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| 1 | Clinicopathological significance of altered Notch signaling in extrahepatic cholangiocarcinoma and gallbladder carcinoma显示文摘AIM:To investigate the role and clinicopathological significance of aberrant expression of Notch receptors and Delta-like ligand-4 (DLL4) in extrahepatic cholangiocarcinoma and gallbladder carcinoma.METHODS:One hundred and ten patients had surgically resected extrahepatic cholangiocarcinoma (CC) and gallbladder carcinoma specimens examined by immunohistochemistry of available paraffin blocks.Immunohistochemistry was performed using anti-Notch receptors 1-4 and anti-DLL4 antibodies.We scored the immunopositivity of Notch receptors and DLL4 expression by percentage of positive tumor cells with cytoplasmic expression and intensity of immunostaining.Coexistent nuclear localization was evaluated.Clinicopatho-logical parameters and survival data were compared with the expression of Notch receptors 1-4 and DLL4.RESULTS:Notch receptor proteins showed in the cytoplasm with or without nuclear expression in cancer cells,as well as showing weak cytoplasmic expression in non-neoplastic cells.By semiquantitative evaluation,positive immunostaining of Notch receptor 1 was detected in 96 cases (87.3%),Notch receptor 2 in 97 (88.2%),Notch receptor 3 in 97 (88.2%),Notch receptor 4 in 103 (93.6),and DLL4 in 84 (76.4%).In addition,coex- istent nuclear localization was noted [Notch receptor 1;18 cases (18.8%),Notch receptor 2;40 (41.2%),Notch receptor 3;32 (33.0%),Notch receptor 4;99 (96.1%),DLL4;48 (57.1%)].Notch receptor 1 expression was correlated with advanced tumor,node,metastasis (TNM) stage (P=0.043),Notch receptor 3 with advanced T stage (P=0.017),tendency to express in cases with nodal metastasis (P=0.065) and advanced TNM stage (P=0.052).DLL4 expression tended to be related to less histological differentiation (P=0.095).Coexistent nuclear localization of Notch receptor 3 was related to no nodal metastasis (P=0.027) and Notch receptor 4 with less histological differentiation (P=0.036),while DLL4 tended to be related inversely with T stage (P=0.053).Coexistent nuclear localization of DLL4 was related to poor survival (P=0.002).CONCLUSION:Aberrant expression of Notch receptors 1 and 3 play a role during cancer progression,and cytoplasmic nuclear coexistence of DLL4 expression correlates with poor survival in extrahepatic CC and gallbladder carcinoma. | Hyun Ah Yoon Myung Hwan Noh Byung Geun Kim Ji Sun Han Jin Seok Jang Seok Ryeol Choi Jin Sook Jeong Jin Ho Chun | 2011 | World Journal of Gastroenterology2011，17，35： | 14 |
| 2 | Differential diagnosis of left-sided abdominal pain:Primary epiploic appendagitis vs colonic diverticulitis显示文摘AIM:To investigate the clinical characteristics of left primary epiploic appendagitis and to compare them with those of left colonic diverticulitis.METHODS:We retrospectively reviewed the clinical records and radiologic images of the patients who presented with left-sided acute abdominal pain and had computer tomography(CT) performed at the time of presentation showing radiological signs of left primary epiploic appendagitis(PEA) or left acute colonic diverticulitis(ACD) between January 2001 and December 2011. A total of 53 consecutive patients were enrolled and evaluated. We also compared the clinical characteristics,laboratory findings,treatments,and clinical results of left PEA with those of left ACD.RESULTS:Twenty-eight patients and twenty-five patients were diagnosed with symptomatic left PEA and ACD,respectively. The patients with left PEA had focal abdominal tenderness on the left lower quadrant(82.1%). On CT examination,most(89.3%) of the patients with left PEA were found to have an oval fatty mass with a hyperattenuated ring sign. In cases of left ACD,the patients presented with a more diffuse abdominal tenderness throughout the left side(52.0%vs 14.3%; P = 0.003). The patients with left ACD had fever and rebound tenderness more often than those with left PEA(40.0% vs 7.1%,P = 0.004; 52.0% vs14.3%,P = 0.003,respectively). Laboratory abnormalities such as leukocytosis were also more frequently observed in left ACD(52.0% vs 15.4%,P = 0.006).CONCLUSION:If patients have left-sided localized abdominal pain without associated symptoms or laboratory abnormalities,clinicians should suspect the diagnosis of PEA and consider a CT scan. | Jeong Ah Hwang Sun Moon Kim Hyun Jung Song Yu Mi Lee Kyung Min Moon Chang Gi Moon Hoon Sup Koo Kyung Ho Song Yong Seok Kim Tae Hee Lee Kyu Chan Huh Young Woo Choi Young Woo Kang Woo Suk Chung | 2013 | World Journal of Gastroenterology2013，19，40： | 6 |
