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| 1 | 国际疼痛研究协会疼痛定义修订版:概念、挑战和折中显示文摘现行国际疼痛研究协会(IASP)将疼痛定义为'与实际或潜在组织损伤,或描述的类似损伤相关的一种不愉快的感觉和情感体验',该定义是由一个分类小组委员会推荐,并于1979年被IASP理事会所采纳。这一定义已被疼痛领域的卫生保健专业人士和研究人员广泛接受,并被一些行业、政府及非政府组织(包括世界卫生组织)所采用。近年来,一些业内人士认为,随着对疼痛更深入的了解,有必要对这个定义重新审定,并提出了修改建议。因此,2018年,IASP成立了一个主席特别工作小组,该小组是由14名来自多个国家的在疼痛相关的临床和基础科学方面拥有广泛专业知识的人员组成,其任务是评估现行定义及其附带注释,并对其保留还是修改提出建议。本文提供了关键概念的摘要、对IASP会员和公众评论的分析以及两年内委员会对疼痛定义和注释的最终修订意见。特别工作小组最后建议将疼痛定义修改为'与组织损伤或潜在组织损伤相关或类似相关的一种不愉快的感觉和情感体验',并将原来的附带注释更新为一系列简要说明并提供相关词源。今年年初,IASP理事会一致接受了修订后的定义和注释。 | Raja SN.Carr DB Cohen M.Finnerup NB Flor H.Gibson S Keefe FJ.Mogil JS Ringkamp M.Sluka KA Song XJ.Stevens B Sullivan MD.Tutelman PR Ushida T.Vader K 程志祥(译) 许继军(译) 程建国(审校) 刘先国(审校) 刘延青(审校) | 2020 | 中华疼痛学杂志2020,16,5: | 137 |
| 2 | D-二聚体预测稳定型冠状动脉性心脏病患者的长期病因特异性死亡率、心血管事件和癌症显示文摘交联纤维蛋白的降解产物D-二聚体是高凝状态和血栓形成事件的标志。D-二聚体水平中度升高与血管疾病患者静脉和动脉事件的风险相关。在缺血性疾病长期普伐他汀干预(long-term intervention with pravastatin in ischemic disease,LIPID)试验中,研究者在存在其他危险因素的背景下,评估了D-二聚体水平在预测长期血管转归、病因特异性死亡率和新发癌症中的作用。 | 刘青 叶鹏 Simes J Robledo KP White HD Espinoza D Stewart RA Sullivan DR Zeller T Hague W Nestel PJ Glasziou PP Keech AC Elliott J Blankenberg S Tonkin AM LIPID study investigators | 2018 | 中华高血压杂志2018,26,3: | 6 |
| 3 | Osteoprotegerin: A Novel Secreted Protein Involved in the Regulation of Bone Density显示文摘 | W.S Simonet D.L Lacey C.R Dunstan M Kelley M.-S Chang R Lüthy H.Q Nguyen S Wooden L Bennett T Boone G Shimamoto M DeRose R Elliott A Colombero H.-L Tan G Trail J Sullivan E Davy N Bucay L Renshaw-Gegg T.M Hughes D Hill W Pattison P Campbell S Sander G Van | 1997 | Cell1997,,2: | 6 |
| 4 | Osteoprotegerin Ligand Is a Cytokine that Regulates Osteoclast Differentiation and Activation显示文摘 | D.L Lacey E Timms H.-L Tan M.J Kelley C.R Dunstan T Burgess R Elliott A Colombero G Elliott S Scully H Hsu J Sullivan N Hawkins E Davy C Capparelli A Eli Y.-X Qian S Kaufman I Sarosi V Shalhoub G Senaldi J Guo J Delaney W.J Boyle | 1998 | Cell1998,,2: | 4 |
| 5 | 脂质组学改善传统危险因素预测的2型糖尿病患者的心血管事件显示文摘临床脂质测定并未显示出糖尿病或心血管病相关的脂质代谢改变的复杂性。脂质组学则能够评估可作为疾病风险潜在标志物的数百种脂质种类。方法:纳入来自糖尿病治疗和血管保护行动。 | 刘莉 叶鹏 Alshehry ZH Mundra PA Barlow CK Mellett NA Wong G McConville MJ Simes J Tonkin AM Sullivan DR Barnes EH Nestel PJ Kingwell BA Marre M Neal B Poulter NR Rodgers A Williams B Zoungas S Hillis GS Chalmers J Woodward M Meikle PJ | 2016 | 中华高血压杂志2016,24,10: | 3 |
| 6 | Novel en-bloc resection of locally advanced hilar cholangiocarcinoma: the Rex recess approach显示文摘Loco-regional recurrence after potentially curative resection remains a problem in hilar cholangiocarcinoma. Hilar dissection risks local spillage of tumor cells leading to suboptimal disease free survival. We have developed a new technique of radical resection for hilar cholangiocarcinoma based on the distinctive anatomy of the Rex recess of the liver, which has been assessed in two patients with locally advanced hilar cholangiocarcinoma. This technique included a right hepatectomy with en-bloc resection of the hepatoduodenal ligament and portal venous reconstruction to the left portal vein at the Rex recess. Both patients had R0 resection and have been disease-free for 26 and 38 months, respectively. | Mohamed Rela Rajesh Rajalingam Vivekanandan Shanmugam Adrian O' Sullivan Mettu S Reddy Nigel Heaton | 2014 | Hepatobiliary & Pancreatic Diseases International2014,13,1: | 3 |
