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| 1 | Combined carriership of TLR9 -1237C and CD14 -260T alleles enhances the risk of developing chronic relapsing pouchitis显示文摘AIM: To investigate the single nucleotide polymorphisms (SNPs) in genes involved in bacterial recognition and the susceptibility to pouchitis or pouchitis severity.METHODS: Analyses of CD14 -260C>T, CARD15/NOD2 3020insC, Toll-like receptor (TLR)4 +896A>G,TLR9 -1237T>C, TLR9+ 2848G>A, and IRAKM +22148G>A SNPs were performed in 157 ileal-pouch anal anastomosis (IPAA) patients (79 patients who did not develop pouchitis, 43 infrequent pouchitis patients,35 chronic relapsing pouchitis patients) and 224 Italian Caucasian healthy controls.RESULTS: No significant differences were found in SNP frequencies between controls and IPAA patients.However, a significant difference in carriership frequency of the TLR9-1237C allele was found between the infrequent pouchitis and chronic relapsing pouchitis groups [P = 0.028, odd's ratio (OR) = 3.2, 95%CI = 1.2-8.6].This allele uniquely represented a 4-locus TLR9 haplotype comprising both studied TLR9 SNPs in Caucasians.Carrier trait analysis revealed an enhanced combined carriership of the alleles TLR9 -1237C and CD14 -260T in the chronic relapsing pouchitis and infrequent pouchitis group (P = 0.018, OR = 4.1, 95%CI = 1.4 -12.3).CONCLUSION: There is no evidence that the SNPs predispose to the need for IPAA surgery. The significant increase of the combined carriership of the CD14 -260T and TLR9 -1237C alleles in the chronic relapsing pouchitis group suggests that these markers identify a subgroup of IPAA patients with a risk of developing chronic or refractory pouchitis. | KM Lammers S Ouburg SA Morré JBA Crusius P Gionchetti F Rizzello C Morselli E Caramelli R Conte G Poggioli M Campieri AS Pea | 2005 | World Journal of Gastroenterology2005，11，46： | 7 |
| 2 | Diversity of endophytes across the soil-plant continuum for Atriplex spp. in arid environments显示文摘Endophytes are hypothesized to be transferred across the soil-plant continuum, suggesting both the transfers of endophytes from environment to plant and from plant to soil. To verify this hypothesis and to assess the role of locality, we evaluated the similarity of microbial communities commonly found both in soils and endophytic communities in three arid regions, i.e. the Jornada LTER(Long Term Ecological Research) site in New Mexico, USA, and the research station of Jordan University of Science and Technology(JUST) and Khanasri research station in Badia region of Jordan. Rhizosphere and non-rhizosphere soils, leaves and seeds of Atriplex spp. were sampled. Diversity and distribution of bacteria and fungi across the soil-plant continuums were assessed by tag-encoded FLX amplicon pyrosequencing and sequence alignment. Of the total bacterial OTUs(operational taxonomic units), 0.17% in Khanasri research station, 0.16% in research station of JUST, and 0.42% in Jornada LTER site were commonly found across all the plant and soil compartments. The same was true for fungi in two regions, i.e. 1.56% in research station of JUST and 0.86% in Jornada LTER site. However, in Khanasri research station, 12.08% of total fungi OTUs were found in at least one soil compartment and one plant compartment. Putative Arthrobacter, Sporosarcina, Cladosporium and members of Proteobacteria and Actinobacteria were found across all the soil-plant continuums. Ascomycota, mainly including