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| 1 | Recurrent headaches may be caused by cerebral toxoplasmosis显示文摘AIM: To establish seroprevalence and provide characteristics of Toxoplasma gondii(TG) infection in children with recurrent headaches. METHODS: The study was performed in 178 children aged 7-17 years admitted consecutively to the Department of Pediatric Neurology from November 2009 to July 2011. The children were surveyed with a questionnaire with the help and assistance of their parents and blood samples taken on admission were studied for the presence of specific anti-TG Ig M, Ig G antibodies and Ig G avidity using enzyme immunoassay Platelia Toxo Ig M, Ig G. RESULTS: The study showed that 19 children(8 boys, 11 girls; 8-17 years old, mean age 14.36 years) hadhigh serum anti-TG Ig G antibody levels(range: 32.2 > 240 UI/m L, mean 120.18 UI/m L; positive value for Ig G was ≥ 9 UI/m L). The avidity index(AI) ranged from 0.202 to 0.925(scale: ≥ 0.5 high AI). The results for Ig M antibodies were all negative and the obtained results ranged from 0.113 to 0.25 U/m L(mean = 0.191 IU/m L) and all values below 0.8 IU/m L were considered negative. The most frequent complaints found in the seropositive patients were headaches that affected the frontal(13 children), occipital(4) and parietal areas(5). Headaches usually had a pulsating(in 7 patients) and squeezing(6) character and rarely were piercing, dull or expanding. Interestingly, 8 children did not feel discomfort during the headaches, probably because they did not have sufficiently increased intracranial pressure yet. The headaches usually appeared 1-2 times/mo, lasted for 2-6 h, and had a mean intensity of 5.5 points in a 10 point subjective scale. The comorbidities included epilepsy(5 patients), various infections in 3 children(chronic eustachitis, chronic rhinitis, chronic purulent tonsillitis, streptococcal pharyngitis, meningitis, allergic diseases), disturbances of behavior, deficits of attention, and ocular and motor concentration disorders in 1 child. The electroencephalographic and neuroimaging studies performed in our patients had a very limited value in establishing cerebral toxoplasmosis.CONCLUSION: Ten point six seven percent of the studied children had markedly increased serum anti-TG Ig G antibodies and high AI indicated chronic infestation. It is suggested that tests for TG infection should be introduced to routine diagnostics in patients with recurrent headaches. | Joseph Prandota Anna Gryglas Aleksander Fuglewicz Agata Zesawska-Faleńczyk Barbara Ujma-Czapska Leszek Szenborn Janusz Mierzwa | 2014 | World Journal of Clinical Pediatrics2014，3，3： | 4 |
| 2 | Passive acquired immunity against measles in infants born to naturally infected and vaccinated mothers 显示文摘 | Szenborn L Tischer A Pejcz J | 2003 | Med Sci Monit2003，9，12： | 1 |
| 3 | Randomized, placebo- controlled trial of tenofovir disoproxil fumarate in adolescents with chronic hepatitis B 显示文摘 | Murray KF Szenborn L Wysocki J | 2012 | Hepatology2012，56，6： | 1 |
| 4 | Immunogenicity ofroutinely used childhood vaccines when coadministered withthe 10-valent pneumococcal non-typeable Haemophilus influ-enzae protein D conjugate vaccine(PHiD-CV)显示文摘 | Knuf M Szenborn L Moro M | 2009 | PediatrInfect Dis J2009，28，4： | 1 |
| 5 | Safety, reactogenicity and immunogenicity of the human rotavirus vaccine in preterm European Infants: a randomized phase IIIb study 显示文摘 | Omenaca F Sarlangue J Szenborn L | 2012 | Pediatr Infect Dis J2012，31，5： | 1 |
| 6 | The 10-valent pneumo- coccal non-typeable Haemophilus influenzae protein D conjugate vaccine (PHiD-CV) coadministered with DTPw-HBV / Hib and po- liovirus vaccines: assessment of immunogenicity 显示文摘 | Bermal N Szenborn L Chrobot A | 2009 | Pediatr infect Dis J2009，28，4： | 1 |
| 7 | Safety, reactogenicity and immunogenicity of the human rotavirus vaccine in preterm European infants: a randomized Phase Ib study 显示文摘 | Omenaca F Sarlangue J Szenborn L | 2012 | Pediatr Infect Dis J2012，31，5： | 1 |
| 8 | Respiratory tract infections in children in primary healthcare in Poland显示文摘 | Kuchar E Miskiewicz K Szenborn L | 2015 | Adv Exp Med Biol2015，35，11： | 1 |
| 9 | Immunogenicity of routinely used childhood vaccines when coadministered with the 10-valent pneumococcal non-typeable Haemophilus influenzae Protein D conjugate vaccine (PHiD-CV)显示文摘 | Knuf M Szenborn L Moro M | 2009 | Pediatr Infect Dis J2009，28，4： | 1 |
| 10 | The use of immunoglobulins in the treatment of infectious diseases 显示文摘 | Szenborn L | 2011 | Pol Merkur Lekarski2011，30，180： | 1 |
| 11 | Liver steatosis in Polish children assessed by medicolegal autopsies显示文摘 | Marta Rorat Tomasz Jurek Ernest Kuchar Leszek Szenborn Wojciech Golema Agnieszka Halon | 2013 | World Journal of Pediatrics2013，，1： | 1 |
| 12 | The 10-valentpneumococcal non-typeable Haemophilus influenzae protein Dconjugate vaccine(PHiD-CV)coadministered with DTPw-HBV/Hib and poliovirus vaccines:assessment of immunogenicity显示文摘 | Bermal N Szenborn L Chrobot A | 2009 | Pediatr Infect Dis J2009，28，4： | 1 |
| 13 | Immunogenicity of routinely used childhood vaccines when coadministered with the10-valent pneumococcal non-typeable Haemophilus influenzaeProtein D conjugate vac-cine(PHiD-CV)显示文摘 | Knuf M Szenborn L Moro M | 2009 | Pediatr Infect Dis J2009，28，4： | 1 |
| 14 | Procalcitonin and C-reactive protein-based decision tree model for distinguishing PFAPA flares from acute infections显示文摘 | Kraszewska-G|omba B Szymafiska-Toczek Z Szenborn L | 2016 | Bosn J Basic Med Sci2016，16，2： | 1 |
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