| 3 | N-terminal pro-B-type natriuretic peptide as prognostic marker for patients of non ST-segment elevation myocardial infarction显示文摘In this work, we analyzed only the patients of the NSTEMI (non ST-segment elevation myocardial infarction) who arrived at the hospital within 12 h after symptoms started. Using NSTEMI follow-up data within, the characteristics of the clinical data, the risk factor, and the blood tested in the hospital visit were analyzed for MACE (major adverse cardiac events) patients. MACE includes cardiac death, MI (myocardial infarction), Re-PCI, and CABG (coronary artery bypass graft). As a result, from the NSTEMI patients which can be followed up for over 12 m, NT-ProBNP (p=0.014) and age (p=0.045) are found to be the independent risk factors related to MACE. Accordingly, they can be useful for the diagnosis and prognosis for NSTEMI patients as a biomarker. | SHON Ho Sun HWANG Kyung Kuk BAE Jang Whan KIM Kyung Ah LEE Jong Yun RYU Keun Ho | 2013 | Journal of Central South University2013，20，8： | 2 |
| 4 | Corticosteroid pharmacokinetics in the inner ear fluids:an animal study followed by clinical application显示文摘 | Parnes LS Sun AH Freeman DJ | 1999 | Laryngoscope1999，109，： | 1 |
| 5 | Rapid discrimination of newly isolated BaciUales with industrial applications using Raman spectroscopy显示文摘 | Deng AH Sun ZP Zhang GQ | 2012 | Laser Phys Lett2012，，： | 1 |
| 6 | Usefulness of continuous renal replacement therapy for correcting hypernatremia in a patient with severe congestive heart failure显示文摘 | Hoon Suk Park Yu Ah Hong Hyun Gyung Kim Sun Ryoung Choi In O. Sun Byung Ha Chung Cheol Whee Park Chul Woo Yang Yong Soo Kim Bum Soon Choi | 2012 | Hemodial Int2012，，4： | 1 |
| 7 | An effective method for determining the ingredients of Shuanghuanglian formula in blood samples using high-resolution LC-MS coupled with background subtraction and a multiple data processing approach显示文摘 | Yan GL Zhang AH Sun H | 2013 | J Sep Sci2013，36，19： | 1 |
| 8 | C orticosteroid phannacokinetics in theinner ear fluids :an animal study followed by clinical application显示文摘 | Parnes LS Sun AH Freeman DJ | 1999 | Larynogoscope1999，109，7： | 1 |
| 9 | Akt phosphorylates and negatively regulates apoptosis signal-regaling kinase 1 显示文摘 | Kim AH Klarsigma G Sun X el al | 2001 | Mol Cell Biol2001，21，3： | 1 |
| 10 | Phase I Clinical trial of Glivec in combination with tetra-arsenlc tetra-sulfide in the treatment of CML patients in advanced phase 显示文摘 | Li JM Wang AH Sun HP | 2004 | Blood2004，104，： | 1 |
| 11 | Comparison of serological detection effects of ELISA using rTpNl7 or rTpN47 of Treponema pallidum as antigen with that of TPHA and TRUST 显示文摘 | Sun AH Fan XL Mao YF | 2008 | J Zhejiang Uni (Med Ed)2008，37，1： | 1 |
| 12 | Corticsteroid pharmacokinetics in the inner ear fluids: an animal study followed by clinical application显示文摘 | Parnnes LS Sun AH Freeman DJ | 1999 | Laryngoscope1999，，： | 1 |
| 13 | Significance of COX-1, COX-2 and iNOS expression in superficial gastritis, gastric mucosa atypical hyperplasia and gastric carcinoma显示文摘 | Luo YQ Wu KC Sun AH Pan BR Zhang XY Fan DM | 2000 | Chin J Digestion(中华消化杂志)2000，20，4： | 1 |
| 14 | NMR structure and mutagenesis of the inhibitor of apoptosis protein XIAP J显示文摘 | Sun C Cai M Gunascdcra AH | 1999 | Nature1999，401，6755： | 1 |
| 15 | Ultra-performance liquid chromatography coupled to mass spectrometry as a sensitive and powerful technology for metabolomic studies 显示文摘 | Wang XJ Sun H Zhang AH | 2011 | J Sep Sci2011，34，24： | 1 |
| 16 | Treatment of Borrmann type IV gastric cancer with a neoadjuvant chemotherapy combination of docetaxel,cisplatin and 5-fluorouracil/leucovorin显示文摘 | Sun XC Lin J Ju AH | 2011 | J Int Med Res2011，39，6： | 1 |
| 17 | NMR structure and mutage ne- sis of the inhibition of apopotosis protein XIAP 显示文摘 | Sun C Cai M Gunasekera AH | 1999 | Nature1999，401，6755： | 1 |
| 18 | NMR structure and mutagenesis of the inhibitor of apoptosis protein XIAP显示文摘 | Sun CM C ai AH Gunasekera RP | 2001 | Nature2001，401，： | 1 |
| 19 | An effective method for determining the ingredients of Shuanghuanglian formula in- blood samples using high-resolution LC-MS coupled with background subtraction and a multiple data processing ap- proach显示文摘 | Yan GL Zhang AH Sun H | 2013 | Journal of Separation Science2013，36，19： | 1 |
| 20 | Surface Modification of Glass Epoxy Resin Using the Photocatalytic Reaction in TiO2 Dispersed Solution 显示文摘 | Gyung Guk Kim Joung Ah Kang Sun Jae Kim | 2008 | Journal of Alloys and Compounds2008，449，12： | 1 |
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