Didymellaceae, Pleosporaceae and Davidiellaceae were present across all the soil-plant continuums. Microbial communities in two regions of Jordan were similar to each other, but both of them were different from the Jornada LTER site of USA. SIMPER(similarity percentage) analysis of bacterial and fungal taxa for both soil and endophyte communities revealed that dissimilarities of two bacterial genera(Arthrobacter and Sporosarcina) and two fungal genera(Cladosporium and Alternaria) are very high, so they play key roles in the soil-plant continuums. A weighed Pearson correlation analysis for the specific bacterial OTUs in the soil-plant continuums only showed high similarity between the two regions of Jordan. However, fungal groups showed higher similarities among all regions. This research supports the hypothesis of continuity of certain bacterial and fungal communities across the soil-plant continuums, and also explores the influences of plant species and geographic specificity on diversity and distribution of bacteria and fungi. | Mohammad E TAHTAMOUNI Sa'eb KHRESAT Mary LUCERO Jesus SIGALA Adrian UNC | 2016 | Journal of Arid Land2016，8，2： | 4 |
| 3 | 添加乳酸菌对慢性疲劳综合症(CFS)的影响显示文摘有关研究显示:肠道菌群失衡和免疫系统遭破坏是造成慢性疲劳综合症(CFS)发病原因之一,乳酸菌可以用来预防和减轻肠道功能紊乱,使身体内各细胞水平恢复正常,这对患有慢性疲劳综合症的病人或许有帮助。研究的目的是评价副乾酪乳杆菌(lactobacillus paracasei F19)、嗜酸乳杆菌(Lactobacillus acidophilus NCFB1748)和乳双歧杆菌(Bifidobacterium lactis Bb12)对慢性疲劳综合症病人的治疗效果。根据1994年美国疾病控制和预防中心制定的CFS标准,15个符合该标准的病人参与了此项研究。这些病人都患有严重的疲劳综合症。试验前2周观察,接下来4周服用乳酸菌,然后观察4周,最后对其健康状况进行评估,并且对粪便中的微生物数量也进行分析研究。在研究期间,这些病人的精神面貌和神经认知能力都得到了改善,在疲劳程度和身体运动评分方面没有明显变化。在肠胃菌群方面的变化差异不显著。结果显示其中6名病人的病情得到明显改善。研究表明利用乳酸菌来改善健康和治疗慢性疲劳综合症是有可能的,值得进一步研究。 | Sa Sullivan Carl E Nord Birgitta Evengrd 赵剑闯 周勃 | 2011 | 饲料与畜牧(新饲料)2011，，3： | 2 |
| 4 | 视网膜病变、视网膜微血管异常与脑卒中、脑血管病的关系显示文摘视网膜循环异常可能与脑血管病有关。该研究基于英国的三民族人口的基础队列调查了视网膜微血管异常与脑卒中和亚临床脑梗死及脑白质病变之间的相关性。方法:纳入1185名受试者[年龄(68.8±6.1)岁,77%为男性]进行视网膜成像和脑磁共振成像。利用磁共振成像识别脑梗死和脑白质高信号,对视网膜病变进行分级,并测量视网膜血管参数。 | 刘莉 叶鹏 Hughes AD Falaschetti E Witt N Wijetunge S Thom SA Tillin T Aldington SJ Chaturvedi N | 2016 | 中华高血压杂志2016，24，11： | 2 |
| 5 | 卒中介入治疗培训指南:国际多学会共识文件显示文摘1背景
缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞(emergent large vesselocclusion,ELVO)患者都会遗留长期残疾。事实上,这些颅内大动脉闭塞经常会导致大面积脑损伤,进而造成患者死亡或严重致残。 | Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩 孙瑞 郭芮兵 | 2017 | 国际脑血管病杂志2017，25，5： | 2 |
| 6 | Non-pharmacological management of pediatric functional abdominal pain disorders:Current evidence and future perspectives显示文摘Functional abdominal pain disorders(FAPDs) are an important and prevalent cause of functional gastrointestinal disorders among children, encompassing the diagnoses of functional dyspepsia, irritable bowel syndrome, abdominal migraine, and the one not previously present in Rome Ⅲ, functional abdominal pain not otherwise specified. In the absence of sufficiently effective and safe pharmacological treatments for this public problem, non-pharmacological therapies emerge as a viable means of treating these patients, avoiding not only possible side effects, but also unnecessary prescription, since many of the pharmacological treatments prescribed do not have good efficacy when compared to placebo. Thus, the present study provides a review of current and relevant evidence on non-pharmacological management of FAPDs, covering the most commonly indicated treatments, from cognitive behavioral therapy to meditation, acupuncture, yoga, massage, spinal manipulation, moxibustion, and physical activities. In addition, this