摘Gould E Beylin A Tanapat P 1999Nat Neurosci1999,2,3:1
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