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| 1 | An Assessment of the Effects of General Anesthetics on Developing Brain Structure and Neurocognitive Function显示文摘 | Andreas W. Loepke Sulpicio G. Soriano | 2008 | Anesthesia & Analgesia2008，，6： | 1 |
| 2 | Levels of Soluble Adhesion Molecules Are Elevated in the Cerebrospinal Fluid of Children with Moyamoya Syndrome显示文摘 | Sulpicio G. Soriano Douglas B. Cowan Mark R. Proctor R. Michael Scott | 2002 | Neurosurgery2002，，： | 1 |
| 3 | 全身麻醉是否会影响婴儿和儿童的神经发育?显示文摘全身麻醉与中枢神经系统的异常发育明确相关,在实验模型中可导致神经认知功能损害。体外和体内研究都一致地显示GABA激动剂(如挥发性吸入麻醉剂、咪达唑仑和丙泊酚)或NMDA拮抗剂(如氯胺酮、异氟烷和一氧化二氮)的暴露能对多种神经传递系统产生剂量依赖和发育年龄依赖的作用。使用这些药物能增加幼龄动物包括大鼠、小鼠和非人灵长类神经元的死亡。麻醉剂诱导的神经毒性有可能发生在儿童身上,这引起了人们对小儿麻醉安全性的关注。据文献报道,儿童全身麻醉后可出现一系列行为改变,包括苏醒期谵妄,这可能是药物毒性的证据。不过,大部分是回顾性的临床研究,缺乏专门针对药物或监测的结果,而且很多结果指标不够敏感,难以发现微小的神经认知功能损害。这些回顾性研究中,有些显示了幼年时麻醉剂的暴露与神经认知功能损害相关,但其他研究则没有。因此,医生和家属应该放心,虽然全身麻醉药有可能诱发神经毒性,但几乎没有临床证据支持这种说法。 | Mary Ellen McCann Sulpicio G Sorianol 毛晨晖(译) | 2021 | 英国医学杂志中文版2021，24，2： | 1 |
| 4 | Levels of soluble adhesion molecules are elevated in the cerebrospinal fluid of children with moyamoya syndrome显示文摘 | Soriano MD Douglas B | 2002 | Neurosurgery2002，50，： | 1 |
| 5 | Levels of soluble adhesion molecules are elevated in the cerebrospinal fluid of children with moyamoya syndrome显示文摘 | Soriano MD Douglas B | 2002 | Neurosurgery2002，50，： | 1 |
| 6 | 反方:麻醉药物对发育期大脑的毒性作用——临床层面的考量显示文摘“所有模型都是错误,但有些模型却是有用的。
这句引自统计学家George E.P.Box的话似乎适用于时下关于儿科麻醉的一场激烈争论:即发育尚不成熟的大脑暴露于麻醉药物后是否会导致神经细胞凋亡。 | Andreas W. Loepke Francis X. McGowan Sulpicio G. Soriano 张宇(译) 米卫东(校) | 2009 | 麻醉与镇痛2009，，5： | 0 |
| 7 | Leukocyte function-associated antigen-1 deficiency impairs responses to polymicrobial sepsis显示文摘AIM: To determine the role of leukocyte functionassociated antigen-1(LFA-1) in polymicrobial sepsis model in mice.METHODS: Cecal ligation and puncture model was used to study polymicrobial sepsis in wild type and LFA-1 knockout(KO)(= CD11 a KO) mice. Their survivals were examined. Neutrophil recruitment to the abdominal cavity, bacterial tissue load and bacterial killing by neutrophils, tissue cytokine profiles, and serum cytokines were examined. Apoptosis of tissues was assessed using cleaved-caspase 3 and TUNNEL staining. The recruitment of neutrophils to various tissues was assessed using myeloperoxidase staining or measuring myeloperoxidase activity. RESULTS: LFA-1 deficiency significantly decreased survival(P = 0.0024) with the reduction of neutrophil recruitment to the abdominal cavity and higher bacterial load in blood. It was also associated with increased apoptosis in spleen and more organ injuries probed by interleukin-6 m RNA level. However, the deficiency of LFA-1 did not prevent neutrophil recruitment to lung, liver, spleen or kidney, which suggested the existence of LFA-1 independent recruitment mechanism in these organs. CONCLUSION: LFA-1 deficiency did not attenuate neutrophil recruitment to various organs to adequately mitigate secondary tissue injury in sepsis. It was associated with decreased neutrophil recruitment to the abdominal cavity, higher bacterial load, leading to increased mortality in an abdominal, polymicrobial sepsis. | Jia-Ren Liu Xiaohui Han Sulpicio G Soriano Koichi Yuki | 2015 | World Journal of Clinical Cases2015，3，9： | 0 |
| 8 | Anesthetic-Induced Developmental Neurotoxicity显示文摘1 IntroductionMillions of newborn and infants receive anesthetic,sedative and analgesic drugs for surgery and painful procedures on a daily basis.Recent laboratory reports clearly demonstrate that anesthetic and sedative drugs induced both neuroapoptosis and | Jia-Ren Liu Qian Liu Jing Li Sulpicio G. Soriano | 2011 | 赣南医学院学报2011，31，6： | 0 |
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