| 7 | 一种房颤风险评分系统的建立(Framingham心脏研究):基于社区的队列研究显示文摘背景房颤导致了发病率和病死率的显著上升。本研究旨在建立一种预测个体罹患房颤绝对风险的风险评分系统,并提供研究人员评价新危险因素的流程。方法作者评估了Framingham心脏研究中于1968年6月至1987年9月间进行了8044次检测的4764例参与者(55%为女性,年龄45~95岁)。此后,参与者被随访至房颤首发,随访期最长达10年。多变量Coxi回归确认出1(1年内罹患房颤的临床危险因素。次级分析纳入了常规超声心动图检测指标(5152例4参与者,7156次检测)对房颤风险进行再分层评估,并评价超声检测指标能否提高风险预测能力。结果4764例参与者中的457例4(10%)罹患房颤。年龄、性别、体重指数、收缩压、降压治疗、PR间期、有临床意义的心脏杂音及心力衰竭与房颤相关,并被纳入了风险评分模型(除体重指数P=0.08外,其余均为P〈0.05),模型的C统计量为0.78(95%CI0.76~0.80)。10年房颤风险随年龄变化:年龄〈65岁的人群中53例(1%)风险高于15%,而〉65岁的人群中为783例(27%)。为提高预测能力而纳入超声检测指标仅使模型C统计量略微增高,由0.78(95%C10.75~0.80)增至0.79(95%CI0.77~0.82:P=0.005)。超声心动图检测指标并不能改善风险再分层评估(P=0.18)。结论基于社区医疗中易得的临床因素建立的风险评分系统,有助于确认社区个体罹患房颤的风险,评估技术或标志物能否改善风险预测,以及针对高危个体采取预防措施。 | Renate B Schnabel Lisa M Sullivan Daniel Levy Michael J Pencina Joseph M Massaro Ralph B D'Agostino Sr Christopher Newton-Cheh Jennifer F Yamamoto Jared W Magnani Thomas M Tadros William B Kannel Thomas J Wang Patrick T Ellinor Philip A Wolf Ramachanclran S Vasan Emelia J Benjamin 黄刚(译) | 2009 | 世界临床医学2009,,9: | 2 |
| 8 | Purification and characterization of toxins A and B of Clostridium difficile显示文摘 | Sullivan NM Pellet S Wilkins TD | 1982 | Infect Immun1982,35,: | 2 |
| 9 | Cause-related marketing How generation Y responds 显示文摘 | Cui Yanli Trent Elizabeth S Sullivan Pauline M Matiru Grace N | 2003 | International Journal of Retail & Distribution Management2003,31,67: | 1 |
| 10 | SV40- encoded microRNAs regulate viral gene expression and reduce susceptibility to cytotoxic T cells 显示文摘 | Sullivan C S Grundhoff A T Tevethia S | 2005 | Nature2005,435,7042: | 1 |
| 11 | A range of clinical phenotypes associated with mutations in CRX,a photoreceptor transcription-factor gene显示文摘 | Sullivan L S Mintz-Hittner H A | 1998 | Am J Hum Genet1998,63,: | 1 |
| 12 | Identification and characterization of an off virus homo logue of the vaccinia virusgene encoding the major envelop antigen p37k显示文摘 | Mercer A A Flening S B | 1994 | Virology1994,202,: | 1 |
| 13 | Automated DNA profiling by fluorescent labeling of PCR product显示文摘 | Sullivan KM Pope S Gill P | 1992 | PCR Methods Appl1992,2,1: | 1 |
| 14 | Characterization of plant p23-like proteins for their co-chaperone activities 显示文摘 | Zhang Z M Sullivan W Felts S J | 2010 | Cell Stress Chaperones2010,15,5: | 1 |
| 15 | Inflammatory markers and risk of heart failure in elderly subjects without prior myocardial infarction : the Framingham Heart Study 显示文摘 | VASAN R S SULLIVAN L M ROUBEN R | 2003 | Circulartion2003,107,11: | 1 |
| 16 | FoxD5a, a Xenopus winged helix gene, maintains an immature neural ectoderm via transcriptional repression that is dependent on the C-terminal domain显示文摘 | Sullivan S A Akers L Moody S A | 2001 | Dev Biol2001,232,: | 1 |
| 17 | Kumada-Corriu Reactions in a Pressure-Driven Microflow Reactor显示文摘 | Haswell S J O'Sullivan B Styring P | 2001 | Lab Chip2001,1,2: | 1 |
| 18 | Diffusion tensor ima- ging of thalamus correlates with cognition in CADASIL without dementia显示文摘 | O'Sullivan M Singhal S Charlton R | 2004 | Neurology2004,62,5: | 1 |
| 19 | The place of eprints in scholarly information delivery显示文摘 | Garner J Horwood L Sullivan S | 2001 | Online Information Review2001,25,4: | 1 |
| 20 | Dexmedetomidine vs haloperidol in delirious, agitated, intubed patients: a randomised open-label trial显示文摘 | Reade MC O'Sullivan K Bates S | 2009 | Crit Care2009,13,3: | 1 |