article also analyzes the quality of publications in the area, assessing whether it is possible to state if non-pharmacological therapies are viable, safe, and sufficiently well-based for an appropriate and effective prescription of these treatments. Finally, it is possible to observe an increase not only in the number of publications on the non-pharmacological treatments for FAPDs in recent years, but also an increase in the quality of these publications. Finally, the sample selection of satisfactory age groups in these studies enables the formulation of specific guidelines for this age group, thus avoiding the need for adaptation of prescriptions initially made for adults, but for children use. | Maria Luísa Cordeiro Santos Ronaldo Teixeira da Silva Júnior Breno Bittencourt de Brito Filipe Antônio França da Silva Hanna Santos Marques Vinícius Lima de SouzaGonçalves Talita Costa dos Santos Carolina Ladeia Cirne Natália Oliveira e Silva Márcio Vasconcelos Oliveira Fabrício Freire de Melo | 2022 | World Journal of Clinical Pediatrics2022，11，2： | 2 |
| 7 | 血管生成素样蛋白2水平与肾移植术后主动脉僵硬度和死亡率呈正相关显示文摘血管生成素样蛋白2(angiopoietin-like-2,ANGPTL2)是一种分泌性糖蛋白,可诱发血管内皮功能障碍、动脉粥样硬化和心血管病。循环ANGPTL2在慢性肾脏病(chronic kidney disease,CKD)患者中增加,加重患心血管病的风险。 | Desjardins MP Thorin-Trescases N Sidibé A Fortier C DeSerres SA Larivière R Thorin E Agharazii M 陈云 叶鹏 | 2017 | 中华高血压杂志2017，25，12： | 2 |
| 8 | Reduction of blood flow impedance in the uterine arteries of infertile women with electro-acupuncture 显示文摘 | Stener-Vietofin E Waldenstrom U Andersson SA | 1996 | Hum Reprod1996，11，6： | 1 |
| 9 | Role for a bidentate ribonuelease in the initiation step of RNA interference 显示文摘 | Bernstein E Caudy AA Hammond SA | 2001 | Nature2001，409，： | 1 |
| 10 | Mitochondrio-nuclear translocation of AIF in apoptosis and necrosis显示文摘 | DAUGAS E SUSIN SA ZAMZAMI N | 2000 | FASEB J2000，14，： | 1 |
| 11 | Peritumoral CD1a-positive dendritic cells are associated with improved survival in patients with tongue carcinoma显示文摘 | Goldman SA Baker E Weyant RJ | 1998 | Arch Otolaryngol Head Neck Surg1998，124，： | 1 |
| 12 | Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death显示文摘 | Joza N Susin SA Daugas E | 2001 | Nature2001，410，6828： | 1 |
| 13 | Optimal arrangement of magnetic coils for functional magnetic stimulation of the inspiratory muscles in dogs显示文摘 | Lin VW Zhu E Sasse SA | 2005 | IEEE Trans Neural Syst Rehabil Eng2005，13，4： | 1 |
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| 15 | A randomized, double-blind comparison of olanzapine/fluoxetine combination,olanzapine, and fluoxetine in treatment-resistant major depressivedisorder显示文摘 | Thasem E Copya SA Osuntokun O | 2007 | JClin Psychiatry2007，68，2： | 1 |
| 16 | A Prospective Audit of the Complications of Loop ileostomy Construction and Takedown 显示文摘 | Garcta-Botello SA Garcfa-Armengol J Garcia-Granero E | 2004 | Dig Surg2004，21，56： | 1 |
| 17 | Antioxidant phospholipid calix[4]arene mimics as micellular delivery systems显示文摘 | James E Eggers PK Harvey AR Dunlop SA Fitzgerald M Stubbs KA Raston CL | | 0，，： | 1 |
| 18 | Prevalence and impact of mental and physical comorbidity in the adult Singapore population显示文摘 | Chong SA Abdin E Nan L | | 0，，： | 1 |
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| 20 | The Incidence of Neuro- Ophthalmic Diseases in Singapore: a prospective study in public hospitals 显示文摘 | Lim SA Wong WL Fu E | 2009 | Ophthalmic Epidemiol2009，2，： | 1 |
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